scholarly journals Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expressions in Striatum and Thalamus

2019 ◽  
Author(s):  
Margarita Heredia ◽  
Natalia Rodríguez ◽  
Virginia Sánchez Robledo ◽  
José María Criado ◽  
Antonio de la Fuente ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Cortical Cell ◽  
Motor Recovery ◽  
The Other ◽  
Dominant Hemisphere ◽  
Proliferating Cells ◽  
Cortical Ablation ◽  
Ventral Nucleus ◽  
Contralateral Motor

Previously we demonstrated, in rats, that the treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or vehicle (V), for five days. At 1 dpi (days after injury), 5 rats received daily injections (4 days) of bromodeoxyuridine and were sacrificed. The other 15 rats (n = 5 / group) underwent treatment and rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent of GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery.

scholarly journals Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus

2019 ◽  
Vol 20 (22) ◽  
pp. 5770 ◽  
Author(s):  
Margarita Heredia ◽  
Natalia Rodríguez ◽  
Virginia Sánchez Robledo ◽  
José María Criado ◽  
Antonio de la Fuente ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Cortical Cell ◽  
Motor Recovery ◽  
Proliferating Cells ◽  
Post Injury ◽  
Cortical Ablation ◽  
Actin Expression ◽  
Ventral Nucleus ◽  
Contralateral Motor

Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (n = 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery.

scholarly journals The Role of the Contralesional Motor Cortex for Motor Recovery in the Early Days after Stroke Assessed with Longitudinal fMRI

2010 ◽  
Vol 21 (4) ◽  
pp. 756-768 ◽  
Author(s):  
Anne K. Rehme ◽  
Gereon R. Fink ◽  
D. Yves von Cramon ◽  
Christian Grefkes
Keyword(s):  
Motor Cortex ◽  
Motor Recovery

scholarly journals Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Katherine Cora Ames ◽  
Mark M Churchland
Keyword(s):  
Motor Cortex ◽  
Muscle Activity ◽  
Population Level ◽  
The Other ◽  
Contralateral Hemisphere ◽  
Population Response

Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were strongly arm-dependent, raising two possibilities. First, population-level signals might differ depending on the arm used. Second, the same population-level signals might be present, but distributed differently across neurons. The data supported this second hypothesis. Muscle activity was accurately predicted by activity in either the ipsilateral or contralateral hemisphere. More generally, we failed to find signals unique to the contralateral hemisphere. Yet if signals are shared across hemispheres, how do they avoid impacting the wrong arm? We found that activity related to each arm occupies a distinct subspace, enabling muscle-activity decoders to naturally ignore signals related to the other arm.

scholarly journals Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Margarita Heredia ◽  
Jesús Palomero ◽  
Antonio de la Fuente ◽  
José María Criado ◽  
Javier Yajeya ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Brain Injuries ◽  
Time Window ◽  
Brain Plasticity ◽  
Critical Time ◽  
Gh Treatment ◽  
Cortical Ablation ◽  
Severe Motor ◽  
Motor Improvement ◽  
Contralateral Motor

We previously demonstrated that the administration of GH immediately after severe motor cortex injury, in rats, followed by rehabilitation, improved the functionality of the affected limb and reexpressed nestin in the contralateral motor cortex. Here, we analyze whether these GH effects depend on a time window after the injury and on the reexpression of nestin and actin. Injured animals were treated with GH (0.15 mg/kg/day) or vehicle, at days 7, 14, and 35 after cortical ablation. Rehabilitation was applied at short and long term (LTR) after the lesion and then sacrificed. Nestin and actin were analyzed by immunoblotting in the contralateral motor cortex. Giving GH at days 7 or 35 after the lesion, but not 14 days after it, led to a remarkable improvement in the functionality of the affected paw. Contralateral nestin and actin reexpression was clearly higher in GH-treated animals, probably because compensatory brain plasticity was established. GH and immediate rehabilitation are key for repairing brain injuries, with the exception of a critical time period: GH treatment starting 14 days after the lesion. Our data also indicate that there is not a clear plateau in the recovery from a brain injury in agreement with our data in human patients.

