scholarly journals Necrotic Skin Infection by Sphingomonas Paucimobilis in Amazonia Region

2019 ◽  
Author(s):  
Talles Henrique Pichinelli Maffei ◽  
Frederico Alberto Bussolaro ◽  
Arlei Belaus ◽  
Alexandra Prevedello ◽  
Claudine Thereza-Bussolaro
Keyword(s):  
Pain Control ◽  
Skin Infection ◽  
Complete Healing ◽  
Sphingomonas Paucimobilis ◽  
Empirical Antibiotic Therapy ◽  
Rare Occurrence ◽  
Gram Negative ◽  
The Third ◽  
Purulent Drainage ◽  
Opportunist Pathogen

Sphingomonas paucimobilis is an opportunist pathogen bacillus gram-negative aerobic with a rare occurrence. We present a case in an immunocompetent man successfully treated by surgical debridement, purulent drainage and with an associated course of antibiotics. A large necrotic infection, approximately 5 cm x 3 cm, in a 74-year-old man was identified. Empirical antibiotic therapy with ciprofloxacin 400mg EV 12/12 hours, associated with clindamycin 600mg EV 6/6 hours and pain control was done through dipyrone 1gr, tramadol 400 mg. Deep venous thrombosis was prevented through the prescription of enoxaparin 40mg subcutaneous once a day during hospitalization. The case was well illustrated with pictures throughout treatment. Complete healing was achieved after 90 days. Herein, we present a case of cutaneous contamination. The presented case is the third cutaneous contamination case reported in the literature and the first reported case in the Amazonia region in Brazil.

Tubercular Abscess of the Spleen in a Child: Conservative Management and Long-Term Follow-Up

2017 ◽  
Vol 13 (04) ◽  
pp. 316-318
Author(s):  
Vijai Williams ◽  
Sarvanan Chandrasekaran ◽  
Keerthivasan Seetharaman ◽  
Kushaljit Sodhi ◽  
Devi Dayal
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Splenic Abscess ◽  
Complete Healing ◽  
Rare Occurrence ◽  
Line Probe Assay ◽  
Rare Manifestation ◽  
Long Term Follow Up ◽  
Probe Assay

AbstractIsolated involvement of the spleen is a rare manifestation of childhood tuberculosis. The rare occurrence and presence of nonspecific clinical features often pose diagnostic challenges even in countries where tuberculosis is endemic. Splenectomy is often performed for establishing the diagnosis or achieving a cure in combination with antitubercular therapy (ATT). In this report, we describe a boy who presented with nonspecific symptoms and was detected to have a well-defined lesion in the spleen on ultrasonography. The diagnosis of tubercular splenic abscess was made after line probe assay for the detection of Mycobacterium tuberculosis and cytomorphology of the aspirated material. The tubercular abscess showed complete healing after 9 months of four-drug ATT.

scholarly journals Synthesis of Some New Nucleoside Analogues Containing Seven Membered Ring and Studying Their Biological Activity

2016 ◽  
Vol 13 (3) ◽  
pp. 531-546
Author(s):  
Baghdad Science Journal
Keyword(s):  
Antibacterial Activity ◽  
Membered Ring ◽  
Nucleoside Analogues ◽  
Second Step ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
The Third ◽  
Ft Ir ◽  
Fourth Step ◽  
Propiolic Acid

In this work, a series of new Nucleoside analogues (D-galactopyranose linked to oxepanebenzimidazole moiety) was synthesized via multisteps synthesis. The first step involved preparation of two benzimidazoles 2-styrylbenzimidazole and 2-(phenyl ethynyl) benzimidazole via reaction of phenylenediamine with cinnamic acid or ?-phenyl propiolic acid. Electrophilic addition of the prepared benzimidazoles by three anhydrides in the second step afforded (4-6) and (14-16) which in turn were treated with 1,2,3,4-di-O-isopropylidene galactopyranose in the third step to afford a series of the desirable protected nucleoside analogues (7-9) ,(17-19)which after hydrolysis in methanolic sodium methoxidein the fourth step afforded the free nucleoside analogues (10-12) and (20-22) .The synthesized compounds were identified by FT-IR and some of them by 1H-NMR and13C-NMR. The synthesized oxepane nucleoside analogues were screened for their antibacterial activity against three types of bacteria including Staphylococcusaureus ,Bacillus(gram positive) andE.coli (gram negative) bacteria repectively.

