scholarly journals EFFECTS OF GROSSHEMIN AND GROSSMISIN ON THE ACUTE HYPERLIPIDEMIA MODEL INDUCED BY ETHANOL

2014 ◽  
Vol 13 (1) ◽  
pp. 67-72 ◽  
Author(s):  
A. V. Ratkin ◽  
O. A. Kaidash ◽  
V. V. Ivanov ◽  
A. I. Vengerovsky ◽  
S. M. Adekenov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nicotinic Acid ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Total Cholesterol ◽  
Sesquiterpene Lactones ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density

Objective: study sesquiterpene lactones grosshemin and grossmisin lipid-lowering properties on the model of acute hyperlipidemia induced by ethanol in rats.Materials and methods. Rats during 7 days injected into the stomach grosshemin and grossmisin in a dose 10 mg/kg or reference drug nicotinic acid in a dose 25 mg/kg. Hyperlipidemia caused by single introduction of ethanol into the stomach in a dose 5 g/kg. In blood serum of tail vein measured the triacylglycerols, total cholesterol, high density and low density lipoproteins cholesterol, also the level of free fatty acids. Calculated the ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol and the index of atherogenicity.Results. A single dose of ethanol increased serum level of triacylglycerols in 1.9 times, free fatty acids – in 3.2 times, low density lipoproteins – on 44% in comparison with the intact animals indices. It shows the development of acute hyperlipidemia. Serum total cholesterol, high density lipoproteins cholesterol and the index of atherogenicity were not changed. Course sesquiterpene lactones grosshemin and grossmisin introduction against the background of acute hyperlipidemia was accompanied by a decrease in the serum of triacylglycerols levels respectively by 19.8% and 34.1%. Nicotinic acid lowered the content of triacylglycerols by 42.4%. Grosshemin and nicotinic acid reduced the increased level of free fatty acids in the blood serum by 60.7–67.9%. Grossmisin and nicotinic acid decreased by 14.6–17.2% of total cholesterol in the blood serum. In acute hyperlipidemia grosshemin and grossmisin reduced low density lipoproteins cholesterol by 17.6% and 20%, respectively, nicotinic acid – by 15.7%. Both of sesquiterpene lactone and nicotinic acid did not modify the content of high density lipoproteins cholesterol. When introduction grosshemin, grossmisin and nicotinic acid ratio of high density lipoproteins cholesterol to the amount of low density lipoproteins cholesterol significantly increased by 42.8%, 38,6% and 22.1% respectively.Conclusion. Sesquiterpene lactones grosshemin and grossmisin posses hypolipidemic effect in acute experimental hyperlipidemia caused by the ethanol introduction. Lactones normalize many indices of lipid metabolism, which can be caused by different biochemical targets of these molecules. Lactones, as nicotinic acid, in the model of acute hyperlipidemia decrease in blood serum triacylglycerols, total cholesterol, and low density lipoproteins cholesterol content. Grosshemin and nicotinic acid also reduce the free fatty acids level.

scholarly journals The effect of oil phytopreparations on the lipid status in an experiment

2012 ◽  
Vol 93 (4) ◽  
pp. 561-563
Author(s):  
A K Berdgaleeva ◽  
N T Aldiyarova ◽  
S K Sakhanova
Keyword(s):  
Fatty Acids ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Phospholipid Content ◽  
Low Density ◽  
Cholesterol Diet ◽  
Lipid Status ◽  
Oil Extract

