scholarly journals Dysfunction of the Clinical Effect of Levonorgestrel Treatment of Dysfunctional Uterine Bleeding

2013 ◽  
Vol 2 ◽  
pp. 4
Author(s):  
Xinhui Mi ◽  
Caixia Qin
Keyword(s):  
Adverse Reaction ◽  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Endometrial Thickness ◽  
Hemoglobin Concentration ◽  
Uterine Bleeding ◽  
Dysfunctional Uterine Bleeding ◽  
Curative Effect ◽  
Intrauterine Treatment

<strong>Objective: </strong>Study clinical curative effect of levonorgestrel treatment on perimenopausal dysfunctional uterine bleeding. Method: Selected 126 outpatient of dysfunctional uterine bleeding which hospitalize from December 2010 to December 2012 at department of gynaecology to undergo levonorgestrel treatment on the 5‒7 days of menstruation. The endometrial thickness, hemoglobin, and the PBAC score of before and 3, 6, and 12 months after placement were observed and recorded. To observation the adverse reactions after levonorgestrel treatment. <strong>Results: </strong>After treatment, the thickness of the endometrium, the amount of menstruation and the hemoglobin concentration increased in 126 patients. During the treatment, 21 patients experienced mild dizziness and nausea, but did not affect the drug use and efficacy. <strong>Conclusion: </strong>Effects of levonorgestrel on intrauterine treatment of perimenopausal dysfunctional uterine bleeding can effectively reduce the amount of menstruation and increase hemoglobin levels. It is economic, simple, less adverse reaction, and widely entrenched in clinical practice.

scholarly journals The role of Sevista (ormeloxifene) in the management of dysfunctional uterine bleeding

2016 ◽  
Vol 6 (1) ◽  
pp. 219 ◽  
Author(s):  
Nikita Gandotra ◽  
Preeti Sharma ◽  
Abhinav Sharma ◽  
Syed Masuma Rizvi
Keyword(s):  
Side Effects ◽  
Outcome Measures ◽  
Medical Management ◽  
Endometrial Thickness ◽  
Hemoglobin Concentration ◽  
Uterine Bleeding ◽  
Secondary Outcome ◽  
Dysfunctional Uterine Bleeding ◽  
The Mean

Background: Dysfunctional uterine bleeding (DUB) is a common gynaecological disorder that usually ends up in hysterectomy and causes psychological and physiological stress. Medical management with hormones and NSAIDS has inherited side effects. Ormeloxifene, a selective estrogen receptor modulator, is emerging as a safe and effective agent for dysfunctional uterine bleeding. The objective of the study was to evaluate the role of ormeloxifene in medical management of dysfunctional uterine bleeding.Methods: 30 patients, on whom diagnosis of dysfunctional uterine bleeding was made, were included in the study. Patients were given ormeloxifene 60mg twice a week for 12 weeks and then once a week for 12 weeks. The primary outcome measures were menstrual blood loss (assessed by pictorial blood assessment chart score), hemoglobin concentration and endometrial thickness. The secondary outcome measures were acceptability and side effects of ormeloxifene.Results: There was a significant reduction in mean PBAC score from 316 to 52 after six months of treatment. The mean hemoglobin concentration increased significantly from 8.4 to 9.8 gms/dl with a rise of 1.4gm/dl (p <0.05). The mean pretreatment endometrial thickness was 10.8mm and it decreased significantly to 8.1mm after 6 months of treatment with ormeloxifene (p < 0.05). 76.7% of the women showed marked subjective improvement in symptoms. The most common side effect reported was amenorrhea (13.3%).Conclusions: Ormeloxifene can be considered as an effective and safe therapeutic option for the medical management of dysfunctional uterine bleeding.

scholarly journals Ormeloxifene versus Tranexamic acid in dysfunctional uterine bleeding comparative evaluation

2018 ◽  
Vol 7 (2) ◽  
pp. 566
Author(s):  
Kaliki Hymavathi ◽  
Malini Devi Gottipati ◽  
Prasuna . ◽  
Sudha V.
Keyword(s):  
Tranexamic Acid ◽  
Endometrial Thickness ◽  
Hemoglobin Concentration ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Double Blind Study ◽  
Loss Assessment ◽  
Dysfunctional Uterine Bleeding ◽  
Double Blind ◽  
Beneficial Effects

