Multi-factor regression analysis of risk factors of developing microvascular complications of 2 type diabetes mellitus

2020 ◽  
pp. 58-67
Author(s):  
Elena V. NEVZOROVA ◽  
Andrey K. ZASYADKO ◽  
Oksana N. ZAGUMENNOVA
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Regression Analysis ◽  
Lipid Metabolism ◽  
Type Diabetes ◽  
Type Diabetes Mellitus ◽  
Microvascular Complications ◽  
Significant Risk ◽  
Carbohydrate And Lipid Metabolism ◽  
Factor Regression

Introduction. The relevance of the study of diabetes mellitus is due to social importance due to the high prevalence and progression of the disease in the form of late vascular complications, the first among which is vascular angiopathies. The results of studies on the dynamics of carbohydrate and lipid metabolism in the development of microvascular complications of 2 type diabetes mellitus remain quite contradictory. At the same time, the range of risk factors for the development of microvascular complications of 2 type diabetes mellitus and the strength of their effects vary greatly between studies and regions. Due to these circumstances, we are interested in studying the risk factors of developing microvascular complications of 2 type sugar diabetes as one of the main fatal complications of 2 type diabetes mellitus. Purpose and objectives. The most significant risk factors for developing microvascular complications of 2 type diabetes mellitus are determined using multi-factor regression analysis. Materials and methods. We used a multiple logistical regression model. Main results. As a result of multi-factor regression analysis, we determined the most significant risk factors for developing microvascular complications of 2 type diabetes mellitus: unsatisfactory compensation of carbohydrate and lipid metabolism, presence of arterial hypertension and dyslipidemia.

scholarly journals Epidemiology of diabetes mellitus and microvascular complications

2011 ◽  
Vol 14 (3) ◽  
pp. 6-11 ◽  
Author(s):  
Oksana Vladimirovna Maslova ◽  
Yury Ivanovich Suntsov
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetic Complications ◽  
Microvascular Complications ◽  
Adult Population ◽  
Significant Risk ◽  
High Prevalence ◽  
The World ◽  
Epidemiological Situation

The present work is devoted studying of epidemiological situation of diabetes mellitus (DM). The data on prevalence and incidence of DM and itsmicrovascular complications among adult population in the different countries of the world is presented. The analysis of numerous researches allowsto speak about high prevalence of this disease all over the world and to allocate a number of the most significant risk factors of development andprogressing of diabetic complications.

scholarly journals Incidence and Risk Factors of Contrast Induced Nephropathy in Patients Following Coronary Angiography

2018 ◽  
Vol 15 (1) ◽  
pp. 20-25
Author(s):  
Mohammed Rashed Anwar ◽  
Abu Noim Md Abdul Hai ◽  
Dilip Kumar Debnath ◽  
Md Anwarul Hoque Faraji ◽  
KAM Mahbub Hasan
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Coronary Angiography ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Estimated Gfr ◽  
Contrast Induced Nephropathy ◽  
Contrast Volume

Background: Contrast induced nephropathy (CIN) is a common complication after administration of contrast medium. As the third leading cause of hospital acquired acute kidney injury, CIN occurs in half of the patients undergoing coronary angiography (CAG).Objective: The purpose of the present study was to see the frequency of contrast induced nephropathy in patients after coronary angiography and its risk factors.Methodology: This comparative cross sectional study was performed at National Institute of Kidney Diseases and Urology, Dhaka and Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from July, 2016 to December 2016 for a period of six (06) months. All patients 18 years and above who underwent coronary angiography with or without percutaneuous Transluminal coronary angioplasty with normal or impaired renal function, with or without Diabetes Mellitus or hypertension were included in the study. The patients were divided into two groups named as group A who did not develop CIN and group B developed CIN. Pre- and Post procedure serum creatinine was estimated at 48 hours after coronary angiogram. Independent characteristics associated with CIN were identified.Results: A total number of 250 patients were recruited for this study. Older age ≥70 years, diabetes mellitus were significant risk factor for CIN whereas hypertension was not statistically significant. Logistic regression analysis of risk factors were identified 05 (five) risk factors in this study which were baseline estimated GFR <60mi/min/1.73m2 BSA, diabetes mellitus, contrast volume >100ml, PTCA and LVEF < 40%). Effect of drugs used in the development of CIN by logistic regression analysis. None of the drugs showed significant relationship on development of CIN.Conclusion: Older age, baseline estimated GFR <60mi/min/1.73m2 BSA, diabetes mellitus, contrast volume >100ml, PTCA and LVEF < 40%) were significant risk factor to developed CIN. Journal of Science Foundation 2017;15(1):20-25

