Synchronous Pulmonary Carcinoma and Pleural Diffuse Malignant Mesothelioma

2006 ◽  
Vol 130 (5) ◽  
pp. 721-724
Author(s):  
Timothy Craig Allen ◽  
Cesar Moran
Keyword(s):  
Malignant Mesothelioma ◽  
English Language ◽  
Asbestos Exposure ◽  
Smoking History ◽  
Pulmonary Carcinoma ◽  
Average Survival ◽  
History Of ◽  
Patient’S History ◽  
Pleural Involvement ◽  
Diffuse Malignant Mesothelioma

Abstract Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma is rare. Cases from the archives of 2 large referral centers were reviewed to identify cases of synchronously occurring pulmonary carcinoma and pleural diffuse malignant mesothelioma. Three cases of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma were identified from more than 16 000 pleuropulmonary cases and were reviewed for demographic, clinical, radiographic, histologic, and immunohistochemical findings. The patients were men who were 63, 67, and 77 years old. Two had positive smoking histories; the smoking history of the other patient is unknown. One patient had a positive history of asbestos exposure; one patient had no history of asbestos exposure; and one patient's history of asbestos exposure is unknown. The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively. Two of the adenocarcinomas were of a predominantly bronchioloalveolar pattern. No diffuse malignant mesothelioma was identified preoperatively. Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma. Tumor immunostaining supported the diagnoses. The average survival after diagnosis was 6 weeks or less. In summary, the paucity of cases at 2 large referral centers and the paucity of cases reported in the English language literature highlights the rarity of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. These synchronous neoplasms occur in patients who have risk factors for both neoplasms independently. Length of survival following diagnosis is bleak.

Malignant Mesothelioma of Spermatic Cord in an Elderly Man With a History of Asbestos Exposure

Urology ◽  
2016 ◽  
Vol 87 ◽  
pp. e1-e3 ◽  
Author(s):  
Antonio D'Antonio ◽  
Federica Mastella ◽  
Angelo Colucci ◽  
Gianmarco Silvestre
Keyword(s):  
Malignant Mesothelioma ◽  
Spermatic Cord ◽  
Asbestos Exposure ◽  
History Of

scholarly journals Peritoneal (Paraovarian) Malignant Mesothelioma

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Erna Kristiani ◽  
Stephanie Marisca
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Strong Association ◽  
Uncommon Disease ◽  
Microscopic Features ◽  
Adenocarcinoma Of The Ovary ◽  
History Of ◽  
Desmoplastic Stroma ◽  
Mitotic Figures ◽  
Columnar Cells

<p>Peritoneal Malignant Mesothelioma (PMM) is uncommon disease, but increasing in frequency nowadays. This highly aggressive malignancy occurs most commonly in older men and has a strong association with asbestos exposure. It manifests most often as diffuse sheet-like or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. The very large variations of its clinical features and its histological appearance mimicking adenocarcinoma make this tumor is difficult to diagnose.<br />We report a case of PMM that previously diagnose as adenocarcinoma of the ovary. A 29 year-old female came to gynecology clinic with para-ovarian mass. She had no history of asbestos exposure. The mass was oval 9x6x6 cm in size, whitish and firm. Microscopic features showed papillary dense structure with desmoplastic stroma, covered by a layer of cuboidal to columnar cells. The cells with mild pleomorphism and hyperchromatic nuclei, mitotic figures were minimal. The immunohistochemistry tests revealed positive for D2-40, Calretinin, CK8 and CK 18, weakly positive for Inhibin and EMA, and negative for CEA and AFP. Patient had been received chemotherapy, there were no metastasis.</p>

Malignant peritoneal mesothelioma in a 76-year-old woman with a history of asbestos fiber ingestion

2004 ◽  
Vol 14 (1) ◽  
pp. 162-165
Author(s):  
P. Van Kesteren ◽  
J. Bulten ◽  
C. Schijf ◽  
H. Boonstra ◽  
L. Massuger
Keyword(s):  
Electron Microscopy ◽  
Weight Loss ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Asbestos Fiber ◽  
Malignant Peritoneal Mesothelioma ◽  
Small Tumor ◽  
Contaminated Food ◽  
History Of ◽  
Omental Cake

