scholarly journals Effects of Herbal Forte Rice as Replacement of Carbohydrate to Insulin Resistance in Patients with Type 2 Diabetes in Sumbersari Health Center Jember

2017 ◽  
Vol 3 (2) ◽  
pp. 11
Author(s):  
Dina Faizatur Rahmah ◽  
Ancah Caesarina Novi Marchianti ◽  
Rini Riyanti
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Center ◽  
Glycemic Index ◽  
Control Group ◽  
Unhealthy Diet ◽  
Experimental Group

The population of type 2 diabetes mellitus sufferer continuously increases due to the increase of insulin resistance characterised by the rise of the secretion insulin. Insulin resistance is affected by several factors such as the lack of physical activity, obesity, and unhealthy diet. One of the characteristics of the unhealthy diet is the high consumption of carbohydrates.Whereas Indonesian prefers to have carbohydrate sources from food which has high glycemic index such as rice so thatit makes the glucose in the blood increased rapidly. This condition causes more and faster insulin secretion and can affect insulin resistance. The purpose of this study is to know the effectiveness of herbal forte rice as a substitute of the main carbohydrate in the state of hyperinsulinemia suffered by 15 patients of type 2 diabetes mellitus in Puskesmas (community health center) Sumbersari Jember. This study is a clinical trial with a quasi experimental method and crossover design. In this study, the sample is interviewed by characteristics (age, gender) and the early consumption patterns using 24-hour food recall three times at different times. Samples acted as a control group once the experimental group. The control group did not receive any treatment, while the experimental group received the herbal forte rice as much as 100 grams for 7 consecutive days in the morning (at 06.30 am). After washing out period for 9 days, experimental group switched into control group. At the end of the period (7 days), data of fasting blood glucose and fasting insulin were collected then counted by HOMA-IR formula. The result of the study based on the paired t test p=0.001 in comparison to the state of the control and experimental group. The conclusion of this study is there is a changing state of insulin resistance with the replacement of food based on glycemic index.

scholarly journals Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients

2017 ◽  
Vol 14 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Wen-Jia Chen ◽  
Yue Liu ◽  
Yu-Bin Sui ◽  
Bo Zhang ◽  
Xiao-Hui Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Levels ◽  
Control Group ◽  
Diabetic Patients ◽  
Model Assessment ◽  
Newly Diagnosed

Background: Musclin is a newly identified skeletal muscle–derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. Materials and methods: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects. Plasma musclin levels were examined by radioimmunoassay. Results: Compared with the control group, musclin plasma levels were significantly higher in untreated type 2 diabetes mellitus patients. Musclin levels in the plasma of newly diagnosed type 2 diabetes mellitus patients were positively correlated with fasting plasma glucose, haemoglobin A1c, serum insulin, triglycerides and homeostasis model assessment of insulin resistance. Furthermore, multivariate logistic regression analysis showed that the level of musclin was associated with the presence of type 2 diabetes mellitus. Receiver operating characteristic curve analysis yielded an area under the curve for musclin of 0.718 in type 2 diabetes mellitus. Conclusion: The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Our results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.

scholarly journals Effects of Brain Breaks Videos on the Motives for the Physical Activity of Malaysians with Type-2 Diabetes Mellitus

2020 ◽  
Vol 17 (7) ◽  
pp. 2507
Author(s):  
Aizuddin Hidrus ◽  
Yee Cheng Kueh ◽  
Bachok Norsaádah ◽  
Yu-Kai Chang ◽  
Tsung-Min Hung ◽  
...  
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Analysis Of Variance ◽  
Repeated Measure ◽  
Control Group ◽  
Brain Breaks ◽  
Experimental Group

Brain Breaks videos are web-based structured physical activity (PA) videos that aim at stimulating an interest in learning and promoting health. Exercise is one of the important treatment regimens for people with type 2 diabetes mellitus (T2DM). Thus, the objective of this study was to determine the effects that Brain Breaks videos have on the motives for PA, as measured by the Physical Activity and Leisure Motivation Scale-Malay (PALMS-M), and the amount of PA, as measured by the International Physical Activity Questionnaire-Malay (IPAQ-M), in T2DM patients (the most common type of diabetes mellitus patients). This study was conducted using a randomized, double-blind design and grouped subjects under two research conditions: an experimental group given Brain Breaks videos and a control group. Purposive sampling was employed to recruit 70 T2DM patients (male = 39, female = 31) with the mean age of 57.6 (SD = 8.5) from Hospital Universiti Sains Malaysia, Kelantan. Over a four-month period, the participants in the experimental group were asked to perform PA daily based on a Brain Breaks video (10 min in duration) that was shared through a WhatsApp group. All participants from both groups answered the PALMS-M questionnaire five times: pre-intervention, the end of the first month, second month, and third month, and post-intervention. A repeated measure multivariate analysis of variance and a repeated measure analysis of variance were performed for the analyses of the data. The results demonstrated that four (appearance, others’ expectations, physical condition, and mastery) out of eight motives for PA produced a significant mean score difference between the two study groups. All eight motives for PA showed an upward trend for the experimental group during the study period, while the control group showed a downward trend for all motives during the study period. As for the amount of PA, both groups showed significant differences (p = 0.001). The amount of PA increased in the experimental group during the study period, while it decreased in the control group. Therefore, Brain Breaks videos can be considered as an effective intervention for motivating T2DM patients for PA and improving their amount of PA.

