scholarly journals Biogenic amines in wine : a review of analytical methods

OENO One ◽  
1996 ◽  
Vol 30 (2) ◽  
pp. 85 ◽  
Author(s):  
Olga Busto ◽  
Josep Guasch ◽  
Francesc Borrull
Keyword(s):  
High Performance Liquid Chromatography ◽  
Biogenic Amines ◽  
Analytical Methods ◽  
High Performance ◽  
Rapid Evolution ◽  
Analytical Techniques ◽  
Point Of View ◽  
Physiological Effects ◽  
Fermented Beverages ◽  
Hygienic Conditions

<p style="text-align: justify;">The content of biogenic amines in wines and other fermented beverages has been extensively studied over the last 25 years because of the physiological effects which their consumption might lead to, in particular in the presence of alcohol. From the health point of view, this may indicate that the hygienic conditions while the beverage in question was being produced were deficient. Thanks to the rapid evolution of analytical techniques, there is now a better knowledge of the origin and the content of biogenic amines in wines. At present, data about concentrations are suufficiently reliable for rules to be established about the maximum recommendable limits in each country, although as yet there are no legal, unified regulations. The most widely used analytical methods for determining biogenic amines nowadays are based on chromatographic separation procedures and, in particular, on High Performance Liquid Chromatography (HPLC). This study reviews research which has compiled data about the presence of biogenic amines in wines and about the analytical techniques used to determine them, putting special emphasis on HPLC methods and the sampling treatments necessary to carry out the analyses.</p>

scholarly journals METHODICAL INSIGHTS INTO REPORTED SOPHISTICATED ANALYTICAL TECHNIQUES FOR THE DETERMINATION OF ANTI-DIABETIC DRUG EMPAGLIFLOZIN IN VARIOUS PHARMACEUTICAL PRODUCTS

2021 ◽  
Vol 10 (4) ◽  
pp. 3206-3211
Author(s):  
Kishor Danao
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Human Plasma ◽  
Analytical Methods ◽  
High Performance ◽  
Competitive Inhibition ◽  
Analytical Techniques ◽  
Pharmaceutical Products ◽  
Good Precision ◽  
Medical Practitioners

Empagliflozin (EMPA), chemically known as (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol is an oral anti-diabetic drug used for treating type 2 diabetes mellitus that produces hypoglycemia by selective and competitive inhibition of sodium/glucose co-transporter-2 (SGLT2) protein. Currently, EMPA is an emerging drug being prescribed by medical practitioners. The quality-oriented scheduled investigation of diverse commercially obtainable formulations of EMPA is a foremost challenge and recently few sophisticated analytical methods are reported for industrial-scale quantitative analysis. Review of analytical method of antidiabetic drug Empagliflozin. This interesting review article covered the recently published sophisticated instruments-based analytical methods in numerous pharmaceutical databases like PubMed, Google Scholar, Science Direct, etc. of diverse areas like spectrophotometry (Ultraviolet-Visible), Ultra-high Performance Liquid Chromatography (UPLC), High-Performance Liquid Chromatography (HPLC), High-Performance Thin Layer Chromatography (HPTLC), and analytical methods for estimation of EPMA in human plasma. From literature, about 19 HPLC methods, 4 UPLC methods, 15 UV-Vis methods, 3 HPTLC methods, and 4 human plasma-based methods were reported for the estimation of EMPA alone or in combination with other drug substances (Linagliptin, Canagliflozin, Dapagliflozin, and Metformin). The methodical insights outlined the reported characteristics like method, detection wavelength, solvent, % recovery, LOD, LOQ, mobile phase composition, flow-rate, column type, retention time, etc. This review concluded that the developed validated analytical methods have a high degree of accuracy, superior reliability, economical to apply, bears good precision, possess better robustness, and greater reproducible attributes which are compulsory features of an ideal method.

