Differentiation of malignant mesothelioma from adenocarcinoma

1993 ◽  
Vol 51 ◽  
pp. 312-313
Author(s):  
John Garancis ◽  
John Cafaro ◽  
Anthony Cafaro ◽  
Raymond Venezia
Keyword(s):  
Malignant Mesothelioma ◽  
Clinical Course ◽  
Wide Spectrum ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Etiologic Agent ◽  
Parietal Pleura ◽  
Metastatic Adenocarcinoma ◽  
Microscopic Appearance ◽  
History Of

Malignant mesothelioma (MM) is a rare tumor arising predominantly from either the visceral or parietal pleura or peritoneal surfaces. It primarily effects individuals between 45 and 75 years. of age and asbestos is felt to be the single most important etiologic agent. Studies suggest that the incidence of MM is increasing perhaps at a rate of as high as 13% per year. The diagnosis of MM can be difficult and is often complicated by the tumors similarity to metastatic adenocarcinoma, both in it's microscopic appearance and to some extent clinical course.In this particular study the immunohistochemical properties of 22 malignant mesotheliomas (20 pleural and two peritoneal) are compared with 20 pulmonary adenocarcinomas. Each tissue was examined using monoclonal antibodies to wide-spectrum cytokeratin, CEA, Leu-M1 and B72.3. Extensive asbestos exposure was identified in all but 1 of the mesothelioma cases. The cases of peritoneal MM were found to have a history of chrysctile exposure only (Fig.1). Distant metastases were present in four cases of MM.

scholarly journals Scalp Metastasis of Mesothelioma

2021 ◽  
Author(s):  
İlkin Yetişkin ◽  
Berna Eren Kömürcüoğlu ◽  
Eylem Yıldırım
Keyword(s):  
Adrenal Gland ◽  
Malignant Mesothelioma ◽  
Malignant Tumor ◽  
Late Stage ◽  
Poor Prognosis ◽  
Early Stage ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Rare Neoplasm ◽  
Scalp Metastasis

Mesothelioma is a primary malignant tumor of the mesothelial cells lining the pleura, pericardium and peritoneum, which is frequently seen between the ages of 40-60. Malignant mesothelioma (MM) is a rare neoplasm with a poor prognosis, usually associated with asbestos exposure. It is characterized by aggressive local invasion and metastatic spread. Extrathoracic lymphogenous-hematogenous metastases are rare at the time of diagnosis and in the early stage. However, metastases develop in at least half of the cases in the late stage of the disease. After the spread of serous membranes, distant metastases to the bone, adrenal gland, and liver are frequently observed. Skin and scalp metastases are rarely observed. Our case MPM is presented because it is a rare scalp metastasis.

Malignant Pericardial Mesothelioma. Report of two Cases, Review of the Literature and Differential Diagnosis

2005 ◽  
Vol 91 (3) ◽  
pp. 276-279 ◽  
Author(s):  
Maximilian Papi ◽  
Giovenzio Genestreti ◽  
Davide Tassinari ◽  
Paolo Lorenzini ◽  
Silvia Serra ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Radical Surgery ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Cardiac Neoplasm ◽  
Fibrous Stroma ◽  
Pericardial Mesothelioma ◽  
History Of

Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac neoplasm. The presentation of pericardial mesothelioma is aspecific and pathologically mesothelioma is not the most common among primary tumors of the pericardium. It is characterized by atypical solid growth of mesothelium with formation of atypical cavities surrounded by fibrous stroma. Antemortem diagnosis is difficult and distant metastases are extremely rare. Radical surgery can be used to treat localized mesothelioma. The treatment for advanced primary pericardial mesothelioma is usually palliative because the tumor is resistant to radiotherapy and chemotherapy. The prognosis is unfavorable. The median survival from the onset of symptoms is six months. In this paper we report two cases of patients with primary mesothelioma of the pericardium without a definite history of asbestos exposure.