Impact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved Areas

2017 ◽  
Vol 32 (3) ◽  
pp. 753-762 ◽  
Author(s):  
Edelweiss Ramal ◽  
Andrea Champlin ◽  
Khaled Bahjri
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medically Underserved ◽  
Self Management ◽  
Control Group ◽  
Medically Underserved Areas ◽  
The Impact ◽  
Experimental Group

Purpose: To determine the impact that a high-fiber, low-fat diet, derived from mostly plant-based sources, when coupled with support has upon self-management of type 2 diabetes mellitus in Latinos from medically underserved areas (MUAs). Design: Experimental randomized controlled community pilot study. Setting: Three community clinics in MUAs located within San Bernardino County, California. Participants: Thirty-two randomly assigned Latinos with A1C greater than 6.4: 15 control and 17 experimental. Intervention: Participants completed a 5-week education program. Researchers provided follow-up support for 17 randomly assigned experimental group participants through focus groups held at participating clinics—1, 3, and 6 months posteducation. Measures: Changes in fat and fiber consumption were measured using a modified Dietary Screener for Mexican Americans. Self-management was measured through the Self-Efficacy for Exercise Scale and Diabetes Quality of Life Measure. Analysis: Baseline characteristics for both groups were analyzed using independent t tests and χ2 tests. A 2-way repeated-measures analysis of variance was used to analyze biometric data between baseline and 6 months for both groups. Results: Mean A1C levels decreased from baseline to 6 months for both groups: control, μ1 = 9.57, μ2 = 9.49; experimental, μ1 = 8.53, μ2 = 7.31. Conclusion: The experimental group demonstrated a statistically significant reduction in mean A1C levels ( P = .002) when compared to the control group.

scholarly journals THE EFFECT OF PUGUNTANO (CURANGA FEL-TERRAE [LOUR.]) EXTRACT ON ADIPONECTIN RECEPTOR (ADIPOR) IN RATS WITH TYPE 2 DIABETES MELLITUS

2019 ◽  
pp. 551-553
Author(s):  
DHARMA LINDARTO ◽  
YETTY MACHRINA ◽  
SANTI SYAFRIL ◽  
AWALUDDIN SARAGIH
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Treatment Group ◽  
Control Group ◽  
Model Assessment ◽  
Anti Inflammatory

Objective: This study aimed to determine whether the antidiabetic effects of puguntano (Curanga fel-terrae [Lour.]) extract involve anti-inflammatory effects mediated through adiponectin receptors (AdipoRs). Methods: Type 2 diabetes mellitus (T2DM) Wistar rats were induced by a combination of high-fat diet for 5 weeks and injection small dose streptozotocin 30 mg/kg bw/rat. This study was conducted in 48 T2DM rats, which were randomly assigned into two weight-matched groups (n=24, each). Only the treatment group received 0.2 mg/g bw of puguntano extract suspension through oral for 10 days. The clinical characteristics of T2DM and AdipoR were assessed before and after the treatment period. Results: The treatment group demonstrated significantly lower body weight, fasting blood glucose, and homeostasis model assessment-insulin resistance (HOMA-IR) but higher AdipoR than the control group (all, p<0.001). Furthermore, there were also negative correlations between AdipoR to body weight and HOMA-IR (all, p<0.05). Conclusion: Our data suggest that puguntano could improve glucose metabolism and ameliorate insulin resistance and have anti-inflammatory effects mediated through AdipoR in T2DM.

scholarly journals Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu Bai ◽  
Ke Mo ◽  
Guirong Wang ◽  
Wanling Chen ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptors ◽  
Control Group ◽  
Sensitivity Index