Isolation of Moraxella canis from an Ulcerated Metastatic Lymph Node

2000 ◽  
Vol 38 (10) ◽  
pp. 3870-3871 ◽  
Author(s):  
Mario Vaneechoutte ◽  
Geert Claeys ◽  
Sophia Steyaert ◽  
Thierry De Baere ◽  
Renaat Peleman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Metastatic Lymph Node ◽  
Upper Airway ◽  
Blood Cultures ◽  
Human Isolate ◽  
Supraclavicular Lymph Node ◽  
Gram Negative ◽  
The Third ◽  
Terminal Patient ◽  
Large Numbers

Moraxella canis was isolated in large numbers from an ulcerated supraclavicular lymph node of a terminal patient, who died a few days later. Although the patient presented with septic symptoms and with a heavy growth of gram-negative diplococci in the lymph node, blood cultures remained negative. M. canis is an upper-airway commensal from dogs and cats and is considered nonpathogenic for humans, although this is the third reported human isolate of this species.

scholarly journals Culturing Periprosthetic Tissues in BacT/Alert® Virtuo Blood Culture Bottles for a Short Duration of Post-operative Empirical Antibiotic Therapy

2020 ◽  
Vol 5 (3) ◽  
pp. 145-150
Author(s):  
Claire Duployez ◽  
Frédéric Wallet ◽  
Henri Migaud ◽  
Eric Senneville ◽  
Caroline Loiez
Keyword(s):  
Blood Culture ◽  
Antibiotic Therapy ◽  
Joint Infection ◽  
Length Of Hospital Stay ◽  
Empirical Antibiotic Therapy ◽  
Gram Positive ◽  
Gram Negative ◽  
Surgical Interventions ◽  
Joint Infections ◽  
Gram Positive Cocci

Abstract. Introduction: A post-operative empirical antibiotic therapy (PEAT) is required in periprosthetic joint infections. It commonly uses broad-spectrum antibiotics to cover most Gram-positive cocci and Gram-negative bacilli. It is currently continued until first microbiological results are available, no less than five days later.Methods: We performed a retrospective study in order to evaluate duration of incubation required for surgical samples using the BacT/Alert® Virtuo blood culture bottles system.Results: Among 216 surgical interventions and 199 clinical strains (53.8% staphylococci, 22,1% streptococci and enterococci, 14,6% Gram-negative bacilli, 5,5% anaerobes), 90.5% of the strains were detected between day 0 and day 2; 15 infective strains are cultured from day 3 including 8 Cutibacterium sp., 4 staphylococci, 2 streptococci and 1 Enterococcus.Conclusions: We suggest that the duration of PEAT in patients operated for a periprosthetic joint infection may be shortened to three days as Gram-negative rods are unlikely to grow after three days of culture by using BacT/Alert® Virtuo blood culture bottles. This is likely to shorten the overall length of hospital stay, to diminish the occurrence of adverse side effects, and the emergence of antimicrobial resistance. However, coverage of Gram-positive cocci should be maintained for 14 days until the definite culture results are available.

Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate

2009 ◽  
Vol 55 (5) ◽  
pp. 627-632 ◽  
Author(s):  
Thomas Candela ◽  
Marie Moya ◽  
Michel Haustant ◽  
Agnès Fouet
Keyword(s):  
In Silico Analysis ◽  
Fusobacterium Nucleatum ◽  
Gram Negative Bacteria ◽  
Negative Bacterium ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
The Third ◽  
Gram Negative Organisms ◽  
First Time

Poly-γ-glutamate has been described in many Gram-positive organisms. When anchored to the surface, it is a capsule and as such a virulence factor. Based on sequence similarities, few Gram-negative organisms have been suggested to synthesize poly-γ-glutamate. For the first time, a Gram-negative bacterium, Fusobacterium nucleatum , is shown to produce and secrete poly-γ-glutamate. Putative poly-γ-glutamate-synthesizing genes from Gram-negative organisms have been compared with their Gram-positive homologs by in silico analysis, i.e., gene sequence and phylogenetic analysis. Clusters of three instead of four genes were highlighted by our screen. The products of the first two genes display similarity with their Gram-positive equivalents, yet the sequences from the Gram-negative organisms can be distinguished from those of the Gram-positives. Interestingly, the sequence of the predicted product of the third gene is conserved among Gram-negative bacteria but displays no similarity to that of either the third or fourth gene of the Gram-positive operons. It is suggested that, like for Gram-positive bacteria, poly-γ-glutamate has a role in virulence for pathogens and one in survival for other Gram-negative bacteria.

