scholarly journals Association Between Serum Selenium and Serum C-Reactive Protein Concentrations in Persons Infected With Human Immunodeficiency Virus Infection

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1323-1323
Author(s):  
Kalpana Poudel-Tandukar ◽  
Krishna !Poudel
Keyword(s):  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
Serum Selenium Levels ◽  
Serum Selenium Concentration ◽  
Serum Crp

Abstract Objectives Chronic inflammation and selenium deficiency are common in persons infected with the human immunodeficiency virus (HIV). Both C-reactive protein, a pro-inflammatory biomarker, and selenium deficiency have been associated with accelerated disease progression and poorer survival among persons infected with HIV-infection. However, research on the role of serum selenium levels in inflammation is limited. We assessed the association between serum selenium levels and C-reactive protein (CRP) concentrations in a cohort of persons infected with HIV. Methods A cross-sectional survey was conducted among 233 HIV-infected persons (124 men and 109 women) aged 18–60 years who were residing in Kathmandu, Nepal. Regular serum CRP and selenium concentrations were measured by the latex agglutination turbidimetric and the atomic absorption method, respectively. Relationships were assessed using multiple linear regression analysis to adjust for potential confounding factors including sociodemographic, smoking, body mass index, chronic diseases, CD4+ T-cell count, and anti-retroviral therapy. Results The geometric means of serum selenium and CRP concentrations were 9.65 µg/dL and 1.43 mg/L, respectively. Mean serum CRP concentration was significantly decreased with increasing serum selenium concentration across selenium tertiles (P for trend = 0.019), with mean serum CRP concentration in the highest tertile of serum selenium concentration was 40.8% lower than that in the lowest tertile. We found a significant inverse relation between log selenium and log CRP concentrations (beta for 1 unit change in log selenium; β = −1.01, p = 0.06). Conclusions Serum selenium levels may be inversely associated with serum CRP concentrations in persons infected with HIV. Further prospective study to confirm the role of serum selenium levels in inflammation among persons infected with HIV is warranted. Funding Sources University of Massachusetts Amherst.

scholarly journals The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome

2021 ◽  
Author(s):  
Csaba Attila Kósa ◽  
Krisztina Nagy ◽  
Ottó Szenci ◽  
Boglárka Baska-Vincze ◽  
Emese Andrásofszky ◽  
...  
Keyword(s):  
Vitamin E ◽  
Serum Vitamin ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Severe Form ◽  
Serum Selenium ◽  
Muscle Enzymes ◽  
Affected Area ◽  
Recurrent Rhabdomyolysis

Abstract A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

scholarly journals INTERACTIONS OF C-REACTIVE PROTEIN WITH THE COMPLEMENT SYSTEM

1974 ◽  
Vol 140 (3) ◽  
pp. 631-647 ◽  
Author(s):  
Joan Siegel ◽  
Rosemarie Rent ◽  
Henry Gewurz
Keyword(s):  
Normal Serum ◽  
Protamine Sulfate ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Phosphoryl Choline ◽  
Heat Stable ◽  
Health And Disease ◽  
Serum Crp ◽  
The Complement System

Protamine sulfate was found to consume large amounts of C selectively during preincubation with sera of individuals in the "acute phase". Marked depletion of C1, C4, and C2 with minimal, if any, depletion of C3-9, was observed. The consumption was time and temperature dependent, occurring most rapidly and extensively at 37°C, 0.10 M relative salt concentration and pH 7.5–8.0; it required calcium ions. It was mediated by a heat-stable nondialyzable factor which separated with C-reactive protein (CRP) during fractionation and purification, correlated with serum CRP levels, and, like other known reactivities of CRP, was inhibited by phosphoryl choline. Preparations of CRP purified either from serum or ascites resulted in consumption of large amounts of C1, C4, and C2 when preincubated with normal serum and protamine. We conclude that CRP is a potent activator of the C system at the level of C1, and that polycations such as protamine sulfate are substrates of CRP which can bring about this activation. It seems not unlikely that one role of CRP in health and disease involves its ability to interact with the C system.