Risk Factors for Postoperative Intra-Abdominal Abscess after Laparoscopic Appendectomy: Analysis for Consecutive 1,817 Experiences

2015 ◽  
Vol 32 (5) ◽  
pp. 375-381 ◽  
Author(s):  
Jinbeom Cho ◽  
Ilyoung Park ◽  
Dosang Lee ◽  
Kiyoung Sung ◽  
Jongmin Baek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Risk Factor ◽  
Laparoscopic Appendectomy ◽  
Significant Risk ◽  
Perforated Appendicitis ◽  
Abdominal Abscess ◽  
Peritoneal Drainage

Background: Possible risk factors for postoperative intra-abdominal abscess (IAA) formation after laparoscopic appendectomy (LA) remain controversial. A perforated appendicitis, diabetes mellitus, peritoneal irrigation, obesity and age are considered to be possible risk factors for postoperative IAA, but the existing evidence is insufficient. This study aimed to identify the risk factors for IAA formation in patients receiving LA. Methods: Between January 2010 and December 2013, 1,817 patients who underwent 3-port LA were enrolled in this study. Patients were classified into 2 groups according to the development of postoperative IAA, and the differences between the groups were analyzed. Results: The incidence of IAA after LA was 1.5%, and the only identified risk factor for IAA was peritoneal irrigation. On logistic regression analysis of those patients who received peritoneal irrigation, suppurative appendicitis and non-placement of the peritoneal drain were found to be significant risk factors for the development of IAA. Conclusions: Peritoneal irrigation in a case of abdomen contamination was shown to be a risk factor for the development of postoperative IAA after LA. When peritoneal irrigation is performed, surgeons should consider using peritoneal drainage and postoperative antibiotics (including anti-anaerobic antibiotics) to prevent postoperative IAA formation.

Renal Failure after Coronary Bypass Surgery and the Associated Risk Factors

2015 ◽  
Vol 18 (1) ◽  
pp. 006
Author(s):  
Hasan Reyhanoglu ◽  
Kaan Ozcan ◽  
Murat Erturk ◽  
Fatih İslamoglu ◽  
İsa Durmaz
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Renal Failure ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Significant Risk ◽  
High Morbidity ◽  
Factors Associated

<strong>Objective:</strong> We aimed to evaluate the risk factors associated with acute renal failure in patients who underwent coronary artery bypass surgery.<br /><strong>Methods:</strong> One hundred and six patients who developed renal failure after coronary artery bypass grafting (CABG) constituted the study group (RF group), while 110 patients who did not develop renal failure served as a control group <br />(C group). In addition, the RF group was divided into two subgroups: patients that were treated with conservative methods without the need for hemodialysis (NH group) and patients that required hemodialysis (HR group). Risk factors associated with renal failure were investigated.<br /><strong>Results:</strong> Among the 106 patients that developed renal failure (RF), 80 patients were treated with conservative methods without any need for hemodialysis (NH group); while <br />26 patients required hemodialysis in the postoperative period (HR group). The multivariate analysis showed that diabetes mellitus and the postoperative use of positive inotropes and adrenaline were significant risk factors associated with development of renal failure. In addition, carotid stenosis and postoperative use of adrenaline were found to be significant risk factors associated with hemodialysis-dependent renal failure (P &lt; .05). The mortality in the RF group was determined as 13.2%, while the mortality rate in patients who did not require hemodialysis and those who required hemodialysis was 6.2% and 34%, respectively.<br /><strong>Conclusion:</strong> Renal failure requiring hemodialysis after CABG often results in high morbidity and mortality. Factors affecting microcirculation and atherosclerosis, like diabetes mellitus, carotid artery stenosis, and postoperative vasopressor use remain the major risk factors for the development of renal failure.<br /><br />

Features of the course of coronavirus infection in patients with diabetes mellitus

