scholarly journals Association Between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines - Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

2017 ◽  
Author(s):  
Andrzej Prystupa ◽  
Paweł Kiciński ◽  
Dorota Luchowska-Kocot ◽  
Anna Blazewicz ◽  
Jarosław Niedziałek ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Interleukin 6 ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Control Group ◽  
Serum Selenium ◽  
Alcoholic Liver Cirrhosis ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Serum Selenium Concentration

According to some authors, the serum selenium level is strongly associated with the severity of liver diseases including liver cirrhosis. The aim of the study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines – interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in serum of 99 alcoholic liver cirrhosis patients divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

Reduction of Liver Glutathione Peroxidase Activity and Deficiency of Serum Selenium in Patients with Hepatocellular Carcinoma

1986 ◽  
Vol 72 (6) ◽  
pp. 617-619 ◽  
Author(s):  
Roberto Corrocher ◽  
Massimo Casaril ◽  
Giuseppe Bellisola ◽  
Giovanbattista Gabrielli ◽  
Minerva Hulpe ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Glutathione Peroxidase ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Normal Liver ◽  
Serum Selenium ◽  
Glutathione Peroxidase Activity ◽  
Increased Risk ◽  
Serum Selenium Concentration ◽  
Reduced Activity

Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with hystologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p < 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.

scholarly journals Association Between Serum Selenium and Serum C-Reactive Protein Concentrations in Persons Infected With Human Immunodeficiency Virus Infection

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1323-1323
Author(s):  
Kalpana Poudel-Tandukar ◽  
Krishna !Poudel
Keyword(s):  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
Serum Selenium Levels ◽  
Serum Selenium Concentration ◽  
Serum Crp

Abstract Objectives Chronic inflammation and selenium deficiency are common in persons infected with the human immunodeficiency virus (HIV). Both C-reactive protein, a pro-inflammatory biomarker, and selenium deficiency have been associated with accelerated disease progression and poorer survival among persons infected with HIV-infection. However, research on the role of serum selenium levels in inflammation is limited. We assessed the association between serum selenium levels and C-reactive protein (CRP) concentrations in a cohort of persons infected with HIV. Methods A cross-sectional survey was conducted among 233 HIV-infected persons (124 men and 109 women) aged 18–60 years who were residing in Kathmandu, Nepal. Regular serum CRP and selenium concentrations were measured by the latex agglutination turbidimetric and the atomic absorption method, respectively. Relationships were assessed using multiple linear regression analysis to adjust for potential confounding factors including sociodemographic, smoking, body mass index, chronic diseases, CD4+ T-cell count, and anti-retroviral therapy. Results The geometric means of serum selenium and CRP concentrations were 9.65 µg/dL and 1.43 mg/L, respectively. Mean serum CRP concentration was significantly decreased with increasing serum selenium concentration across selenium tertiles (P for trend = 0.019), with mean serum CRP concentration in the highest tertile of serum selenium concentration was 40.8% lower than that in the lowest tertile. We found a significant inverse relation between log selenium and log CRP concentrations (beta for 1 unit change in log selenium; β = −1.01, p = 0.06). Conclusions Serum selenium levels may be inversely associated with serum CRP concentrations in persons infected with HIV. Further prospective study to confirm the role of serum selenium levels in inflammation among persons infected with HIV is warranted. Funding Sources University of Massachusetts Amherst.

scholarly journals Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial

2022 ◽  
Vol 8 ◽  
Author(s):  
Edward J. M. Joy ◽  
Alexander A. Kalimbira ◽  
Joanna Sturgess ◽  
Leonard Banda ◽  
Gabriella Chiutsi-Phiri ◽  
...  
Keyword(s):  
Rural Community ◽  
Controlled Trial ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
Selenium Status ◽  
Maize Flour ◽  
Hidden Hunger ◽  
Serum Selenium Concentration ◽  
Women And Children