scholarly journals Dietary B Vitamins and Serum C-Reactive Protein in Persons With Human Immunodeficiency Virus Infection

2016 ◽  
Vol 37 (4) ◽  
pp. 517-528 ◽  
Author(s):  
Kalpana Poudel-Tandukar ◽  
Ram Krishna Chandyo
Keyword(s):  
Geometric Mean ◽  
Latex Agglutination ◽  
B Vitamins ◽  
C Reactive Protein ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Mean ◽  
Serum Crp

Background: B vitamins may have beneficial roles in reducing inflammation; however, research on the role of B vitamins in inflammation among HIV-infected persons is lacking. Objective: This study assessed the association between B vitamins and serum C-reactive protein (CRP) concentrations in HIV-infected persons. Methods: A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 years residing in the Kathmandu, Nepal. High-sensitive and regular serum CRP concentrations were measured by the latex agglutination nephelometry and latex agglutination turbidimetric method, respectively. Dietary intake was assessed using 2 nonconsecutive 24-hour dietary recalls. The relationships between B vitamins and serum CRP concentrations were assessed using multiple regression analysis. Results: The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin ( P for trend = .007), pyridoxine ( P for trend = .042), and cobalamin ( P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin ( P for trend = .084) and pyridoxine ( P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile. Conclusion: High intake of niacin, pyridoxine, or cobalamin was independently associated with decreased serum CRP concentrations among HIV-infected men. Further prospective studies are warranted to confirm the role of B vitamins in inflammation among HIV-infected persons.

scholarly journals Association Between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines - Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

2017 ◽  
Author(s):  
Andrzej Prystupa ◽  
Paweł Kiciński ◽  
Dorota Luchowska-Kocot ◽  
Anna Blazewicz ◽  
Jarosław Niedziałek ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Interleukin 6 ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Control Group ◽  
Serum Selenium ◽  
Alcoholic Liver Cirrhosis ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Serum Selenium Concentration

According to some authors, the serum selenium level is strongly associated with the severity of liver diseases including liver cirrhosis. The aim of the study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines &ndash; interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in serum of 99 alcoholic liver cirrhosis patients divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

Reduction of Liver Glutathione Peroxidase Activity and Deficiency of Serum Selenium in Patients with Hepatocellular Carcinoma

1986 ◽  
Vol 72 (6) ◽  
pp. 617-619 ◽  
Author(s):  
Roberto Corrocher ◽  
Massimo Casaril ◽  
Giuseppe Bellisola ◽  
Giovanbattista Gabrielli ◽  
Minerva Hulpe ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Glutathione Peroxidase ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Normal Liver ◽  
Serum Selenium ◽  
Glutathione Peroxidase Activity ◽  
Increased Risk ◽  
Serum Selenium Concentration ◽  
Reduced Activity

Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with hystologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p < 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.

scholarly journals Role of Doppler Ultrasonography and C-Reactive Protein in Patients with Acute Scrotum

2016 ◽  
Vol 9 (1) ◽  
pp. 10
Author(s):  
Abdulwahid G. Mohammed ◽  
Bahaaedin A. Elkhader ◽  
Charbel Saade ◽  
Maram A. Fagiri ◽  
Mustafa Z. Mahmoud
Keyword(s):  
Doppler Ultrasonography ◽  
Clinical Symptoms ◽  
Acute Scrotum ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Array Transducer ◽  
Preoperative Diagnostic ◽  
Turbidimetric Analysis ◽  
Serum Crp