2022 ◽  
pp. 18-21
Author(s):  
Vladimir Anatolievich Klimov ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Human Population ◽  
Fatal Outcome ◽  
Significant Risk ◽  
Adverse Outcomes ◽  
Concomitant Disease ◽  
Patients With Diabetes ◽  
Coronavirus Infection ◽  
Population Mortality

Diabetesmellitus, overweight and the age of a patient over 65 years old are identified by clinicians as themain factors that can complicate the course of the coronavirus infection and increase the likelihood of fatal outcome. Although in the general human population mortality from coronavirus fluctuateswithin 3–5 %, sometimes very significantly differing in individual countries, this level can reach 15–25 % among patientswith diabetes, especially for those receiving insulin therapy. Diabetes mellitus as a concomitant disease in COVID-19 is considered one of the most significant risk factors for the development of adverse outcomes due to a more severe course of infection in conditions of hyperglycemia and other aggravating factors.

Clinical factors and mortality rates for non-traumatic upper extremity amputations

2021 ◽  
pp. 175319342110427
Author(s):  
Yong-Zheng Jonathan Ting ◽  
An-Sen Tan ◽  
Chi-Peng Timothy Lai ◽  
Mala Satku
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Lower Extremity ◽  
Upper Extremity ◽  
Significant Risk ◽  
Arterial Disease ◽  
Mortality Rates ◽  
Level Of Evidence ◽  
Peripheral Arterial ◽  
Extremity Amputation

Non-traumatic upper extremity amputations are an increasing concern with the rising prevalence of diabetes mellitus. To ascertain the risk factors and mortality rates for these amputations, the demographic information, amputation history, comorbidities and clinical outcomes of 140 patients who underwent non-traumatic upper extremity amputations between 1 January 2004 and 31 October 2017 were studied. Correlations were assessed using Cochran-Armitage chi-squared tests, odds ratios and multivariate binomial logistic regression as appropriate. Diabetes mellitus, coronary artery disease, end-stage renal failure, peripheral arterial disease and prior lower extremity amputation were significant risk factors for multiple upper extremity amputations. One-year, 2-year and 5-year mortality rates were 12%, 15% and 38%, respectively, following first upper extremity amputation. The risk factors for upper extremity amputations correspond with those for lower extremity amputations, comprising mainly diabetes mellitus and its related comorbidities. The mortality rates for non-traumatic upper extremity amputations highlight their significant burden on patients. Level of evidence: III

scholarly journals Abdominal Wall Injuries at the Elite Level in Australian Male Professional Cricketers

2015 ◽  
Vol 49 (4) ◽  
pp. 155-158 ◽  
Author(s):  
David Humphries ◽  
John Orchard ◽  
Alex Kountouris
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Abdominal Wall ◽  
Data Extraction ◽  
Statistical Significance ◽  
Significant Risk ◽  
Oblique Muscle ◽  
Minimal Risk ◽  
Risk Increase ◽  
Elite Level

ABSTRACT Background Injuries to the abdominal wall, particularly muscular injuries, are relatively common in professional cricketers. The Cricket Australia injury database holds data on these injuries over a 20 years span. Methods This study is a combination of (1) a descriptive outline of the parameters associated with side strains and abdominal wall injuries in elite male cricketers, based on deidentified data extraction from the Cricket Australia database from 1995 to 1996 and 2014 to 2015; (2) multivariate regression analysis of risk factors for abdominal wall strains, taking into account the risk factors of player position, player age and previous abdominal wall injury history. Results There were 183 injuries recorded over a 20 years period at Australian state or national player level. Significant risk factors in logistic regression analysis were: being a Pace Bowler RR 10.0 (95% CI 3.1—32.1) and being 24 years old or younger RR 3.4 (95% CI 1.7—6.8). Surprisingly, there was only minimal risk increase, not reaching statistical significance, for recent injury in the same season (p = 0.18) and no association at all with past injury in previous season (p = 0.99). Discussion The internal oblique muscle is reported the most commonly injured component of the abdominal wall, the injuries are overwhelmingly sustained by pace bowlers and the peak incidence of the injury is in the early part of the cricket season. Younger fast bowlers are more likely to be injured than older ones. A history of abdominal wall strain in either the recent or distant past does not increase or decrease future risk of strain, which is in contrast to other muscle strains. How to cite this article Humphries D, Orchard J, Kountouris A. Abdominal Wall Injuries at the Elite Level in Australian Male Professional Cricketers. J Postgrad Med Edu Res 2015;49(4): 155-158.

