scholarly journals Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes

2017 ◽  
Author(s):  
Rahman Rahimi ◽  
Hamid Shoker Nejad
Keyword(s):  
Resistance Exercise ◽  
Repeated Measures ◽  
Bench Press ◽  
Serum Concentrations ◽  
Double Blind ◽  
Acute Bout ◽  
Leg Extension ◽  
Time Points ◽  
Repeated Measures Analysis ◽  
Post Hoc

The aim of this study was to investigate the effect of β-Hydroxy-β-methylbutyrate (HMB) supplementation on anti-inflammatory cytokines including IL-4, IL-10 and TGF-β during an acute bout of resistance exercise (RE) in young resistance trained men. Ten resistance-trained men in a randomized, double-blind, placebo-controlled and crossover study, were administered a 7-day HMB supplementation (3×1 g.d-1 of HMB) and placebo (3×1 g.d-1 of Maltodextrin) with a 7 days washout period. After supplementation periods, subjects performed three sets of bench press, lat pull down, leg extension, leg curl, biceps curl, triceps curl and shoulder press to failure with 85% of one repetition to maximum (1RM). Blood samples were obtained before- (Pre), immediately post- (IP) and 1 hour-post RE (1h P) to assess serum concentrations of IL-4, IL-10 and TGF-β1. The data were analyzed using 2 (treatment: HMB and PL) × 3 (time points: Pre, IP and 1hP) repeated measures analysis of variance (ANOVA) followed by the Bonferroni post hoc test with a significant level of p<0.05. Serum IL-4 was significantly higher at IP resistance exercise in HMB compared to placebo. Circulating IL-4 and TGF-β1 were significantly raised at IP compared to Pre in both HMB and placebo treatments. No significant differences between treatments were observed for IL-10 and TGF-β1at any time points. In conclusion, HMB supplementation increased the circulating level of IL-4 during RE in resistance-trained men, which may attenuate inflammation and facilitate adaptation to RE.

Carbohydrate mouth rinsing improves resistance training session performance

2018 ◽  
Vol 13 (5) ◽  
pp. 804-809 ◽  
Author(s):  
Luciana S Decimoni ◽  
Victor M Curty ◽  
Livia Almeida ◽  
Alexander J Koch ◽  
Jeffrey M Willardson ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Exercise Performance ◽  
Repeated Measures ◽  
Perceived Exertion ◽  
Bench Press ◽  
Statistical Significance ◽  
Training Session ◽  
Rating Of Perceived Exertion ◽  
Double Blind ◽  
Mouth Rinsing

We investigated the effect of carbohydrate mouth rinsing on resistance exercise performance. Fifteen recreationally trained women (age 26 ± 4 y; height 1.61.9 ± 5.1 m; weight 59.5 ± 8.2 kg) completed two resistance exercise bouts consisting of three sets of five exercises (half-squat, leg press, bench press, military press, and seated row) to volitional fatigue with a 10 repetition-maximum load. Immediately prior to and during the middle of each exercise bout, subjects mouth rinsed for 10 s with 100 mL of either a 6% maltodextrin solution (CHO) or an artificially flavored solution (PLA) in a randomized, double-blind, counterbalanced fashion. Heart rate and perceived exertion were compared between conditions using a 2 (conditions) × 15 (time points) repeated measures ANOVA. Significant main effects were further analyzed using pairwise comparisons with Bonferroni post hoc tests. Total volume (exercises * sets * repetitions * load) between sessions was compared with a Student’s t-test. Statistical significance was set at p ≤ 0.05 level of confidence. The CHO resulted in more repetitions performed during half-squat, bench press, military press, and seated row, for a significantly greater (∼12%) total volume load lifted versus PLA ( p = 0.039, ES: 0.49). Rating of perceived exertion was also significantly lower in the CHO versus PLA ( p = 0.020, ES: 0.28). These data indicate that CHO mouth rinsing can enhance high-volume resistance exercise performance and lower ratings of perceived exertion.