As a severe metabolic disease, type 2 diabetes mellitus (T2DM) has become a serious threat to human health in recent years. Gastrodin, as a primary chemical constituent in Gastrodia elata Blume, has antidiabetic effects. However, the possible mechanisms are unclear. The aim of the present study was to investigate the effects and possible mechanisms of gastrodin on the treatment of T2DM. In vivo, after treatment with gastrodin for 6 weeks, fasting blood glucose levels, blood lipid metabolism, and insulin sensitivity index values were remarkably reduced compared with those of the diabetic control group. The values of aspartate aminotransferase and alanine aminotransferase also showed that gastrodin alleviates liver toxicity caused by diabetes. Moreover, gastrodin relieved pathological damage to the pancreas in T2DM rats. In vitro, gastrodin alleviated insulin resistance by increasing glucose consumption, glucose uptake, and glycogen content in dexamethasone-induced HepG2 cells. The Western blotting results showed that gastrodin upregulated the expression of insulin receptors and ubiquitin-specific protease 4 (USP4) and increased the phosphorylation of GATA binding protein 1 (GATA1) and protein kinase B (AKT) in vivo and in vitro. Furthermore, gastrodin decreased the ubiquitin level of the insulin receptor via UPS4 and increased the binding of GATA1 to the USP4 promoter. Additionally, administration of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway inhibitors MK-2206 and LY294002 abolished the beneficial effects of gastrodin. Our results indicate that gastrodin promotes the phosphorylation of GATA1 via the PI3K/AKT pathway, enhances the transcriptional activity of GATA1, and then increases the expression level of USP4, thereby reducing the ubiquitination and degradation of insulin receptors and ultimately improving insulin resistance. Our study provides scientific evidence for the beneficial actions and underlying mechanism of gastrodin in the treatment of T2DM.

scholarly journals EFFECTS OF DIABETIC CAMP ON SELF EFFICACY AMONG MIDDLE-AGED AND ELDERL Y PEOPLE WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
Author(s):  
Junaidy Rustam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly People ◽  
Self Efficacy ◽  
Control Group ◽  
Middle Aged ◽  
Type 2 Dm ◽  
Experimental Group

Introduction: The benefits of Diabetic Camp as known can be applied to promote knowledge and self management among diabetes people. Nevertheless, empirical data of its effect on diabetes self-efficacy are still limited, especially on middle aged and elderly people with type 2 Diabetes Mellitus. Objectives: The purpose of this intervention study was to investigate the change of self-efficacy among middle-aged and elderly people living with type 2 DM after attending camp. Methods: A quasi-experimental study was used. Eighty-four participants were recruited form two public health center in Bukittnggi City West Sumatra Indonesia were randomly assigned into either the experimental group (n=42) or control group (n=42) by matching technique based on gender , age, and duration of illness. The experimental group participated in diabetic camp for two days continuing with weekly follow up for over 1 month while those in the control group participated in routine activities. Outcome was measured by using Self-efficacy Questionnaire for Diabetes at the first day before receiving the intervention as pretest data, and on the four weeks after the intervention was completed as the posttest data. The reliability of the Self-efficacy Questionnaire for Diabetes with Cronbach's alpha coefficient was 0.81. Descriptive and inferential statistics were performed to analyze the data. Results: Mean of self-efficacy score in the experimental group after receiving the intervention was significantly higher than those in the control group (t =4.27; p&lt;0.05). The mean of self-efficacy score after receiving the intervention in the experimental group was increased significantly from before receiving the intervention (t = 8.15; p&lt;0.05). Conclusions: The results showed that Diabetic camp was effective in promoting self-efficacy of middle-aged and elderly people with type 2 DM. Thus, this diabetes care program can be recommended for practice

scholarly journals Correlation between Insulin Resistance and Thyroid Nodule in Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yunzhao Tang ◽  
Tiantian Yan ◽  
Gang Wang ◽  
Yijun Chen ◽  
Yanjuan Zhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Thyroid Nodule ◽  
Thyroid Nodules ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Free Triiodothyronine

Objective. The present study explored the association between insulin resistance (IR) and the clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM).Methods. All the patients were newly diagnosed with T2DM. 201 patients with thyroid nodule disease and 308 patients without the nodular thyroid disease. The participants were evaluated by relevant examination. Correlation analyses and regression analyses were performed to examine the relationships between the two groups.Results. HOMA-IR values, serum FT4 (free thyroxine) levels, and age were higher in the thyroid nodule group than in the control group. The proportion of women in the thyroid nodule group is greater than the proportion of women in the control group. Logistic regression analysis showed that age, sex, FT4, and HOMA-IR were positive factors for thyroid nodule. The volume and size of the thyroid nodule were positively correlated with HOMA-IR, irrespective of gender. The thyroid nodule volume and size and the TSH (thyroid stimulating hormone) were greater in females than in males, whereas FT3 (free triiodothyronine) was lower in females.Conclusion. IR might be a risk factor for thyroid nodule. Whether alleviating the IR might slow the growth, or diminish the volume and size of the thyroid nodules, is yet to be elucidated.

