scholarly journals Expression level ofhTERTis regulated by somatic mutation and common single nucleotide polymorphism at promoter region in glioblastoma

Oncotarget ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 3399-3407 ◽  
Author(s):  
Chul-Kee Park ◽  
Se-Hoon Lee ◽  
Ji Young Kim ◽  
Ja Eun Kim ◽  
Tae Min Kim ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Somatic Mutation ◽  
Promoter Region ◽  
Expression Level ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Common Single Nucleotide Polymorphism

The −5 A/G single-nucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer

2014 ◽  
Vol 280 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Katarzyna Starska ◽  
Anna Krześlak ◽  
Ewa Forma ◽  
Jurek Olszewski ◽  
Alina Morawiec-Sztandera ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Nucleotide Polymorphism ◽  
Promoter Region ◽  
Core Promoter ◽  
Specific Gene ◽  
Nucleotide Polymorphism ◽  
Core Promoter Region ◽  
Single Nucleotide ◽  
The Core ◽  
Allele Specific

scholarly journals miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Matteo Forloni ◽  
Shaillay Kumar Dogra ◽  
Yuying Dong ◽  
Darryl Conte ◽  
Jianhong Ou ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Notch Signaling ◽  
Cell Lines ◽  
Somatic Mutation ◽  
Melanoma Cell ◽  
Human Melanoma ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Oncogenic Mutations ◽  
Melanoma Cell Lines

Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of miR-146a has the opposite effects. We show these oncogenic activities are due to miR-146a targeting the NUMB mRNA, a repressor of Notch signaling. Previous studies have shown that pre-miR-146a contains a single nucleotide polymorphism (C>G rs2910164). We find that the ability of pre-miR-146a/G to activate Notch signaling and promote oncogenesis is substantially higher than that of pre-miR-146a/C. Analysis of melanoma cell lines and matched patient samples indicates that during melanoma progression pre-miR-146a/G is enriched relative to pre-miR-146a/C, resulting from a C-to-G somatic mutation in pre-miR-146a/C. Collectively, our results reveal a central role for miR-146a in the initiation and progression of melanoma.

​Identification of Single Nucleotide Polymorphism (SNP) C-2161G in the Promoter Region of Prolactin Gene and its Association with Egg Production in Tellicherry Native Chicken

2021 ◽  
Author(s):  
Azhaguraja Manoharan ◽  
S. Sankaralingam ◽  
P. Anitha ◽  
Binoj Chacko ◽  
T.V. Aravindakshan
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Promoter Region ◽  
Egg Production ◽  
Rflp Analysis ◽  
Genotypic Frequency ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Chicken Population ◽  
Native Chicken ◽  
Prolactin Gene

Background: Prolactin is a physiological candidate gene which has significant effects on egg production in poultry. Also, it plays a major role on incubation behaviour (broodiness) in birds. The main objective of the present study was identification of single nucleotide polymorphism (SNP) C-2161G in the promoter region of prolactin gene and its association with egg production in Tellicherry native chicken population. Methods: A total of 200 blood samples were collected from the randomly selected birds of Tellicherry native chicken in All India Co-ordinated Research Project on Poultry improvement (AICRP) farm, Mannuthy, Thrissur, Kerala. Isolation of Genomic DNA was done and the isolated samples were subjected to polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis to identify the SNP C-2161G of prolactin gene. Result: On the basis of RFLP patterns, birds were designated with three different genotypes namely CC, CG and GG. The allelic and genotypic frequency was calculated. The observed genotypic frequency at the SNP site C-2161G was CC (0.61), CG (0.160) and GG (0.23) and the frequency of allele was 0.69 for C and 0.31 for G. The egg production was shown to be statistically similar for the genotypes of SNP C-2161G.

scholarly journals Thymidylate synthase expression pattern, expression level and single nucleotide polymorphism are predictors for disease-free survival in patients of colorectal cancer treated with 5-fluorouracil

2006 ◽  
Author(s):  
María-Encarnación Fernández-Contreras ◽  
Sandra Sánchez-Prudencio ◽  
José-Javier Sánchez-Hernández ◽  
María-Luisa García de Paredes ◽  
Javier Gisbert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Single Nucleotide Polymorphism ◽  
Expression Pattern ◽  
Thymidylate Synthase ◽  
Disease Free Survival ◽  
Expression Level ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Free Survival ◽  
Disease Free

Association of a Single-Nucleotide Polymorphism in the Promoter Region of the VEGF Gene with the Risk of Renal Cell Carcinoma

2011 ◽  
Vol 15 (9) ◽  
pp. 653-657 ◽  
Author(s):  
Sadia Ajaz ◽  
Shagufta Khaliq ◽  
Aiysha Abid ◽  
Asad Shehzad Hassan ◽  
Altaf Hashmi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Single Nucleotide Polymorphism ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Promoter Region ◽  
Nucleotide Polymorphism ◽  
Vegf Gene ◽  
Single Nucleotide
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