scholarly journals Resistance Patterns of Escherichia coli and Klebsiella pneumoniae Bacteria Against Amikacin, Ceftazidime, Meropenem, Nitrofurantoin Antibiotics in Elderly Patients with UTI in RSUD Dr. Soetomo

2019 ◽  
Vol 10 (1) ◽  
pp. 20
Author(s):  
Herdiyanti Herdiyanti ◽  
Lindawati Alimsardjono ◽  
Danti Nur Indiastuti
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
Elderly Patients ◽  
The Elderly ◽  
Resistance Pattern ◽  
Resistance Patterns ◽  
Logbook Data

Introduction: Urinary tract infection (UTI) is an infection that involves the urinary tract, including the urethra, bladder, ureter, and kidneys. UTI is caused by microorganisms that breed in the urinary tract which are supposed to be free of microorganisms. Two bacterias that cause UTI in general are Escherichia coli and Klebsiella pneumoniae. UTI can occur at any age but generally occurs in the elderly. UTI caused by gram-negative bacteria can be killed with several examples of antibiotics namely amikacin, ceftazidime, meropenem and nitrofurantoin. These antibiotics found resistance to the bacteria that cause the UTI. This research is to determine the resistance patterns of Escherichia coli and Klebsiella pneumoniae bacteria against amikacin, ceftazidime, meropenem, nitrofurantoin antibiotics in elderly patients with UTI in Dr. Soetomo Surabaya January-June 2017 period.Methods: A descriptive retrospective study in accordance with the logbook data of Clinical Microbiology Installation at Dr. RSUD. Soetomo Surabaya. Data from this study were taken from all populations that met the inclusion criteria. The results are presented by tables. Results: There are 163 elderly patient data which diagnosed with urinary tract infection. Escherichia coli resistance pattern against ceftazidime (75.6%), nitrofurantoin (12.6%) and meropenem (2.4%). Meanwhile, Klebsiella pneumoniae against ceftazidime (72.2%), nitrofurantoin (55.6%), meropenem (11.1%) and amikacin (2.8%). Conclusion: There were resistance number of Escherichia coli and Klebsiella pneumoniae bacteria against antibiotics amikacin, ceftazidime, meropenem, nitrofurantoin in elderly patients with UTI.

Escherichia coli and Klebsiella pneumoniae Sensitivity/Resistance Pattern Towards Antimicrobial Agents in Primary and Simple Urinary Tract Infection Patients Visiting University Hospital of Jamia Hamdard New Delhi

Drug Research ◽  
2018 ◽  
Vol 68 (07) ◽  
pp. 415-420 ◽  
Author(s):  
Mohd Rizwan ◽  
Mohd Akhtar ◽  
Abul Najmi ◽  
Kuldeep Singh
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
High Resistance ◽  
Resistance Pattern ◽  
Age Group ◽  
E Coli ◽  
Number Of Patients

Abstract Aim This study was carried out to record the sensitivity/resistance pattern of Escherichia coli and Klebsiella pneumoniae towards antimicrobial drugs prescribed to urinary tract infection (UTI) patients. Materials and Methods A total of 68 bacteriologically proven simple UTI patients were included in the study, based on inclusion and exclusion criteria. Subjects demographics, antibiotics prescribed, sensitivity pattern of antibiotics towards the urinary pathogens were recorded in drug utilization and documentation form. Results The mean age of the patients was 29.32 years. The maximum number of patients fell under the age group 21–30 years. The maximum no of male and female patients belonged to the age group 21–30 years, 82.35% were females and 17.64% were males. E. coli found to be the most common uropathogens followed by Klebsiella pneumoniae. Nitrofurantoin was the most commonly prescribed drug followed by ciprofloxacin, levofloxacin and amoxicillin + clavulanic acid and amikacin. E. coli isolates showed high resistance for ampicillin followed by cotrimoxazole, norfloxacin, ciprofloxacin, gentamicin, tetracycline and ceftazidime and least resistance to amikacin, nitrofurantoin. Klebsiella pneumoniae isolates were highly resistant against ceftazidime, ampicilline, cotrimoxazole, nitrofurantoin, gentamicin, amoxicillin + sulbactam. Overall, the antibiotic against with high resistance found was ampicillin followed by cotrimoxazole, gentamicin, ceftazidime, norfloxacin, ciprofloxacin, tetracycline, levofloxacin, cefepime and least resistance to amikacin, netilmicin and nitrofurantoin. Conclusion Majority of UTIs in this study were caused by E. coli followed by Klebsiella pneumoniae. The high resistance was found with ampicillin (75%). Nitrofurantoin was the most commonly prescribed drug followed by other flouroquinolones.

