Clinicopathological profile and molecular characteristics in lung cancer patients in a tertiary care hospital

Abstract Aims: The primary objective of this study was to estimate the clinicopathological and molecular profile of lung cancer patients along with the evaluation of their clinical characteristics at a tertiary care hospital in Northern India. Subjects and Methods: A total of 421 patients with lung cancer histology who were treated at Max Super Speciality Hospitals were included in the study. The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and permission was obtained from the Ethics Committee before the start of the study. Clinical characteristics and molecular profiling data were collected from the patient's medical records. Results: There were 330 (78.4%) men and 91 (21.6%) women with a median age of 62 years (range: 30–93 years). Of the 421 patients, 388 (92.2%) patients had the nonsmall cell lung cancer (NSCLC) histology whereas 33 (7.8%) patients were of SCLC histology. Histology and gender had a significant association with NSCLC and SCLC (P < 0.05). Epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene testing was done in 120 and 93 patients, respectively. Of the 120 patients, 24 (20%) cases were positive for EGFR mutations whereas EML4-ALK fusion gene was present in 8 (8.6%) out of 93 patients. Conclusions: Our study confirms the importance of molecular testing in the NSCLC patient subgroup with an aim to identify the exact molecular targets that can benefit from the newer generation of targeted therapies.

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PROFILE OF LUNG CANCER PATIENTS AT TERTIARY CARE HOSPITAL OF NORTH INDIA

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/952 ◽

2017 ◽

Vol 6 (60) ◽

pp. 4403-4406

Author(s):

Anand Kumar ◽

Luvkush Luvkush ◽

Sanjay Verma ◽

Prashant Yadav ◽

Avadhesh Kumar ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

North India ◽

Care Hospital ◽

Lung Cancer Patients

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A study to assess prevalence of treatment default among lung cancer patients registered at a tertiary care hospital

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182843 ◽

2018 ◽

Vol 6 (7) ◽

pp. 2499

Author(s):

Lokendra Dave ◽

Vikas Mishra ◽

Rakesh C. Gupta ◽

Neeraj Gour ◽

Nishant Shrivastava ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Tertiary Care ◽

Primary Lung Cancer ◽

Drop Out ◽

Primary Data ◽

Care Hospital ◽

Cross Sectional ◽

Lung Cancer Patients ◽

Treatment Default

Background: Lung cancer is among the five main types of cancer leading to overall cancer mortality contributing about 1.3 million deaths/year globally. Completion of treatment among lung cancer patients is one of key factor for the survival and longevity of patients. So, we have tried to find out prevalence of treatment default through this study.Methods: This is a cross-sectional descriptive study (including retrospective secondary and prospective primary data) using data base of patients of primary lung cancer diagnosed between 1st January 2006 to 31st December 2012 in indoor and outdoor of department of Respiratory Medicine, J.L.N. Medical College, Ajmer, a tertiary level hospital and teaching center.Results: Incidence of lung cancer is significantly higher among young female (10.23%) as compared to young male (8.74 %). Whereas in older group number of male suffering from lung cancer than female. Total 269 (20.7%) patients defaulted from planned treatment and most of them ultimately drop-out from chemotherapy cycles. Intercycle delay of 2 weeks-1m commonly seen.Conclusions: It provides future implication to researchers to explore reasons of these defaults and drop outs so that more evidences can be generated in this direction for the ultimate betterment of lung cancer patients.

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