scholarly journals Platelet Count and Platelet Indices in Pregnant Saudi Women with Gestational Diabetes Mellitus

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Osama M Alshehri
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Count ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Platelet Indices ◽  
Saudi Women

Relationship between the paraoxonase 1 gene glutamine 192 to arginine polymorphism and gestational diabetes mellitus in Saudi women

2014 ◽  
Vol 47 (15) ◽  
pp. 122-125 ◽  
Author(s):  
Malak Mohammed Al-Hakeem ◽  
Zeinab Abotalib ◽  
Khalid Khalaf Alharbi ◽  
Imran Ali Khan
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Paraoxonase 1 ◽  
Saudi Women

scholarly journals The Effect of Dietary Intake of Vitamin D on Gestational Diabetes Mellitus

2020 ◽  
Vol 13 ◽  
pp. 117863882093216
Author(s):  
Alanood Aljanahi ◽  
Huda Hadhiah ◽  
Wejdan Al-Nasr ◽  
Omar Abuzaid ◽  
Nourah Al Qahtani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Dietary Intake ◽  
Eastern Region ◽  
Dietary Counseling ◽  
Dietary Recall ◽  
Saudi Women ◽  
And Control

Diabetes mellitus (DM) is a growing health issue that has been reaching epidemic proportions in the recent years. Low intake of some nutrients like vitamin D may increase the risk of gestational diabetes mellitus (GDM). This study was to investigate the association between the dietary intake of Vitamin D and GDM among women in the Eastern Region of Saudi Arabia. A case-control study was conducted in a sample of 121 women, among those 72 were with GDM and 49 were controls. Vitamin D was estimated using food frequency questionnaire. Also, the 24-h’s dietary recall was carried out for 3 days to determine the nutrient intake as well as biochemical analysis for blood glucose level. In this study, GDM subjects were consuming significantly more eggs ( P = .040). Vitamin D and vitamin C intakes in GDM and control pregnant women were lower than recommended dietary allowances (RDA). It was also found that low-fat milk, full-fat milk, fortified yogurt, and fortified orange juice were significantly associated with GDM ( P < 0.05). Saudi women with GDM need a well-organized dietary counseling before, during pregnancy, and after delivery especially for vitamin D sources.

scholarly journals Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Khalid Khalaf Alharbi ◽  
Imran Ali Khan ◽  
Zeinab Abotalib ◽  
Malak Mohammed Al-Hakeem
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Receptor ◽  
Critical Role ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1 ◽  
Female Population ◽  
Women Subjects ◽  
Saudi Women

Pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share a common pathophysiology associated with similar risk factors. Genetic variants used to determine the risk of developing T2DM might also be associated with the prevalence of GDM. The aim of the present study was to scrutinize the relationship between the G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene with GDM in the Saudi female population. This is a case-control study that monitored 500 Saudi women. Subjects with GDM (n=200) were compared with non-GDM (n=300) controls. We opted to evaluate rs1801278 polymorphism in the IRS1 gene, which plays a critical role in the insulin-signaling pathway. Genotyping was performed with the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The frequency of the rs1801278 polymorphism was significantly higher in women with GDM than in women with non-GDM (for TT + CT versus CC:P=0.02). Additionally, there was a significant increase in the frequency of the Arg-encoding mutant allele from GDM to non-GDM (for T versus C:P=0.01). Our results suggest that the rs1801278 polymorphism in theIRS-1gene is involved in the occurrence of GDM in the Saudi population.

scholarly journals Thrombocyte Alterations in Pregnant Women with Gestational Diabetes Mellitus

2018 ◽  
Vol 24 (1) ◽  
pp. 12 ◽  
Author(s):  
Senol Senturk ◽  
Mehmet Kagitci ◽  
Emine Seda Guvendag Guven
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Count ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Mean Platelet Volume ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width

<p><strong>Objective:</strong> Inflammation and its complications might develop in patients diagnosed with diabetes mellitus. It is shown that number, shape and functions of thrombocytes are important for development and prediction of inflammatory process. We aimed to show the changes of number, morphology and functions of platelets in the patients with gestational diabetes mellitus.</p><p><strong>study design:</strong> In a retrospective study, 928 cases in 24-28th weeks of gestation followed regularly in the same clinic were included. We performed 75g oral glucose tolerance test to all cases. Mean platelet volume, platelet distribution width and plateletcrit values of the cases with and without gestational diabetes mellitus according to American Diabetes Association criteria were compared to evaluate the platelet count, morphology, functions and activity.</p><p><strong>Results:</strong> Platelet count and plateletcrit values of cases were significantly higher in the patients with gestational diabetes mellitus. No significant differences were found between the cases with and without gestational diabetes mellitus in mean platelet volume and platelet distribution width values.</p><p><strong>Conclusion:</strong> There is tendency to inflammation in GDM and platelets are part of inflamatuary process in human metabolism. Our findings show that, platelets are affected in GDM. We believe that further studies in this subject will help understanding of pathophysiology of GDM.</p>

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