scholarly journals The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome

2021 ◽  
Author(s):  
Csaba Attila Kósa ◽  
Krisztina Nagy ◽  
Ottó Szenci ◽  
Boglárka Baska-Vincze ◽  
Emese Andrásofszky ◽  
...  
Keyword(s):  
Vitamin E ◽  
Serum Vitamin ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Severe Form ◽  
Serum Selenium ◽  
Muscle Enzymes ◽  
Affected Area ◽  
Recurrent Rhabdomyolysis

Abstract A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.

scholarly journals Association Between Serum Selenium and Serum C-Reactive Protein Concentrations in Persons Infected With Human Immunodeficiency Virus Infection

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1323-1323
Author(s):  
Kalpana Poudel-Tandukar ◽  
Krishna !Poudel
Keyword(s):  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Serum Selenium ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Immunodeficiency Virus ◽  
Serum Selenium Levels ◽  
Serum Selenium Concentration ◽  
Serum Crp

Abstract Objectives Chronic inflammation and selenium deficiency are common in persons infected with the human immunodeficiency virus (HIV). Both C-reactive protein, a pro-inflammatory biomarker, and selenium deficiency have been associated with accelerated disease progression and poorer survival among persons infected with HIV-infection. However, research on the role of serum selenium levels in inflammation is limited. We assessed the association between serum selenium levels and C-reactive protein (CRP) concentrations in a cohort of persons infected with HIV. Methods A cross-sectional survey was conducted among 233 HIV-infected persons (124 men and 109 women) aged 18–60 years who were residing in Kathmandu, Nepal. Regular serum CRP and selenium concentrations were measured by the latex agglutination turbidimetric and the atomic absorption method, respectively. Relationships were assessed using multiple linear regression analysis to adjust for potential confounding factors including sociodemographic, smoking, body mass index, chronic diseases, CD4+ T-cell count, and anti-retroviral therapy. Results The geometric means of serum selenium and CRP concentrations were 9.65 µg/dL and 1.43 mg/L, respectively. Mean serum CRP concentration was significantly decreased with increasing serum selenium concentration across selenium tertiles (P for trend = 0.019), with mean serum CRP concentration in the highest tertile of serum selenium concentration was 40.8% lower than that in the lowest tertile. We found a significant inverse relation between log selenium and log CRP concentrations (beta for 1 unit change in log selenium; β = −1.01, p = 0.06). Conclusions Serum selenium levels may be inversely associated with serum CRP concentrations in persons infected with HIV. Further prospective study to confirm the role of serum selenium levels in inflammation among persons infected with HIV is warranted. Funding Sources University of Massachusetts Amherst.

scholarly journals Antioxidant defense in centenarians (a preliminary study).

2000 ◽  
Vol 47 (2) ◽  
pp. 281-292 ◽  
Author(s):  
B Kłapcińska ◽  
J Derejczyk ◽  
K Wieczorowska-Tobis ◽  
A Sobczak ◽  
E Sadowska-Krepa ◽  
...  
Keyword(s):  
Vitamin E ◽  
Defense Mechanisms ◽  
Antioxidant Defense ◽  
Potential Role ◽  
Serum Vitamin ◽  
Antioxidant Defenses ◽  
Human Longevity ◽  
Healthy Female ◽  
Preliminary Study

The study was designed to assess the antioxidant defense mechanisms, either enzymatic or non-enzymatic, in a group of sixteen centenarians (one male and fifteen female subjects aged 101 to 105 years) living in the Upper Silesia district (Poland) in order to evaluate the potential role of antioxidant defenses in human longevity. The results of our preliminary study showed that in comparison with young healthy female adults the centenarians had significantly higher red blood cell glutathione reductase and catalase activities and higher, although insignificantly, serum vitamin E level.

scholarly journals Nutritional myodegeneration as a cause of dysphagia in adult horses: three case reports

2008 ◽  
Vol 52 (No. 6) ◽  
pp. 267-272 ◽  
Author(s):  
E. Ludvikova ◽  
P. Jahn ◽  
Z. Lukas
Keyword(s):  
Sodium Selenite ◽  
Case Reports ◽  
Selenium Deficiency ◽  
Selenium Concentration ◽  
Bilateral Symmetry ◽  
Muscle Injuries ◽  
Glutathione Peroxidase Activity ◽  
Muscle Enzymes ◽  
Low Selenium ◽  
Large Groups

Three cases of nutritional myodegeneration caused by selenium deficiency in adult horses are described. Difficulty in eating and drinking was a common clinical sign in all horses. Blood biochemistry revealed a marked elevation of muscle enzymes and low glutathione peroxidase activity or low selenium concentration in whole blood in all cases. The treatment with sodium selenite and vitamin E was instituted in all horses. Two of them were euthanized because of continuing muscle injuries, one patient was cured. The post-mortem examination of euthanized horses revealed pale muscles that were distributed with bilateral symmetry on hind and thoracic limbs, diaphragm, tongue, masticatory and intercostal muscles and the myocardium. Histopathology revealed the areas of degeneration and necrosis. Large groups of regenerating fibres and pronounced lymphoplasmocytic reaction among the groups of intact fibres were also present. The clinical outcome of the disease is probably influenced by timely diagnosis and treatment.