scholarly journals Efficacy and safety of abatacept in biologic-naïve patients with active rheumatoid arthritis by background methotrexate dose: post hoc analysis of a randomized, placebo-controlled, phase 4 study

2021 ◽  
Author(s):  
Yoshiya Tanaka ◽  
Tsukasa Matsubara ◽  
Koichi Hashizume ◽  
Norihito Amano ◽  
Tsutomu Takeuchi
Keyword(s):  
Rheumatoid Arthritis ◽  
Repeated Measures ◽  
Active Rheumatoid Arthritis ◽  
Japanese Patients ◽  
Similar Efficacy ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Post Hoc Analysis ◽  
Repeated Measures Analysis ◽  
Post Hoc

ABSTRACT Objectives The objective of this study is to evaluate efficacy and safety of abatacept in biologic-naïve, anti-citrullinated protein antibody (ACPA)-positive Japanese patients with active rheumatoid arthritis (RA) by background methotrexate (MTX) dose. Methods In this post hoc analysis of a randomized, double-blind, placebo-controlled phase 4 study (NCT01758198), patients received intravenous abatacept (∼10 mg/kg) or placebo both with MTX (≥6 mg/week). Efficacy (Disease Activity Score 28 using C-reactive protein [DAS28 (CRP)] and Health Assessment Questionnaire-Disability Index [HAQ-DI]) was assessed by baseline MTX dosage (≤8 and >8 mg/week) to week 16; safety was assessed by MTX dosage ≤8 and >8 mg/week. Change from baseline in DAS28 (CRP) and HAQ-DI was assessed using longitudinal repeated measures analysis. Results Overall, 101 and 102 patients received abatacept + MTX ≤8 and >8 mg/week, while 96 and 106 patients received placebo + MTX ≤8 and >8 mg/week, respectively. Regardless of baseline MTX dose received, mean changes from baseline in DAS28 (CRP) and HAQ-DI in abatacept groups were similar; repeated measures analysis showed similar trends in changes from baseline in DAS28 (CRP) and HAQ-DI. Abatacept safety profile was consistent with previous observations. Conclusions Post hoc analysis demonstrated similar efficacy and safety of abatacept in biologic-naïve ACPA-positive Japanese patients with RA regardless of baseline MTX dose.

scholarly journals Efficacy of galcanezumab in patients with migraine who did not benefit from commonly prescribed preventive treatments

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dulanji K. Kuruppu ◽  
Joshua Tobin ◽  
Yan Dong ◽  
Sheena K. Aurora ◽  
Laura Yunes-Medina ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Migraine Headache ◽  
Mixed Model ◽  
Preventive Treatment ◽  
Response Rates ◽  
Toxin A ◽  
Double Blind ◽  
Preventive Medication ◽  
Onabotulinum Toxin A ◽  
Post Hoc

Abstract Background Galcanezumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) indicated for the preventive treatment of migraine. While galcanezumab has demonstrated efficacy in patients who did not respond to prior preventive medications in general, its efficacy in patients who did not benefit from individual, commonly prescribed preventive treatments due to inadequate efficacy or safety/tolerability remains unknown. Methods CONQUER was a 3-month, randomized, double-blind, placebo-controlled, phase 3b study that enrolled patients with episodic or chronic migraine who had 2 to 4 migraine preventive medication category failures in the past 10 years. Patients were randomly assigned 1:1 to receive placebo (N = 230) or galcanezumab 120 mg/month (240 mg loading dose; N = 232). Post hoc analyses were conducted to determine the efficacy of galcanezumab in patients who had not benefited from six of the most commonly prescribed migraine preventive medications. The mean change from baseline in monthly migraine headache days and ≥ 50 % response rates were assessed over months 1–3. Improvement in Migraine-Specific Questionnaire Role Function-Restrictive (MSQ-RFR) scores were assessed at month 3. The endpoints were estimated via mixed model with repeated measures. Results The most common treatment failures due to inadequate efficacy or safety/tolerability, which at least 20 % of patients reported trying without benefit, included topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and metoprolol. Patients who had not previously benefited from these treatments had a greater mean reduction in monthly migraine headache days across months 1–3 in the galcanezumab group compared to placebo (all p < 0.01). More patients treated with galcanezumab experienced a ≥ 50 % reduction from baseline in monthly migraine headache days across months 1–3 compared to placebo (all p < 0.05). Galcanezumab-treated patients had a greater improvement in mean MSQ-RFR scores at month 3 compared to placebo (all p < 0.01). Conclusions In this population, galcanezumab was effective in reducing monthly migraine headache days, improving response rates, and enhancing quality of life in patients who had not previously benefited from topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and/or metoprolol due to inadequate efficacy or safety/tolerability. Trial registration ClinicalTrials.gov NCT03559257 (CONQUER).