We report on a woman with malignant mesothelioma of the peritoneum. This is the first report of a subject with this disease who revealed a history of asbestos ingestion by asbestos-contaminated food. She presented with episodes of sweating and fever, ascites, and weight loss. At laparotomy, small tumor deposits were noted on the peritoneum. The omental cake was removed, together with the uterus, ovaries, and tubes which were all macroscopically normal. The diagnosis was established by immunohistochemistry and electron microscopy. Postoperatively, her complaints of fever and sweating disappeared. She refused further chemotherapy. After questioning her for asbestos exposure, she told us that, years ago, she used to prepare vegetables for cooking in rain water collected from a roof made of asbestos.

Differentiation of malignant mesothelioma from adenocarcinoma

1993 ◽  
Vol 51 ◽  
pp. 312-313
Author(s):  
John Garancis ◽  
John Cafaro ◽  
Anthony Cafaro ◽  
Raymond Venezia
Keyword(s):  
Malignant Mesothelioma ◽  
Clinical Course ◽  
Wide Spectrum ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Etiologic Agent ◽  
Parietal Pleura ◽  
Metastatic Adenocarcinoma ◽  
Microscopic Appearance ◽  
History Of

Malignant mesothelioma (MM) is a rare tumor arising predominantly from either the visceral or parietal pleura or peritoneal surfaces. It primarily effects individuals between 45 and 75 years. of age and asbestos is felt to be the single most important etiologic agent. Studies suggest that the incidence of MM is increasing perhaps at a rate of as high as 13% per year. The diagnosis of MM can be difficult and is often complicated by the tumors similarity to metastatic adenocarcinoma, both in it's microscopic appearance and to some extent clinical course.In this particular study the immunohistochemical properties of 22 malignant mesotheliomas (20 pleural and two peritoneal) are compared with 20 pulmonary adenocarcinomas. Each tissue was examined using monoclonal antibodies to wide-spectrum cytokeratin, CEA, Leu-M1 and B72.3. Extensive asbestos exposure was identified in all but 1 of the mesothelioma cases. The cases of peritoneal MM were found to have a history of chrysctile exposure only (Fig.1). Distant metastases were present in four cases of MM.

Diffuse malignant mesothelioma of the pleura in Ontario and Quebec: a retrospective study of 332 patients.

1989 ◽  
Vol 7 (8) ◽  
pp. 1157-1168 ◽  
Author(s):  
P Ruffie ◽  
R Feld ◽  
S Minkin ◽  
Y Cormier ◽  
A Boutan-Laroze ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Chemotherapeutic Agents ◽  
Delay In Diagnosis ◽  
Therapeutic Trials ◽  
Therapeutic Measures ◽  
Diffuse Malignant Mesothelioma

Three-hundred thirty-two cases of pleural diffuse malignant mesothelioma (DMM) seen at large centers in Ontario and Quebec from 1965 to 1984 were reviewed retrospectively. Previous asbestos exposure was found in 44% of patients. Diagnosis was most often made by exploratory thoracotomy; pleural biopsy or cytology were rarely contributory. The delay in diagnosis was often long (median time, 3.5 months) and thrombocytosis (platelets greater than or equal to 400,000/microL) was common (41% of cases). The median survival (MS) was only 9 months. Eleven clinical variables were analyzed for prognostic significance. The three most important prognostic factors using a univariate analysis were stage, weight loss, and histologic type. For 118 patients with complete data, multivariate analysis showed that the stage of disease, high platelet count, and asbestos exposure were the most important prognostic factors. There was no cure of DMM, and we did not find any drastic differences in survival among groups of patients subjected to the different therapeutic measures. Radical surgery and radiotherapy were ineffective and we confirmed the low response rate to chemotherapeutic agents. This large retrospective trial can serve as a baseline for future studies in this field. In particular, it provides the basis for appropriate stratification variables to be used in future therapeutic trials.