This research was designate with an intention to find the role of Doppler ultrasonography (DUS) and C-reactive protein (CRP) in patients with acute scrotum. A sum of 80 (mean age 23±2.1 years) consequential patients were recruited for a period of six months between July 2015 and January 2016 in this prospective study. Collected data confined age, medical history, and clinical symptoms. DUS was performed with a linear array transducer (10-15 MHz) connected to HI vision Avius ultrasound unit; Hitachi. CRP was measured using turbidimetric analysis through the Cobas Integra analyzer system (Test CRPL2, 0-293); Roche Diagnostics. Statistical analysis was accomplished using the standard Statistical Package for the Social Sciences version 20 for Windows; Microsoft. Fitted achievement values for DUS in the diagnosis of testicular torsion, epididymo-orchitis, and varicocele were respectively 100%, 91% and 88% for sensitivity, 92%, 71%, and 90% for specificity, and 94%, 83%, and 89% for accuracy. An increased in the serum CRP level (63.2±40.2 mg/L) was seen in an inflammatory cause of the acute scrotum. In contrast, there was no increase in CRP level (8±3.1 mg/L) in the non-inflammatory cases (P < 0.0001). Scrotal DUS is a highly precise preoperative diagnostic instrument, thereby confirm its course application in the incipient triage of patients with acute scrotum. Serum level of CRP can afford useful advice for differentiation between inflammatory and other reasons of the acute scrotum.

Prognostic role of C-reactive protein levels in patients with hepatocellular carcinoma undergoing sorafenib therapy.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 340-340
Author(s):  
Jean Kyung Lee ◽  
James J. Harding ◽  
Joanne F. Chou ◽  
Marinela Capanu ◽  
Leonard Saltz ◽  
...  
Keyword(s):  
Time Dependent ◽  
C Reactive Protein ◽  
Prognostic Role ◽  
Sorafenib Treatment ◽  
Advanced Hcc ◽  
Reactive Protein ◽  
Ajcc Stage ◽  
Sorafenib Therapy ◽  
Serum Crp

340 Background: Markers of systemic inflammatory response including C-reactive protein (CRP) are associated with the prognosis of various malignancies including HCC. We investigated the significance of the serum CRP level as a prognostic factor in patients with advanced HCC on sorafenib therapy. Methods: The MSKCC institutional database was retrospectively queried for patients diagnosed with advanced HCC who received sorafenib therapy from 2002-2012 and had available serum CRP measurements. Patient demographics and outcomes were extracted under an IRB-approved waiver. Baseline CRP levels within 30 days of starting of sorafenib and while on sorafenib treatment were correlated with clinical outcomes. CRP levels after the initiation of sorafenib were analyzed as a time dependent covariate in a Cox regression model. Results: 51 patients had available CRP levels and received sorafenib: Median age 65 years (range 45-82); KPS 80 (70-90%); 9 females (17.6%); 32 AJCC stage IV disease (62.7%); 10 AJCC stage III (19.6%); 12 hepatitis C (23.5%), 10 hepatitis B (19.6%), 12 alcohol (23.5%), and 20 non-alcoholic steatohepatitis (39%); and 43 Child-Pugh A (84.3 %). The median time on sorafenib was 2.4 months (range 0.2-21.6). The median overall survival (OS) was 9.2 months [CI 5.8 – 13.6] and the median progression-free survival (PFS) was 2.1 months [CI 1.6 – 2.6]. 46 of 51 patients had baseline CRP levels available for analysis. Baseline CRP level was associated with OS [hazard ratio (HR) 1.2 (CI 0.996 – 1.4, p=0.056)] but not with PFS [HR 1.1 (CI 0.96-1.3, p=0.14)]. Time dependent covariate analysis demonstrated an association between CRP levels during sorafenib therapy and overall OS [HR 1.08 (CI 1.01-1.16, p=0.02)] as well as PFS [HR 1.09 (CI 1.02 – 1.16, p=0.009)]. Conclusions: Baseline CRP level prior to the start of sorafenib therapy showed a borderline significant association with OS but no association with PFS. Higher CRP levels showed a significant association with increased risk of disease progression and death for sorafenib treated HCC patients. Potential prognostic role of CRP in HCC patients undergoing sorafenib therapy is to be further studied prospectively.

