scholarly journals Association between Serum Vitamin D and Diabetic Retinopathy in Portuguese Patients with Type 1 Diabetes

2020 ◽  
Vol 33 (7-8) ◽  
pp. 459
Author(s):  
Miguel Lopes ◽  
Rita Laiginhas ◽  
Carolina Madeira ◽  
João Sérgio Neves ◽  
Margarida Barbosa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Metabolic Control ◽  
Serum Vitamin ◽  
Duration Of Diabetes ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Introduction: Recently, vitamin D has gained importance as a diabetes risk modifier. Our aim was to assess the association between serum vitamin D levels and the prevalence of diabetic retinopathy in patients with type 1 diabetes.Material and Methods: Retrospective review of a population of patients with type 1 diabetes followed in a Portuguese tertiary center. Patients were included if they had an ophthalmological evaluation and a serum 25-hydroxyvitamin D level determination within the same year. Logistic regression analysis was used to adjust for possible confounders.Results: We included 182 patients (47% male), and 57% (n = 103) had signs of diabetic retinopathy. We found a significant association between lower circulating levels of 25-hydroxyvitamin D levels and a greater prevalence of diabetic retinopathy after adjusting for confounders (duration of diabetes, estimated glomerular filtration rate, age, sex, metabolic control, season, dyslipidemia and hypertension) (OR = 0.94; 95% CI 0.90 - 0.99, p = 0.023). Longer duration of diabetes and worse metabolic control also remained associated with diabetic retinopathy in the multivariate analysis (OR = 1.20; 95% CI 1.13 - 1.27, p < 0.001 and OR = 4.13; 95% CI 1.34 - 12.7, p = 0.013, respectively).Conclusion: Lower levels of vitamin D were associated with an increased prevalence of diabetic retinopathy in patients with type 1 diabetes, after adjusting for possible confounders. Future controlled studies may elucidate the molecular routes for this association as well as the role of supplementation in the prevention of diabetes microvascular complications.

scholarly journals Serum Vitamin D Level in Children with Type 1 diabetes mellitus in Duhok city, Iraq

2019 ◽  
Vol 7 (1) ◽  
pp. 10-13
Author(s):  
Azad A. Haleem
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Body Mass ◽  
Serum Vitamin ◽  
Duration Of Diabetes ◽  
Serum Vitamin D

Type 1 Diabetes Mellitus is an autoimmune disorder that occurs in the Β-cells of pancreatic islets. Vitamin D is essential in maintaining the bone health. It has proven that Vitamin D has an autoimmune disorders including T1DM. Hence, the aim is to detect the prevalence of vitamin D deficiency among children with T1DM. A case control study conducted in Duhok, North of Iraq between 15th of February and 15th of August 2016. 100 enrolled participants aged from 5 to 15 years of both genders were divided in to two groups. Fifty of them had T1DM and 50 children who were healthy and non-diabetic. All participants were studied in terms of age, gender, duration of diabetes, glycemic control (HbA1c) and Body Mass index .Samples of blood were taken to measure serum Vitamin D and HbA1c levels. Mean serum Vitamin D level in diabetic group was 6.068 ±2.45 ng/mL while in the control group it was 21.101 ±9.23 ng/mL. Vitamin D were lower in the diabetic patients than controls (P= 0.01). Vitamin D level was indirectly correlated with duration of diabetes (P=0.01).Level of Vitamin D was decreased with increasing HbA1C (P=0.01). Level of Vitamin D was not significantly related to body mass index. Vitamin D level is not significantly related to body mass index.

scholarly journals Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Bankole Peter Kuti ◽  
Alex Ifeoluwa Akinwumi ◽  
Demilade Kehinde Kuti ◽  
Kazeem Olanrewaju Amoo
Keyword(s):  
Vitamin D ◽  
Total Antioxidant Capacity ◽  
Serum Vitamin ◽  
Severe Pneumonia ◽  
Lower Serum ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Nigerian Children ◽  
Total Antioxidant ◽  
25 Hydroxyvitamin D

Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.

Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

2021 ◽  
Author(s):  
Jianbo Shu ◽  
Xinhui Wang ◽  
Mingying Zhang ◽  
Xiufang Zhi ◽  
Jun Guan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Serum Vitamin ◽  
Chinese Children ◽  
Serum Vitamin D ◽  
Significant Difference

Abstract Objective: Diabetic ketoacidosis is a common complication in children with type 1 diabetes mellitus. The purposes of the present study were to explore clinical correlates of serum vitamin D level in Chinese children with type 1 diabetes.Methods: A total of 143 inpatients (boys/girls = 60/83) were recruited from Tianjin Children’s Hospital. Their demographic and clinical characteristics were collected. These patients were divided into the non-DKA group(n=43) and DKA group(n=100).Results: The positive ZnT8-ab was significantly higher in DKA patients compared with non-DKA patients (p=0.038). There was a negative correlation between plasma glucose and the concentration of vitamin D(r =−0.188, p=0.024), although there was no significant difference in vitamin D between two groups of T1DM patients with or without DKA (p=0.317). The multiple logistic regression revealed that sex(male) and BMI were independent risk factors to predict the deficiency or insufficiency of Vitamin D in T1DM children. When BMI is lower than 16 kg/m2 according to the cut-off value of the ROC curve, it provides some implications of Vitamin D deficiency or insufficiency in TIDM children ( 95%CI:0.534~0.721, P=0.014). Conclusions: Our results suggested that positive ZnT8-ab was associated with a greater risk of DKA at T1DM onset. Additionally, neither vitamin D levels nor the proportion of patients with different levels of vitamin D differed between the two groups inT1DM children with or without DKA. Furthermore, Vitamin D level was negatively correlated with plasma glucose, lower BMI and male children with T1DM were prone to be deficient or insufficient of Vitamin D.

scholarly journals Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4260
Author(s):  
Liana Najjar ◽  
Joshua Sutherland ◽  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Low Frequency ◽  
Nucleotide Polymorphisms ◽  
Hydroxyvitamin D ◽  
Quantitative Synthesis ◽  
25 Hydroxyvitamin D

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

Variation of circulating 25-Hydroxyvitamin D levels with life style in a cohort group in Sri Lanka

2019 ◽  
Vol 49 (4) ◽  
pp. 506-516 ◽  
Author(s):  
Shirani Ranasinghe ◽  
Thilak Jayalath ◽  
Sampath Thennakoon ◽  
Ranjith Jayasekara ◽  
Ran Shiva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sri Lanka ◽  
Feeding Habits ◽  
Serum Vitamin ◽  
Healthy Adults ◽  
Vitamin D Status ◽  
Content Type ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Purpose Purpose of this study is to measure the Vitamin D status of healthy adults and to correlate with their lifestyle and feeding habits. Plasma 25-Hydroxyvitamin D (25(OH)D) is the most common marker of vitamin D status of an individual. Deficiency of vitamin D is defined as the serum level less than 20 ng/mL and insufficiency as 30 ng/mL which can be prevented. Design/methodology/approach Vitamin D status of healthy adults (n = 82), both male and females between the age of 18 – 50 years who were attending to the National Transport Authority, Kandy, Sri Lanka from February to March 2016, was measured and correlated with their lifestyle, feeding habits, etc. Findings The mean total serum D (25(OH)D in this study was 40.15 ± 3.74 nmol/l with the mean value of 42.8 ± 28.8 and 37.5 ± 16.6 for women and men, respectively. The serum calcium levels of both female and male were around 8 mg/dl and the serum total protein was 6.5 and 7 g/dl in women and men, respectively. The serum Vitamin D, calcium and total protein were not statistically significantly different between the sexes. In this study, 84 per cent of the total subjects were normocalcemic, and there was no significant relationship between vitamin D levels and their calcium levels. Research limitations/implications This study demonstrates that there was no statistically significant correlation between the serum vitamin D with age, serum calcium or total proteins. The majority of participants who had exposure to the sunlight more than 30 mins/day had sufficient level of vitamin D and less than 30 min/day exposure had deficiency of vitamin D. Daily intake of multivitamin influenced vitamin D status of the study group. Practical implications These findings will implicate the importance of cultural, feed and social habits for the nutritional status of an individual.and there are no reported studies on vitamin D status with reference to the variation of life style. Social implications It is very important to investigate the factors affecting to the vitamin D status of a population as such, vitamin D insufficiency or deficiency can be prevented. In Sri Lanka, the population is consisting with many ethnic groups, different ethnic groups may find some nutritional problems according to their main cultural habits. Originality/value The objectives of this study are to evaluate the Vitamin D status in a group of healthy adults between 20 and 50 years in both men and women and to find out the correlation of their vitamin D status with their lifestyle and feeding habits, etc.