scholarly journals Factors associated with depression in the patients with diabetes mellitus type 2

2019 ◽  
Vol 76 (11) ◽  
pp. 1178-1183 ◽  
Author(s):  
Admir Sabanovic ◽  
Natasa Maksimovic ◽  
Mirjana Stojanovic-Tasic ◽  
Marijan Bakic ◽  
Anita Grgurevic
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Diabetes Mellitus Type 2 ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Factors Associated

Background/Aim. The assessment of association of depression and diabetes mellitus type 2 using the Patient Health Questionaire (PHQ-9) has not been done in Montenegro. The aim of this study was to assess the prevalence of depression in the patients with type 2 diabetes mellitus, and to identify the risk factors associated with the presence of depression. Methods. A cross-sectional study was conducted at the General Hospital in Bijelo Polje, from July to September, 2015. It included 70 patients over 35 years of age with the diagnosis of diabetes for at least six months. For the assessment of depression presence and intensity PHQ?9 was used. All variables associated with the presence of depression at a significance level of p < 0.05 were included into the final method of the multivariate logistic regression analysis. Results. Comorbidities were statistically significant more frequent among patients with depression (?2 = 5.40; p = 0.020). Duration of diabetes over five years was significantly associated with depression (?2 = 12.48; p < 0.001). Depression occurred more frequently among physically inactive subjects (?2 = 10.74; p = 0.005). The presence of diabetic polyneuropathy (?2 = 6.04; p = 0.014) and cataract (?2 = 5.351; p = 0.021) were also significantly associated with depression. A multivariate logistic regression analysis showed that the duration of diabetes over five years and presence of cataract were independently associated with depression. Conclusion. The risk factors for depression among the subjects with diabetes were disease duration more than five years and the presence of cataract. Since depression is a serious disease and can be a risk factor for many chronic diseases, the best way of prevention is its early detection and treatment.

scholarly journals Predictive value of the risk factors for amputation of lower extremity in patients with diabetic foot in Al-Karama teaching hospital

2019 ◽  
Vol 6 (5) ◽  
pp. 1549
Author(s):  
Mohammed Hillu Surriah ◽  
Amir Naif Kadum Al-Imari ◽  
Amine Mohammed Bakkour ◽  
Riad Rahman Jallod Al-Asadi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Teaching Hospital ◽  
Diabetic Foot ◽  
Significant Risk ◽  
Female Ratio ◽  
Duration Of Diabetes ◽  
Long Duration ◽  
Control Of Diabetes ◽  
Foot Disease

Background: Diabetic foot disease is a foot that exhibits any pathology that results directly from diabetic mellitus or any long-term chronic complication of diabetes mellitus. The aim of the study was to determine the risk factors and indications for amputations among diabetics.Methods: this clinical prospective study includes 120 diabetic foot patients admitted to AL- Karama teaching hospital from 1st January 2015 to 1st January 2019. All patients assessed for age, gender, duration of diabetes, hyperglycemia at admission and control of diabetes, history of smoking, hypertension, assess dominant foot and examination of diabetic foot lesion and classify it according to Meggit-Wagner grading status, indications for amputation and outcome.Results: The male to female ratio was 2:1. Most frequent age group of patients treated by amputation was between 50-80 years. Among patients treated with amputation (68.33%) of patients had diabetes mellitus for 11-20 years. From patients admitted with diabetic foot (53.33%) were smokers. Regarding hypertension (93.33%) of all patients were hypertensive. It was noted that (65%) of patients lesion occur in dominant foot Regarding Wagner's grading system (36.66%) of patients were grade 4 followed by grade 1 (21.66%). regarding mode of treatment (53.33%) of patients treated by amputation and other treated conservatively. Only 3 patients from 60 died while other discharged well after complete treatment.Conclusions: Increasing in age, long duration of diabetes mellitus, poor control of diabetes, smoking and occurrence of lesion in dominant foot all considered as a significant risk factors for increase liability amputation.

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