scholarly journals Serum C-reactive protein concentrations in dogs with idiopathic epilepsy

2017 ◽  
Vol 86 (2) ◽  
pp. 79-83
Author(s):  
E. Segers ◽  
V. Martlé ◽  
S. Piepers ◽  
L. Van Ham ◽  
S. F. M. Bhatti
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Idiopathic Epilepsy ◽  
Control Group ◽  
C Reactive Protein ◽  
Inflammatory Reactions ◽  
Reactive Protein ◽  
Cluster Seizures ◽  
Serum Crp

Inflammatory reactions in dogs are associated with systemic changes in serum, called the acute phase response; changes in the concentration of acute phase proteins in the serum take place. C-reactive protein (CRP) is a positive acute phase protein, which increases during inflammation. The role of inflammation in epilepsy remains unclear. In this study, the inflammatory response in dogs with idiopathic epilepsy (IE) was investigated. The aims of the study were: 1. to measure serum CRP concentrations in dogs with IE and in healthy dogs, 2. to measure serum CRP concentrations in dogs with acute cluster seizures and in dogs with isolated seizures and 3. to observe the evolution of serum CRP concentrations in time after the last seizure. This study showed no significant differences in serum CRP concentrations between dogs with IE (7.8 mg/l) and dogs of the control group (8.3 mg/l). Furthermore, the results showed higher mean serum CRP concentrations in dogs with IE exhibiting cluster seizures (11,8 mg/l) than in dogs with isolated seizures (5.7 mg/l). However, these results were not statistically significant (P = 0,077). Finally, no statistically significant decrease in serum CRP concentrations was seen with time after the last epileptic seizure in dogs with IE (P = 0,077).

scholarly journals Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial

2022 ◽  
Vol 8 ◽  
Author(s):  
Edward J. M. Joy ◽  
Alexander A. Kalimbira ◽  
Joanna Sturgess ◽  
Leonard Banda ◽  
Gabriella Chiutsi-Phiri ◽  
...  
Keyword(s):  
Rural Community ◽  
Controlled Trial ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
Selenium Status ◽  
Maize Flour ◽  
Hidden Hunger ◽  
Serum Selenium Concentration ◽  
Women And Children

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agronomic biofortification, is effective at alleviating selenium deficiency.Objectives: The aim of the Addressing Hidden Hunger with Agronomy (AHHA) trial was to determine whether consumption of maize flour, agronomically-biofortified with selenium, affected the serum selenium concentrations of women, and children in a rural community setting.Design: An individually-randomized, double-blind placebo-controlled trial was conducted in rural Malawi. Participants were randomly allocated in a 1:1 ratio to receive either intervention maize flour biofortified with selenium through application of selenium fertilizer, or control maize flour not biofortified with selenium. Participant households received enough flour to meet the typical consumption of all household members (330 g capita−1 day−1) for a period of 8 weeks. Baseline and endline serum selenium concentration (the primary outcome) was measured by inductively coupled plasma mass spectrometry (ICP-MS).Results: One woman of reproductive age (WRA) and one school-aged child (SAC) from each of 180 households were recruited and households were randomized to each group. The baseline demographic and socioeconomic status of participants were well-balanced between arms. No serious adverse events were reported. In the intervention arm, mean (standard deviation) serum selenium concentration increased over the intervention period from 57.6 (17.0) μg L−1 (n = 88) to 107.9 (16.4) μg L−1 (n = 88) among WRA and from 46.4 (14.8) μg L−1 (n = 86) to 97.1 (16.0) μg L−1 (n = 88) among SAC. There was no evidence of change in serum selenium concentration in the control groups.Conclusion: Consumption of maize flour biofortified through application of selenium-enriched fertilizer increased selenium status in this community providing strong proof of principle that agronomic biofortification could be an effective approach to address selenium deficiency in Malawi and similar settings.Clinical Trial Registration:http://www.isrctn.com/ISRCTN85899451, identifier: ISRCTN85899451.

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