scholarly journals Seasonal variation of idiopathic benign paroxysmal positional vertigo correlates with serum 25-hydroxyvitamin D levels: a six-year registry study in Shanghai, China

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liang Shu ◽  
Jing Wu ◽  
Chun-Yan Jiang ◽  
Xu-Hong Sun ◽  
Hui Pan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Benign Paroxysmal Positional Vertigo ◽  
Serum Vitamin ◽  
Chinese Patients ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Positional Vertigo ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Paroxysmal Positional Vertigo

Abstract Seasonal variation of benign paroxysmal positional vertigo (BPPV) occurrence has been reported in recent years. Whether the seasonality of BPPV also exists in Chinese patients and whether it correlates with serum vitamin D levels is unexplored. We retrospectively analyzed the data of 1269 new-onset idiopathic BPPV patients registered in our vertigo outpatient clinic over a six-year period. Additionally, serum 25-hydroxyvitamin D levels during this period were measured in 877 patients by chemiluminescence immunoassay. We delineated the changing trend of the monthly BPPV patient numbers and serum 25-hydroxyvitamin D levels, and the correlation between them was explored. December to next March is the top 4 months with higher BPPV patient numbers. The median BPPV patient numbers in winter group were higher than those in summer group (20 vs. 16 patients, p < 0.05). Median 25-hydroxyvitamin D levels in winter group were much lower than those in summer group (16.3 vs. 20.8 ng/ml, p < 0.001) and autumn group (16.3 vs. 19.3 ng/ml, p < 0.05). A moderate negative correlation was observed between median serum 25-hydroxyvitamin D levels and BPPV patient numbers each month. The onset of BPPV also shows a seasonal fluctuation in Chinese patients. This phenomenon may be related to serum vitamin D levels.

scholarly journals Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes

2017 ◽  
Vol 87 (6) ◽  
pp. 385-395 ◽  
Author(s):  
Debika Nandi-Munshi ◽  
Maryam Afkarian ◽  
Kathryn B. Whitlock ◽  
Jamie L. Crandell ◽  
Ronny A. Bell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Serum Vitamin ◽  
Nutrition Survey ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Urine Albumin ◽  
Health And Nutrition ◽  
Vitamin D Levels

Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6–19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.

scholarly journals Serum vitamin D content in children with SARS-CoV-2 infection

2021 ◽  
Vol 6 ◽  
pp. 79-82
Author(s):  
V.N. Peregoedova ◽  
◽  
I.K. Bogomolova ◽  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Immunochemical Method ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Aim of study. To study the total level of 25-hydroxyvitamin D in children with SARS-CoV-2 infection (COVID-19). Material and мethods. A total of 82 children aged 0-17 diagnosed with SARS-CoV-2 infection were enrolled. Depending on the severity of clinical symptoms, all children were divided into three groups according to the COVID-19 severity: asymptomatic, mild and moderate. The serum level of vitamin D in all patients was tested via the immunochemical method. Results. It was found that children with SARS-CoV-2 infection had lower serum level of vitamin D (29.92 [22.22; 28.07] ng/ml) as compared with the control group (36.43 [32.05; 44.08] ng/ml; p<0.001). A total of 90% of the children with SARS-CoV-2 infection were diagnosed with insufficiency or deficiency of vitamin D (<30 ng/ml). Only 10 % of the patients had normal levels of vitamin D. The insufficiency of vitamin D was found more often amongst children aged 0-11 and deficiency of total 25-hydroxyvitamin D was more common for children aged 12-17. The difference in serum levels of vitamin D depending on the severity of SARS-CoV-2 infection was not found. Male children with SARS-CoV-2 infection showed lower levels of vitamin D (p=0.013). Conclusion. A total of 90 % of the children with SARS-CoV-2 infection had insufficiency or deficiency of vitamin D regardless of the severity of clinical symptoms.

scholarly journals Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

2021 ◽  
pp. 216-221
Author(s):  
Khalil Ahmed Memon ◽  
Hazoora Shaikh ◽  
Rukhsana Soomoro ◽  
Yasmeen Joyo ◽  
Saira Parveen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Multinomial Logistic Regression ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia. Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.

Sign in / Sign up

Export Citation Format

Share Document