The Effects of Pioglitazone on Respiratory Function Test in Patients with Asthma and Type 2 Diabetes Mellitus- A before –after Study

Objective: Pioglitazone is one of the oral medications of type 2 diabetes (T2DM). The purpose of this study was to evaluate the effect of pioglitazone on asthma and diabetes treatment outcomes among patients with concurrent asthma and T2DM. Materials and Methods: We conducted a quasi-experimental study on 11 patients with concurrent asthma and T2DM in Yazd Afshar Hospital and Yazd diabetic research center 2014-2017. The inclusion criteria were patients between 20-60 years old, at least one year with concurrent asthma and T2DM (documented with spirometer, bronchodilator test), ejection fraction more than 50%. Patients who were smoker, on oral corticosteroids, phenobarbital, methotrexate, rifampin, phenytoin and gemfibrozil were excluded. Laboratory tests (FBS, HbA1c, 2hpp, leptin), spirometer test, exhaled nitric oxide were done before and after 10 weeks of pioglitazone medication. All patients were visited every two weeks. The before and after pioglitazone treatment differences were checked by paired t-test and Wilcoxon Rank sum test. Results: The mean (± SD) age of participants was 55.81 (±7.66). The median of differences of leptin (p-value: 0.885), FEV1 to FVC ( P -value: 0.185), FEV1 (p-value: 0.386), NO ( P -value: 0.574), FVC percent ( P -value: 0.477), FEV1 percent ( P -value: 0.515) did not differ before and after pioglitazone treatment. Conclusion: Our finding suggested that pioglitazone may not be effective in the treatment and improvement of respiratory function in T2DM with concurrent asthma.

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Factors Associated with the Remission of Type 1 Diastolic Dysfunction after Dapagliflozin Treatment in Patients with Type 2 Diabetes

Journal of Clinical Medicine ◽

10.3390/jcm9113779 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3779

Author(s):

Adina Braha ◽

Alin Albai ◽

Romulus Timar ◽

Laura Diaconu ◽

Lucian Vasiluță ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diastolic Dysfunction ◽

Liver Stiffness ◽

Initial Stiffness ◽

Reduced Ejection Fraction ◽

Before And After ◽

Background Therapy ◽

One Year

Patients with type 2 diabetes (T2DM) are at high risk of developing cardiovascular disease and heart failure (HF), both with preserved and reduced ejection fraction of the left ventricle. Previous research demonstrated that dapagliflozin treatment is associated with the remission of type 1 diastolic dysfunction (DD1) in patients with T2DM. The main aim of this study was to evaluate the possible baseline predictors associated with the remission of DD1 in patients with T2D after one year of dapagliflozin treatment. In this prospective and observational study, 45 patients with T2DM were evaluated before and after one year of treatment with 10 mg dapagliflozin daily added to their background therapy. In the studied group, 73.3% (33/45) of the patients had DD1 at baseline. The primary outcome of this research was DD1 remission. DD1 remission was associated with improvement of liver stiffness, an increase in estimated glomerular filtration rate (eGFR), and a decrease in hemoglobin A1c (HbA1c). Independent predictors for the remission of DD1 were a more than 0.4 kPa difference in the initial stiffness score and the 1-year assessment fibrosis score and a duration of diabetes ≤8 years. Age, body mass index (BMI), or patient weight after one year did not influence the DD1 outcome. Patients with a T2DM duration of less than eight years have the additional benefit of DD1 remission associated with dapagliflozin treatment beyond the conventional benefits such as improvements in glycemic control, cardiovascular, renal, and hepatic risk reductions. In patients with T2DM, the remission of DD1 was associated with decrease of liver stiffness.

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Motivational Interviewing to Improve Self-efficacy in Type 2 Diabetes Management

10.21203/rs.3.rs-22939/v1 ◽

2020 ◽

Author(s):

Masumeh Hemmati Maslakpak ◽

Naser Parizad ◽

Amir Ghahremani ◽

Vahid Alinejad

Keyword(s):

