Antimicrobial Susceptibility Pattern of the Blood Stream Infection Isolates in Neutropenic Patients on Chemotherapy for Solid Malignancies

Aim of this study was to know the prevalence of Coagulase Negative Staphylococci (CoNS) in Blood Stream Infection (BSI) among patients attending a Superspeciality hospital in North India. Objective of this study was to compare incidence of CoNS in ICU and ward patients suffering from BSI and their antimicrobial susceptibility pattern. This retrospective hospital based study was conducted in the Microbiology Department, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow for a period of two years (January, 2017 -December, 2018). Blood samples from a total of 6498 patients from Out-Patient, In-Patient and Intensive care unit departments were subjected to aerobic and anaerobic bacterial culture. Culture positive broth was subcultured on Blood Agar and MacConkey Agar to isolate pathogens in pure culture. Pure cultured isolates were tested for antimicrobial susceptibility pattern by Kirby Bauer Disk Diffusion method as per CLSI 2018.During the study period, out of total 3284 samples in 2017 and 3214 in 2018, 663 and 595 were found to be culture positive respectively.Staphylococci were isolated from 636 (9.78%) patients (10.2% in 2017 and 9.2% in 2018). Staphylococcus aureus was isolated from 18.8% and CoNS from 81.2% of total Staphylococcal isolates. Among CoNS isolates 70.7% were found to be Methicillin Resistant CoNS (MRCoNS). This study observed CoNS as a major cause of BSI as compared to Staphylococcus aureusThe significance of CONS bacteremia should be evaluated better in light of clinical profile of the patient. Better screening and infection control practices in the future can decrease the rate of methicillin resistant CoNS in our centre.

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Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi

BMC Infectious Diseases ◽

10.1186/s12879-020-05725-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pizga Kumwenda ◽

Emmanuel C. Adukwu ◽

Ebot S. Tabe ◽

Victor. C. Ujor ◽

Pocha S. Kamudumuli ◽

...

Keyword(s):

Antimicrobial Susceptibility ◽

Bacterial Infections ◽

Blood Stream ◽

Tertiary Hospital ◽

Sub Saharan Africa ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Management Options ◽

Subsequent Increase ◽

Antimicrobial Susceptibility Pattern

Abstract Background Bacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients accessing medical care at a tertiary hospital in Malawi. Methods We retrospectively reviewed bacteria culture and antimicrobial susceptibility records for 4617 patients from 2002 to 2014 at Mzuzu Central Hospital (MCH). No inclusion and exclusion criteria were followed. Data was analysed using excel (Microsoft office, USA) and GraphPad prism 7 software programs. Results The most prevalent isolates were S. aureus (34.7%, n = 783), Klebsiella species (17.4%, n = 393) and Proteus species (11.4%, n = 256). Most microorganisms were isolated from adults (88.3%, n = 3889) and pus was the main source (69.3%, n = 1224). S. pneumoniae was predominantly isolated from cerebrospinal fluid (60.3%, n = 44) largely collected from children (88.2%, n = 64). Overall, most bacteria exhibited high resistance to all regularly used antimicrobials excluding ciprofloxacin. Conclusions Our report demonstrates an increase in bacterial infection burden in sites other than blood stream and subsequent increase in prevalence of antimicrobial resistance for all major isolates. Creating an epidemiological survey unit at MCH will be essential to help inform better treatment and management options for patients with bacterial infections.

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Prevalence, Distribution and Antimicrobial Susceptibility Pattern of Bacterial Isolates from a Tertiary Hospital in Malawi

10.21203/rs.3.rs-36411/v2 ◽

2020 ◽

Author(s):

Pizga Kumwenda ◽

Emmanuel C. Adukwu ◽

Ebot S. Tabe ◽

Victor C Ujor ◽

Pocha S. Kamudumuli ◽

...

Keyword(s):

Antimicrobial Susceptibility ◽

Bacterial Infections ◽

Blood Stream ◽

Tertiary Hospital ◽

Sub Saharan Africa ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Management Options ◽

Subsequent Increase ◽

Antimicrobial Susceptibility Pattern

Abstract Background Bacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients accessing medical care at a tertiary hospital in Malawi. Methods We retrospectively reviewed bacteria culture and antimicrobial susceptibility records for 4,617 patients from 2002 to 2014 at Mzuzu Central Hospital (MCH). No inclusion and exclusion criteria were followed. Data was analysed using excel (Microsoft office, USA) and GraphPad prism 7 software programs. Results The most prevalent isolates were S. aureus (34.7%, n = 783), Klebsiella species (17.4%, n = 393) and Proteus species (11.4%, n = 256). Most microorganisms were isolated from adults (88.3%, n = 3889) and pus was the main source (69.3%, n = 1224). S. pneumoniae was predominantly isolated from cerebrospinal fluid (60.3%, n = 44) largely collected from children (88.2%, n = 64). Overall, most bacteria exhibited high resistance to all regularly used antimicrobials excluding ciprofloxacin. Conclusions Our report demonstrates an increase in bacterial infection burden in sites other than blood stream and subsequent increase in prevalence of antimicrobial resistance for all major isolates. Creating an epidemiological survey unit at MCH will be essential to help inform better treatment and management options for patients with bacterial infections.

