scholarly journals Fear of Death as the Foundation of Modern Political Philosophy and Its Overcoming by Transhumanism

2020 ◽  
Vol 11 (4) ◽  
pp. 323-333
Author(s):  
Matías Quer ◽  
Keyword(s):  
Political Philosophy ◽  
Old Age ◽  
Central Place ◽  
Specific Role ◽  
Fear Of Death ◽  
Modern Politics ◽  
Modern Development ◽  
Political Effects ◽  
Final Consequence

Fear, which has always been one of the most powerful of human passions, has grown in importance during modernity. First with Machiavelli and later especially with Hobbes, fear has become one of the foundational ideas of modern political philosophy. If fear, especially fear of death, does indeed occupy a central place in the foundation of modern politics, then it is necessary to study carefully the implications and consequences of the transhumanist attempt to overcome death. Among the main aspirations of transhumanism is the search for almost infinite longevity and, eventually, the total abolition of aging. Therefore, it is necessary to understand the specific role that fear of death has played in modern political philosophy to understand the possible effects that an eventual overcoming of death would have, albeit partial, as wanted by transhumanists. While the possibility of achieving immortality seems unlikely, this doesn’t mean that we shouldn’t study what’s behind this transhumanist aspiration. In this way, transhumanism seems the final consequence of modern development, since it’s in continuity with the modern attempt to respond to the fear of death, but it does so by trying an ultimate solution to it through the elimination of death, at least by sickness and old age. In this paper, we will review the role of fear of death in the founding of modern political philosophy by Machiavelli and Hobbes, and then we will analyse the transhumanist attempt to overcome death as a consequence of this fear and its possible political effects.

Interpassivity and Misdemeanours: The Art of Thinking in Examples and the Žižekian Toolbox

2018 ◽  
Author(s):  
Robert Pfaller
Keyword(s):  
Specific Role ◽  
Slavoj Zizek ◽  
Slavoj Žižek ◽  
The Sublime

Starting from a passage from Slavoj Žižek`s brilliant book The Sublime Object of Ideology, the very passage on canned laughter that gave such precious support for the development of the theory of interpassivity, this chapter examines a question that has proved indispensable for the study of interpassivity: namely, what does it mean for a theory to proceed by examples? What is the specific role of the example in certain example-friendly theories, for example in Žižek’s philosophy?

Political Communication: Redefining Contemporary Political Management Practices

2019 ◽  
Vol 118 (11) ◽  
pp. 255-268
Author(s):  
Amit Kumar
Keyword(s):  
Social Media ◽  
Political Communication ◽  
Management Practices ◽  
Complex Nature ◽  
Political Event ◽  
Indian Politics ◽  
Modern Politics ◽  
Political Branding ◽  
General Elections

Modern politics, particularly prevalent in the Western Democracies, is replete with instances wherein communication has come to play a pivotal role in the formation or dislodging a government. This is not to say that in traditional political scenario, the role of communication was any lesser. Far from it, communication has always characterized the build-up of events in politics. However, the significance of the same has increased manifold thanks to the advent of social media and complex nature of modern politics as well as due to rise of such concepts as political branding which has gained traction in the wake of proliferation of technology. The same holds true in the Indian political scenario as well. The last few years have redefined the role of communication and its tools in Indian politics, especially during a mega-political event like election. The last two general elections were testimonies to the same. The might of social media has been realized by even its staunchest critics. Along with it, the popular concept of permanent campaign has also characterized the phenomenon of political communication. This paper goes on to explore the underlying concept of political communication and how the same has come to influence the turn of events as well as the final outcome of an election.

Role of Rasayana in Geriatric Care - A Review

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Yagyik Mishra ◽  
Negalur Vijay ◽  
Thakor Krunal ◽  
Bhat Nagaraj ◽  
Shubhasri B.
Keyword(s):  
Older People ◽  
Old Age ◽  
Statistical Data ◽  
Geriatric Care ◽  
The Body ◽  
Psychological Improvement

The growth of any country or society depends on the number of youth dwelling in that country but according to recent statistical data we soon will have older people more than children and more people at extreme old age than ever before. The number of people aged 65 or older is projected to grow from an estimated 524 million in 2010 to nearly 1.5 billion in 2050. Geriatrics (Jarachikitsa) is the branch of medicine dealing exclusively with the problems of aging and the diseases of elderly. The term Rasayana (rejuvination) refers to nourishment or nutrition. Rasayana therapy act essentially on nutrition dynamics and rejuvenate the body on both physical and mental levels. The problems of health due to modernization can be solved by increasing resistance against diseases and psychological improvement by implementing Rasayana therapy. Aging (Jara) is one among the Swabhavika Vyadhis. Jara Chikitsa is one among the Astanga of Ayurveda which is specifically dedicated for geriatric care. As per estimation, India currently has around 75 million persons over 65 years. By proper administration of Rasayana therapy as preventive tool one can delay Jara Janita Vyadhis to occur. This paper highlights the role of Rasayana in geriatric care.

