scholarly journals Neurophysiological justification of the G. F. Lang hypothesis about the occurrence of essential hypertension

2021 ◽  
Vol 27 (5) ◽  
pp. 499-508
Author(s):  
E. V. Shlyakhto ◽  
V. A. Tsyrlin ◽  
N. V. Kuzmenko ◽  
M. G. Pliss
Keyword(s):  
Spinal Cord ◽  
Essential Hypertension ◽  
Arterial Hypertension ◽  
Neuronal Activity ◽  
Paraventricular Nucleus ◽  
Medulla Oblongata ◽  
Blood Circulation ◽  
Vascular Tone ◽  
Morphological Changes ◽  
Sympathetic Neurons

This article is an analysis of modern data on the morphological, functional and neurochemical organization of the central mechanisms of blood circulation regulation, the violation of which can cause the development of essential hypertension. The data indicating the validity of the hypothesis of G.F. Lang that prolonged emotional stress leads to a violation of the neuronal activity of the hypothalamus structures are presented. The article describes the morphological connections of the hypothalamus with the neurons of the ventrolateral region of the medulla oblongata and the structures of the spinal cord that provide neurogenic vascular tone. The evidence of convergence of axons of neurons of the paraventricular nucleus of the hypothalamus on the preganglionic neurons of the spinal cord is presented. Neurochemical processes in the vasomotor center of the medulla oblongata are considered, morphological changes of preganglionic sympathetic neurons in experimental arterial hypertension are indicated.

scholarly journals IX . Researches on the intimate structure of the brain.—Second series

1868 ◽  
Vol 158 ◽  
pp. 263-331 ◽  
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Medulla Oblongata ◽  
Morphological Changes ◽  
The Other ◽  
Other Hand ◽  
Close Study ◽  
The Subject ◽  
The One ◽  
The Brain

Before I begin to describe the parts which form the subject of this communication, and to show how some of them are merely modified portions or developments of others that belong to the medulla oblongata , it will be advisable to recur to those morphological changes in the medulla, which I formerly pointed out as themselves arising from modifications of the spinal cord . And while in unravelling structures so extremely complex, such a course seems almost necessary to facilitate their comprehension, and convey to the reader a just notion of their morphological changes, in relation on the one hand, to the remaining parts of the encephalon, and on the other hand, to the spinal cord, it will afford me an opportunity of adding to this recapitulation some new facts that have been elicited by subsequent observation and a more extended experience. It is gratifying to know that many of the results of my previous researches have been found to throw considerable light on certain diseases of the nervous system, especially on some forms of paralysis; and my own pathological investigations, as well as a close study of nervous disorders, have not only enabled me to shape my present researches as much as possible in accordance with the requirements of the pathologist, but, by pointing to the probability of certain anatomical connexions suggested by morbid symptoms, they have sometimes been the means of directing the course of my dissections in a very peculiar way.

NO-ergic Control of Blood Circulation in the Medulla Oblongata of Rats with Experimental Hemiparkinsonism under Prolonged Exposure to Continuous Light

2017 ◽  
Vol 8 (4) ◽  
pp. 363-374
Author(s):  
Lyudmila M. Shapoval ◽  
Bogdan S. Kop'yak ◽  
Olga V. Dmytrenko ◽  
Volodymyr O. Mayskiy ◽  
Olena P. Mankivska ◽  
...  
Keyword(s):  
Medulla Oblongata ◽  
Blood Circulation ◽  
Prolonged Exposure ◽  
Continuous Light

PROTECTIVE EFFECT OF SOME SALTS 2-AMINOETHANESULFONIC ACID IN AN EXPERIMENTAL MODEL OF DEGENERATIVE SPINAL CORD INJURY

2020 ◽  
pp. 41-47
Author(s):  
Semeleva E.V. ◽  
Blinova E.V. ◽  
Zaborovsky A.V. ◽  
Vasilkina O.V. ◽  
Shukurov A.S.
Keyword(s):  
Spinal Cord ◽  
Morphological Changes ◽  
Male Rats ◽  
Zinc Salt ◽  
Control Group ◽  
Morphological Studies ◽  
Cord Injury ◽  
The Central Nervous System ◽  
Acid Compound ◽  
Lateral Sclerosis