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Distribution and Antimicrobial Susceptibility Pattern of Blood Stream Pathogens in a Tertiary Care Hospital from Suburban, Mumbai

Indian Journal of Public Health Research & Development ◽

10.5958/0976-5506.2015.00177.1 ◽

2015 ◽

Vol 6 (3) ◽

pp. 258

Author(s):

AR Chauhan ◽

PM Ukey ◽

PS Desai ◽

M Mathur

Keyword(s):

Antimicrobial Susceptibility ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Blood Stream ◽

Care Hospital ◽

Susceptibility Pattern ◽

Antimicrobial Susceptibility Pattern

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The Bacterial Profile And Antibiotic Susceptibility Pattern Among Patients With Suspected Blood Stream Infection

The Journal of Sylhet Women’s Medical College ◽

10.47648/jswmc2021v11-06 ◽

2021 ◽

Vol 11 (Number 1) ◽

pp. 44-52

Author(s):

Jilwatun-Noor ◽

Golam Rob Mahmud ◽

Firoza Sultana ◽

Kaniz Fatema ◽

Mohsina Khatoon ◽

...

Keyword(s):

Antimicrobial Susceptibility ◽

Antibiotic Susceptibility ◽

Blood Stream Infection ◽

Bacterial Pathogens ◽

Blood Stream ◽

Multi Drug Resistance ◽

Susceptibility Pattern ◽

Positive Role ◽

Antibiotic Susceptibility Pattern ◽

Blood Samples

Background: Blood stream infection cause by bacterial pathogens are common in Bangladesh and are often treated empirically. Knowledge of local antimicrobial activity profiles of the most common bacteria causing such infections are of great importance and may play a positive role in healthcare management.The aim of the study was to identify the bacterial pathogens causing bacteraemiaamong the patients of SylhetWomens Medical College,Bangladesh and to determine their antibiotic susceptibility pattern. Method:This retrospective cross-sectional study was conducted from April 2019 to January 2020. A total of 2085 blood samples were studied for the etiological and antimicrobial susceptibility pattern .The blood cultures positive isolates were identified by Versa TREK automated blood culture machine. Further identification of bacterial pathogens and their antimicrobial susceptibility test were performed using standard microbiological procedures. Result: Overall, 19.4% of the culture blood samples were positive and Gram positive bacteria were predominant throughout the study period. Staphylococci aureus was the most frequently isolated organism (55%) followed by Escherichia Coli (21%) and a high percentage of these isolates were multidrug resistant (MDR). Conclusion:This study reveals a significant prevalence of bacterial isolates in blood with multi drug resistance and it highlights the need for periodic surveillance of etiologic agent and antibiotic susceptibility to prevent further emergence and spread of resistant bacterial pathogens.

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Prevalence, Distribution and Antimicrobial Susceptibility Pattern of Bacterial Isolates from a Tertiary Hospital in Malawi

10.21203/rs.3.rs-36411/v3 ◽

2021 ◽

Author(s):

Pizga Kumwenda ◽

Emmanuel C. Adukwu ◽

Ebot S. Tabe ◽

Victor C Ujor ◽

Pocha S. Kamudumuli ◽

...

Keyword(s):

Antimicrobial Susceptibility ◽

Bacterial Infections ◽

Blood Stream ◽

Tertiary Hospital ◽

Sub Saharan Africa ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Management Options ◽

Subsequent Increase ◽

Antimicrobial Susceptibility Pattern

Abstract Background Bacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients accessing medical care at a tertiary hospital in Malawi. Methods We retrospectively reviewed bacteria culture and antimicrobial susceptibility records for 4,617 patients from 2002 to 2014 at Mzuzu Central Hospital (MCH). No inclusion and exclusion criteria were followed. Data was analysed using excel (Microsoft office, USA) and GraphPad prism 7 software programs. Results The most prevalent isolates were S. aureus (34.7%, n = 783), Klebsiella species (17.4%, n = 393) and Proteus species (11.4%, n = 256). Most microorganisms were isolated from adults (88.3%, n = 3889) and pus was the main source (69.3%, n = 1224). S. pneumoniae was predominantly isolated from cerebrospinal fluid (60.3%, n = 44) largely collected from children (88.2%, n = 64). Overall, most bacteria exhibited high resistance to all regularly used antimicrobials excluding ciprofloxacin. Conclusions Our report demonstrates an increase in bacterial infection burden in sites other than blood stream and subsequent increase in prevalence of antimicrobial resistance for all major isolates. Creating an epidemiological survey unit at MCH will be essential to help inform better treatment and management options for patients with bacterial infections.

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