scholarly journals Relationship between plasma asymmetric dimethylarginine and nitric oxide levels affects aerobic exercise training-induced reduction of arterial stiffness in middle-aged and older adults

2021 ◽  
Vol 25 (1) ◽  
pp. 16-22
Author(s):  
Mio Shimomura ◽  
Shumpei Fujie ◽  
Kiyoshi Sanada ◽  
Hiroki Kajimoto ◽  
Takafumi Hamaoka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Asymmetric Dimethylarginine ◽  
Aerobic Exercise Training ◽  
Middle Aged

scholarly journals Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults

Aging ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 1201-1212 ◽  
Author(s):  
Shumpei Fujie ◽  
Natsuki Hasegawa ◽  
Kiyoshi Sanada ◽  
Takafumi Hamaoka ◽  
Seiji Maeda ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Middle Aged

Effects of aerobic exercise training on mental health and arterial stiffness in middle-aged and older adults

2021 ◽  
Vol 61 (10) ◽  
Author(s):  
Nobuhiko AKAZAWA ◽  
Koichiro TANAHASHI ◽  
Keisei KOSAKI ◽  
Satoshi OIKAWA ◽  
Hiroshi KUMAGAI ◽  
...  
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Middle Aged

scholarly journals Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults

2018 ◽  
Vol 314 (1) ◽  
pp. R94-R101 ◽  
Author(s):  
Natsuki Hasegawa ◽  
Shumpei Fujie ◽  
Naoki Horii ◽  
Masataka Uchida ◽  
Toshiyuki Kurihara ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Body Fat ◽  
Training Group ◽  
Aerobic Exercise Training ◽  
Serum Adiponectin ◽  
Control Group ◽  
Middle Aged

Adiponectin regulates endothelial nitric oxide synthase in endothelial cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines and are paralogs of adiponectin, but the association between exercise training-induced reduction of arterial stiffness and circulating CTRPs levels remains unclear. This study aimed to clarify whether the reduction of arterial stiffness in middle-aged and older adults is associated with the change in serum levels of CTRPs induced by exercise training. A total of 52 middle-aged and older participants were randomly divided into two groups: a training group ( n = 26) and a sedentary control group ( n = 26). Participants in the training group completed 8 wk of aerobic exercise training (60–70% peak oxygen uptake for 45 min, 3 days/wk). The reduction of percent whole body fat, abdominal visceral fat area, and carotid-femoral pulse-wave velocity (cfPWV) was significantly greater in the training group than in the control group ( P < 0.05). Moreover, the increase in serum adiponectin, CTRP3, and CTRP5 from baseline to 8 wk was significantly higher in the training group compared with the control group ( P < 0.05). Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = −0.51, r = −0.48, r = −0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). These results suggest that the exercise training-induced increase in serum CTRPs levels may be associated with the reduction of arterial stiffness in middle-aged and older adults.

62 Time course of improvement in secretory unbalance of asymmetric dimethylarginine and nitric oxide productions in response to exercise training in middle-aged and older adults

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
S Fujie ◽  
N Hasegawa ◽  
K Sanada ◽  
T Hamaoka ◽  
S Maeda ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Time Course ◽  
Exercise Intervention ◽  
Training Group ◽  
Middle Aged ◽  
Plasma Adma ◽  
Before And After

