scholarly journals Prevalence of Carbapenem Resistance in Nonfermenting Gram Negative Bacteria in Patients with Respiratory Tract Infection Admitted in Intensive Care Units in Tertiary Care Centre

2020 ◽  
Vol 9 (2) ◽  
pp. 1363-1371
Author(s):  
Seematai Prakash katole ◽  
Nilekar Sandeep Laxmikant
Keyword(s):  
Intensive Care ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Tertiary Care ◽  
Carbapenem Resistance ◽  
Gram Negative Bacteria ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Gram Negative

scholarly journals Frequency and predictors of colonization of the respiratory tract by VIM-2-producing Pseudomonas aeruginosa in patients of a newly established intensive care unit

2006 ◽  
Vol 55 (10) ◽  
pp. 1435-1439 ◽  
Author(s):  
Maria Horianopoulou ◽  
Nicholas J. Legakis ◽  
Maria Kanellopoulou ◽  
Sotiris Lambropoulos ◽  
Athanassios Tsakris ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Pseudomonas Aeruginosa ◽  
Intensive Care ◽  
Respiratory Tract ◽  
Tertiary Care ◽  
Nucleotide Sequencing ◽  
Gram Negative Bacteria ◽  
Care Hospital ◽  
Gram Negative ◽  
Icu Stay

The aim of this study was to examine the frequency and predictors of colonization of the respiratory tract by metallo-β-lactamase (MBL)-producing Gram-negative bacteria in patients admitted to a newly established intensive care unit (ICU) of a tertiary care hospital. Specimens of tracheobronchial aspirates for microbiological studies were obtained every day for the first 3 days of the ICU stay and subsequently every third day for the rest of the ICU stay. PCR analysis and nucleotide sequencing were performed to identify bacteria that had MBL genes. Thirty-five patients (20 male, 15 female) were hospitalized during the initial 3 month period of functioning of the ICU. Colonization of the lower respiratory tract by Gram-negative bacteria was found in 29 of 35 patients (83 %) during the first 6–20 days (median 13 days) following admission to the ICU (13 patients with Acinetobacter baumannii, ten with Pseudomonas aeruginosa, three with Enterobacter aerogenes, two with Klebsiella pneumoniae and one with Stenotrophomonas maltophilia). Six of 29 patients (21 %) colonized with Gram-negative bacteria had bla VIM-2-positive P. aeruginosa isolates; one of these patients developed clinical infection due to this micro-organism. Previous use of carbapenems (P=0.01) or other β-lactams (P=0.03), as well as a stay in the ICU of >20 days (P<0.001), were associated with colonization with bla VIM-2-producing P. aeruginosa. In conclusion, colonization by Gram-negative bacteria of the respiratory tract of patients in this newly established ICU was common (83 %). Use of β-lactams, including carbapenems, was associated with subsequent colonization of the respiratory tract with MBL-positive P. aeruginosa.

scholarly journals Microbiology of lower respiratory tract infection in workers of garment industry of Kathmandu

2015 ◽  
Vol 10 (3) ◽  
pp. 14-22
Author(s):  
S Pant ◽  
KR Bhusal ◽  
S Manandhar
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Culture Media ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

By mistake the wrong PDF was loaded for this article. The correct PDF was loaded on 19th September 2016. OBJECTIVES This study was designed with the objectives of describing the distribution pattern of microorganisms responsible for causing LRTI in the workers of garment industries.MATERIALS AND METHODS A total of 198 cases of suspected person of Lower Respiratory Tract infection (LRTI) LRTI were included in this study. This study was conducted between November 2009 to April 2010. Specimen for the study was expectorated sputum. Gram-stain, Ziehl-Neelsen stains and culture were performed.RESULTS On direct microscopic examination, 20.51% were Gram positive bacteria, 79.48% were Gram negative bacteria and 4% were smear positive AFB. On culture sensitivity examination, 22% percent showed growth of different bacteria in different culture media. The bacteria isolated from the samples included Klebsiella pneumoniae (15.38%), Proteus mirabilis (15.38%) and Citrobacterfruendii (15.38%). Gram Negative bacteria were found most susceptible to Ciprofloxacin (92.30%, 24/26) and Amikacin (92.30%, 24/26). Similarly, Gram Positive bacteria were found most susceptible to Ciprofloxacin (100%, 8/8) followed by Cloxacillin and Cephalexin (87.5%, 7/8). Smear positive AFB was significantly associated with not using the protective measures (mask) by workers and presence of symptoms (cough for more than two weeks, night sweat, hemoptysis and anorexia) (p=0.031). Culture positivity was significantly associated with symptoms like production of purulent sputum (p=0.045).CONCLUSION There was insignificant association between LRTI and risk factors present in working room of garment industries. Most of the isolates were sensitive to Ciprofloxacin and resistance to Ampicillin and Cephalexin.Journal of College of Medical Sciences-Nepal, 2014, Vol-10, No-3, 14-22

