Topical treatment of chronic dermatoses with kertoplastic agents

2016 ◽  
Vol 19 (3) ◽  
pp. 170-172
Author(s):  
O. V Grabovskaya ◽  
E. Yu Vertieva ◽  
L. A Shestakova ◽  
Ekaterina V. Grekova
Keyword(s):  
Atopic Dermatitis ◽  
Topical Treatment ◽  
Psoriasis Vulgaris ◽  
Skin Diseases ◽  
Systemic Treatment ◽  
Skin Condition ◽  
Results Of Treatment ◽  
Severity Of The Disease

Atopic dermatitis and psoriasis are common chronic dermatosis characterized by prolonged recurrent course. Depending on the severity of the disease topical and systemic treatment are applied. Keratoplastic agents play an important role in treatment of skin diseases. These agents include Naftalan Cream 30%, which significantly improves the skin condition. The results of treatment of 10 patients with atopic dermatitis and 10 patients with psoriasis vulgaris Naftalan cream 30% are presented.

scholarly journals The Effect of SARS-CoV-2 Virus Infection on the Course of Atopic Dermatitis in Patients

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 521
Author(s):  
Martyna Miodońska ◽  
Agnieszka Bogacz ◽  
Magdalena Mróz ◽  
Szymon Mućka ◽  
Andrzej Bożek
Keyword(s):  
Atopic Dermatitis ◽  
Immunosuppressive Therapy ◽  
Systemic Treatment ◽  
Immunosuppressive Treatment ◽  
Skin Lesions ◽  
Skin Condition ◽  
Severe Form ◽  
Immune Mediated ◽  
Skin Symptoms ◽  
The Impact

Background and objectives: Atopic dermatitis (AD) is a disease with a complex pathophysiology involving immune-mediated reactions that lead to skin lesions that are typically localized and recurrent. Following the outbreak of the COVID-19 (coronavirus disease 2019) pandemic, attempting to assess the impact of SARS-CoV-2 infection on diseases caused by complex immune mechanisms has become important. The aim of this study was to assess the impact of SARS-CoV-2 infection on the course of AD, including immunosuppressive therapy, in patients with a severe form of the disease. Materials and methods: A retrospective analysis of 21 adults aged 18 to 52 years with AD diagnosed with COVID-19, including patients requiring hospitalization, was performed. Results: During SARS-CoV-2 infection, temporary exacerbation of skin lesions and/or skin pruritus was observed in nine (43%) patients but without the need for systemic treatment intervention. Patients with severe AD who received immunosuppressive therapy most often manifested mild exacerbation of skin symptoms. The skin condition improved in three patients. There was no significant effect of disease severity on the risk of severe COVID-19 (HR = 0.45; 95% CI: 0.32–0.65). Conclusions: The course of atopic dermatitis during SARS-CoV-2 infection may be different from the severity of its symptoms due to the lack of a significant influence. The immunosuppressive treatment used in patients with severe AD did not significantly affect the course of SARS-CoV-2 infection.

scholarly journals The role of Dwaya Haridra with Nimbadi tail in the management of of vicharchika W.S.R. to Eczema

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Dr. Subhash B. Jamdhade ◽  
Namrata kende ◽  
Dr. S. K. Jaiswal ◽  
Dr. Pradnya. S. Jamdhade
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disease ◽  
Skin Diseases ◽  
Skin Condition ◽  
Inflammatory Skin ◽  
Scaly Skin

ABSTRACT In ayurveda all skin diseases describes under the heading of kushta .  "Kushnatee iti kushtham."       ( Ma.Ni/kushta/Tika 1) The disease that destroyes the affected part of skin . Both charak samhita and sushrut samhita  classify skin disease into 2 categories . 1) Mahakushtha (major) 2) Kshudrakushtha (minor)                                               ....... Ch.ni 5/4 Ayurvedically, Eczema is considered to be a type of kushtha. i. e.type of kushdrakushtha which is disease of the skin .It is also known as a type of twak roga .which also signifies that it is a skin disease that twak translates to skin and rog translates to pain . Vicharchika is characterised by the following symptoms ati kandu ,bahu strav ,rukshta ,shyavata ,pidika,raji. As described in terms od nidan ,purvarupa,samprapti and chikitsa vicharchika can most certainly be corelated with the modern interpretation of eczema or atopic dermatitis .Eczema or atopic dermatitis is chronic inflammatory skin condition. Atopic dermatitis is characterised by  cracked or scaly skin discolored patches,erythma(red skin),papules, exudate(oozing) and intence pruritus (itching ).

scholarly journals Nanodelivery Strategies for Skin Diseases with Barrier Impairment: Focusing on Ceramides and Glucocorticoids

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 275
Author(s):  
Cíntia Almeida ◽  
Patrícia Filipe ◽  
Catarina Rosado ◽  
Catarina Pereira-Leite
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Safety Profile ◽  
Topical Treatment ◽  
Crucial Role ◽  
Skin Diseases ◽  
Skin Barrier ◽  
Treatment Efficiency ◽  
Efficient Delivery ◽  
Water Holding

The human epidermis has a characteristic lipidic composition in the stratum corneum, where ceramides play a crucial role in the skin barrier homeostasis and in water-holding capacity. Several skin diseases, such as atopic dermatitis and psoriasis, exhibit a dysfunction in the lipid barrier with altered ceramide levels and increased loss of transepidermal water. Glucocorticoids are normally employed in the therapeutical management of these pathologies. However, they have shown a poor safety profile and reduced treatment efficiency. The main objective of this review is to, within the framework of the limitations of the currently available therapeutical approaches, establish the relevance of nanocarriers as a safe and efficient delivery strategy for glucocorticoids and ceramides in the topical treatment of skin disorders with barrier impairment.

Questionnaire Survey of Female Patients with Atopic Dermatitis Regarding Genital Skin Condition

2010 ◽  
Vol 72 (4) ◽  
pp. 385-389
Author(s):  
Miwa KOBAYASHI ◽  
Yoshiki TOKURA ◽  
Noriko SATO ◽  
Yutaka TAKAGI ◽  
Takashi KITAHARA ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Questionnaire Survey ◽  
Skin Condition ◽  
Female Patients

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

scholarly journals EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 1: treatment and monitoring recommendations

2020 ◽  
Vol 34 (11) ◽  
pp. 2461-2498
Author(s):  
A. Nast ◽  
C. Smith ◽  
P.I. Spuls ◽  
G. Avila Valle ◽  
Z. Bata‐Csörgö ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Systemic Treatment

scholarly journals Practical algorithm to inform clinical decision‐making in the topical treatment of atopic dermatitis

2021 ◽  
Author(s):  
Thomas Luger ◽  
Uladzimir Adaskevich ◽  
Maryna Anfilova ◽  
Xia Dou ◽  
Nikolay N. Murashkin ◽  
...  
Keyword(s):  
Decision Making ◽  
Atopic Dermatitis ◽  
Topical Treatment ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Practical Algorithm

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 2: specific clinical and comorbid situations

2021 ◽  
Vol 35 (2) ◽  
pp. 281-317
Author(s):  
A. Nast ◽  
C. Smith ◽  
P.I. Spuls ◽  
G. Avila Valle ◽  
Z. Bata‐Csörgö ◽  
...  
Keyword(s):  
Psoriasis Vulgaris ◽  
Systemic Treatment
Sign in / Sign up

Export Citation Format

Share Document