Type 2 Diabetes ◽

Motivational Interviewing ◽

Self Efficacy ◽

Diabetes Management ◽

Intervention Group ◽

Significant Difference ◽

Before And After ◽

Quasi Experimental ◽

The Mean

Abstract Background Self-efficacy predicts adherence to treatment in patients with diabetes. Motivational interviewing could be a promising intervention to increase the patients’ motivation to follow therapeutic recommendations. The present study aimed to assess the effects of motivational interviewing on self-efficacy in type 2 diabetes management. Methods This quasi-experimental study with a pretest-posttest design was conducted on 60 patients with type 2 diabetes, who were members of the Bukan Diabetes Association in Iran. The patients were selected using a random number table and were randomly allocated into intervention (n = 30) and control (n = 30) groups. Five motivational interviewing sessions (30–45 minutes) were held for the intervention group (two sessions per week). Data were collected using a demographic questionnaire and the diabetes management self-efficacy scale (DMSES). Data were analyzed with SPSS software version 14.0 using descriptive and inferential statistics. Results Sixty patients entered the analysis. A significant difference was observed in the mean score of diabetes management self-efficacy between the two groups before and after the intervention (P = 0.014). The mean score of self-efficacy in diabetes management was increased significantly in the intervention group after MI (P = 0.001). Conclusions Motivational interviewing improved self-efficacy in diabetes management. Thus, this approach is recommended to be used in patients with type 2 diabetes in order to increase their self-efficacy.

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Literacy in health and self-care in people with type 2 diabetes mellitus

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2018-0291 ◽

2019 ◽

Vol 72 (3) ◽

pp. 700-706 ◽

Cited By ~ 1

Author(s):

Nádya dos Santos Moura ◽

Bárbara Brandão Lopes ◽

João Joadson Duarte Teixeira ◽

Mônica Oliveira Batista Oriá ◽

Neiva Francenely Cunha Vieira ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Self Care ◽

Family Health ◽

Educational Interventions ◽

Functional Health ◽

Before And After ◽

Quasi Experimental

ABSTRACT Objective: To evaluate the effect of educational intervention in the adherence to self-care activities and functional health literacy and numeracy in people with type 2 diabetes mellitus. Methods: This was a quasi-experimental study conducted in two units of the Brazilian Family Health Strategy, involving people with diabetes. Educational interventions occurred in three meetings, weekly, lasting 60 minutes on average. Data were collected using the Questionário de Autocuidado com o Diabetes, before and after the interventions. Results: 55 people participated in the study. After the interventions, the greatest difference for a better adherence to self-care was the item “inspecting the inside of the shoes before putting them on”, with 3.29 days in the week delta at analytical level. The worst was “taking insulin shots as recommended”, with 0.00 days a week delta at basic level. Conclusion: Educational interventions had a positive effect on adherence to self-care and functional literacy in health.

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Evaluation of the of Positive Psychology Training Effectiveness on Rumination and Depression in Women with Type 2 Diabetes

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v13i3.7185 ◽

2021 ◽

Author(s):

Shabnam Homayoun Rad ◽

Fatemeh Hasani Adeliyan ◽

Fatemeh Raesi ◽

Seyedeh Afsaneh Sehat ◽

Javad Seyed Jafari ◽

...

Keyword(s):

Type 2 Diabetes ◽

Positive Psychology ◽

Control Group ◽

P Value ◽

Educational Training ◽

Statistical Population ◽

Medical Centers ◽

Post Test ◽

Quasi Experimental

Objective: Preventing chronic diseases is important for public health. The aim of this study was evaluation the effectiveness of positive psychology (PP) training on rumination and depression in women with type 2 diabetes mellitus (T2DM). Materials and Methods: This research was a quasi-experimental design and a pre-test-post-test with a control group. The statistical population of the present study consisted of women with T2DM. By referring to the medical centers of regions 7, 4, 11, and 16 in Tehran, 30 people were selected by purposive sampling method. Data collection tools in this study were two standard questionnaires of Nolen-Hoeksema and Beck Depression (1978) and positive educational training and guidance protocol. Data were analyzed using SPSS ver. 21. Results: The results showed that PP training has a positive and significant effect on decrease rumination in women with T2DM (Pvalue= 0.001). Also, PP training has a positive and significant effect on reducing depression in women with T2DM (P-value= 0.002). The PP training had a greater effect on rumination in women with T2DM than depression. Conclusion: Positive training in psychology has an impact on rumination and depression in women with T2DM, according to the findings. The findings of the study show that therapeutic intervention for rumination and stress is subordinated to the health network's planned working processes.