scholarly journals Antimicrobial Susceptibility Pattern of Gram-Negative Bacteria Causing Lower Respiratory Tract Infections in Kathmandu University Hospital

2021 ◽  
Vol 18 (4) ◽  
pp. 661-666
Author(s):  
Jatan Bahadur Sherchan ◽  
Sanjay Humagain
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Multidrug Resistant ◽  
P Value ◽  
Diabetic Patients ◽  
Gram Negative Bacteria ◽  
Predisposing Factor ◽  
Gram Negative

Background: Respiratory tract infection due to Gram-negative bacteria is a common cause of morbidity and mortality worldwide. This study was carried out to determine the antimicrobial susceptibility pattern of Gram-negative bacteria from patients with lower respiratory tract infection visiting Kathmandu University Hospital.Methods: A total of 3,403 respiratory samples including sputum and endotracheal aspirates were processed and antibiotic resistance pattern was determined following Clinical Laboratory Standard Institute guidelines. Patients’ information was obtained after informed consent.Results: Growth of Gram-negative bacteria was 210 (6.17%). 83(39.52%) were Klebsiella pneumoniae followed by Escherichia coli, Pseudomonas aeruginosa, Acinetobacter species, Klebsiella oxytoca, Enterobacter species, Proteus mirabilis and Haemophilus influenzae. 151(71.90%) isolates were multidrug resistant. None of the strains were resistant to colistin. 51(24.29%) were resistant to carbapenem and out of these 3(1.43%) were metallo-? lactamase producers. 89(65.92%) of the patients having both pneumonia along with other respiratory illnesses were above 60 years of age indicating that old age might be a predisposing factor. (p value is less than 0.0001). 92(81.42%) of patients of age above 60 years had multidrug resistant isolates indicating that old age might be a predisposing factor for getting infection my multidrug resistant isolates. (p value equals 0.0012) Among 36 diabetic patients 33(91.67%) had multidrug resistant isolates. Whereas out of 174 non-diabetic patients only 118(67.82%) had multidrug resistant isolates (p value equals 0.0037).Conclusions: Multidrug-resistant Gram negative bacteria were observed in respiratory samples. Effective treatment of lower respiratory tract infection need detailed microbiological diagnosis and drug susceptibility testing.Keywords: ESBL; LRTI; MBL; MDR

scholarly journals Pathogenic Bacteria and Drug Sensitivity Analysis of Lower Respiratory Tract Infections in Patients

2014 ◽  
Vol 3 ◽  
pp. 4
Author(s):  
Qianqian Wang ◽  
Chuanhui Wang
Keyword(s):  
Internal Medicine ◽  
Drug Resistance ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Pathogenic Bacteria ◽  
Gram Negative Bacteria ◽  
Gram Negative

<strong>Objective: </strong>To study drug resistance of pathogenic bacteria in lower respiratory tract infection in patients in Respiratory Department of Internal Medicine. <strong>Method: </strong>On October 2011 to October 2013, there were 112 patients with lower respiratory tract infection in the hospital respiratory medicine ward were reviewed for analysis by collected patient’s infected blood, urine and sputum for laboratory analysis and investigation of drug resistance. <strong>Results: </strong>In a total of 112 strains of pathogenic bacteria, gram negative bacteria, the number of strains was 68, accounting for 60.7% of all strains. The analysis of gram positive bacteria had the lowest drug resistance to vancomycin, but the resistance to erythromycin and penicillin was the highest, while gram negative bacteria were the lowest, but the drug resistance was high. <strong>Conclusion: </strong>In Respiratory Department Of Internal Medicine, patients with lower respiratory tract infection, the pathogenic bacteria which is gram negative bacterial infection is more common, to clarify the distribution of the infection of pathogenic bacteria, and the drug resistance to do a good grasp of the lower respiratory tract infection in patients with lower respiratory tract infection in patients with the role of a thing.

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