Outcome of community-onset ESBL-producing Escherichia coli and Klebsiella pneumoniae bacteraemia and urinary tract infection: a population-based cohort study in Denmark

2020 ◽  
Vol 75 (12) ◽  
pp. 3656-3664
Author(s):  
Rasmus Richelsen ◽  
Jesper Smit ◽  
Henrik Carl Schønheyder ◽  
Pavithra Laxsen Anru ◽  
Belen Gutiérrez-Gutiérrez ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Cohort Study ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
Population Based ◽  
Esbl Production ◽  
E Coli ◽  
Community Onset

Abstract Objectives To assess the impact of ESBL production on mortality and length of hospital stay (LOS) of community-onset infections due to Escherichia coli or Klebsiella pneumoniae. Methods A population-based cohort study including all adult patients hospitalized with a first-time community-onset E. coli or K. pneumoniae bacteraemia or urinary tract infection in the North Denmark Region between 2007 and 2017. For each bacterial agent, we computed 1 year Kaplan–Meier survival curves and cumulative incidence functions of LOS, and by use of Cox proportional hazard regression we computed HRs as estimates of 30 day and 1 year mortality rate ratios (MRRs) and LOS among patients with and without ESBL-producing infections. Results We included 24 518 cases (among 22350 unique patients), of whom 1018 (4.2%) were infected by an ESBL-producing bacterium. The 30 day cumulative mortality and adjusted MRR (aMRR) in patients with and without ESBL-producing isolates was as follows: E. coli bacteraemia (n = 3831), 15.8% versus 14.0%, aMRR = 1.01 (95% CI = 0.70–1.45); E. coli urinary tract infection (n = 17151), 9.5% versus 8.7%, aMRR = 0.97 (95% CI = 0.75–1.26); K. pneumoniae bacteraemia (n = 734), 0% versus 17.2%, aMRR = not applicable; and K. pneumoniae urinary tract infection (n = 2802), 13.8% versus 10.7%, aMRR = 1.13 (95% CI = 0.73–1.75). The 1 year aMRR remained roughly unchanged. ESBL-producing E. coli bacteraemia was associated with an increased LOS compared with non-ESBL production. Conclusions ESBL production was not associated with an increased short- or long-term mortality in community-onset infections due to E. coli or K. pneumoniae, yet ESBL-producing E. coli bacteraemia was associated with an increased LOS.

scholarly journals Multiple-Antibiotic Resistance Mediated by Plasmids and Integrons in Uropathogenic Escherichia coli and Klebsiella pneumoniae

1970 ◽  
Vol 24 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Taslima Taher Lina ◽  
Sabita Rezwana Rahman ◽  
Donald James Gomes
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Urinary Tract Infection ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
High Rate ◽  
E Coli ◽  
Class 1

Antibiotic resistance in urinary tract infection (UTI) is a growing public health problem in the world. In this study, a total of 182 uropathogens were isolated from patients with symptoms of urinary tract infection (UTI). Escherichia coli (88%) was the most prevalent isolate, while Klebsiella pneumoniae was recovered from 12% cases. The male/female ratio was 1:3. About 56% female and 51% male patients belonged to the age group >40 years. The antibiotic resistance rates of the isolates to fifteen different drugs were investigated. E. coli and K. pneumoniae showed variable pattern of susceptibility. The percentage of resistance to different drugs was higher in E. coli isolates compared to that of K. pneumoniae. Among the total number of isolates about 87% were resistant to at least three commonly used antibiotics. All the isolates were sensitive to imipenem. Analysis of the plasmid DNA had shown that the plasmid pattern was very diverse in both E. coli and K. pneumoniae. All the isolates contained multiple numbers of plasmid ranging from 1.0 to >140 MDa. Middleranged plasmids (30 to 80 MDa), the transferable resistance plasmids, were found to be present in 86% E. coli and 85% K. pneumoniae isolates. The strong association observed between plasmid profiles and drug resistance patterns suggest that plasmids other than the common plasmids may have epidemiological significance. The presence of class 1 and class 2 integrons were also investigated. A relatively high occurrence of class 1 integrons, that are associated with lateral transfer of antibacterial resistance genes, was observed in K. pneumoniae (88%) than in E. coli isolates (54%). Class 2 integrons were not found in any of the E. coli and K. pneumoniae isolates. These results show the high rate of drug resistance and the presence of high rate of transferable elements in these MDR isolates. Keywords: Uropathogens, Escherichia coli, Klebsiella pneumoniae, Multidrug-resistant (MDR) bacteria, Plasmid profiles, IntegronsDOI: http://dx.doi.org/10.3329/bjm.v24i1.1231 Bangladesh J Microbiol, Volume 24, Number 1, June 2007, pp 19-23