The diagnostic utility of D2-40 for malignant mesothelioma versus pulmonary carcinoma with pleural involvement

2006 ◽  
Vol 34 (12) ◽  
pp. 801-806 ◽  
Author(s):  
Reda S. Saad ◽  
Jennifer L. Lindner ◽  
Xiaoqi Lin ◽  
Yulin L. Liu ◽  
Jan F. Silverman
Keyword(s):  
Malignant Mesothelioma ◽  
Diagnostic Utility ◽  
Pulmonary Carcinoma ◽  
Pleural Involvement

scholarly journals Survival of Korean Patients with Malignant Pleural Mesothelioma Compensated for the Asbestos Injury Relief

2021 ◽  
Vol 11 (20) ◽  
pp. 9713
Author(s):  
Min-Sung Kang ◽  
Sung-Soo Lee ◽  
Soon-Chan Kwon ◽  
Da-An Huh ◽  
Yong-Jin Lee
Keyword(s):  
Prognostic Factors ◽  
Occupational Exposure ◽  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Performance Status ◽  
Smoking History ◽  
Pleural Mesothelioma ◽  
Histological Subtype ◽  
Epidemiologic Characteristics

Background: The purpose of this study was to identify the epidemiologic characteristics and prognostic factors for malignant pleural mesothelioma in Korea, which are currently insufficient. The data were derived from malignant mesothelioma patients who registered under the Asbestos Injury Relief Act; Methods: A total of 728 patients received compensation from the Asbestos Injury Relief Act due to malignant mesothelioma between 2011 and 2015. Of these, 313 patients (43.0%) with malignant pleural mesothelioma were included in the study. The study variables were sex (male, female), age at diagnosis (<59, 60–69, ≥70), smoking history (yes, no), surgery (yes, no), chemotherapy (yes, no), occupational exposure to asbestos (yes, no), and histological subtype (epithelioid, nonepithelioid); Results: Median survival of mesothelioma was 8.0 months (95% confidence interval: 6.2 to 9.8). The 1-year, 2-year, and 5-year survival rates (%) were 43.5%, 23.6%, and 12.5%, respectively. In multivariate analysis of Cox’s proportional hazards model; sex, age, smoking history, occupational asbestos exposure, and histological subtype were not significant prognostic factors, but surgery and chemotherapy combined was a significant predictor; Conclusions: Although the representativeness of these data is limited, our study estimates the epidemiologic characteristics of malignant pleural mesothelioma. Non-occupational exposure had a similar prognosis to occupational asbestos exposure, and there was no sex difference. In addition, it was found that receiving a combination of surgery and chemotherapy affects the survival rate, but there is a limitation in that factors such as performance status, comorbidities, and stage that contribute to survival are not considered.

scholarly journals Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Shan-shan Su ◽  
Guo-qi Zheng ◽  
Ya-gang Liu ◽  
Yue-feng Chen ◽  
Zhao-wei Song ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Liver Involvement ◽  
Review Of Literature ◽  
Malignant Peritoneal Mesothelioma ◽  
Single Institution ◽  
Hepatic Involvement ◽  
Computed Tomography Images ◽  
History Of

Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours.

scholarly journals Malignant Mesothelioma of the Tunica Vaginalis Testis—A Malignancy Associated With Asbestos Exposure and Trauma: A Case Report and Literature Review

2019 ◽  
Vol 7 ◽  
pp. 232470961982733 ◽  
Author(s):  
AAM A. Baqui ◽  
Nicholas A. Boire ◽  
Tajruba T. Baqui ◽  
Dhanan J. Etwaru
Keyword(s):  
Case Report ◽  
Occupational Exposure ◽  
Literature Review ◽  
Malignant Mesothelioma ◽  
Unusual Case ◽  
Surgical Intervention ◽  
Asbestos Exposure ◽  
Tunica Vaginalis ◽  
Tunica Vaginalis Testis ◽  
History Of

In this article, we report an unusual case of a malignant mesothelioma of the testis, presenting as hydrocele. The patient has a known medical history of trauma and occupational exposure to asbestos. The clinical features of this injury are discussed together with its immunohistochemistry. Surgical intervention is discussed due to the nature of this pathology.

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