Aim. To study the effect of oil extracts of the burdock root and elecampane on the lipid profile in an experimental model of cholesterolosis. Methods. Experiments were performed on 60 white nonlinear rats, weighing 180-300 g. The oil extract from the burdock root was administered intragastrically at a dose of 2.5 ml/kg, and an extract from the root of elecampane - at a dose of 1.0 ml/kg during the last 30 days on the background of a cholesterol diet. After removal of the animals from the experiment the levels of cholesterol, triglycerides, high and low density lipoproteins, phospholipids, free fatty acids were determined in the blood serum and in liver homogenates with the use of standardized sets. Results. Administration of oil extracts of the burdock root and elecampane on the background of a cholesterol diet resulted in a significant reduction in serum cholesterol level by average of 1.48 times, triglycerides level - by 1.9 times, low-density lipoproteins level - by 1.8 times, as well as in a significant increase in the level of high-density lipoproteins on average by 1.5 times compared with the pathology model. In the same conditions the oil extracts of the burdock root and elecampane significantly increased the phospholipid content in the liver tissue by 1.4 and 1.7 times, respectively, the content of free fatty acids - by 2 times in average, the content of esterified cholesterol - by about 1.5 times as compared with the pathology model. Conclusion. The studied oils have a unidirectional positive effect on the lipid content in blood serum and liver in an experimental cholesterolosis; the oil extract from the root of elecampane has a more pronounced effect.

scholarly journals Haplotype Analysis of Genomic Prediction Using Structural and Functional Genomic Information for Seven Human Phenotypes

2020 ◽  
Vol 11 ◽  
Author(s):  
Zuoxiang Liang ◽  
Cheng Tan ◽  
Dzianis Prakapenka ◽  
Li Ma ◽  
Yang Da
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Genomic Prediction ◽  
Prediction Accuracy ◽  
Haplotype Analysis ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Genomic Information

Genomic prediction using multi-allelic haplotype models improved the prediction accuracy for all seven human phenotypes, the normality transformed high density lipoproteins, low density lipoproteins, total cholesterol, triglycerides, weight, and the original height and body mass index without normality transformation. Eight SNP sets with 40,941-380,705 SNPs were evaluated. The increase in prediction accuracy due to haplotypes was 1.86-8.12%. Haplotypes using fixed chromosome distances had the best prediction accuracy for four phenotypes, fixed number of SNPs for two phenotypes, and gene-based haplotypes for high density lipoproteins and height (tied for best). Haplotypes of coding genes were more accurate than haplotypes of all autosome genes that included both coding and noncoding genes for triglycerides and weight, and nearly the same as haplotypes of all autosome genes for the other phenotypes. Haplotypes of noncoding genes (mostly lncRNAs) only improved the prediction accuracy over the SNP models for high density lipoproteins, total cholesterol, and height. ChIP-seq haplotypes had better prediction accuracy than gene-based haplotypes for total cholesterol, body mass index and low density lipoproteins. The accuracy of ChIP-seq haplotypes was most striking for low density lipoproteins, where all four haplotype models with ChIP-seq haplotypes had similarly high prediction accuracy over the best prediction model with gene-based haplotypes. Haplotype epistasis was shown to be the reason for the increased accuracy due to haplotypes. Low density lipoproteins had the largest haplotype epistasis heritability that explained 14.70% of the phenotypic variance and was 31.27% of the SNP additive heritability, and the largest increase in prediction accuracy relative to the best SNP model (8.12%). Relative to the SNP additive heritability of the same regions, noncoding genes had the highest haplotype epistasis heritability, followed by coding genes and ChIP-seq for the seven phenotypes. SNP and haplotype heritability profiles showed that the integration of SNP and haplotype additive values compensated the weakness of haplotypes in estimating SNP heritabilities for four phenotypes, whereas models with haplotype additive values fully accounted for SNP additive values for three phenotypes. These results showed that haplotype analysis can be a method to utilize functional and structural genomic information to improve the accuracy of genomic prediction.

