The role of herpes and human papillomavirus infection in prostate and bladder carcinogenesis

Human papillomavirus (HPV) is a small epithelial, non-enveloped, double-stranded DNA virus that belongs to the Papillomaviridae family. HPV infection is one of the most common sexually transmitted infections, and certain types of HPV are known to be carcinogenic to humans. According to the scientific literature, there is reliable information about the role of highly oncogenic HPV types in the development of cervical, anal, vulvar, vaginal, penile, and oropharyngeal cancer.Currently, a relevant and promising research area is the study of the role of HPV infection in prostate cancer (PC) and bladder cancer (BC), but scientific data on the potential pathogenetic relationship between these phenomena remain contradictory. An in-depth study of the question how herpes and human papillomavirus affect the origin of malignant tumors of the prostate and bladder, as well as the course of these diseases, and the prognosis of their development can become a source of information for development of new approaches to their diagnosis, prevention, and monitoring of morbidity. This literature review analyzes the results of modern studies on the role of oncogenic HPV types in the carcinogenesis of PC and BC.

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Vaginal microbiota and human papillomavirus infection among young Swedish women

npj Biofilms and Microbiomes ◽

10.1038/s41522-020-00146-8 ◽

2020 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Liqin Cheng ◽

Johanna Norenhag ◽

Yue O. O. Hu ◽

Nele Brusselaers ◽

Emma Fransson ◽

...

Keyword(s):

Human Papillomavirus ◽

Alpha Diversity ◽

Hpv Infection ◽

Cross Sectional Study ◽

Vaginal Microbiota ◽

Microbial Composition ◽

Cross Sectional ◽

Sexually Transmitted ◽

Hpv Types ◽

Oncogenic Hpv

Abstract Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.

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Human papillomavirus (HPV) vaccine acceptance and perceived effectiveness, and HPV infection concern among young New Zealand university students

Sexual Health ◽

10.1071/sh10005 ◽

2010 ◽

Vol 7 (3) ◽

pp. 394 ◽

Cited By ~ 9

Author(s):

Carol Chelimo ◽

Trecia A. Wouldes ◽

Linda D. Cameron

Keyword(s):

Human Papillomavirus ◽

Undergraduate Students ◽

Hpv Vaccine ◽

Hpv Vaccination ◽

Hpv Infection ◽

Infection Risk ◽

Vaccine Acceptance ◽

Sexually Transmitted ◽

Behavioural Characteristics

Two-hundred undergraduate students completed an anonymous questionnaire after viewing a human papillomavirus (HPV) vaccine television commercial. Eight-four percent of participants would accept a free HPV vaccine, whereas 47% were unconcerned about future personal HPV infection risk. Males were less likely to accept a free HPV vaccine and to be concerned about future personal HPV infection risk. Perceived HPV vaccine effectiveness was significantly greater among participants who had previously heard of the vaccine and who knew that HPV is sexually transmitted. More education on the role of sexual behavioural characteristics of both males and females in HPV transmission is necessary to promote awareness and concern of personal HPV infection risk and acceptance of HPV vaccination.

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Prevalence of Human Papillomavirus (HPV) infection in women living in remote riverine communities in the Amazonas, Brazil

10.21203/rs.2.12030/v1 ◽

2019 ◽

Author(s):

Marco Antonio Zonta ◽

Karina Bonilha Roque ◽

Yara Juliano ◽

Anne Liljander ◽

Markus Cavalar ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Hpv Infection ◽

Public Health Services ◽

Cervical Lesions ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Remote Areas ◽

Hpv Types ◽

Crucial Part

Abstract Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Since some HPV types are associated with the development of cervical cancer, routine screening for HPV plays a crucial part in cancer prevention programs at global level. In Brazil, the cervical cancer rate is among the highest in the world, in particular in indigenous women living in remote areas with limited access to public health services. The objective of this study was to determine the prevalence of HPV infections and their co-occurrence with cervical lesions in Brazilian women living in isolated riverine communities. Moreover, the association between social environment, sexual activity and prevalence of HPV infection was assessed.

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Progress in the Research on the Relationship between Infection with Human Papillomavirus and Tumorigenesis

Infection International ◽

10.1515/ii-2017-0138 ◽

2016 ◽

Vol 5 (4) ◽

pp. 99-104

Author(s):

Jin Zhang

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Malignant Tumors ◽

Hpv Infection ◽

Sexually Active ◽

Organ Systems ◽

Mucous Membranes ◽

Hpv Types ◽

High Risk Hpv ◽

The Relationship

AbstractHuman papillomavirus (HPV) is a DNA virus that infects the skin and mucous membranes of the human body. Approximately 80% of sexually active women are likely infected with HPV. Cervical cancer is one of the most common malignant tumors and is second in incidence only to breast cancer. Infection with high-risk HPV types is the main risk factor for cervical cancer, which is currently the only malignant tumor with a clearly defined etiology. HPV infection is also closely related to the incidence and development of other malignant tumors. In addition to cervical cancer, HPV can cause other urogenital tumors, as well as tumors in the digestive tract, lungs, eyes, skin, and other organ systems. This paper provides a review of the progress in HPV infection-related research and provides novel ideas for the study of tumor etiology and mechanisms.

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HPV infection in semen: results from a new molecular approach

Epidemiology and Infection ◽

10.1017/s0950268819000621 ◽

2019 ◽

Vol 147 ◽

Cited By ~ 5

Author(s):

G. Capra ◽

R. Schillaci ◽

L. Bosco ◽

M. C. Roccheri ◽

A. Perino ◽

...