Location, Location, Location: Accelerometer Placement Affects Steps-Based Physical Activity Outcomes During Pregnancy and Postpartum

2021 ◽  
pp. 155982762110304
Author(s):  
Mallory R. Marshall ◽  
Alexander H. K. Montoye ◽  
Michelle R. Conway ◽  
Rebecca A. Schlaff ◽  
Karin A. Pfeiffer ◽  
...  
Keyword(s):  
Physical Activity ◽  
Repeated Measures ◽  
Time Points ◽  
Repeated Measures Analysis ◽  
Pregnancy And Postpartum ◽  
Vigorous Intensity ◽  
The Right ◽  
Physical Changes ◽  
Intensity Classification ◽  
Measurement Validity

As pregnancy progresses, physical changes may affect physical activity (PA) measurement validity. n = 11 pregnant women (30.1 ± 3.8 years) wore ActiGraph GT3X+ accelerometers on the right hip, right ankle, and non-dominant wrist for 3–7 days during the second and third trimesters (21 and 32 weeks, respectively) and 12 weeks postpartum. Data were downloaded into 60-second epochs from which stepping cadence was calculated; repeated-measures analysis of variance was used to determine significant differences among placements. At all time points, the wrist accelerometer measured significantly more daily steps (9930–10 452 steps/d) and faster average stepping cadence (14.5–14.6 steps/min) than either the hip (4972–5944 steps/d, 7.1–8.6 steps/min) or ankle (7161–8205 steps/d, 10.3–11.9 steps/min) placement, while moderate- to vigorous-intensity activity at the wrist (1.2–1.7 min/d) was significantly less than either hip (3.0–5.9 min/d) or ankle (6.1–7.3 min/d). Steps, cadence, and counts were significantly lower for the hip than the ankle at all time points. Kappa calculated for agreement in intensity classification between the various pairwise comparisons ranged from .06 to .41, with Kappa for hip–ankle agreement (.34–.41) significantly higher than for wrist–ankle (.09–.11) or wrist–hip (.06–.16). These data indicate that wrist accelerometer placement during pregnancy likely results in over counting of PA parameters and should be used with caution.

scholarly journals Effect of Educational Workshops on Disaster Risk Perception in Nurses

2020 ◽  
pp. 270-278
Keyword(s):  
Risk Perception ◽  
Repeated Measures ◽  
Intervention Group ◽  
Round Table ◽  
Disaster Risk ◽  
National Standards ◽  
Control Group ◽  
Repeated Measures Analysis ◽  
Post Hoc ◽  
And Control

INTRODUCTION: The enhancement of nurses’ risk perception plays a significant role in their preparedness during disasters and emergencies. Therefore, this study aimed to investigate the effect of educational workshops on disaster risk perception in nurses METHODS: This randomized controlled field trial study included 62 nurses working at Razi Hospital, Birjand, Iran. The participants were divided into intervention and control groups. The intervention group was then requested to participate in a one-day intensive educational workshop based on the current national standards. The workshop content included a combination of lecturing methods, round-table exercises, and film display. The data were collected using the demographic characteristic form and researcher-made questionnaires measuring the nurses’ risk perception during disasters and emergencies. Subsequently, the data were analyzed using independent t-test, repeated measures analysis, and Bonferroni post hoc tests. FINDINGS: The mean total score of risk perception were significantly higher in the intervention group before, immediately, and two months after the workshop session, compared to those in the control group (P˂0.001). CONCLUSION: The implementation of nurses’ national preparation program during disasters and emergencies can result in an increase in the nurses’ risk perception during these events. Therefore, regarding the importance of nurses’ preparedness in confrontation with disasters and emergencies, it seems necessary to integrate the National Preparedness Program into the educational programs immediately after recruitment and in the form of in-service courses.