Metabolism of palmitate and linoleate in intact dogs

1962 ◽  
Vol 203 (5) ◽  
pp. 914-918 ◽  
Author(s):  
P. J. Nestel ◽  
A. Bezman ◽  
R. J. Havel
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Milk Fat ◽  
Plasma Lipids ◽  
Corn Oil ◽  
Low Density Lipoproteins ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Two Populations

Palmitate-9, 10-H3 and linoleate-1-C14 were infused simultaneously into intact dogs as albumin-bound free fatty acids or as esterified fatty acids in chylomicrons. Linoleate bound to albumin was removed more rapidly from the plasma and was incorporated more extensively into triglycerides of very low density lipoproteins of plasma than palmitate. Both linoleate and palmitate were incorporated more slowly into triglyceride fatty acids of low density and high density lipoproteins than into those of very low density lipoproteins. When chylomicrons obtained separately from dogs fed palmitate-9, 10-H3 with milk fat and linoleate-1-C14 with corn oil were mixed and infused into recipients, the rates of removal from the blood of both triglycerides and phospholipids of the two populations of chylomicrons differed, but this did not seem to depend on their chemical composition. Linoleate derived from chylomicron triglycerides disappeared from hepatic triglycerides and phospholipids more rapidly than palmitate and was incorporated more extensively into plasma lipids. Palmitate and linoleate were incorporated in equivalent amounts into circulating free fatty acids, but more linoleate was found in lipids of adipose tissue.

scholarly journals Influence of Functional Sweet White Lupin Biscuits on Lipid Profile and Food Efficiency of Induced Hyperlipidemia Rats

2015 ◽  
Vol 4 (3) ◽  
pp. 14 ◽  
Author(s):  
Rasha Mousa Ahmed Mousa
Keyword(s):  
Weight Gain ◽  
Total Cholesterol ◽  
Low Density Lipoproteins ◽  
High Density ◽  
The Body ◽  
Atherogenic Index ◽  
White Lupin ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Food Efficiency

<p>In recent years, functional foods have attracted much interest to prevent nutrition-related diseases such as hyperlipidemia and weight gain. In this regard, this study was designed to examine the effect of use sweet white lupin (SWL) oil and flour with/without germination as a source of active healthy components to prepare functional biscuits for lowering blood lipids and growth. Functional biscuits were formulated by replacing wheat flour and butter in biscuit formulae by SWL extracted flour and SWL oil in the range of 20-30% (w/w) and 30-40% (v/w), respectively. Results indicated that the feed of hyperlipidemic rats on diets supplemented with different functional SWL biscuits for 6 weeks significantly (P &lt; 0.05) reduced serum total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, ratio of total cholesterol/high density lipoproteins cholesterol, ratio of low density lipoproteins/high density lipoproteins cholesterol and atherogenic index. Furthermore, the feed of functional SWL biscuits significantly reduced the body weight gain of rats and their food efficiency compared to that of rats fed on hyperlipidemic diet. On the other hand, there was an increase in the value of high density lipoproteins cholesterol and its ratio with total cholesterol. All these findings supported that the addition of 25% germinated SWL flour and 35% or 40% germinated SWL oil in biscuits gave interested results compared to the common wheat biscuits. Therefore, the proposed functional SWL biscuits could be able to regulate the blood cholesterol and the body growth levels of individuals and patients.</p>

scholarly journals A Molecular and Biochemical Study for Cholesteryl Ester Transfer Protein (CETP) Taq1B in Iraqi Patients with Hyperlipidemia

2019 ◽  
Vol 16 (3(Suppl.)) ◽  
pp. 0747
Author(s):  
Alkhafajy Et al.
Keyword(s):  
Cholesteryl Ester ◽  
Total Cholesterol ◽  
Cholesteryl Ester Transfer Protein ◽  
Serum Lipid ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Very Low Density Lipoproteins ◽  
Transfer Protein