Malignant Mesothelioma of Spermatic Cord in an Elderly Man With a History of Asbestos Exposure

Urology ◽  
2016 ◽  
Vol 87 ◽  
pp. e1-e3 ◽  
Author(s):  
Antonio D'Antonio ◽  
Federica Mastella ◽  
Angelo Colucci ◽  
Gianmarco Silvestre
Keyword(s):  
Malignant Mesothelioma ◽  
Spermatic Cord ◽  
Asbestos Exposure ◽  
History Of

scholarly journals Peritoneal (Paraovarian) Malignant Mesothelioma

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Erna Kristiani ◽  
Stephanie Marisca
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Strong Association ◽  
Uncommon Disease ◽  
Microscopic Features ◽  
Adenocarcinoma Of The Ovary ◽  
History Of ◽  
Desmoplastic Stroma ◽  
Mitotic Figures ◽  
Columnar Cells

<p>Peritoneal Malignant Mesothelioma (PMM) is uncommon disease, but increasing in frequency nowadays. This highly aggressive malignancy occurs most commonly in older men and has a strong association with asbestos exposure. It manifests most often as diffuse sheet-like or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. The very large variations of its clinical features and its histological appearance mimicking adenocarcinoma make this tumor is difficult to diagnose.<br />We report a case of PMM that previously diagnose as adenocarcinoma of the ovary. A 29 year-old female came to gynecology clinic with para-ovarian mass. She had no history of asbestos exposure. The mass was oval 9x6x6 cm in size, whitish and firm. Microscopic features showed papillary dense structure with desmoplastic stroma, covered by a layer of cuboidal to columnar cells. The cells with mild pleomorphism and hyperchromatic nuclei, mitotic figures were minimal. The immunohistochemistry tests revealed positive for D2-40, Calretinin, CK8 and CK 18, weakly positive for Inhibin and EMA, and negative for CEA and AFP. Patient had been received chemotherapy, there were no metastasis.</p>

Malignant peritoneal mesothelioma in a 76-year-old woman with a history of asbestos fiber ingestion

2004 ◽  
Vol 14 (1) ◽  
pp. 162-165
Author(s):  
P. Van Kesteren ◽  
J. Bulten ◽  
C. Schijf ◽  
H. Boonstra ◽  
L. Massuger
Keyword(s):  
Electron Microscopy ◽  
Weight Loss ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Asbestos Fiber ◽  
Malignant Peritoneal Mesothelioma ◽  
Small Tumor ◽  
Contaminated Food ◽  
History Of ◽  
Omental Cake

We report on a woman with malignant mesothelioma of the peritoneum. This is the first report of a subject with this disease who revealed a history of asbestos ingestion by asbestos-contaminated food. She presented with episodes of sweating and fever, ascites, and weight loss. At laparotomy, small tumor deposits were noted on the peritoneum. The omental cake was removed, together with the uterus, ovaries, and tubes which were all macroscopically normal. The diagnosis was established by immunohistochemistry and electron microscopy. Postoperatively, her complaints of fever and sweating disappeared. She refused further chemotherapy. After questioning her for asbestos exposure, she told us that, years ago, she used to prepare vegetables for cooking in rain water collected from a roof made of asbestos.

Synchronous Pulmonary Carcinoma and Pleural Diffuse Malignant Mesothelioma

2006 ◽  
Vol 130 (5) ◽  
pp. 721-724
Author(s):  
Timothy Craig Allen ◽  
Cesar Moran
Keyword(s):  
Malignant Mesothelioma ◽  
English Language ◽  
Asbestos Exposure ◽  
Smoking History ◽  
Pulmonary Carcinoma ◽  
Average Survival ◽  
History Of ◽  
Patient’S History ◽  
Pleural Involvement ◽  
Diffuse Malignant Mesothelioma

Abstract Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma is rare. Cases from the archives of 2 large referral centers were reviewed to identify cases of synchronously occurring pulmonary carcinoma and pleural diffuse malignant mesothelioma. Three cases of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma were identified from more than 16 000 pleuropulmonary cases and were reviewed for demographic, clinical, radiographic, histologic, and immunohistochemical findings. The patients were men who were 63, 67, and 77 years old. Two had positive smoking histories; the smoking history of the other patient is unknown. One patient had a positive history of asbestos exposure; one patient had no history of asbestos exposure; and one patient's history of asbestos exposure is unknown. The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively. Two of the adenocarcinomas were of a predominantly bronchioloalveolar pattern. No diffuse malignant mesothelioma was identified preoperatively. Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma. Tumor immunostaining supported the diagnoses. The average survival after diagnosis was 6 weeks or less. In summary, the paucity of cases at 2 large referral centers and the paucity of cases reported in the English language literature highlights the rarity of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. These synchronous neoplasms occur in patients who have risk factors for both neoplasms independently. Length of survival following diagnosis is bleak.

scholarly journals Localized Biphasic Malignant Peritoneal Mesothelioma with Rhabdoid Features Involving the Liver: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Dalal Hassan ◽  
Saverio Ligato
Keyword(s):  
Abdominal Wall ◽  
Surgical Resection ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Microscopic Appearance ◽  
Lateral Abdominal Wall ◽  
Rare Tumors ◽  
History Of ◽  
Rhabdoid Features