Abstract Funding Acknowledgements Supported by Grants-in-Aid for Scientific Research (#17H02182, #16K13059, M. Iemitsu; #18J01024, S. Fujie) Introduction Aging is well known to elevate risks of cardiovascular diseases. As a mechanism of these increased risks with aging, a reduction of nitric oxide (NO) production via augmented secretion of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthesis is related. Habitual aerobic exercise has shown to improve secretory unbalance of endothelium-derived regulating factors with aging, such as increase in NO and decrease in ADMA, resulting in the reduction of arterial stiffness. However, the time course of improvement in secretory unbalance of NO and ADMA productions in response to exercise training in middle-aged and older adults remains unclear. Purpose This study aimed to determine the time course of changes in plasma nitrite/nitrate (NOx) and ADMA levels related to exercise-training effects of arterial stiffness in healthy middle-aged and older adults. Methods Thirty-two Japanese healthy middle-aged and older subjects (67 ± 1 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). We evaluated plasma NOx and ADMA concentrations and carotid-femoral pulse wave velocity (cfPWV) as an index of arterial stiffness, measured every 2 weeks for 8-week in the training group. Results cfPWV was gradually declined from baseline to 8-week and significantly decreased from baseline at weeks 6 (P &lt; 0.05) and 8 (P &lt; 0.01). Plasma NOx level was gradually elevated during exercise intervention and significantly increased from baseline at weeks 6 (P &lt; 0.05) and 8 (P &lt; 0.01). Interestingly, plasma ADMA level was significantly decreased at 8-week intervention (P &lt; 0.05). Furthermore, the exercise training-induced reduction in plasma ADMA level was negatively correlated with the change in plasma NOx level before and after the 8-week (r = -0.483, P &lt; 0.05). The exercise training-induced change in plasma ADMA concentration was positively correlated with training-induced change in cfPWV before and after the 8-week (r = 0.633, P &lt; 0.01). Additionally, there was a negative correlation between the changes in plasma NOx level and cfPWV before and after the 8-week (r = -0.642, P &lt; 0.05). Conclusions These results suggest that habitual aerobic exercise can normalize the secretory unbalance of NO and ADMA productions in 6 to 8 weeks, and these balance normalizations may be contributed to the reduction of arterial stiffness in the middle-aged and older adults.

Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

2020 ◽  
Vol 45 (7) ◽  
pp. 715-722 ◽  
Author(s):  
Kenichiro Inoue ◽  
Shumpei Fujie ◽  
Natsuki Hasegawa ◽  
Naoki Horii ◽  
Masataka Uchida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Animal Study ◽  
Human Study ◽  
Aerobic Exercise Training ◽  
No Production ◽  
Circulating Levels

This study aimed to clarify whether muscle-derived irisin secretion induced by aerobic exercise training is involved in reduction of arterial stiffness via arterial nitric oxide (NO) productivity in obesity. In animal study, 16 Otsuka Long-Evans Tokushima Fatty (OLETF) rats with obesity were randomly divided into 2 groups: sedentary control (OLETF-CON) and 8-week aerobic treadmill training (OLETF-EX) groups. In human study, 15 subjects with obesity completed 8-week aerobic exercise training for 45 min at 60%–70% peak oxygen uptake intensity for 3 days/week. As a result of animal study, carotid-femoral pulse wave velocity (cfPWV) was decreased, and arterial phosphorylation levels of AMP-activated protein kinase (AMPK), protein kinase B (Akt), and endothelial NO synthase (eNOS), circulating levels of nitrite/nitrate (NOx) and irisin, and muscle messenger RNA expression of fibronectin type III domain containing 5 (Fndc5) were increased in the OLETF-EX group compared with OLETF-CON group. In a human study, regular aerobic exercise reduced cfPWV and elevated circulating levels of NOx and irisin. Furthermore, change in circulating irisin levels by regular exercise was positively correlated with circulating NOx levels and was negatively correlated with cfPWV. Thus, aerobic exercise training-induced increase in irisin secretion may be related to reduction of arterial stiffness achieved by NO production via activated arterial AMPK–Akt–eNOS signaling pathway in obesity. Novelty Aerobic exercise training promoted irisin secretion with upregulation of muscle Fndc5 gene expression in rats with obesity. Irisin affected the activation of arterial AMPK–Akt–eNOS signaling by aerobic exercise training. Increased serum irisin level by aerobic exercise training was associated with reduction of arterial stiffness in obese adults.

scholarly journals Effects of Individualized Aerobic Exercise Training on Physical Activity and Health-Related Physical Fitness among Middle-Aged and Older Adults with Multimorbidity: A Randomized Controlled Trial

2020 ◽  
Vol 18 (1) ◽  
pp. 101
Author(s):  
Yi-Pang Lo ◽  
Shang-Lin Chiang ◽  
Chia-Huei Lin ◽  
Hung-Chang Liu ◽  
Li-Chi Chiang
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Exercise Training ◽  
Physical Fitness ◽  
Motivational Interviewing ◽  
Aerobic Exercise ◽  
Controlled Trial ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Health Related

