scholarly journals Granulomas Sarcóides Sobre Cicatriz: Além da Sarcoidose

2021 ◽  
Vol 34 (13) ◽  
Author(s):  
Francisca Morgado ◽  
Mariana Batista ◽  
José Carlos Cardoso ◽  
Margarida Gonçalo
Keyword(s):  
Contact Dermatitis ◽  
Angiotensin Converting Enzyme ◽  
Skin Biopsy ◽  
Positive Reaction ◽  
Converting Enzyme ◽  
Cutaneous Sarcoidosis ◽  
Systemic Involvement ◽  
Patch Tests ◽  
Wide Range ◽  
Strong Positive Reaction

Sarcoid granulomas can be found in a wide range of diseases and differentiating sarcoidosis from a sarcoid-like reaction may be a challenge. We present a woman with erythematoviolaceous papulonodular lesions located on the ears where piercings were placed. A skin biopsy showing an infiltrate of sarcoid and focal tuberculoid granulomas did not exclude sarcoidosis. There was a slight increase in the level of angiotensin-converting enzyme. Systemic involvement due to sarcoidosis was excluded. Epicutaneous tests performed revealed a strong positive reaction to palladium and nickel, supporting the diagnosis of granulomatous contact dermatitis. There are only a few reports of granulomatous contact dermatitis to palladium with piercings as the source of sensitization. The formation of sarcoid granulomas can represent either a sarcoid-like reaction or a form of cutaneous sarcoidosis, and patch tests are essential in order to establish the diagnosis.

In vivo measurement of coronary circulation angiotensin-converting enzyme activity in humans

2003 ◽  
Vol 284 (1) ◽  
pp. H17-H22 ◽  
Author(s):  
Cezar Staniloae ◽  
Andreas J. Schwab ◽  
André Simard ◽  
Richard Gallo ◽  
Ihor Dyrda ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Coronary Circulation ◽  
Coronary Vessels ◽  
Capillary Endothelium ◽  
Converting Enzyme ◽  
In Vivo Measurement ◽  
Atherosclerotic Burden ◽  
Wide Range ◽  
Ace Activity

Angiotensin-converting enzyme (ACE) is present on the luminal surface of the coronary vessels, mostly on capillary endothelium. ACE is also expressed on coronary smooth muscle cells and on plaque lipid-laden macrophages. Excessive coronary circulation (CC)-ACE activity might be linked to plaque progression. Here we used the biologically inactive ACE substrate3H-labeled benzoyl-Phe-Ala-Pro ([3H]BPAP) to quantify CC-ACE activity in 10 patients by means of the indicator-dilution technique. The results were compared with atherosclerotic burden determined by coronary angiography. There was a wide range of CC-ACE activity as revealed by percent [3H]BPAP hydrolysis (30–74%). The atherosclerotic extent scores ranged from 0.0 to 66.97, and the plaque area scores ranged from 0 to 80 mm2. CC-ACE activity per unit extracellular space ( V max/ K m V i), an index of metabolically active vascular surface area, was correlated with myocardial blood flow ( r = 0.738; P = 0.03) but not with measures of the atherosclerotic burden. These results show that CC-ACE activity can be safely measured in humans and that it is a good marker of the vascular area of the perfused myocardium. It does not, however, reflect epicardial atherosclerotic burden, suggesting that local tissue ACE may be more important in plaque development.

Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Ayobami Dare ◽  
Gloria E. Okotie ◽  
Charles O. Adetunji ◽  
Babatunde O Ibitoye ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Germ Cell ◽  
Reproductive Age ◽  
Seminiferous Tubules ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Male Reproductive Function ◽  
Wide Range ◽  
Blood Testis Barrier

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS- CoV-2) that causes COVID-19 infections penetrates body cells by binding to angiotensin-converting enzyme-2 (ACE2) receptors. Evidence shows that SARS-CoV-2 can also affect the urogenital tract. Hence, it should be given serious attention when treating COVID-19-infected male patients of reproductive age group. Other viruses like HIV, mumps, papilloma and Epstein–Barr can induce viral orchitis, germ cell apoptosis, inflammation and germ cell destruction with attending infertility and tumors. The blood-testis barrier (BTB) and blood-epididymis barrier (BEB) are essential physical barricades in the male reproductive tract located between the blood vessel and seminiferous tubules in the testes. Despite the significant role of these barriers in male reproductive function, studies have shown that a wide range of viruses can still penetrate the barriers and induce testicular dysfunctions. Therefore, this mini-review highlights the role of ACE2 receptors in promoting SARS-CoV-2-induced blood-testis/epididymal barrier infiltration and testicular dysfunction.

scholarly journals The angiotensin converting enzyme inhibitors – alternative clinical applications