scholarly journals INCREASING SELF-EFFICACY TO REGULATE EXERCISE IN ADULT PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 4 (6) ◽  
pp. 596-601
Author(s):  
Rinco Siregar ◽  
Sunantha Stongpat ◽  
Boontuan Wattanakul
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Physical Exercise ◽  
Self Efficacy ◽  
Routine Care ◽  
Adult Patients ◽  
Control Group ◽  
Experimental Group

Background: Self-efficacy has been described as dominan factor associated with physical exercise in adult patients with type 2 diabetes mellitus, but to improve self-efficacy to regulate exercise of adult patients with type 2 diabetes mellitus is a challenge for health workers.Objective: This study was to determine the effect of exercise consultation program on self - efficacy to regulate exercise adults’ patients of type 2 diabetes mellitus.Methods: A quasi-experimental study with two comparison groups was purposively designed for pre-test and post-test procedures. Sixty-one patients of type 2 diabetes mellitus were allocated into the experimental group (31 patients) and the control group (29 patients). While the experimental group received the exercise consultation for 12 weeks and routine care, the control group received routine care only. Comparative assessments on differences in self-efficacy to regulate exercise were examined both within and between groups using paired or unpaired t-test.Results: After receiving exercise consultation program, self-efficacy to regulate exercise significantly increased within the experimental group (p < .05), but there was no significant change with in the control group.  Between groups, there was a significant difference self-efficacy to regulate exercise in adult patients with type 2 diabetes mellitus (p < .05).Conclusion: The exercise consultation program could increase self-efficacy to promote the physical exercise among adults patients of type 2 diabetes mellitus.

scholarly journals The correlation between serum resistin and toll-like receptor-4 with insulin resistance in hypertensive subjects with or without type 2 diabetes mellitus

2021 ◽  
Vol 2 (04) ◽  
pp. 203-217
Author(s):  
Mustafa Al-Taie ◽  
Rayah Baban ◽  
Mouayed Hamed
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Hypertensive Patients ◽  
Patient Groups

Background: The most chronic disease prevalence in the Iraqi population are type-2 diabetes mellitus (T2DM) and hypertension (HT). One of the important causes of these chronic diseases is obesity. Resistin (RETN) is a major link between obesity and insulin resistance (IR) or T2DM (which induces IR). The action of RETN on IR is mediated by Toll-like receptor-4 (TLR4). TLR4 is a putative RETN receptor that has been suggested to participate in RETN-inducing inflammation and IR. Objectives: To study the association between serum RETN/TLR4 and IR in hypertensive patients with or without T2DM subjects. Methods: This cross-sectional study was conducted on 120 men that classified into four different groups. These groups consist of the following: 30 apparently control group, 30 patients with hypertension, 30 patients with T2DM but without HT and 30 hypertensive patients with T2DM. For all the subjects, serum RETN, TLR4 and serum insulin was estimated by using the ELISA technique. Results: Our results showed that mean levels of the serum RETN and TLR4 were significantly elevated in all patient groups when compared with the control group. Also, a positive correlation between serum RETN and TLR4 was found in hypertensive patients with T2DM patients. Conclusions: Serum RETN and TLR4 were higher in all patient groups when compared with the control group. In addition, a positive correlation between RETN and IR in all study groups was noted. Then, we suggested a close association between RETN and TLR4 and their positive correlations with IR.

scholarly journals Association between Adiponectin and Insulin Resistance among Sudanese Males with Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Eman Ahamed Almakey ◽  
Ahmed Mohamed Makeen ◽  
Osman Khalafalla Saeed ◽  
Khalid Abdelsamea Mohamedahmed
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Adiponectin ◽  
Control Group ◽  
P Value ◽  
Model Assessment ◽  
Positive Effects

Abstract Background Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increasing mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide. Objectives The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus. Methodology: A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2 ± 5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7 ± 5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)-IR were analyzed. SPSS (v 20.0) was used for data analysis. Results The mean of serum adiponectin in the cases group (3.03 ± 0.90µg/ml) was lower than the control group (6.02 ± 4.24µg/ml) giving highly significant differences -between them (P = value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002). Conclusion We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.

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