Carbohydrate Supplementation and Immune Responses after Acute Exhaustive Resistance Exercise

2008 ◽  
Vol 18 (3) ◽  
pp. 247-259 ◽  
Author(s):  
Lara A. Carlson ◽  
Samuel Headley ◽  
Jason DeBruin ◽  
Alex P. Tuckow ◽  
Alexander J. Koch ◽  
...  
Keyword(s):  
Immune Responses ◽  
Resistance Exercise ◽  
Serum Cortisol ◽  
Weight Lifting ◽  
Ice Hockey ◽  
Track And Field ◽  
Plasma Lactate ◽  
Double Blind ◽  
Acute Bout ◽  
Carbohydrate Supplementation

This investigation sought to study changes in leukocyte subsets after an acute bout of resistance exercise (ARE) and to determine whether ingestion of carbohydrate (CHO) could attenuate those immune responses. Nine male track-and-field athletes (21.1 ± 1.4 yr, 177.2 ± 5.5 cm, 80.9 ± 9.7 kg, 8.7% ± 3.8% fat) and 10 male ice hockey athletes (21.0 ± 2.2 yr, 174.3 ± 6.2 cm, 79.6 ±11.1 kg, 13.9% ± 3.73% fat) participated in 2 different ARE protocols. Both experiments employed a counterbalanced double-blind research design, wherein participants consumed either a CHO (1 g/kg body weight) or placebo beverage before, during, and after a weight-lifting session. Serum cortisol decreased (p < .05) at 90 min into recovery compared with immediately postexercise. Plasma lactate, total leukocyte, neutrophil, and monocyte concentrations increased (p < .05) from baseline to immediately postexercise. Lymphocytes decreased significantly (p < .05) from baseline to 90 min postexercise. Lymphocytes were lower (p < .05) for the CHO condition than for placebo. The findings of this study indicate the following: ARE appears to evoke changes in immune cells similar to those previously reported during endurance exercise, and CHO ingestion attenuates lymphocytosis after ARE.

scholarly journals Acute Arginine Supplementation Is Associated with Increased Growth Hormone in Younger Healthy Males: A Randomized Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 609-609
Author(s):  
John Apolzan ◽  
Jennifer Rood ◽  
Robbie Beyl ◽  
Shengping Yang ◽  
Frank Greenway ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Repeated Measures ◽  
Controlled Trial ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Sex Hormone Binding Globulin ◽  
Double Blind ◽  
Time Points ◽  
Arginine Supplementation ◽  
Time Point

