scholarly journals The Effect of Hydroalcoholic Rosmarinus Officinalis (Rosemary) on Memory Retention Deficit in Young Offspring Rat Induced by Maternal Sleep Deprivation

2020 ◽  
Author(s):  
Fatemeh Khodabandeh Shahraki ◽  
Mohammad Nabiuni ◽  
Mona Farhadi ◽  
Elaheh Amini
Keyword(s):  
Sleep Deprivation ◽  
Brain Slices ◽  
Rosmarinus Officinalis ◽  
Hippocampal Neurogenesis ◽  
Rosemary Extract ◽  
Control Group ◽  
Pregnant Rats ◽  
Maternal Sleep ◽  
Avoidance Memory ◽  
Maternal Sleep Deprivation

Background:  Maternal sleep deprivation is known to reduce neurogenesis in the hippocampus during pregnancy. Also, it damages and impairs cognitive functions such as learning and memory in the neonates. Objectives: Rosmarinus officinalis (rosemary) extract can play an important role in the treatment of cognitive impairments by inhibiting oxidative stress. This study aimed to investigate the role of hydroalcoholic extract of rosemary in the treatment of cognitive impairment caused by decreased hippocampal neurogenesis in neonates, which was attributed to maternal sleep deprivation during pregnancy. Methods: For this purpose, pregnant rats in the control group underwent sleep deprivation for 72 hours inside a total sleep deprivation machine. The treatment groups comprised pregnant rats, receiving 50, 100, and 200 mg/kg of rosemary extracts per day during pregnancy and underwent sleep deprivation for 72 hours. Next, the avoidance memory of 21-day-old neonatal rats was examined using a shuttle box. These 21-day-old rats were then subjected to evaluate the structure of the hippocampus. Neurogenesis in the neonatal hippocampus was examined under light microscopy by staining of brain slices and counting of neurons and cells shape study. Results: Compared with the control group, the neurogenesis and avoidance memory decreased in neonates affected by maternal sleep deprivation. Conclusion: The results of this study showed that rosemary extract at a dose of 100 mg/kg was able to improve disorders in the infants affected by maternal sleep deprivation.

scholarly journals The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Fawzi Mohammad Al Sheyab ◽  
Nizar Abuharfeil ◽  
Lina Salloum ◽  
Rehan Bani Hani ◽  
Dalal Saleh Awad
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coconut Oil ◽  
Normal Diet ◽  
Rosmarinus Officinalis ◽  
Immunoglobulin M ◽  
Rosemary Extract ◽  
Control Group ◽  
Immunomodulatory Activity ◽  
Rosmarinus Officinalis L

The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(- 68.57%), low density lipoprotein (LDL) (- 56.34%), and triglycerides (TG) (- 182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

scholarly journals Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice

2016 ◽  
Vol 21 (4) ◽  
pp. NP85-NP90 ◽  
Author(s):  
Mosayeb Noori Ahmad Abadi ◽  
Mohsen Mortazavi ◽  
Navid Kalani ◽  
Hadi Zare Marzouni ◽  
Wesam Kooti ◽  
...  
Keyword(s):  
Side Effects ◽  
Statistical Tests ◽  
Rosmarinus Officinalis ◽  
Rosemary Extract ◽  
Control Group ◽  
Standard Drug ◽  
Hydroalcoholic Extract ◽  
Plus Maze ◽  
Significant Difference ◽  
Rosmarinus Officinalis L

In today’s stressful world, psychopathy (especially anxiety) is receiving increased importance. Most of the drugs used to treat this disease have several side effects. Medicinal plants derived from natural products have fewer side effects and can be used in the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of Rosmarinus officinalis L. on anxiety in mice. In this experimental study, 50 male mice were randomly divided into 5 groups. To evaluate anxiety, the Elevated Plus Maze test was performed. The control group received normal saline, the positive control group received diazepam (1 mg/kg) as intraperitoneal injection, and the experimental groups received doses of 100, 200, and 400 mg/kg body weight of rosemary extract. The data were analyzed using SPSS 15 and ANOVA statistical tests. The results show that rosemary extract dose-dependently increases the mice spending time and the entries number of mice in plus maze open arms (indicating less stress). This effect at a dose of 400 mg/kg was similar to diazepam, which, in comparison to the control group, was statistically significant ( P < .01), while the evaluation of locomotor activity in treated groups, compared with the control groups, showed no significant difference ( P > .05). On the other hand, the rosemary extract, similar to the standard drug diazepam, showed an anti-anxiety effect. This effect is probably due to the presence of flavonoids in this plant and their antioxidant property.

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