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Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance

ISRN Endocrinology ◽

10.1155/2013/148497 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Lisa Arnetz ◽

Neda Rajamand Ekberg ◽

Charlotte Höybye ◽

Kerstin Brismar ◽

Michael Alvarsson

Keyword(s):

Type 2 Diabetes ◽

Adipose Tissue ◽

Insulin Sensitivity ◽

Acth Stimulation Test ◽

Acth Stimulation ◽

Igf I ◽

Before And After ◽

Subcutaneous Adipose ◽

Pioglitazone Treatment

Background. Hypercortisolism and type 2 diabetes (T2D) share clinical characteristics. We examined pioglitazone's effects on the GH-IGF-I and HPA axes in men with varying glucose intolerance. Methods. 10 men with T2D and 10 with IGT received pioglitazone 30–45 mg for 12 weeks. OGTT with microdialysis in subcutaneous adipose tissue and 1 μg ACTH-stimulation test were performed before and after. Glucose, insulin, IGF-I, IGFBP1, and interstitial measurements were analyzed during the OGTT. Insulin sensitivity was estimated using HOMA-IR. Results. HOMA-IR improved in both groups. IGF-I was initially lower in T2D subjects () and increased during treatment ( to SD; ); no change was seen in IGT ( SD before and during treatment). Fasting glycerol decreased in T2D (), indicating reduced lipolysis. Fasting cortisol decreased in T2D ( to nmol/L; ) but increased in IGT ( to nmol/L; ). Peak cortisol was lower in T2D during treatment ( to , versus to nmol/L in IGT; ). Conclusions. Pioglitazone improved adipose tissue and liver insulin sensitivity in both groups. This may explain increased IGF-I in T2D. Pioglitazone affected cortisol levels in both groups but differently, suggesting different mechanisms for improving insulin sensitivity between T2D and IGT.

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Diabetes Remission after Nonsurgical Intensive Lifestyle Intervention in Obese Patients with Type 2 Diabetes

Journal of Diabetes Research ◽

10.1155/2015/468704 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 11

Author(s):

Adham Mottalib ◽

Mahmoud Sakr ◽

Mohamed Shehabeldin ◽

Osama Hamdy

Keyword(s):

Type 2 Diabetes ◽

Complete Remission ◽

Lifestyle Intervention ◽

Weight Reduction ◽

Diabetes Remission ◽

Obese Patients ◽

Intensive Lifestyle Intervention ◽

Oral Medications ◽

One Year

Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week intensive program for diabetes weight management in real-world clinical practice. Among 120 obese patients with type 2 diabetes who completed the program, 88 patients returned for follow-up at one year. Nineteen patients (21.6%) had major improvement in their glycemic control, defined as achieving an A1C <6.5% after one year. Four patients (4.5%) achieved either partial or complete diabetes remission defined as A1C <6.5% and <5.7%, respectively, on no antihyperglycemic medications for one year; 2 achieved partial remission (2.3%) and 2 achieved complete remission (2.3%). At the time of intervention, patients who achieved diabetes remission had shorter diabetes duration (<5 years) and lower A1C (<8%) and were treated with fewer than 2 oral medications. They achieved a weight reduction of >7% after 12 weeks. These results indicate that a subset of obese patients with type 2 diabetes is appropriate for intensive lifestyle intervention with the aim of inducing diabetes remission.

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Edukasi Senam Kaki terhadap Kemampuan Melakukan Senam Kaki pada Penderita Diabetes Melitus Tipe 2 di Puskesmas Kereng Bangkirai Palangka Raya

Jurnal Surya Medika ◽

10.33084/jsm.v5i1.951 ◽

2019 ◽

Vol 5 (1) ◽

pp. 100-114

Author(s):

Yuyun Christyanni ◽

Novi Mery Kala Aheng ◽

Yongwan Nyamin

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Health Center ◽

Sampling Technique ◽

P Value ◽

Audiovisual Media ◽

Before And After ◽

Post Test

The incidence of diabetes mellitus shows an increasing prevalence today. This condition is influenced by the lack of knowledge of clients in the management of Diabetes Mellitus. Efforts to increase knowledge can be done through education using media and effective methods. The use of audiovisual media is believed to be the most effective media in conveying information. Education in this study used audiovisual media that was applied in conjunction with the demonstration method. The purpose of this study was to analyze the effect of education with audiovisual media and demonstration methods on the ability to do foot exercises in patients with Type 2 Diabetes Mellitus in the work area of KerengBangkirai Health Center, Palangka Raya. The research method used was a quasy experiment with one group pre and post-test design. The sampling technique was done by purposive sampling as many as 30 peoples. The results showed that there were differences in knowledge and ability to do foot exercise before and after the education which was shown from the results of the paired t-test obtained p-value = 0,000 <a = 0.05. Foot exercise education with audiovisual media and demonstrations had an effect on the ability to do foot exercise in patients with Type 2 Diabetes Mellitus in the working area of Kereng Bangkirai Health Center.