Abstract Objectives Assess the effects of the amino acid arginine on growth hormone (GH), other metabolites, and mood. Arginine is reported to increase GH, but the mechanism is not known. It was hypothesized prolactin mediated this effect since it is similar in structure to GH and, like GH, is secreted by the pituitary gland. Methods Thirty physically active healthy young males (18–39 y; 18.5–25 kg/m2) were enrolled in a randomized, double-blind, placebo-controlled, crossover trial. Two days prior and 1 day following each treatment a standardized diet was provided that maintained arginine at 3–5 g/d. Arginine or placebo treatments in the form of a beverage were consumed after an overnight fast. Treatment conditions were separated by at least a one week washout period. The beverages contained either 10 g of arginine or 0 g (placebo). Blood was collected at baseline and 1.5, 3.0, and 24 hr post treatment. Plasma GH, prolactin, amino acids, glucose, insulin, triacylglycerols, thyroid hormones, sex hormone binding globulin (SHBG), testosterone, cortisol, and dehydroepiandrosterone (DHEA) were assessed. The Profile of Mood States (POMS) was administered at the same time as blood draws. Repeated measures ANOVAs were used to estimate treatment effects at each time point. Results Arginine increased plasma arginine at 1.5, 3.0, and 24 hr (P ≤ 0.001) and GH at 24 hr (P ˂ 0.05) but not other time points. Arginine increased glucose and insulin at the 1.5 and 3.0 hr (P ˂ 0.05) but not 24 hr. Arginine did not affect any other dependent measure (P &gt; 0.05) including prolactin. When only individuals with detectable levels of GH (responders; n = 16) were analyzed separately, arginine increased GH at the 1.5 (P ˂ 0.05) but not the 3.0 or 24 hr time points. Among the responders, arginine also increased thyroid stimulating hormone (TSH) at the 24 hr time point (P ˂ 0.05) but not the 1.5 and 3.0 hr time points. Conclusions Arginine supplementation modestly increased growth hormone. Despite their similar structures, prolactin secretion was not elevated following arginine supplementation, thus another mechanism is responsible for growth hormone secretion. Funding Sources DoD and NIH P30DK072476. Views expressed are those of the authors and do not reflect official policy of the Army, DoD, or US Government.

23 THE EFFECT OF WITHDRAWAL TIMING OF CONTROLLED INTERNAL DRUG RELEASE (CIDR) ON EWE REPRODUCTIVE PERFORMANCE

2017 ◽  
Vol 29 (1) ◽  
pp. 119 ◽  
Author(s):  
A. Swelum ◽  
A. Moumen ◽  
A. Alowaimer
Keyword(s):  
Drug Release ◽  
Pregnancy Rate ◽  
Repeated Measures ◽  
Detection Rate ◽  
Serum Concentrations ◽  
Chi Square ◽  
Withdrawal Time ◽  
Repeated Measures Analysis ◽  
Significant Difference ◽  
Equine Chorionic Gonadotropin

This study was carried out using 80 multiparous Awassi ewes during breeding season to compare the effects of controlled internal drug release (CIDR) withdrawal time on ewe fertility. Ewes were equally and randomly allotted into 4 groups (n = 20/group). Ewes had a CIDR inserted for 3, 6, 9, or 12 days with intramuscular administration of 300 IU of equine chorionic gonadotropin (eCG) at withdrawal time. Oestrus was detected using vasectomized ram starting 12 h after CIDR withdrawal and repeated every 12 h up to 84 h. Blood samples were collected from all groups at the time of CIDR withdrawal for measuring of oestradiol (E2) and progesterone (P4) serum concentrations using commercial ELISA kits and micro-titrimetric plates. Timed insemination was performed 48 h post CIDR withdrawal in all groups. Pregnancy was diagnosed by ultrasonography at day 23 post-insemination and confirmed at day 35. Comparisons among groups were evaluated using Chi Square (χ2) test in all measured parameters except hormones levels, which analysed by repeated-measures analysis of variance (ANOVA), using SAS (SAS Institute Inc., Cary, NC, USA). A difference was considered significant at P < 0.05 level. The results revealed that the retention, vaginal discharge and drawstring breakage rates after CIDR removal were insignificantly differed between all groups. On the other hand, pregnancy rate was significantly (P ≤ 0.05) higher in 9-d and 6-d groups (68.4 and 60%, respectively) than the 3-d group. While, no significant difference was detected between 12d group and other groups. The heat detection rate was significantly (P ≤ 0.05) higher in 12d group (100%) than 6-d and 3-d groups (80 and 45%, respectively). While, no significant difference was detected between 12-d and 9-d groups in heat detection rate. P4 was significantly higher in the 12-d group (13.4 ± 3.06 ng mL−1) than other groups. While E2 was significantly lower in the 12-d group (1.6 ± 0.06 pg mL−1) than other groups. These results indicated that withdrawal of CIDR devices after 9 days are efficient in synchronizing oestrus in ewes and provided higher pregnancy rate.

scholarly journals The Acute Post-Activation Performance Enhancement of the Bench Press Throw in Disabled Sitting Volleyball Athletes