Background: Dysfunctional Uterine bleeding (DUB) is the most common cause of abnormal uterine bleeding (AUB). Medical therapy being the first line of management, an ideal drug should be able to block the estrogenic effects on the Endometrium without interfering with its beneficial effects on other tissues. Both Ormeloxifene - a selective estrogen receptor modulator (SERM) and Tranexamic acid-an anti fibrinolytic inhibitor is important in the treatment of DUB. The aim of this study is to assess the efficacy and safety of Ormeloxifene v/s Tranexamic acid in the treatment of DUB.Methods: This is a prospective double blind study conducted for 2 years in 200 women presenting with DUB attending to the Gynaecology outpatient department (OPD) of Narayana Medical College and Hospital, Nellore, AP, India. Two hundred women presenting with DUB were recruited into this study (after fulfilling inclusion and exclusion criteria) with informed consent and randomly divided into two equal groups (Group-A and Group-B) after obtaining college ethical committee approval.Results: The reduction in the mean pictorial blood loss assessment chart (PBAC) score with Ormeloxifene (from 278 to 97.6) was significantly more than that of Tranexamic acid (from 261 to 134.5) at six months (p <0.0001). The rise in Hemoglobin concentration (8.4g% to 11.15g% vs. 8.5 to 9.7gm%; p <0.008) and reduction in Endometrial thickness (from 10.57mm to 6.5mm v/s 9.96mm to 7.24mm p <0.0001) were also significantly more with Ormeloxifene than with Tranexamic acid. Relief from dysmenorrhoea and subjective improvement were also found to be considerable with Ormeloxifene.Conclusions: Both Ormeloxifene and Tranexamic acid can be considered for DUB treatment but Ormeloxifene is found to be superior to Tranexamic acid in various aspects.

scholarly journals Ormeloxifene versus combined oral contraceptive pills to control blood loss in cases of dysfunctional uterine bleeding

2019 ◽  
Vol 8 (12) ◽  
pp. 4909
Author(s):  
Ankita Gupta ◽  
Rishika Raj
Keyword(s):  
Oral Contraceptive ◽  
Blood Loss ◽  
Endometrial Thickness ◽  
Uterine Bleeding ◽  
Menstrual Blood ◽  
Control Group ◽  
Dysfunctional Uterine Bleeding ◽  
Oral Contraceptive Pills ◽  
Combined Oral Contraceptive ◽  
Contraceptive Pills

Background: Dysfunctional uterine bleeding is one of the most often encountered gynecologic problems causing anemia, reduced quality of life and unnecessary hysterectomies. A prospective study was conducted on women with DUB to study the effect of ormeloxifene versus combined oral contraceptive pills in controlling blood loss in them.Methods: 100 Women with DUB were enrolled randomly in three groups. After baseline assessment each patient in group A was treated with iron tablets, containing 100 mg elemental iron and folic acid 1.5 mg, for three months and were termed as control group. Group B patients were treated with ormeloxifene in dose of 60 mg twice a week for twelve weeks. Group C patients were treated with combined oral contraceptive pills for twenty- one days starting from third day of their LMP. The treatment was continued for three consecutive cycles. The efficacy of the studied drugs was analyzed by comparing the baseline and post treatment PBAC score, haemoglobin level and endometrial thickness, using appropriate statistical tests.Results: Ormeloxifene was more effective than only iron or combined oral contraceptive therapy in controlling menstrual blood loss (79.11% versus 58.57%). There was a reduction in endometrial thickness in group receiving ormeloxifene as well as in the group receiving combined oral contraceptive pills (p=0.486), however this was statistically not significant.Conclusions: Ormeloxifene was significantly better than combined OCP in reduction of menstrual blood flow in cases of DUB. It has better compliance and marked improvement in subjective symptoms as compared to OCP.

The clinical effect an Nao Wan Merger risperdal on schizophrenia

2016 ◽  
Vol 33 (S1) ◽  
pp. S621-S621
Author(s):  
Y. Zhang
Keyword(s):  
Medical Records ◽  
Recovery Time ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Clinical Observation ◽  
Treatment Cycle ◽  
Mental Health Center ◽  
Drug Compliance ◽  
Curative Effect ◽  
Competing Interest

ObjectiveTo evaluate the clinical curative effect of risperdal merger An Nao Wan for schizophrenia.MethodsScreening a mental health center in the first half of 2012 hospitalized patients with schizophrenia, which alone give risperdal or merger An Nao Wan give risperdal with 28 days treatment cycle, were as a clinical observation objects. Efficacy was assessed using symptoms scale (PANSS), evaluation of adverse reactions was with side effects scale (TESS). And through collecting the clinical data, related testing results, the daily detailed medical records to record adverse reactions.ResultsFifty cases of screened 427 patients meet the conditions, including 11 cases with risperdal merger An Nao Wan, and 39 cases only used risperdal. All of 50 cases after two weeks treatment, the symptoms were down significantly (P < 0.01). The adverse reactions rate of patients only with risperdal was 53.8%, of patients with risperidone merger An Nao Wan was only 27.3%.ConclusionRisperdal merger An Nao Wan can improve the therapeutic effect of risperidone, short the recovery time of schizophrenia, prevent the adverse reaction of psychotic drug, also improve the safety and patient drug compliance.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

scholarly journals Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

2013 ◽  
Vol 2 ◽  
pp. 7
Author(s):  
Li Liu
Keyword(s):  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
And Control ◽  
Group Observation