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HYPOGLYCEMIC EFFECT OF KAIDARYADI KWATHA YOGA IN TYPE 2 DIABETES MELLITUS

10.36106/paripex/5601760 ◽

2020 ◽

pp. 47-49

Author(s):

Archana V S ◽

N. Subhash Babu ◽

Aswathy. S

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Hypoglycemic Effect ◽

Control Group ◽

P Value ◽

Before And After ◽

Insulin Dependent ◽

Behavioural Factors

Type 2 diabetes mellitus, previously referred to as ‘Non insulin dependent’ or ‘maturity onset diabetes’ is a heterogenous condition characterised by variable defects in both insulin secretion and insulin action. In conjunction with genetic susceptibility, type 2 diabetes mellitus is brought on by environmental and behavioural factors such as sedentary lifestyle and obesity. Due the resultant microvascular and macrovascular complications, it possess great economic and functional burden. This study was undertaken to clinically evaluate the hypoglycemic effect of the well known Ayurvedic formulation Kaidaryadi kwatha yoga in Type 2 Diabetes mellitus. The study was conducted pre and post without control group in 30 patients. FBS, PPBS and HbA1c was done before and after treatment. Statistical analysis revealed significant reduction in FBS, PPBS and HbA1c levels with a p value <0.001. Thus the formulation was found to be effective in reducing the glycemic levels and symptoms of Type 2 Diabetes mellitus.

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Impact of COVID 19 Lockdown on Glycemic Control in Patients with Type 2 Diabetes Mellitus in Dubai

Current Diabetes Reviews ◽

10.2174/1573399818666211208102729 ◽

2021 ◽

Vol 18 ◽

Author(s):

Ibtehal Makki ◽

Nouf Alnoon ◽

Najma Rahmani ◽

Jawaher Almulla ◽

Asma Alamiri ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

P Value ◽

Before And After ◽

The Mean ◽

Design And Methods ◽

The Impact

Objective: The objective of this study is to evaluate the impact of the COVID-19 lockdown on glycemic control and accompanying laboratory parameters in patients with type 2 Diabetes Mellitus. Research design and methods: This study is a retrospective cohort study that was done on a multicenter level. It was conducted during the lockdown in 341 individuals. HbA1c was tested to measure glycemic control immediately before and after the lockdown period that lasted for 13 weeks. Results: The primary outcome was the improvement of mean HbA1C after 13 weeks of lockdown compared to the pre-lockdown HbA1C. It was found that the mean HbA1C improved from 7.5±1.5 to 7.3±1.5 with a p-value of 0.001. Conclusion: Our study showed that patients with type 2 diabetes mellitus exhibited an improvement in their glycemic control after the period of lockdown.

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Motivational Interviewing to Improve Self-efficacy in Type 2 Diabetes Management

10.21203/rs.3.rs-22939/v2 ◽

2020 ◽

Author(s):

Masumeh Hemmati Maslakpak ◽

Naser Parizad ◽

Amir Ghahremani ◽

Vahid Alinejad

Keyword(s):

Type 2 Diabetes ◽

Motivational Interviewing ◽

Self Efficacy ◽

Diabetes Management ◽

Intervention Group ◽

Significant Difference ◽

Before And After ◽

Quasi Experimental ◽

The Mean

Abstract Background: Self-efficacy predicts adherence to treatment in patients with diabetes. Motivational interviewing could be a promising intervention to increase the patients’ motivation to follow therapeutic recommendations. The present study aimed to assess the effects of motivational interviewing on self-efficacy in type 2 diabetes management. Methods: This quasi-experimental study with a pretest-posttest design was conducted on 60 patients with type 2 diabetes, who were members of the Bukan Diabetes Association in Iran. The patients were selected using a random number table and were randomly allocated into intervention (n=30) and control (n=30) groups. Five motivational interviewing sessions (30-45 minutes) were held for the intervention group (two sessions per week). Data were collected using a demographic questionnaire and the diabetes management self-efficacy scale (DMSES). Data were analyzed with SPSS software version 14.0 using descriptive and inferential statistics.Results: Sixty patients entered the analysis. A significant difference was observed in the mean score of diabetes management self-efficacy between the two groups before and after the intervention (P=0.014). The mean score of self-efficacy in diabetes management was increased significantly in the intervention group after MI (P=0.001).Conclusions: Motivational interviewing improved self-efficacy in diabetes management. Thus, this approach is recommended to be used in patients with type 2 diabetes in order to increase their self-efficacy.

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