scholarly journals Effect of vitamin E- and selenium-deficiency on rat liver chemiluminescence

1987 ◽  
Vol 242 (2) ◽  
pp. 383-386 ◽  
Author(s):  
C G Fraga ◽  
R F Arias ◽  
S F Llesuy ◽  
O R Koch ◽  
A Boveris
Keyword(s):  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Selenium Deficiency ◽  
Serum Levels ◽  
Hepatic Necrosis ◽  
Deficient Diet ◽  
Control Value ◽  
Weanling Rats

The role of vitamin E and selenium as protective agents against oxidative stress was evaluated by measuring liver chemiluminescence in situ. Weanling rats fed a vitamin E- and selenium-deficient diet showed liver chemiluminescence that was increased 60 and 100% over control values at 16 and 18 days respectively after weaning. At day 21, the double deficiency led to hepatic necrosis, as observed by optical and electron microscopy, and increased serum levels of lactate dehydrogenase and alanine aminotransferase. Single deficiencies, in either vitamin E or selenium, did not produce liver necrosis but increased liver chemiluminescence. Vitamin E deficiency led to a 23 and 50% increase in liver emission at days 18 and 20 respectively; selenium deficiency produced a 64% increase at day 16. The activity of liver selenium-glutathione peroxidase diminished to 13% of the control value in the rats fed doubly deficient and selenium-deficient diets. Activities of superoxide dismutase, catalase and non-selenium-glutathione peroxidase were not modified by the different diets. These results suggest that oxy-radical generation may play a major role in hepatic necrosis in vitamin E- and selenium-deficiency.

scholarly journals Clinical study of experimentally induced vitamin E and selenium deficiency in Awassi ewes and their newborn lambs

2012 ◽  
Vol 36 (2) ◽  
pp. 158-162
Author(s):  
H. K. Abood
Keyword(s):  
Body Weight ◽  
Clinical Study ◽  
Vitamin E ◽  
Clinical Signs ◽  
Selenium Deficiency ◽  
Serum Selenium ◽  
Deficient Diet ◽  
Sheep Industry ◽  
Experimental Induction ◽  
Deficient Group

Experimental induction of vitamin E and selenium deficiency by deficient diet was carried out on Awassi ewes and their newborn lambs. The clinical signs were characterized by sudden death in 4 lambs out of 14 lambs in deficient group and other lambs showed a variable signs included inability to suckle, arched back, weakness, dullness, emaciation and recumbency. Serum selenium and vitamin E levels of these lambs were 0.01 ppm and 0.34 mg/L respectively. The clinical signs in ewes included loss of body weight and loss of wool, Weakness, dullness and recumbency. Serum selenium and vitamin E levels of these ewes were 0.02 ppm and 0.61mg/L respectively. It was concluded that vitamin E and selenium are essential antioxidants and their deficiency exposes the sheep industry to many serious losses.

scholarly journals Vitamin E and Selenium Decreased Cortisol in Cattle

2020 ◽  
Vol 64 (4) ◽  
pp. 49-54
Author(s):  
P. Mudroň
Keyword(s):  
Vitamin E ◽  
Abdominal Surgery ◽  
Dairy Cows ◽  
Serum Vitamin ◽  
Selenium Concentration ◽  
Serum Cortisol ◽  
Average Concentration ◽  
Tocopheryl Acetate ◽  
Control Group ◽  
Stress Changes

AbstractTwenty dairy cows with left abomasal displacement were used to investigate the effects of vitamin E and selenium treatment on blood cortisol in dairy cows stressed by omentopexy. The cows were randomly divided into two groups. Ten hours before surgery 6 g of DL-α-tocopheryl acetate (6 mg.kg−1) and 67 mg of natrium selenite (0.1 mg.kg−1) in a volume of 40 ml were administered subcutaneously to 10 cows; the control animals (n = 10) received an equivalent volume of injectable water (40 ml). The injection of vitamin E and selenium produced a rapid rise (P < 0.05) in blood α-tocopherol and selenium concentrations. The serum vitamin E increased several times ten hours after vitamin E and Se injection and raised continuously to the highest average concentration of 21.6 mg.l−1 at hour 24 after the surgery. The highest selenium concentration was seen ten hours after selenium administration with holding the increased concentrations in comparison to initial ones during the whole study. Serum cortisol increased in both groups after surgery. The highest cortisol concentrations were reached at one hour after surgery in the experimental and control group (56.7 ± 28.8 and 65.3 ± 26.1 μg.l−1, respectively). A return to the levels similar to the initial ones was recognized 24 hours after the surgery. The ANOVA revealed a significant effect of vitamin E and selenium injection on serum cortisol (P < 0.05). In conclusion, we have demonstrated that abdominal surgery resulted in typical stress changes with a weaker cortisol response to the abdominal surgery in animals treated with vitamin E and selenium.