In this work, we studied the pharmacological activity of zinc and magnesium salts of 2-aminoethanesulfonic acid in white non-linear male rats with amyotrophic lateral sclerosis, which was modeled by neurotoxicantsimplication into the pelvic part of spinal cord. After the reproduction of the pathology in animals, the indices of motor activity were recorded in the Rotarod test, and morphological studies of spinal cord sections stained according to Nisl in the Belshovsky modification were carried out. It was shown that the magnesium salt of 2-aminoethanesulfonic acid (compound LHT-317) to a greater extent reduces the development of motor disorders in experimental animals compared with the control group on the 4th day of observation. The course of intravenous administration of the studied compounds of 2-aminoethanesulfonic acid did not inhibit morphological changes in the spinal cord that develop in degenerative-dystrophic pathology of the central nervous system: connections. Moreover, if, against the background of treatment with zinc salt, the total area of motor zones in animals of the experimental group exceeded that of control rats, then the number of motoneurons did not differ from the control.

Vascular endothelial growth factor as a potential marker of subclinical organ damage mediated by arterial hypertension

2019 ◽  
Vol 34 (3) ◽  
pp. 40-44
Author(s):  
E. Yu. Gubareva ◽  
I. V. Gubareva
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Essential Hypertension ◽  
Growth Factor ◽  
Arterial Hypertension ◽  
Organ Damage ◽  
Cardiovascular Complications ◽  
Vascular Endothelial ◽  
Potential Marker ◽  
Endothelial Growth Factor

The authors’ report presents a brief review of the key studies, providing the reason for the use of vascular endothelial growth factor as a marker for stratification of the risk of cardiovascular complications in patients with essential hypertension.

Leptinemia, parameters of heart rate variability, and prognosis in patients with essential arterial hypertension with obesity

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
O. Radchenko ◽  
N. Bek ◽  
V. Potapov
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Essential Hypertension ◽  
Arterial Hypertension ◽  
Cardiovascular Events ◽  
Serum Leptin ◽  
Ventricular Systole ◽  
Essential Arterial Hypertension

An examination of 103 patients with essential hypertension and obesity showed the dependence of autonomic cardioregulation, electrical ventricular systole, and prediction of adverse cardiovascular events on the serum leptin concentration (hyper-, normo – or hypoleptinemia).

The Golgi Material of the Neurones of the Central Nervous System of Sheep Infected with Louping-Ill

1947 ◽  
Vol s3-88 (1) ◽  
pp. 55-63
Author(s):  
R. A. R. GRESSON ◽  
I. ZLOTNIK
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Purkinje Cells ◽  
Medulla Oblongata ◽  
Motor Nerve ◽  
Pyramidal Cells ◽  
Cell Processes ◽  
The Central Nervous System ◽  
Louping Ill

1. The Golgi material of the pyramidal cells of the cerebral cortex, the Purkinje cells of the cerebellum, and the multipolar cells of the medulla oblongata and ventral horns of the spinal cord of the sheep is present as filaments and as irregularly shaped bodies. In some of the cells, particularly in the lamb (Sheep V), the Golgi material has the appearance of a network. As it is frequently present as separate bodies it is suggested that it may always consist of discrete Golgi elements which are sometimes situated in close proximity or in contact with one another. Filamentous Golgi elements are present in the basal part of the cell processes. 2. An examination of neurones from the corresponding regions of the central nervous system of sheep infected experimentally with louping-ill showed that the Golgi material undergoes changes consequent upon the invasion of the cells by the virus. The Golgi material undergoes hypertrophy, and at the same time there is a reduction in the number of filamentous Golgi elements and a reduction in the amount of Golgi substance present in the cell processes. These changes are followed by fragmentation. All the neurones of a particular region are not affected equally at the same time. The Golgi material of the Purkinje cells tends to form groups in the cytoplasm prior to fragmentation. In the multipolar cells of the medulla oblongata the hypertrophy of the Golgi material is not as great as in the other regions of the central nervous system. The Golgi material of the motor nerve-cells of the ventral horns of the spinal cord undergoes considerable hypertrophy which is followed by a grouping of the Golgi elements and fragmentation.

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