2021 ◽  
Vol 18 (7) ◽  
pp. 3818
Author(s):  
Michal Krzysztofik ◽  
Patryk Matykiewicz ◽  
Diana Celebanska ◽  
Jakub Jarosz ◽  
Eliza Gawel ◽  
...  
Keyword(s):  
Body Mass ◽  
Repeated Measures ◽  
Peak Power ◽  
Bench Press ◽  
Performance Enhancement ◽  
Peak Power Output ◽  
Volleyball Players ◽  
Before And After ◽  
Bar Velocity ◽  
Post Hoc

The purpose of the present study was to examine the acute effects of the bench press exercise with predetermined velocity loss percentage on subsequent bench press throw (BPT) performance with raised legs or feet on the floor among disabled, sitting volleyball players. Twelve elite sitting volleyball athletes (age = 33 ± 9 years; body mass = 84.7 ± 14.7 kg; relative bench press maximum strength = 1.0 ± 0.3 kg/body mass) took part in this study. The experiment was performed following a randomized crossover design, where each participant performed a single set of bench press with a 60% one-repetition maximum (1RM) to a 10% decrease of mean bar velocity as a conditioning activity (CA). The BPT with a 60%1RM was performed to assess changes in peak power (PP), peak velocity (PV) before and after the CA. The differences between analyzed variables before and after the CA were verified using two-way repeated-measures ANOVA (condition × time; 2 × 2). The ANOVA showed a significant main effect of time for peak bar velocity (p = 0.03; η2 = 0.312) and peak power output (p = 0.037; η2 = 0.294). The post hoc comparison showed a significant increase in post-CA peak bar velocity and peak power for raised legs condition in comparison with pre-CA value (p = 0.02, p = 0.041, respectively). The present study showed that the subsequent BPT performed with raised legs could be enhanced by the bench press with a 60% 1RM to a 10% mean bar velocity decrease as a CA among disabled sitting volleyball players. Therefore, athletes and coaches can consider performing a bench press throw with raised legs without compromising performance.

Effects of Breathy Voice Source on Ratings of Hypernasality

2005 ◽  
Vol 42 (6) ◽  
pp. 641-648 ◽  
Author(s):  
Setsuko Imatomi
Keyword(s):  
Cleft Palate ◽  
Repeated Measures ◽  
Voice Disorder ◽  
Academic Training ◽  
Clinical Experiences ◽  
Point Scale ◽  
Voice Source ◽  
Cleft Palate Speech ◽  
Repeated Measures Analysis ◽  
Post Hoc

Objective To investigate the effects of breathy voice sources on ratings of hypernasality using synthesized speech. Methods Speech samples were obtained from children with cleft palates who demonstrated varying degrees of hypernasality and from a child with a voice disorder. Sources with 6 degrees of breathiness were created: a breathy source and five synthesized sources with lowered harmonics-to-noise ratio (HNR) values by the addition of impulses. These sources and each original (clear) source were combined with three kinds of filters: mild, moderate, and severely hypernasal. Consequently, 21 ([6 + 1] × 3) stimuli for each vowel (/a/ and /i/) were obtained for ratings. Participants Thirteen speech pathologists with academic training and various clinical experiences with cleft palate speech rated hypernasality of the stimuli on a 5-point scale. Main Outcome Measures Ratings of hypernasality for breathy and clear stimuli were analyzed using a repeated measures analysis of variance. Results The effects of breathy source on ratings of hypernasality were significant for the following filters: mild hypernasal /a/, severe hypernasal /a/, mild hypernasal /i/, and moderate hypernasal /i/. A post-hoc comparison test demonstrated that the more breathy sources (BH0 or BH2) generally increased the hypernasality score for mild hypernasal filters and decreased it for moderate and severe hypernasal filters. The less breathy sources (BH3, BH4, and BH5) hardly affected the ratings. Conclusion The effects of breathiness on ratings of hypernasality seem to moderate rather than to mask perceived hypernasality. That is, breathiness raises slight hypernasality, whereas it reduces severe hypernasality.

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