Politics and Kingship in the Historical Books, with Attention to the Role of Political Theory in Interpretation

2020 ◽  
pp. 186-200
Author(s):  
Geoffrey Parsons Miller
Keyword(s):  
Political Philosophy ◽  
Comparative Analysis ◽  
Distributive Justice ◽  
Political Theory ◽  
Hebrew Bible ◽  
Historical Narratives ◽  
Political Organizations ◽  
Abstract Ideas ◽  
Theological Message

This chapter explores the thesis that the historical narratives of the Hebrew Bible address abstract ideas about politics, government, and law. Taking issue with critics who view the Bible’s spiritual and theological message as incommensurable with political philosophy, the chapter argues that the stories of politics and kingship in the Hebrew Bible’s historical books set forth set forth an impressive political theory that rivals, in some respects, the work of Plato, Aristotle, and other Greek thinkers. The key is to bring out the general ideas behind the specific narrative elements. The chapter illustrates this thesis by examining the Hebrew Bible’s treatment of a number of classic problems of political theory: anarchy, obligation and sovereignty, distributive justice, and the comparative analysis of political organizations.

scholarly journals A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice

2020 ◽  
Vol 21 (24) ◽  
pp. 9744
Author(s):  
Heng Zeng ◽  
Xiaochen He ◽  
Jian-Xiong Chen
Keyword(s):  
Blood Pressure ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Normal Diet ◽  
Specific Role ◽  
Sirtuin 3 ◽  
Control Female ◽  
Female Mice ◽  
Flow Reserve

Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by a diastolic dysfunction and is highly prevalent in aged women. Our study showed that ablation of endothelial Sirtuin 3 (SIRT3) led to diastolic dysfunction in male mice. However, the sex-specific role of endothelial SIRT3 deficiency on blood pressure and diastolic function in female mice remains to be investigated. Methods and Results: In this study, we demonstrate that the ablation of endothelial SIRT3 in females elevated blood pressure as compared with control female mice. Diastolic function measurement also showed that the isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were significantly increased, whereas the E’ velocity/A’ velocity (E’/A’) ratio was reduced in the endothelial-specific SIRT3 knockout (SIRT3 ECKO) female mice. To further investigate the regulatory role of endothelial SIRT3 on blood pressure and diastolic dysfunction in metabolic stress, SIRT3 ECKO female mice were fed a normal diet and high-fat diet (HFD) for 20 weeks. The knockout of endothelial SIRT3 resulted in an increased blood pressure in female mice fed with an HFD. Intriguingly, SIRT3 ECKO female mice + HFD exhibited impaired coronary flow reserve (CFR) and more severe diastolic dysfunction as evidenced by an elevated IVRT as compared with control female mice + HFD. In addition, female SIRT3 ECKO mice had higher blood pressure and diastolic dysfunction as compared to male SIRT3 ECKO mice. Moreover, female SIRT3 ECKO mice + HFD had an impaired CFR and diastolic dysfunction as compared to male SIRT3 ECKO mice + HFD. Conclusions: These results implicate a sex-specific role of endothelial SIRT3 in regulating blood pressure and diastolic function in mice. Deficiency of endothelial SIRT3 may be responsible for a diastolic dysfunction in aged female.

scholarly journals Creative leaps in theory: the might of abduction

2021 ◽  
Author(s):  
Mario Veen
Keyword(s):  
Health Professions ◽  
Central Place ◽  
Health Professions Education ◽  
Abductive Reasoning ◽  
The Poor ◽  
The World

AbstractThis paper argues that abductive reasoning has a central place in theorizing Health Professions Education. At the root of abduction lies a fundamental debate: How do we connect practice, which is always singular and unique, with theory, which describes the world in terms of rules, generalizations, and universals? While abduction was initially seen as the ‘poor cousin’ of deduction and induction, ultimately it has something important to tell us about the role of imagination and humility in theorizing Health Professions Education. It is that which makes theory possible, because it allows us to ask what might be the case and calls attention to the role of creative leaps in theory. Becoming aware of the abductive reasoning we already perform in our research allows us to take the role of imagination—something rarely associated with theory—seriously.

scholarly journals Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Angela Jeong ◽  
Shaowu Cheng ◽  
Rui Zhong ◽  
David A. Bennett ◽  
Martin O. Bergö ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Small Gtpases ◽  
Specific Role ◽  
Postmortem Brain ◽  
Effective Prevention ◽  
Postmortem Brain Tissue ◽  
Mtorc1 Signaling ◽  
Behavioral Assessments ◽  
Human Brains

AbstractThe pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key posttranslational modification process called farnesylation, in which the isoprenoid farnesyl pyrophosphate is attached to target proteins, facilitating their membrane localization and their interactions with downstream effectors. Farnesylated proteins, including the Ras superfamily of small GTPases, are involved in regulating diverse physiological and pathological processes. Emerging evidence suggests that isoprenoids and farnesylated proteins may play an important role in the pathogenesis of AD. However, the dynamics of FT and protein farnesylation in human brains and the specific role of neuronal FT in the pathogenic progression of AD are not known. Here, using postmortem brain tissue from individuals with no cognitive impairment (NCI), mild cognitive impairment (MCI), or Alzheimer’s dementia, we found that the levels of FT and membrane-associated H-Ras, an exclusively farnesylated protein, and its downstream effector ERK were markedly increased in AD and MCI compared with NCI. To elucidate the specific role of neuronal FT in AD pathogenesis, we generated the transgenic AD model APP/PS1 mice with forebrain neuron-specific FT knockout, followed by a battery of behavioral assessments, biochemical assays, and unbiased transcriptomic analysis. Our results showed that the neuronal FT deletion mitigates memory impairment and amyloid neuropathology in APP/PS1 mice through suppressing amyloid generation and reversing the pathogenic hyperactivation of mTORC1 signaling. These findings suggest that aberrant upregulation of protein farnesylation is an early driving force in the pathogenic cascade of AD and that targeting FT or its downstream signaling pathways presents a viable therapeutic strategy against AD.

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