Cognitive and Exposure Treatment for Agoraphobia: Reexamination of the Outcome Research

1988 ◽  
Vol 2 (3) ◽  
pp. 165-178 ◽  
Author(s):  
Mia Biran

Researchers working within the behavioral framework have concluded that in vivo exposure is an effective, though incomplete, treatment for agoraphobia. Cognitive treatments (i.e., the modification of internal dialogue) have been found less effective and show little supplemental value to exposure. In this paper it is argued that the behavioral perspective has provided a limited vision of cognitive therapy as an effective supplement to exposure. Reexamination of the research literature engenders different conclusions and opens up some fresh possibilities for a combined exposure-cognitive treatment. From a cognitive perspective, the modification of self-statements and internal dialogue is not enough for producing enduring and generalizable therapeutic results. A complete treatment for agoraphobia requires a combination of in vivo exposure with a bona fide cognitive therapy which addresses core cognitive constructs about the world and the self specific to agoraphobic patients.

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Dobrin Draganov ◽  
Zhen Han ◽  
Aamir Rana ◽  
Nitasha Bennett ◽  
Darrell J. Irvine ◽  
...  

AbstractWe show that treatment with the FDA-approved anti-parasitic drug ivermectin induces immunogenic cancer cell death (ICD) and robust T cell infiltration into breast tumors. As an allosteric modulator of the ATP/P2X4/P2X7 axis which operates in both cancer and immune cells, ivermectin also selectively targets immunosuppressive populations including myeloid cells and Tregs, resulting in enhanced Teff/Tregs ratio. While neither agent alone showed efficacy in vivo, combination therapy with ivermectin and checkpoint inhibitor anti-PD1 antibody achieved synergy in limiting tumor growth (p = 0.03) and promoted complete responses (p < 0.01), also leading to immunity against contralateral re-challenge with demonstrated anti-tumor immune responses. Going beyond primary tumors, this combination achieved significant reduction in relapse after neoadjuvant (p = 0.03) and adjuvant treatment (p < 0.001), and potential cures in metastatic disease (p < 0.001). Statistical modeling confirmed bona fide synergistic activity in both the adjuvant (p = 0.007) and metastatic settings (p < 0.001). Ivermectin has dual immunomodulatory and ICD-inducing effects in breast cancer, converting cold tumors hot, thus represents a rational mechanistic partner with checkpoint blockade.


1992 ◽  
Vol 20 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Lars-Göran Öst

A 68-year old female with a phobia of choking on fluids was treated first with exposure in vivo and then with cognitive therapy. The exposure increased her water drinking to some extent, but the cognitive change was negligible. However, the cognitive therapy led to a dramatic change in the catastrophical misinterpretations and a fourfold increase in her water consumption. The effects of treatment were maintained at a 1-year follow-up.


Author(s):  
Petter I. Andersen ◽  
Klara Krpina ◽  
Aleksandr Ianevski ◽  
Nastassia Shtaida ◽  
Eunji Jo ◽  
...  

Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Re-purposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), human immunodeficiency virus 1 (HIV-1), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FluAV), niclosamide against HSV-2, brequinar against HIV-1, and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vivo tests.


1996 ◽  
Vol 109 (3) ◽  
pp. 569-578 ◽  
Author(s):  
H. Herrmann ◽  
M.D. Munick ◽  
M. Brettel ◽  
B. Fouquet ◽  
J. Markl

We have isolated from a rainbow trout (Oncorhynchus mykiss) spleen cDNA library a clone coding for vimentin. The deduced amino acid sequence reveals a high degree of identity with vimentin from carp (81%), frog (71%), chick and human (73% each). Large stretches in the central alpha-helical rod are identical within all four classes of vertebrates, but in 17 residues spread over the entire rod, the two fish differ distinctly from the tetrapod species. In addition, in the more diverged non-helical head domain, a nonapeptide motif previously shown to be important for regular filament formation is conserved. Recombinant trout vimentin assembles into bona fide filaments in vitro, with a temperature optimum between 18 and 24 degrees C. Above 27 degrees C, however, filament assembly is abruptly abolished and short filaments with thickened ends as well as structures without typical intermediate filament appearance are formed. This distinguishes its assembly properties significantly from amphibian, avian and mammalian vimentin. Also in vivo, after cDNA transfection into vimentin-free mammalian epithelial cells, trout vimentin does not form typical intermediate filament arrays at 37 degrees C. At 28 degrees C, and even more pronounced at 22 degrees C, the vimentin-positive material in the transfected cells is reorganized in the perinuclear region with a partial fibrillar appearance, but typical intermediate filament arrays are not formed. Together with immunoblotting and immunolocalization data from trout tissues, where vimentin is predominantly found in glial and white blood cells, we conclude that vimentin is indeed important in its filamentous form in fish and other vertebrates, possibly fulfilling cellular functions not directly evident in gene targeting experiments carried out in mice.