Plasma Levels of Protein S, Protein C, and Factor X: Effects of Sex, Hormonal State and Age

1995 ◽  
Vol 74 (05) ◽  
pp. 1271-1275 ◽  
Author(s):  
C M A Henkens ◽  
V J J Bom ◽  
W van der Schaaf ◽  
P M Pelsma ◽  
C Th Smit Sibinga ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Postmenopausal Women ◽  
Protein C ◽  
Blood Donors ◽  
Premenopausal Women ◽  
Protein S ◽  
The Other ◽  
Factor X ◽  
Normal Ranges

SummaryWe measured total and free protein S (PS), protein C (PC) and factor X (FX) in 393 healthy blood donors to assess differences in relation to sex, hormonal state and age. All measured proteins were lower in women as compared to men, as were levels in premenopausal women as compared to postmenopausal women. Multiple regression analysis showed that both age and subgroup (men, pre- and postmenopausal women) were of significance for the levels of total and free PS and PC, the subgroup effect being caused by the differences between the premenopausal women and the other groups. This indicates a role of sex-hormones, most likely estrogens, in the regulation of levels of pro- and anticoagulant factors under physiologic conditions. These differences should be taken into account in daily clinical practice and may necessitate different normal ranges for men, pre- and postmenopausal women.

On the role of the dispute between "non-possessors" and "Josephites" in the culture of Moscow's prediction

1998 ◽  
pp. 61-62
Author(s):  
N. S. Jurtueva
Keyword(s):  
The Other ◽  
Moral Transformation ◽  
15Th Century ◽  
The Future ◽  
Secular Power

In the XIV century. centripetal tendencies began to appear in the Moscow principality. Inside the Russian church, several areas were distinguished. Part of the clergy supported the specificobar form. The other understood the need for transformations in society. As a result, this led to a split in the Russian church in the 15th century for "non-possessors" and "Josephites". The former linked the fate of the future with the ideology of hesychasm and its moral transformation, while the latter sought support in alliance with a strong secular power.

From Container to Claustrum: Projective Identification in Couples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman
Keyword(s):  
Psychological Health ◽  
Projective Identification ◽  
The Self ◽  
The Other ◽  
Intimate Partners ◽  
And Control ◽  
The Relationship ◽  
As If

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.

Thomas More's “rule” of pleasure before, after, and inUtopia

Moreana ◽  
2017 ◽  
Vol 54 (Number 207) (1) ◽  
pp. 36-56
Author(s):  
Gerard Wegemer
Keyword(s):  
Human Nature ◽  
The Other ◽  
Biblical Allusions ◽  
De Officiis

After establishing a context of More's lifelong engagement with the “calculus” of pleasure, this essay shows how the section devoted to the Utopians' pleasure philosophy is structured around five formulations of a “rule” to calculate “true and honest [honesta]” pleasure in ways that playfully imitate and echo the “rule” Cicero formulates several times in De officiis to discern one's duty when there seems to be a conflict between honestas et utilitas. When followed, the Utopian pleasure calculus shows the necessary role of societas, officii, iustitia, caritas, and the other aspects of human nature, most importantly friendship, that Cicero stresses in his rule and that he argued Epicurus ignored. Much of the irony and humor of this section depends on seeing the predominance of Ciceronian vocabulary in Raphael's unusual defense [patrocinium] of pleasure, rather than a Ciceronian defense of duty rooted in honestas. Throughout, however, this essay also shows how More goes beyond Cicero by including Augustinian and biblical allusions to suggest ways that our final end is not as Epicurus or the Stoics or Cicero claim; the language and allusions of this section point to a level of good cheer and care for neighbors and for God in ways quite different from any classical thinker.

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