2014 ◽  
Vol 83 (1) ◽  
pp. 57-61
Author(s):  
Beata Stanisz ◽  
Katarzyna Regulska ◽  
Miłosz Regulski
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Biological Effects ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Clinical Applications ◽  
High Dose ◽  
Converting Enzyme ◽  
Human Disturbances ◽  
Converting Enzyme Inhibitors ◽  
Wide Range

Angiotensin converting enzyme inhibitors have emerged as a useful strategy in the management of hypertension and other cardiovascular system-related diseases. However, a wide range of their biological effects has turned the scientific interest towards other possible clinical applications of these drugs. The present review demonstrates the available data on the reported angiotensin-converting enzyme inhibitors – based therapies in the treatment of the following human disturbances: cancer, obesity, Barrett syndrome, erythrocytosis, a high-dose-chemotherapy-induced cardiotoxicity, Marfan syndrome, Duchenne muscular dystrophy, migraine, Raynaud’s syndrome and Alzheimer disease.

scholarly journals Contact Dermatitis Due To A Henna Tattoo: A Case Report

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Contact Dermatitis ◽  
Positive Reaction ◽  
Skin Lesions ◽  
Skin Reactions ◽  
Patch Tests ◽  
Skin Patch ◽  
History Of ◽  
Standard Contact ◽  
Definition Of ◽  
Allergic Contact

Allergic contact dermatitis is a late hypersensitivity reaction caused after the skin is exposed to a specific allergen. Temporary henna tattoos have become very popular in children and adults.The organic compound, p-phenylendiamine (PPD) is frequently added to the henna pigment to make it darker. A 13 year old patient with a personal history of asthma and allergic rhinitis with immunotherapy for sensitization to Dermatophagoides farinae and Dermatophagoides pteronyssinus who presented since once week prior to consultation,skin lesions consisting of pruritic erythematous papules on his right forearm 3 days after applying a henna tattoo. During the physical examination, the skin lesions were marked in the shape and definition of the tattoo and mild desquamation was observed. Skin patch tests (Bial Aristegui Standard Contact Dermatitis Panel, Spain) were applied with positive results to p-phenylendiamine 1% with 2++ (strong positive reaction with vesicular erythema, infiltration and papules) in the first reading 48 hours later. The second reading was performed upon 96 hours of applying the tests, finding a 3 +++ (extreme positive reaction with intense erythema and infiltration, coalescing vesicles, bullous reaction) result and confirming it 7 days later. The patient was treated with a medium potency topical corticosteroid, mometasone 0.1% and cetirizine 10 mg twice a day for 7 days showing resolution of his skin lesions and symptoms. Temporary henna tattoos have been associated with a variety of inflammatory skin reactions.

Impact of angiotensin-converting enzyme substrate conformation on fractional hydrolysis in lung

1996 ◽  
Vol 270 (2) ◽  
pp. L251-L259 ◽  
Author(s):  
M. P. Merker ◽  
I. M. Armitage ◽  
S. H. Audi ◽  
L. T. Kakalis ◽  
J. H. Linehan ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Trans Isomer ◽  
Hydrolysis Rate ◽  
Resonance Spectroscopy ◽  
Converting Enzyme ◽  
Rabbit Lung ◽  
Single Pass ◽  
Wide Range ◽  
Perfused Lung

We examined the hydrolysis kinetics of benzoyl-phenylalanyl-glycyl-proline (BPGP) in the isolated perfused lung and in vitro for evidence of preferential hydrolysis of the trans isomer by angiotensin-converting enzyme (ACE). Nuclear magnetic resonance spectroscopy showed that BPGP exists as cis and trans isomers in a ratio of 44:56. After a single pass through the perfused rabbit lung over a wide range of infused BPGP concentrations, 42% of the BPGP was not hydrolyzed. In single-pass bolus-injection studies, 41% of the injected BPGP was not hydrolyzed, and very little further hydrolysis occurred in a second passage of the bolus through the lungs. In rat lung recirculation and in vitro studies of BPGP hydrolysis by ACE, approximately 60% of the substrate was hydrolyzed rapidly compared with the remaining approximately 40%, and the peptidyl-prolyl cis-trans isomerase cyclophilin increased the rate of the slower phase of the reaction in both kinds of experiments. We conclude that the rapid hydrolysis phase represents primarily the hydrolysis rate of the trans isomer and the slower phase the cis-trans isomerization rate, suggesting that the trans isomer of BPGP is preferentially hydrolyzed by ACE in the perfused lung and in vitro.