2021 ◽  
Vol 12 ◽  
Author(s):  
Amelia K. Pinto ◽  
Mariah Hassert ◽  
Xiaobing Han ◽  
Douglas Barker ◽  
Trevor Carnelley ◽  
...  

The closely related flaviviruses, dengue and Zika, cause significant human disease throughout the world. While cross-reactive antibodies have been demonstrated to have the capacity to potentiate disease or mediate protection during flavivirus infection, the mechanisms responsible for this dichotomy are still poorly understood. To understand how the human polyclonal antibody response can protect against, and potentiate the disease in the context of dengue and Zika virus infection we used intravenous hyperimmunoglobulin (IVIG) preparations in a mouse model of the disease. Three IVIGs (ZIKV-IG, Control-Ig and Gamunex®) were evaluated for their ability to neutralize and/or enhance Zika, dengue 2 and 3 viruses in vitro. The balance between virus neutralization and enhancement provided by the in vitro neutralization data was used to predict the IVIG concentrations which could protect or enhance Zika, and dengue 2 disease in vivo. Using this approach, we were able to define the unique in vivo dynamics of complex polyclonal antibodies, allowing for both enhancement and protection from flavivirus infection. Our results provide a novel understanding of how polyclonal antibodies interact with viruses with implications for the use of polyclonal antibody therapeutics and the development and evaluation of the next generation flavivirus vaccines.


Discourse ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 5-19
Author(s):  
K. A. Ocheretyany

Introduction. The article deals with finding environmental patterns for the digital environment – at the moment, digital environments are more likely to bring a person closer to machine and technical requirements. The article poses a question (and a detailed answer is given) about how and under what conditions technology does not absorb a person, but gives her the opportunity to reveal her potential, turning it into existential capital.Methodology and sources. Methodologically, the work is based on philosophical analytical research and precedents of the digital field, examples of research literature, methods of media philosophy, anarchic epistemology, and topological reflection are applied. In particular, the hypotheses of the digital space as simultaneously communicative and disciplinary (Habermas, Foucault) digital behaviorism by B. Fogg, the economics of forgiveness by D. Graeber, the anthropology of the game by R. Caillois, Internet animals by A. Pscher were analyzed: on their basis, the principles of digital ethology and ecology.Results and discussion. The task of converting interfaces into ecological and pharmacological environments is the task of organizing by means of interfaces of various types of agencies. They should be organized in such a way that the modes of energy consumption and operation are replaced by modes of energy saving and care. In this case, the interfaces of digital devices could be not a continuation of the technical bureaucracy, but the conditions for comprehending and collecting the experience of the world. The project for this reorganization of funds – from exploitation to pharmacology – was proposed in the article. The article shows that the interface of digital devices can be not only a tool (techne) or a form of vision and cognition of the world (episteme), but also an ecological life-saving environment (pharmacy) for this it is necessary to take into account a number of factors: 1) counter-standardization and counter-personalization of the interface – it must to collide not with oneself, but with another, in all the radicalism of one’s otherness; 2) the ability to move from meaning to presence, and focus not on the consumption of ideological texts as standardized scenarios, but on the creation of contexts of existential interaction; 3) rejection of the agonality of digital consumption (which leads to emotional burnout) in favor of recognizing the uniqueness and incommensurability of experience, and, accordingly, creating conditions for mutual recognition and mutual trust, which are the main capital of a modern person in an era of semantic impenetrability in digital, the growth of suspicion and cynicism.Conclusion. The interface turns from a disciplinary space into a field of care when it becomes possible by means of the interface to go beyond itself, when it grants the right to postponement, to inattention, to offline, when instead of a tool of intensifying life, it becomes a condition for its deeper living. To do this, one should turn from techniques of drawing attention in the interface to techniques of organizing and interpreting the experience of the world.