Cholesteryl ester transfer protein gene contains some single nucleotide polymorphisms, which have been associated with serum high-density lipoprotein concentration and other lipoproteins. This study is done for determining of cholesteryl ester transfer protein polymorphism and evaluate its effect on serum lipid profile concentrations in some hyperlipidemic patients compared with healthy subjects in Salah Al-din governorate-Iraq. Blood samples were taken from (90) patients suffering from hyperlipidemia, and (70) samples that were apparently healthy controls.  Serum lipid concentrations were measured by enzymatic assays. The polymorphism was genotyped using polymerase chain reaction restriction fragment length polymorphism analysis.  The results showed that there was a significant decrease (P<0.05) in the frequency B2 allele, and B1B2, B2B2 genotype, and a significant increase (P<0.05) in the frequency B1 allele, and B1B1 genotype between patients and controls groups. There was a non-significant decrease in the levels of high density lipoproteins, total cholesterol, low density lipoproteins, and very low density lipoproteins levels, and non-significant increase in levels of triglycerides in individuals with the B1B1 genotype than in the B1B2 and B2B2 genotype. However, high density lipoproteins showed a significant decrease (P<0.001) between individuals with the B1B1 genotype and B2B2 genotype. Also, there was a non-significant difference in the levels of high density lipoproteins, total cholesterol, low density lipoproteins, and very low density lipoproteins levels, in individuals with the B1B2 genotype when compared with that of the B2B2 genotype.

scholarly journals Comparison of lipid profile in thrombotic and hemorrhagic stroke patients

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Sohail Bashir Sulehria ◽  
Anser Asrar ◽  
Irshad Hussain Qureshi.
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Haemorrhagic Stroke ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Stroke Patients ◽  
Very Low Density Lipoproteins ◽  
The Difference

Objective: To compare lipid profile in thrombotic and haemorrhagic stroke patients. Place of Study: All general medical and neurology wards of Mayo Hospital Lahore. Patients and Methods: Study was conducted in 40 consecutive patients of stroke admitted in hospital. Serum lipid (total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio) were estimated in all selected patients within 7 days of onset of stroke and findings were entered on study proforma specifically designed for this purpose and analyzed statistically by student`s "t" test. Results: Out of 40 patients included in the study, 22(55%) were suffering from thrombotic stroke while 18(45%) suffered from haemorragic stroke. The difference in the values of total cholesterol, triglycerides, low-density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio was not statistically significant between the two groups of patients. Conclusion: It is concluded that serum lipids i.e., total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins, high density lipoproteins and LDL/HDL ratio does not have any differential effect in the causation of thrombotic or haemorrhagic strokes.

scholarly journals Effects of indomie noodle waste (INW) on serum lipid profile of broiler birds fed during the wet season

2020 ◽  
Vol 44 (2) ◽  
pp. 96-100
Author(s):  
S. T. Yakubu ◽  
T. S. Olugbemi ◽  
P. Onimisi ◽  
O. T. Lasisi
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Low Density Lipoproteins ◽  
High Density ◽  
Serum Lipid Profile ◽  
High Density Lipoproteins ◽  
Broiler Chicks ◽  
Low Density ◽  
Wet Season

Instant noodles are widely consumed in Nigeria, with large of its by-products although high in energy but constituting environmental pollution in the production areas if allowed to lay waste. An eight-week feeding trial using 240 five-days old Hubbard flex broiler chicks was conducted to access the effect of feeding graded levels of indomie noodle waste (INW) in isonitrogenous diets on serum lipid profile of birds. Birds were allotted five treatments containing three replicates having sixteen birds per replicate in a completely randomized design. Five diets were compounded containing indomie noodle waste at 0, 25, 50, 75 and 100% replacing maize in the diets. Feed and water were provided ad libitum. At the end of the experiment, blood samples were collected from severed jugular veins of two birds per replicate and subjected to laboratory analysis for Total Cholesterol, High density lipoproteins, Low density lipoproteins and Triglycerides. Results showed that increase in INW in the diets of broilers increased total cholesterol (148.24mg/dl -192.06mg/dl, SD 61.68) and triglyceride (27.07mg/dL-91.52mg/dl, SD 40.79), favored high density lipoproteins (37.38mg/dL - 77.34mg/Dl, SD 31.88), and lowered values for low density lipoproteins (72.18mg/dL - 112.14mg/dL, SD 58.06) though there was no statistical difference (P>0.05) across the treatments. Indomie noodle waste has the potential to replace maize up to 100% with good effects on High Density Lipoproteins, Total Cholesterol within range and lower Low Density Lipoproteins values.

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