Keyword(s):

Clinical Manifestations ◽

Hpv Infection ◽

Viral Dna ◽

New Approach ◽

Hpv Dna ◽

Sexually Transmitted ◽

Viral Genomes ◽

Hpv Genotypes ◽

Oncogenic Hpv

AbstractHuman papillomavirus (HPV) is the agent of the most common sexually transmitted diseases causing a variety of clinical manifestations ranging from warts to cancer. Oncogenic HPV infection is the major cause of cervical cancer and less frequently of penile cancers. Its presence in semen is widely known, but the effects on fertility are still controversial. We developed a new approach to evaluate virus localisation in the different semen components. We analysed also the specific genotype localisation and viral DNA quantity by qPCR. Results show that HPV DNA can be identified in every fraction of semen: spermatozoa, somatic cells and seminal plasma. Different samples can contain the HPV DNA in different fractions and several HPV genotypes can be found in the same fraction. Additionally, different fractions may contain multiple HPV genotypes in different relative quantity. We analysed the wholeness of HPV DNA in sperm cells by qPCR. In one sample more than half of viral genomes were defective, suggesting a possible recombination event. The new method allows to easily distinguish different sperm infections and to observe the possible effects on semen. The data support the proposed role of HPV in decreased fertility and prompt new possible consequences of the infection in semen.

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Faculty Opinions recommendation of Carcinogenicity of Human Papillomavirus (HPV) Types in HIV-Positive Women: A Meta-Analysis From HPV Infection to Cervical Cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727565191.793546767 ◽

2018 ◽

Author(s):

Santosh Kumar

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Meta Analysis ◽

Hpv Infection ◽

Hiv Positive ◽

Hiv Positive Women ◽

Hpv Types

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Cervicovaginal human papillomavirus (HPV)-infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV-positive and HIV-negative women

International Journal of Cancer ◽

10.1002/ijc.27363 ◽

2012 ◽

Vol 131 (6) ◽

pp. 1472-1478 ◽

Cited By ~ 9

Author(s):

Gypsyamber D'Souza ◽

Robert D. Burk ◽

Ye Zhong ◽

Howard Minkoff ◽

L. Stewart Massad ◽

...

Keyword(s):

Human Papillomavirus ◽

Hpv Infection ◽

Hiv Positive ◽

Tissue Tropism ◽

Before And After ◽

Hpv Types ◽

Hiv Negative

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Development of Neutralizing Monoclonal Antibodies for Oncogenic Human Papillomavirus Types 31, 33, 45, 52, and 58

Clinical and Vaccine Immunology ◽

10.1128/cvi.00773-13 ◽

2014 ◽

Vol 21 (4) ◽

pp. 587-593 ◽

Cited By ~ 16

Author(s):

Martha J. Brown ◽

Hanna Seitz ◽

Victoria Towne ◽

Martin Müller ◽

Adam C. Finnefrock

Keyword(s):

Monoclonal Antibodies ◽

Human Papillomavirus ◽

Immune Responses ◽

Neutralizing Antibodies ◽

Cervical Cancers ◽

Hpv Types ◽

Oncogenic Hpv ◽

Neutralizing Epitopes ◽

Selection Of

ABSTRACTHuman papillomavirus (HPV) is the etiological agent for all cervical cancers, a significant number of other anogenital cancers, and a growing number of head and neck cancers. Two licensed vaccines offer protection against the most prevalent oncogenic types, 16 and 18, responsible for approximately 70% of cervical cancer cases worldwide and one of these also offers protection against types 6 and 11, responsible for 90% of genital warts. The vaccines are comprised of recombinantly expressed major capsid proteins that self-assemble into virus-like particles (VLPs) and prevent infection by eliciting neutralizing antibodies. Adding the other frequently identified oncogenic types 31, 33, 45, 52, and 58 to a vaccine would increase the coverage against HPV-induced cancers to approximately 90%. We describe the generation and characterization of panels of monoclonal antibodies to these five additional oncogenic HPV types, and the selection of antibody pairs that were high affinity and type specific and recognized conformation-dependent neutralizing epitopes. Such characteristics make these antibodies useful tools for monitoring the production and potency of a prototype vaccine as well as monitoring vaccine-induced immune responses in the clinic.

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ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals

Scientific Reports ◽

10.1038/s41598-019-56422-x ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Maria Pujantell ◽

Roger Badia ◽

Iván Galván-Femenía ◽

Edurne Garcia-Vidal ◽

Rafael de Cid ◽

...

Keyword(s):

Human Papillomavirus ◽

Immune Activation ◽

Hpv Infection ◽

Innate Immune ◽

Type I ◽

Innate Immune Activation ◽

Enhanced Expression

AbstractInfection by human papillomavirus (HPV) alters the microenvironment of keratinocytes as a mechanism to evade the immune system. A-to-I editing by ADAR1 has been reported to regulate innate immunity in response to viral infections. Here, we evaluated the role of ADAR1 in HPV infection in vitro and in vivo. Innate immune activation was characterized in human keratinocyte cell lines constitutively infected or not with HPV. ADAR1 knockdown induced an innate immune response through enhanced expression of RIG-I-like receptors (RLR) signaling cascade, over-production of type-I IFNs and pro-inflammatory cytokines. ADAR1 knockdown enhanced expression of HPV proteins, a process dependent on innate immune function as no A-to-I editing could be identified in HPV transcripts. A genetic association study was performed in a cohort of HPV/HIV infected individuals followed for a median of 6 years (range 0.1–24). We identified the low frequency haplotype AACCAT significantly associated with recurrent HPV dysplasia, suggesting a role of ADAR1 in the outcome of HPV infection in HIV+ individuals. In summary, our results suggest that ADAR1-mediated innate immune activation may influence HPV disease outcome, therefore indicating that modification of innate immune effectors regulated by ADAR1 could be a therapeutic strategy against HPV infection.

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