Angiotensin-converting Enzyme 2 roles in the Pathogenesis of COVID-19

2020 ◽  
Vol 16 ◽  
Author(s):  
Azra Kenarkoohi ◽  
Maryam Maleki ◽  
Tahereh Safari ◽  
Mohamadreza Kafashian ◽  
Fateme Saljoughi ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Renin Angiotensin System ◽  
Major Product ◽  
Surface Proteins ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Angiotensin Converting Enzyme 2 ◽  
Viral Attachment ◽  
Renin Angiotensin ◽  
Wide Range

: The new pandemic Coronavirus Disease 2019 (COVID-19) causes a wide range of clinical consequences, from asymptomatic infection to acute respiratory failure and it is very heterogeneous. The renin-angiotensin system (RAS) is well recognized as a key regulating system in circulatory homeostasis that play prominent roles in pathophysiological processes in abnormal activation for instance renal and cardiovascular diseases, obesity, and stroke. Angiotensin converting enzyme 2(ACE2) as a component of the RAS system. However, unlike the ACE, its activity is not inhibited by the ACE inhibitors. The major product of ACE2 is Ang1-7, known as a vasodilator peptide and part of the depressant arm of the RAS. There are two form of ACE2. Coronavirus cover with some proteins in order to help viral attachment to the cell membrane ACE2 as a receptor and then fuse and enter the cells. ACE2 was expressed in oral Cavity, salivary glands of the mouth, esophagus, myocardial cells, kidney, and enterocytes, along all the respiratory tract, intestine, and blood vessels. In this article, we explain the renin-angiotensin system and its components. Also, we shortly explain the organs involved in COVID-19 disease and we will talk about the possible causes of damage to these organs. We also reviewed the probable mechanism of using ACE2 in viral attachment and the probable treatment processes will also be discussed based on the surface proteins of the virus and ACE2. In addition, we briefly discuss the anti-angiotensin drugs and why patients with chronic disease are more susceptible to COVID-19 infection and show worse progression.

scholarly journals Angiotensin-Converting Enzyme 2 (ACE2) As a Novel Biorecognition Element in A Cell-Based Biosensor for the Ultra-Rapid, Ultra-Sensitive Detection of the SARS-CoV-2 S1 Spike Protein Antigen

Chemosensors ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 341
Author(s):  
Sofia Mavrikou ◽  
Vasileios Tsekouras ◽  
Kyriaki Hatziagapiou ◽  
Asimina Tsalidou ◽  
Petros Bakakos ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Throughput Screening ◽  
Mammalian Cells ◽  
Limit Of Detection ◽  
Cross Reactivity ◽  
Spike Protein ◽  
Converting Enzyme ◽  
Immobilized Cell ◽  
Angiotensin Converting Enzyme 2 ◽  
Wide Range

Antigen screening for the SARS-CoV-2 S1 spike protein is among the most promising tools for the mass monitoring of asymptomatic carriers of the virus, especially in limited resource environments. Herewith, we report on the possible use of the angiotensin-converting enzyme 2 (ACE2), the natural receptor and entry point of the virus, as a biorecognition element for the detection of the S1 antigen combined with an established bioelectric biosensor based on membrane-engineered cells. The working principle of our approach is based on the measurable change of the electric potential of membrane-engineered mammalian cells bearing ACE2 after attachment of the respective viral protein. We demonstrate that sensitive and selective detection of the S1 antigen is feasible in just three min, with a limit of detection of 20 fg/mL. In a preliminary clinical application, positive patient-derived samples were identified with a 87.9% score compared to RT-PCR. No cross-reactivity was observed against a wide range of nucleocapsid protein concentrations. The novel biosensor is embedded in a commercially ready-to-use testing platform, complete with the consumable immobilized cell–electrode interface and a portable read-out device operable through smartphone or tablet. In addition, the possible application of the system for the high throughput screening of potential pharmacological inhibitors of the ACE2 receptor-S1 RBD interaction is discussed.

scholarly journals The effectiveness of zofenopril in patients with cardiovascular disease

2014 ◽  
Vol 11 (2) ◽  
pp. 59-62
Author(s):  
V G Kukes ◽  
G S Anikin
Keyword(s):  
Cardiovascular Disease ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitor ◽  
Sulfhydryl Group ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Wide Range

Hyperactivity of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of any cardiovascular disease. Angiotensin - converting enzyme inhibitors are the main drugs among many medicines influencing the activity of the renin-angiotensin-aldosterone system, and these inhibitors have a wide range of beneficial effects. The presence of the sulfhydryl group in a molecule of angiotensin-converting enzyme inhibitor (zofenopril) determines the number of unique properties of this drug. Recent results have been showing the effectiveness of treatment in case of combined cardiovascular disease. This article presents the results of the studies showing the efficacy and safety of zofenopril.

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