scholarly journals Prevalence of Urinary Tract Infection among Adult Females in Omu-Aran South-West Nigeria

2020 ◽  
pp. 16-24
Author(s):  
Ndako James A. ◽  
Akinyomade Owolabi ◽  
Oludolapo Olatinsu ◽  
Adedapo O. Omolade ◽  
Ilochi Ifeanyi
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Candida Albicans ◽  
Urinary Tract ◽  
Tract Infection ◽  
Klebsiella Pneumoniae ◽  
Pregnant Women ◽  
Bacterial Growth ◽  
Proteus Species

Background: Urinary tract infection is caused by the presence and replication of microorganisms in the urinary tract. Urinary tract infection is a major health problem among females especially among pregnant women and this is caused by the physiological makeup of the female urinary tract. Objective: This study was designed to assess the epidemiology of UTIs present amidst pregnant women and females residing in the Omu-Aran community. Materials and Methods: A total of 100 individuals were involved of which 50 were pregnant women while the remaining 50 were non-pregnant females. Semi-structured questionnaires were distributed to all participants to obtain their data. Samples of urine (early morning midstream) were collected in universal bottles from participants. The urine specimens were cultured on four different agar plates which were; cystein lactose electrolyte deficient agar, blood agar, MacConkey agar and nutrient agar for significant bacteria growth. Microscopic and macroscopic examination was also carried out on the samples for possible detection of infections. Results: The result of the culture showed a significant bacterial growth of 77% and 23% of the samples collected showed no significant bacterial growth. Bacteria such as Escherichia coli, Klebsiella pneumoniae, Staphylococcus spp., Proteus species, Pseudomonas aeruginosa and Candida albicans were isolated. With Staphylococcus aureus predominantly present and observed as the causative factor for (45.4%) occurrence of UTIs, closely followed by Staphylococcus saprophyticus (13.0%), Escherichia coli (13.0%), Klebsiella pneumoniae (9.1%) Proteus species (9.1%), Staphylococcus epidermidis (7.8%) and Pseudomonas aeruginosa (1.3%). However the only fungi isolated was Candida albicans showing (1.3%) prevalence, Candida is the most common cause of fungal infections in humans. Conclusion: Results obtained in this work showed a high prevalence of Urinary tract infection at our study location. A prompt enlightenment campaign and need for periodic check among females is highly advocated to reduce or out rightly eliminate the spread of common uropathogens in circulation.

scholarly journals ISOLATION AND CHARACTERISATION OF ANTI-BACTERIAL RESISTANCE PATTERNS OF BACTERIAL ISOLATES FROM URINARY TRACT INFECTION IN DIABETICS

2021 ◽  
pp. 57-59
Author(s):  
HARIKRISHNAN S. ◽  
ROSY VENNILA ◽  
R. MONICA
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Resistance ◽  
Resistance Pattern ◽  
Diabetic Patients ◽  
E Coli ◽  
Drug Of Choice ◽  
Resistance Patterns ◽  
Common Infections

Objective: Urinary tract infection (UTI) is one of the most common infections observed in diabetic patients. This study is aimed at identifying the organisms with their anti-bacterial resistance pattern. Methods: A total of 400 diabetic patients over a period of nine months presenting with symptom s of urinary tract infection were taken for the study. Their urine were cultured and an antibiogram done. Results: E. coli, Klebsiella and Enterococci were the commonest organism found. It was found that E. coli, which was the commonest organism E. Coli was sensitive to Norfloxacin and resistant to Ciprofloxacin. Conclusion: Empirical treatment with ciprofloxacin, Which is considered the drug of choice, will lead to failure of treatment.

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