scholarly journals Downregulation of HADH promotes gastric cancer progression via Akt signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76279-76289 ◽  
Author(s):  
Congcong Shen ◽  
Yao-Hua Song ◽  
Yufeng Xie ◽  
Xiaoxiao Wang ◽  
Yunliang Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Gastric Cancer Progression

Nectin-4 promotes gastric cancer progression via the PI3K/AKT signaling pathway

2018 ◽  
Vol 72 ◽  
pp. 107-116 ◽  
Author(s):  
Yan Zhang ◽  
Peisheng Chen ◽  
Wei Yin ◽  
Ye Ji ◽  
Qin Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Gastric Cancer Progression

scholarly journals Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway

2020 ◽  
Vol 12 (11) ◽  
pp. 1237-1254
Author(s):  
Lin Yao ◽  
Peng-Cheng Ye ◽  
Wang Tan ◽  
Ya-Jun Luo ◽  
Wan-Ping Xiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Gastric Cancer Progression

scholarly journals SU6668 modulates prostate cancer progression by downregulating MTDH/AKT signaling pathway

2017 ◽  
Vol 50 (5) ◽  
pp. 1601-1611 ◽  
Author(s):  
Benjiang Qian ◽  
Yi Yao ◽  
Changming Liu ◽  
Jiabing Zhang ◽  
Huihong Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Prostate Cancer Progression ◽  
Akt Signaling Pathway

scholarly journals The tRNA-derived fragment 5026a inhibits the proliferation of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Linwen Zhu ◽  
Zhe Li ◽  
Xiuchong Yu ◽  
Yao Ruan ◽  
Yijing Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Gastric Cancer Cells ◽  
Qrt Pcr

Abstract Background Recently, tRNA-derived fragments (tRFs) have been shown to serve important biological functions. However, the role of tRFs in gastric cancer has not been fully elucidated. This study aimed to identify the tumor suppressor role of tRF-5026a (tRF-18-79MP9P04) in gastric cancer. Methods Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was first used to detect tRF-5026a expression levels in gastric cancer tissues and patient plasma. Next, the relationship between tRF-5026a levels and clinicopathological features in gastric cancer patients was assessed. Cell lines with varying tRF-5026a levels were assessed by measuring tRF-5026a using qRT-PCR. After transfecting cell lines with a tRF-5026a mimic or inhibitor, cell proliferation, colony formation, migration, apoptosis, and cell cycle were evaluated. The expression levels of related proteins in the PTEN/PI3K/AKT pathway were also analyzed by Western blotting. Finally, the effect of tRF-5026a on tumor growth was tested using subcutaneous tumor models in nude mice. Results tRF-5026a was downregulated in gastric cancer patient tissues and plasma samples. tRF-5026a levels were closely related to tumor size, had a certain diagnostic value, and could be used to predict overall survival. tRF-5026a was also downregulated in gastric cancer cell lines. tRF-5026a inhibited the proliferation, migration, and cell cycle progression of gastric cancer cells by regulating the PTEN/PI3K/AKT signaling pathway. Animal experiments showed that upregulation of tRF-5026a effectively inhibited tumor growth. Conclusions tRF-5026a (tRF-18-79MP9P04) is a promising biomarker for gastric cancer diagnostics and has tumor suppressor effects mediated through the PTEN/PI3K/AKT signaling pathway.

Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway

2020 ◽  
Author(s):  
Sun Yalan ◽  
Liu Yanfang ◽  
Chen He ◽  
Tan Yujie
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Circular Rna ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals Garcinol acts as an antineoplastic agent in human gastric cancer by inhibiting the PI3K/AKT signaling pathway

2020 ◽  
Vol 20 (1) ◽  
pp. 667-676
Author(s):  
Yuanyuan Zheng ◽  
Chuanyong Guo ◽  
Xiaoping Zhang ◽  
Xiaoli Wang ◽  
A'Ηuo Ma
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Antineoplastic Agent ◽  
Akt Signaling ◽  
Human Gastric Cancer ◽  
Akt Signaling Pathway

CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway

2021 ◽  
pp. 112914
Author(s):  
Decai Chi ◽  
Dong Wang ◽  
Minghui Zhang ◽  
Hui Ma ◽  
Fuhui Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals DC-SIGN mediates gastric cancer progression by regulating the JAK2/STAT3 signaling pathway and affecting LncRNA RP11-181G12.2 expression

2020 ◽  
Vol 121 ◽  
pp. 109644 ◽  
Author(s):  
Xiaomeng Li ◽  
Heya Na ◽  
Lijie Xu ◽  
Xinsheng Zhang ◽  
Zhen Feng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Gastric Cancer Progression
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