scholarly journals Trace Minerals and Oxidative Stress in Diabetic Retinopathy

2014 ◽  
Vol 13 (2) ◽  
pp. 175-179
Author(s):  
Suchitra Kumari ◽  
Tapaswini Pradhan ◽  
Tarun Kumar Panda
Keyword(s):  
Type 2 Diabetes ◽  
Trace Elements ◽  
Diabetic Retinopathy ◽  
Vitamin E ◽  
Vitamin C ◽  
Medical Science ◽  
Serum Vitamin ◽  
Correlation Study

There is accumulating evidence showing relationship between trace elements and Diabetes mellitus (DM). This study evaluated the role of magnesium, Zinc and other indices of peroxidative status ie MDA, Vitamin C and Vitamin E in pathogenesis of Retinopathy in type 2 diabetes. Seventy two type 2 diabetes cases were enrolled in the study, of which 42 were with retinopathy and 30 without. Patients with nephropathy were excluded. Forty age and sex matched subjects were served as health controls. The results showed that the mean values of Mg and Zn were significantly lower reduced in diabetes more so in diabetic retinopathy cases as compared to control subjects (p<0.05). Lipid peroxidation marker MDA was a significantly higher in both the diabetes groups whereas serum Vitamin C and vitamin E levels were significantly low (p<0.05) as compared to controls. Our correlation study revealed that MDA was negatively associated with serum Mg (r=-0.73, p<0.01) as well as serum Zn (r= -0.82, p<0.01), pointing towards the role of these trace elements in retarding the oxidative process prevailing in diabetic retinopathy. DOI: http://dx.doi.org/10.3329/bjms.v13i2.14963 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.175-179

Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism

1987 ◽  
Vol 114 (4) ◽  
pp. 497-502 ◽  
Author(s):  
P. Goyens ◽  
J. Golstein ◽  
B. Nsombola ◽  
H. Vis ◽  
J. E. Dumont
Keyword(s):  
Glutathione Peroxidase ◽  
Oxygen Toxicity ◽  
Selenium Deficiency ◽  
Serum Levels ◽  
Serum Selenium ◽  
Endemic Cretinism ◽  
Plasma Glutathione Peroxidase ◽  
Plasma Glutathione ◽  
Low Selenium

Abstract. Myxoedematous endemic cretinism is prevalent in African goitre endemies. It has been related to a thyroid 'exhaustion' atrophy occurring near birth. It is proposed that this might result from the low resistance of a fragile tissue to enhanced H2O2 generation under intense thyroid stimulation by thyrotropin. In support of this hypothesis, low selenium and glutathione peroxidase serum levels have been found in the African endemic area of the Idjwi Island (Kivu, Zaire). Serum selenium and plasma glutathione peroxidase were lower in the area of high endemicity of goitre and cretinism (Northern part of the Island). However, only the former difference is statistically significant. These data thus suggest a role of oligoelements and oxygen toxicity in the pathogenesis of endemic cretinism.

Serum vitamin E, serum selenium and the risk of gastrointestinal cancer

1988 ◽  
Vol 42 (6) ◽  
pp. 846-850 ◽  
Author(s):  
Paul Knekt ◽  
Arpo Aromaa ◽  
Jouni Maatela ◽  
Georg Alfthan ◽  
Ritva-Kaarina Aaran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Gastrointestinal Cancer ◽  
Serum Vitamin ◽  
Serum Selenium

Metabolic and functional defects in selenium deficiency

1981 ◽  
Vol 294 (1071) ◽  
pp. 105-117 ◽  
Keyword(s):  
Hydrogen Peroxide ◽  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Membrane Lipids ◽  
Selenium Deficiency ◽  
Human Nutrition ◽  
Keshan Disease ◽  
Lipid Hydroperoxides ◽  
Membrane Phospholipids

This paper is concerned with present-day knowledge of the biological role of selenium, of its interaction with other nutrients including trace elements, and with the importance of selenium in human nutrition and health. Selenium has been shown to be an integral part of glutathione peroxidase, which catalyses the reduction of a large range of lipid hydroperoxides and hydrogen peroxide. The interrelation between vitamin E, selenium and polyunsaturated fatty acids is complex. First, selenium in glutathione peroxidase may control intracellular levels of hydrogen peroxide, which affect the formation of active oxygen metabolites that may serve as initiators of lipid peroxidation; this role of selenium is closely related to that of superoxide dismutases, which control intracellular levels of the superoxide anion. Secondly, vitamin E may control the formation of lipid hydroperoxides through its antioxidant function, as well as possibly entering into a structural relation with membrane phospholipids. Thirdly, glutathione peroxidase may catalyse the reduction of lipid hydroperoxides, formed from membrane lipids, to hydroxyacids without detriment to the cellular economy. In the field of human nutrition, the lack of selenium has been shown to be the cause of a cardiomyopathy known as Keshan disease, occurring in the People’s Republic of China. Blood selenium levels in patients from this area are compared with blood selenium levels in three other parts of the world and the conclusion is reached that the blood selenium level of populations in Keshan disease regions are exceptionally low and that Keshan disease is the first demonstration that selenium is an essential trace element for man.

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