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agronomic biofortification, is effective at alleviating selenium deficiency.Objectives: The aim of the Addressing Hidden Hunger with Agronomy (AHHA) trial was to determine whether consumption of maize flour, agronomically-biofortified with selenium, affected the serum selenium concentrations of women, and children in a rural community setting.Design: An individually-randomized, double-blind placebo-controlled trial was conducted in rural Malawi. Participants were randomly allocated in a 1:1 ratio to receive either intervention maize flour biofortified with selenium through application of selenium fertilizer, or control maize flour not biofortified with selenium. Participant households received enough flour to meet the typical consumption of all household members (330 g capita−1 day−1) for a period of 8 weeks. Baseline and endline serum selenium concentration (the primary outcome) was measured by inductively coupled plasma mass spectrometry (ICP-MS).Results: One woman of reproductive age (WRA) and one school-aged child (SAC) from each of 180 households were recruited and households were randomized to each group. The baseline demographic and socioeconomic status of participants were well-balanced between arms. No serious adverse events were reported. In the intervention arm, mean (standard deviation) serum selenium concentration increased over the intervention period from 57.6 (17.0) μg L−1 (n = 88) to 107.9 (16.4) μg L−1 (n = 88) among WRA and from 46.4 (14.8) μg L−1 (n = 86) to 97.1 (16.0) μg L−1 (n = 88) among SAC. There was no evidence of change in serum selenium concentration in the control groups.Conclusion: Consumption of maize flour biofortified through application of selenium-enriched fertilizer increased selenium status in this community providing strong proof of principle that agronomic biofortification could be an effective approach to address selenium deficiency in Malawi and similar settings.Clinical Trial Registration:http://www.isrctn.com/ISRCTN85899451, identifier: ISRCTN85899451.

scholarly journals The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhiliang Zhang ◽  
Chao Chang ◽  
Yuxin Zhang ◽  
Zhiyong Chai ◽  
Jinbei Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chinese Population ◽  
Selenium Concentration ◽  
Chinese Patients ◽  
Serum Selenium ◽  
Increased Risk ◽  
Patients With Heart Failure ◽  
All Cause Mortality ◽  
Serum Selenium Concentration ◽  
Baseline Information

AbstractWhether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients with heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and the outcomes of patients with HF in a Chinese population. Patients with HF and serum Se examination were retrospectively included. Baseline information were collected at patient’s first admission. The primary and secondary outcomes were all-cause mortality and rehospitalization for HF during follow-up, respectively. The study participants were divided into quartiles according to their serum Se concentrations. The Cox proportional hazard models were adopted to estimate the association of serum Se levels with observed outcomes. A total of 411 patients with HF with a mean age of 62.5 years were included. The mean serum level of Se was 68.3 ± 27.7 µg/L. There was nonsignificant difference of baseline characterizes between the four quartile groups. In comparison with patients in the highest quartile, those with the lowest quartile (17.40–44.35 µg/L) were associated with increased risk of all-cause mortality [adjusted hazard ratios (95% CI) 2.32 (1.43–3.77); Ptrend = 0.001]. Our study suggested that a lower serum Se level was significantly associated with increased risk of all-cause mortality in patients with HF.

Low serum selenium concentration in patients with colonic adenomatous polyps

1993 ◽  
Vol 12 ◽  
pp. 46
Author(s):  
F. Fernández-Bañares ◽  
M. Esteve ◽  
M.D. Mingorance ◽  
A. Abad-Lacruz ◽  
E. Cabré ◽  
...  
Keyword(s):  
Selenium Concentration ◽  
Adenomatous Polyps ◽  
Serum Selenium ◽  
Serum Selenium Concentration ◽  
Low Serum

scholarly journals Serum selenium concentration is associated with metabolic factors in the elderly: a cross-sectional study

2010 ◽  
Vol 7 (1) ◽  
pp. 38 ◽  
Author(s):  
Kuen-Cheh Yang ◽  
Long-Teng Lee ◽  
Yow-Shan Lee ◽  
Hui-Ying Huang ◽  
Ching-Yu Chen ◽  
...  
Keyword(s):  
Selenium Concentration ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Serum Selenium ◽  
Sectional Study ◽  
Metabolic Factors ◽  
Cross Sectional ◽  
Serum Selenium Concentration

scholarly journals The Evaluation of Serum Selenium Concentration in Children with Febrile Convulsion

2016 ◽  
Vol 24 (4) ◽  
pp. 95-103
Author(s):  
Nooshin Taghizadegan ◽  
Sima Afsharnezhad ◽  
Hossein Abbaspour ◽  
◽  
◽  
...  
Keyword(s):  
Selenium Concentration ◽  
Febrile Convulsion ◽  
Serum Selenium ◽  
Serum Selenium Concentration

scholarly journals The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome

2021 ◽  
Author(s):  
Csaba Attila Kósa ◽  
Krisztina Nagy ◽  
Ottó Szenci ◽  
Boglárka Baska-Vincze ◽  
Emese Andrásofszky ◽  
...  
Keyword(s):  
Vitamin E ◽  
Serum Vitamin ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Severe Form ◽  
Serum Selenium ◽  
Muscle Enzymes ◽  
Affected Area ◽  
Recurrent Rhabdomyolysis

Abstract A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

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