Detection and Quantification of Biogenic Amines in Fermented Food Products Sold in Botswana

2010 ◽  
Vol 73 (9) ◽  
pp. 1703-1708 ◽  
Author(s):  
CLEMENT MAGWAMBA ◽  
MAITSHWARELO IGNATIUS MATSHEKA ◽  
SISAI MPUCHANE ◽  
BERHANU ABEGAZ GASHE
Keyword(s):  
Biogenic Amines ◽  
Biogenic Amine ◽  
High Performance ◽  
Fermented Food ◽  
Allowable Limit ◽  
Fermented Beverages ◽  
Sour Milk ◽  
Mean Concentration ◽  
The U.S ◽  
Detection And Quantification

The incidence and concentrations associated with four important biogenic amines in leading commercial fermented beverages consumed in Botswana were determined using high-performance liquid chromatography. In 87 sorghum brew and 84 sour milk (madila, amasi) samples tested, putrescine was the most prevalent biogenic amine (63 and 61%, respectively), while histamine was the least prevalent (24 and 8%, respectively). Cadaverine was the most frequently detected biogenic amine in 79 of the commercial sour maize beverage (mageu/mahewu) samples tested (found in 70% of the samples), while tyramine was the least detected (occurring in 3% of the samples). In sorghum brew and sour milk, tyramine was found to be the most concentrated (mean concentration of 2.08 mg/100 ml and 3.2 mg/100 ml, respectively), and histamine was found to be the least concentrated (mean concentration of 0.94 mg/100 ml and 0.31 mg/100 ml, respectively). Overall, the biogenic amine concentrations of all three fermented products were within acceptable limits. However, one sorghum brew sample had a histamine content of 5.8 mg/100 ml, which was above the 5.0 mg/100 g allowable limit suggested by the U.S. Food and Drug Administration.

scholarly journals ROBUSTNESS EVALUATION OF HPLC DETERMINATION OF ATORVASTATIN AND LISINOPRIL ON COLUMN PUROSPHER C8 STAR IN PHARMACEUTICALS

2021 ◽  
pp. 21-26
Author(s):  
N. S. Shulyak ◽  
A. D. Abbeyquaye ◽  
D. B. Koval
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Analytical Methods ◽  
High Performance ◽  
Antihypertensive Drugs ◽  
Hplc Method ◽  
Fixed Dose ◽  
Control Analysis ◽  
Chromatography Method ◽  
Pharmaceutical Development

Introduction. Innovative pharmaceutical development of various antihypertensive drugs with statins and the creation of domestic fixed-dose combinations of drugs with different effects is an urgent task of modern pharmacy, which will help attract more patients to the treatment and prevention of cardiovascular disease. Pharmaceutical development of atorvastatin and lisinopril by our scientific group proposes for using the ratio of (1/1) for lisinopril (10 mg) and atorvastatin (10 mg). HPLC (High-Performance Liquid Chromatography) technique is adopted as it is considered as the most common technique in realm of quality control analysis. The aim of the study – to evaluate the robustness of HPLC (High-Performance Liquid Chromatography) method for the quantitation of lisinopril and atorvastatin and determine the analytical parameters that present greater influence in the final results of the analysis. Research Methods. An efficient method to assess the robustness of analytical methods is by Youden’s test, by means of an experiment design which involves seven analytical parameters combined in eight tests. In the recent studies, we assessed the robustness of a chromatographic method to quantify lisinopril and atorvastatin in tablets using Youden’s test. Results and Discussion. By using the criteria of Youden’s test, HPLC method proved to be greatly robust regarding content of lisinopril and atorvastatin, when variations in seven analytical parameters were introduced. The most variation in effects of the analytical parameters in retention time (Rt) for lisinopril and atorvastatin HPLC quantitation was when used column supplier. Purospher C8 STAR (55 mm x 4mm, 5 μm) is based on high purity silica and an almost complete surface coverage. Purospher C8 STAR provides excellent peak symmetry for acidic, basic and even chelating compounds, highest column efficiency in terms of the number of theoretical plates, and exceptional stability from pH 1.5 to 10.5. Conclusion. Youden’s test can be applied successfully for the ro­bustness evaluation in validation process of analytical methods and results ontained in our work should be interest to the scientific population dealing with pharmaceutical analytical chemistry.

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