<p><strong>Objective: </strong>To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. <strong>Method: </strong>From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. <strong>Results: </strong>The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, <em>p</em> &lt; 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. <strong>Conclusion: </strong>Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.</p>

scholarly journals Comparison between Ormeloxifene and Norethisterone in reducing menorrhagia in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (12) ◽  
pp. 4966
Author(s):  
Swati Gett ◽  
Shruti Singh
Keyword(s):  
Endometrial Thickness ◽  
Mean Value ◽  
Uterine Bleeding ◽  
The Other ◽  
P Value ◽  
Loss Assessment ◽  
Dysfunctional Uterine Bleeding ◽  
Significant Difference ◽  
Before And After

Background: Dysfunctional Uterine Bleeding (DUB) is a condition that affects nearly every woman at some point in her life. This study aims to compare the efficacy of Ormeloxifene and Norethisterone in reducing menorrhagia in such patients.Methods: This prospective study was done on 100 women presenting with dysfunctional uterine bleeding, of 20-50 years of age, who were ready for follow-up and were allocated into two equal groups, one was given Ormeloxifene and the other was given Norethisterone for a period of 3 months. Haemoglobin levels, endometrial thickness on ultrasound and Pictorial Blood loss Assessment Chart (PBAC) scores were assessed before and after the treatment.Results: It was found that both Ormeloxifene and Norethisterone reduced menorrhagia, with a significant difference in PBAC scores (p value <0.05). There was a notable reduction in PBAC scores in Ormeloxifene group (66.53% change from pretreatment mean value) as compared to Norethisterone group (31.38% change from pretreatment mean value); and same holds true for the change in haemoglobin levels as well as endometrial thickness. Ormeloxifene was found to have a greater effect on heavy menstrual bleeding in comparison to Norethisterone.Conclusions: Ormeloxifene is a new modality and is found to be a better option in reducing menorrhagia in DUB in respect to a greater success rate, better compliance and cost effectiveness.

scholarly journals Observation of the effect on immediate mandibular implant-supported overdenture of micro implant system of Italy

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Yin Xuemeng ◽  
Dai Shasha
Keyword(s):  
Adverse Events ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Alveolar Bone ◽  
Control Group ◽  
Observation Group ◽  
Curative Effect ◽  
Low Incidence ◽  
Implant System

The study was design to investigate the clinical effect of Micro implant system in Italy on immediate mandibular implant-supported overdenture. A total of 192 patients with mandibular edentulous treated in our hospital were randomly divided into 2 groups in which the control group consisted of 96 patients treated with immediate mandibular implant-supported overdenture by Xive implant system, while the observation group included 96 cases treated with the overdenture by Italy Micro implant system. Patients were followed up for 1 year and then the states of implant-borne overdentures, marginal bone resorption around alveolar bone, the compatibility of implant restorations with adjacent teeth, adverse events and satisfaction degree were compared between the groups. According to the results of 1-year follow-up, the resorption around alveolar bone of the observation group was significantly higher than that of the control group (p<0.05). In the observation group the differences in labial gingival margin position, gingival color and texture were significantly better (p<0.05) as compared to control group. The incidence of adverse events was notably lower (p<0.05). The Italy Micro implant system has significant curative effect on mandibular implant-supported overdentures with good compatibility of the implant restorations with adjacent teeth and low incidence rate of adverse reactions, so it is worthy of clinical application and spreading.

scholarly journals Targeted treatments for dysfunctional uterine bleeding based on endometrial thickness

2020 ◽  
Vol 9 (3) ◽  
pp. 900
Author(s):  
Thi Thi Htwe ◽  
Hla Hla Yi ◽  
Saw Kler Ku
Keyword(s):  
Endometrial Thickness ◽  
Hormonal Treatment ◽  
Uterine Bleeding ◽  
Dysfunctional Uterine Bleeding ◽  
Common Presentation ◽  
Targeted Treatments ◽  
One Year ◽  
The One

Background: Dysfunctional uterine bleeding is a common presentation to both general practitioner and gynaecologists which can have a significant effect on a woman’s quality of life. The aim of this study is to assess the effectiveness of treating dysfunctional uterine bleeding according to endometrial thickness.Methods: This study was a hospital based prospective study undertaken in gynecology outpatient clinic of Central Women’s Hospital, Mandalay, Myanmar for one-year period (2016). A total of 60 patients were recruited and divided into 3 groups based on endometrial thickness and offered targeted hormonal treatments. At the end of the one-month treatment, patients were asked to return for a follow-up visit and from their menstrual diaries, the number of bleeding days and bleeding scores were assessed and calculated.Results: Among sixty women with dysfunctional uterine bleeding, 55% of patients had endometrial thickness less than 6 mm, 25% had endometrial thickness 6-11 mm, with 20% of patients having endometrial thickness more than 11 mm. After one month of study period, treatment was found to be effective in 86.6% of the patients according to bleeding days and in 70% of the patients according to bleeding score.Conclusions: In women presenting with dysfunctional uterine bleeding, increased endometrial thickness was found to be associated with increased BMI. In the treatment of dysfunctional uterine bleeding, when the endometrial thickness of the patient was assessed and hormonal treatment was given according to the endometrial thickness, treatment was proven to be effective.

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