Introduction. Localized malignant mesotheliomas, defined as sharply circumscribed tumors of the serosal membrane with the microscopic appearance of diffuse malignant mesothelioma, are rare tumors; their behavior and prognosis are uncertain. Intrahepatic mesotheliomas are postulated to arise from mesothelial cells of Glisson’s capsule. Case Presentation. A 69-year-old female with no history of asbestos exposure presented with a one-month history of increasing abdominal pain associated with constitutional symptoms. Computerized Tomography (CT) scan of the abdomen and pelvis revealed a sizable soft tissue mass within the right paracolic gutter, abutting the inferior hepatic margin, the lateral abdominal wall, and descending colon. Ultrasound-guided biopsy of the mass suggested a poorly differentiated hepatocellular carcinoma. There was no disease elsewhere on PET scan. Surgical resection of the mass was performed. Pathological assessment suggested the tumor to be arising from the liver with invasion of the liver, abdominal wall musculature, and the adventitial surface of the ascending colon. A final diagnosis of localized biphasic malignant peritoneal mesothelioma with rhabdoid features was rendered based on morphology and the result of immunohistochemical studies. The abdominal wall margin was positive. The patient progressed over the course of 6 months despite receiving adjuvant chemotherapy and immunotherapy with metastases and a decline in performance status and was transitioned to hospice. Conclusion. Localized malignant peritoneal mesotheliomas are rare tumors that may present clinically as a liver mass and simulate primary hepatic or secondary tumors. Definitive diagnosis is obtained by surgical resection in most cases. The clinical outcome is variable with most cases having a poor outcome.

scholarly journals Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Shan-shan Su ◽  
Guo-qi Zheng ◽  
Ya-gang Liu ◽  
Yue-feng Chen ◽  
Zhao-wei Song ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Liver Involvement ◽  
Review Of Literature ◽  
Malignant Peritoneal Mesothelioma ◽  
Single Institution ◽  
Hepatic Involvement ◽  
Computed Tomography Images ◽  
History Of

Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours.

scholarly journals Malignant Mesothelioma of the Tunica Vaginalis Testis—A Malignancy Associated With Asbestos Exposure and Trauma: A Case Report and Literature Review

2019 ◽  
Vol 7 ◽  
pp. 232470961982733 ◽  
Author(s):  
AAM A. Baqui ◽  
Nicholas A. Boire ◽  
Tajruba T. Baqui ◽  
Dhanan J. Etwaru
Keyword(s):  
Case Report ◽  
Occupational Exposure ◽  
Literature Review ◽  
Malignant Mesothelioma ◽  
Unusual Case ◽  
Surgical Intervention ◽  
Asbestos Exposure ◽  
Tunica Vaginalis ◽  
Tunica Vaginalis Testis ◽  
History Of

In this article, we report an unusual case of a malignant mesothelioma of the testis, presenting as hydrocele. The patient has a known medical history of trauma and occupational exposure to asbestos. The clinical features of this injury are discussed together with its immunohistochemistry. Surgical intervention is discussed due to the nature of this pathology.

Ultrastructural diagnosis of peritoneal malignant mesothelioma

1994 ◽  
Vol 52 ◽  
pp. 234-235
Author(s):  
S. Siew
Keyword(s):  
Malignant Mesothelioma ◽  
Common Type ◽  
Abdominal Discomfort ◽  
The Body ◽  
Metastatic Adenocarcinoma ◽  
Common Site ◽  
Primary Malignancy ◽  
Peritoneal Implant ◽  
Morphological Diagnosis ◽  
Malignant Neoplasia

Mesothelial cells constitute the lining of the three serous sacs of the body i.e. the pleura, pericardium and peritoneum. The more common type of malignant neoplasia of the serous sacs is seeding by metastatic tumors and primary malignancy of the mesothelium is unusual. Of the three sacs, the pleura is the most common site of malignant mesothelioma. Involvement of the peritoneum is extremely rare.We report 3 cases of malignant mesothelioma of the peritoneum. All of them were female. Their ages were 57, 67 and 72 years, respectively. The patients presented with abdominal discomfort and/or ascites. The extent of the tumors ranged from a peritoneal implant to widespread infiltration of the peritoneum and omentum. Histologic examination in Case 1 showed the presence of a diffusely infiltrating papillary mesothelioma without a sarcomatoid component. A mesodermal element was present in the other two cases. In order to establish a morphological diagnosis of malignant mesothelioma, the possibility has to be excluded of a metastatic adenocarcinoma.

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