2021 ◽  
Author(s):  
Liyuan Hao ◽  
Yinglin Guo ◽  
Qing Peng ◽  
Zhiqin Zhang ◽  
Shenghao Li ◽  
...  

Abstract Hepatocellular carcinoma (HCC) was one of the most malignant cancers in the world. Cisplatin (DDP) was one of the main chemotherapy drugs for HCC, but the mechanism of DDP treatment for HCC remains unclear. In this presentation, we found that DDP inhibited the growth of HCC cells and promoted the expression of PD-1 and its ligand PD-L1 in cancer cells. Meanwhile, flow cytometry analysis revealed that DDP enhanced PD-1-CD8+ T cells expression and decreased PD-1+CD8+ T cells expression. ELISA analysis suggested that DDP decreased TGF-β expression in vivo. Therefore, the study indicated that DDP enhanced PD-1 and PD-L1 expression and inhibited the growth of HCC.


Roteiro ◽  
2018 ◽  
Vol 43 (1) ◽  
pp. 21-42 ◽  
Author(s):  
Patrícia Somers ◽  
Cory Davis ◽  
Jessica Fry ◽  
Lisa Jasinski ◽  
Elida Lee

Since the Worldwide Financial Crisis of 2008, higher education institutions around the world have been forced to change their financial practices to focus on the bottom line. One such approach is academic capitalism, the heart of which is the entrepreneurial university which views faculty members as producers of capital (not educators), students as consumers (not learners), and business/industry, accreditors, and NGOs as valued business partners. This article defines academic capitalism, reviews the research literature, presents perspectives of academic capitalism in the Americas and discusses the implications of academic capitalism for Latin America. The article ends using anthropophagi to assess what is useful about academic capitalism for Brazil.


2021 ◽  
Author(s):  
Shasha Chong ◽  
Thomas G. W. Graham ◽  
Claire Dugast-Darzacq ◽  
Gina M. Dailey ◽  
Xavier Darzacq ◽  
...  

Gene activation by mammalian transcription factors (TFs) requires dynamic, multivalent, and selective interactions of their intrinsically disordered low-complexity domains (LCDs), but how such interactions mediate transcription remains unclear. It has been proposed that extensive LCD-LCD interactions culminating in liquid-liquid phase separation (LLPS) of TFs is the dominant mechanism underlying transactivation. Here, we investigated how tuning the amount and localization of LCD-LCD interactions in vivo affects transcription of endogenous human genes. Quantitative single-cell and single-molecule imaging reveals that the oncogenic TF EWS/FLI1 requires a finely tuned range of LCD-LCD interactions to efficiently activate target genes. Modest or more dramatic increases in LCD-LCD interactions toward putative LLPS repress EWS/FLI1-driven transcription in patient cells. Likewise, ectopically creating LCD-LCD interactions to sequester EWS/FLI1 into a bona fide LLPS compartment, the nucleolus, inhibits EWS/FLI1-driven transcription and oncogenic transformation. Our findings reveal fundamental principles underlying LCD-mediated transcription and suggest mislocalizing specific LCD-LCD interactions as a novel therapeutic strategy for targeting disease-causing TFs.


Author(s):  
Martin R. Kalfatovic ◽  
Constance Rinaldo

Data contained in the the Biodiversity Heritage Library (BHL) describes collections held in the world's major museums. Finding those collections data, however, remains a challenge. A literal needle in a Festuca stack as some have noted. BHL is actively engaging in incorporating tools (including Digital Object Identifier's (DOI's)and the recently launched full-text search) to make finding and linking to collection specimen information better. Still, it is not easy to find specific collections information in the non-semantically tagged BHL content. This session will call for ideas on how to locate this content.. BHL is an international consortium, making research literature openly available to the world as part of a global biodiversity community. The BHL was created in 2006 as a direct response to the needs of the taxonomic community for access to early literature. The original BHL organizational model, based on United States and United Kingdom partners, provided a template for what is now over 80 global partners. Through this extensive network of Members, Affiliates, and partners, over 56 million pages of biodiversity literature are available through the BHL portal. BHL changes the lives of researchers and assists the work of collections managers. By enhancing daily research at the Smithsonian and Harvard, BHL provides a global network of researchers with an easy-to-use digital library of content and services.


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