The presence of multimorbidity in middle-aged and older adults, which reduces their physical activity and quality of life, is a global health challenge. Exercise is one of the most important health behaviors that individuals can engage in. Previous studies have revealed that aerobic exercise training is beneficial for healthy middle-aged and older adults and those with various chronic diseases, but few studies have designed individualized aerobic exercise training for individuals with multimorbidity. Although individuals with multimorbidity are considerably less adherent to physical activity interventions, telephone-based motivational interviewing may help in strengthening motivation and promoting behavioral change for increasing physical activity and health-related physical fitness. This study aimed to examine whether a 12-week individualized aerobic exercise training in a rehabilitation center combined with telephone-based motivational interviewing is effective in promoting physical activity and health-related physical fitness among middle-aged and older adults with multimorbidity. A randomized controlled trial was conducted. Forty-three participants (aged > 40) were recruited and randomly assigned to the intervention group, comparison group, or control group. The participants’ physical activity and health-related physical fitness were assessed at baseline and at 12 weeks. The results indicated that after individualized aerobic exercise training combined with telephone-based motivational interviewing, the participants reported increased total physical activity (Fin = 481.3, p = 0.011), vigorous-intensity physical activity (Fin= 298.9, p = 0.007), dominant and nondominant hand grip (kg) (Fin = 1.96, p = 0.019; Fin = 2.19, p = 0.027, respectively), FEV1/FVC (Fin = 0.045, p = 0.043), VO2 max (ml/kg/min) (Fin = 5.30, p = 0.001), VO2 max predicted (%) (Fin = 21.6, p = 0.001), work (watts) (Fin = 22.5, p = 0.001), and anaerobic threshold (L/min) (Fin = 0.165, p = 0.011). Twelve weeks of individualized aerobic exercise training in the rehabilitation center combined with telephone-based motivational interviewing can increase the total physical activity, vigorous physical activity, and cardiorespiratory fitness of middle-aged and older adults with multimorbidity.

scholarly journals The Effect of Aerobic Exercise Training Frequency on Arterial Stiffness in a Hyperglycemic State in Middle-Aged and Elderly Females

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3498
Author(s):  
Ryota Kobayashi ◽  
Kenji Asaki ◽  
Takeo Hashiguchi ◽  
Hideyuki Negoro
Keyword(s):  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Healthy Elderly ◽  
Glucose Intake ◽  
Training Frequency ◽  
Rate Intensity

The frequency of aerobic exercise training in reducing the increase in arterial stiffness during acute hyperglycemia, a risk factor for cardiovascular disease, is unknown. The aim of the study was to determine the aerobic exercise training frequency on arterial stiffness in a hyperglycemic state in middle-aged and elderly females. Twenty healthy elderly people were randomly assigned to a two-times-a-week (T2, n = 10) and four-times-a-week (T4, n = 10) exercise group. All participants exercised for 35 min per session, which consisted of jogging exercises with a heart rate intensity of 65%. Brachial-ankle (ba), and heart-brachial (hb) pulse wave velocity (PWV) were measured before, 4 and 8 weeks after intervention; before the oral ingestion of 75-g of glucose; and 30, 60, and 90 min after ingestion. The baPWV before and 4 weeks after the intervention increased in both groups (p < 0.05), but only increased 8 weeks after intervention in the T2 group. hbPWV was unchanged before, 4 and 8 weeks after intervention in both groups. These findings show that frequent aerobic exercise suppresses the increase in arterial stiffness following glucose intake. The results of this study can be used to support the implementation of exercise programs for middle-aged and elderly patients.

Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults

2015 ◽  
Vol 309 (10) ◽  
pp. H1642-H1647 ◽  
Author(s):  
Shumpei Fujie ◽  
Natsuki Hasegawa ◽  
Koji Sato ◽  
Satoshi Fujita ◽  
Kiyoshi Sanada ◽  
...  
Keyword(s):  
Exercise Training ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Cross Sectional Study ◽  
Aerobic Exercise Training ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Older Subjects ◽  
Induced Changes

Aging-induced arterial stiffening is reduced by aerobic exercise training, and elevated production of nitric oxide (NO) participates in this effect. Adropin is a regulator of endothelial NO synthase and NO release, and circulating adropin level decreases with age. However, the effect of habitual aerobic exercise on circulating adropin levels in healthy middle-aged and older adults remains unclear. We sought to determine whether serum adropin level is associated with exercise training-induced changes in arterial stiffness. First, in a cross-sectional study, we investigated the association between serum adropin level and both arterial stiffness and cardiorespiratory fitness in 80 healthy middle-aged and older subjects (65.6 ± 0.9 yr). Second, in an intervention study, we examined the effects of 8-wk aerobic exercise training on serum adropin level and arterial stiffness in 40 healthy middle-aged and older subjects (67.3 ± 1.0 yr) divided into two groups: aerobic exercise training and sedentary controls. In the cross-sectional study, serum adropin level was negatively correlated with carotid β-stiffness ( r = −0.437, P < 0.001) and positively correlated with plasma NOx level ( r = 0.493, P < 0.001) and cardiorespiratory fitness ( r = 0.457, P < 0.001). Serum adropin levels were elevated after the 8-wk aerobic exercise training intervention, and training-induced changes in serum adropin level were correlated with training-induced changes in carotid β-stiffness ( r = −0.399, P < 0.05) and plasma NOx level ( r = 0.623, P < 0.001). Thus the increase in adropin may participate in the exercise-induced reduction of arterial stiffness.

scholarly journals Chronic Aerobic Exercise Training Reduces Cerebrovascular Reactivity to a Breath Hold Stimulus in Middle‐aged and Older Adults

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Lyndsey E. DuBose ◽  
Conner Wharff ◽  
Phillip Schmid ◽  
Michael Muellerleile ◽  
Gardar Sigurdsson ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Cerebrovascular Reactivity ◽  
Aerobic Exercise Training ◽  
Breath Hold ◽  
Middle Aged

scholarly journals Examining Bone, Muscle and Fat in Middle-Aged Long-Term Endurance Runners: A Cross-Sectional Study

2020 ◽  
Vol 9 (2) ◽  
pp. 522
Author(s):  
Ulrike H. Mitchell ◽  
Bruce Bailey ◽  
Patrick J. Owen
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Fat Mass ◽  
Lean Mass ◽  
Aerobic Exercise Training ◽  
Middle Aged ◽  
Cross Sectional ◽  
Endurance Runners ◽  
Total Body

Aerobic exercise training has many known cardiovascular benefits that may promote healthy aging. It is not known if long-term aerobic exercise training is also associated with structural benefits (e.g., lower fat mass, higher areal bone mineral density (BMD) and greater muscle mass). We evaluated these parameters in middle-aged long-term endurance runners compared to sex-, age-, height-, and weight-matched non-running controls. Total and regional lean and fat mass and areal BMD were assessed by dual-energy X-ray absorptiometry. Sagittal magnetic resonance images captured the cross-sectional area and thickness of the lumbar multifidus. Runners (n = 10; all male) had a mean (standard deviation; SD) age of 49 (4) years, height of 178.9 (4.9) cm, weight of 67.8 (5.8) kg, body mass index (BMI) of 21.4 (1.4) kg/m2 and had been running 82.6 (27.9) km/week for 23 (13) years. Controls (n = 9) had a mean (SD) age of 51 (5) years, height of 176.0 (5.1) cm, weight of 72.8 (7.1) kg, and BMI of 23.7 (2.1) kg/m2. BMI was greater in controls (p = 0.010). When compared to controls on average, runners had a 10 percentage-point greater total body lean mass than controls (p = 0.001) and 14% greater trunk lean mass (p = 0.010), as well as less total body (8.6 kg; p < 0.001), arm (58%; p = 0.002), leg (52%; p < 0.001), trunk (73%; p < 0.001), android (91%; p < 0.001), and gynoid fat mass (64%; p < 0.001). No differences were observed between groups for BMD outcomes or multifidus size. These results underscore the benefits of endurance running to body composition that carry over to middle-age.

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