Amikacin (BBK8) in Infections Due to Gram-Negative Organisms in Children over the Age of One Month

1976 ◽  
Vol 4 (1) ◽  
pp. 1-14 ◽  
Author(s):  
J I Ramirez ◽  
H Trujillo ◽  
A Uribe ◽  
Nancy H Agudelo ◽  
Esther Luisa de Vidal
Keyword(s):  
Plasma Levels ◽  
Soft Tissues ◽  
Chronic Otitis Media ◽  
Petri Dish ◽  
Gram Negative ◽  
E Coli ◽  
The Third ◽  
Infected Wounds ◽  
Gram Negative Organisms ◽  
Toxic Reactions

Thirty children over the age of one month were treated with amikacin ( BBK8), a new aminoglycoside derived from kanamycin A, with three intramuscular dosage schedules. Each group consisted of ten patients. The first received 7.5 mg/kg/12 hours, the second 7.5 mg/kg/24 hours and the third, 3.75 mg/kg/12 hours. The infections and the bacteria were similar in all three groups: pyelonephritis, abscesses of soft tissues, infected wounds, septicaemia, superinfected empyema, gastro-enteritis, chronic otitis media; the bacteria were E. coli, Klebsiella, Pseudomonas and Salmonella. A were sensitive by the Kirby-Bauer method, although two were resistant by dilution in Petri dish. Of the thirty patients, twenty four (80%) were cured. The schedule of 3.75 mg/kg/12 hours was as effective as the schedule of7.5 mg/kg/12 hours for infections such as pyelonephritis, superficial abcesses, contaminated wounds, gastro-enteritis and sepsis. The cases with infections localized in rather unaccessible sites required double the dose and strict drainage and cleanliness. Plasma levels with the administration of 3.75 mg/kg fluctuated between 8.3 and 12.6 mcg/ml; with 7.5 mg/kg they fluctuated between 8.6 and 13.1. The minimum inhibitory level ( MIL) for the majority of the bacteria was 1.25 mcg/ml. No toxic reactions were observed.

Conjoined Twins with Thoracoabdominopagus Anomaly in the Third Trimester

2014 ◽  
Vol 6 (3) ◽  
pp. 191-194
Author(s):  
G Saranya ◽  
Jaya Vijayaraghavan ◽  
Bhuvana LNU ◽  
Sheela LNU
Keyword(s):  
South Asian ◽  
Cardiopulmonary Arrest ◽  
Conjoined Twins ◽  
Rare Occurrence ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Third Trimester ◽  
Monochorionic Twins ◽  
The Third ◽  
Surgical Separation

ABSTRACT Conjoined twinning is rare; occurrence is about 1% of monochorionic twins. Here, we report a case of 26-year-old multigravida with 29 weeks pregnancy with conjoined twinsthoracoabdominopagus. Two live female babies joined at the chest and abdomen were delivered by cesarean section. The parents refused a separation operation and despite resuscitation the twins died of cardiopulmonary arrest after 16 hours. A review of the literature suggests that early diagnosis by a combination of ultrasound and magnetic resonance imaging is essential for predicting prognosis, management and success of surgical separation. It offers an opportunity for early counseling for parents and option for termination. How to cite this article Saranya G, Vijayaraghavan J, Bhuvana, Sheela. Conjoined Twins with Thoracoabdominopagus Anomaly in the Third Trimester. J South Asian Feder Obst Gynae 2014;6(3):191-194.

scholarly journals Bilateral Hypodontia of Mandibular Second Premolars and Lateral Incisors in a Nonsyndromic Patient: A Rare Case Report

2016 ◽  
Vol 1 (1) ◽  
pp. 24-26
Author(s):  
Shakun Kanjani
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Permanent Teeth ◽  
Rare Occurrence ◽  
Third Molars ◽  
Missing Teeth ◽  
Dental Anomaly ◽  
Mahatma Gandhi ◽  
The Third ◽  
Rare Case Report

ABSTRACT Hypodontia is the term used to describe the developmental absence of one or more primary or permanent teeth, excluding the third molars. It is the most commonly occurring developmental dental anomaly and can be a challenge to manage clinically. Hypodontia can occur in association with syndrome or it may occur in nonsyndromic patient. Bilateral occurrence is common but it is very rare to see two bilateral congenital missing teeth in a nonsyndromic patient. This case report presents a rare occurrence of congenital bilateral missing mandibular second premolars and mandibular lateral incisors in a nonsyndromic patient. How to cite this article Agarwal N, Chaturvedy S, Marwah N, Mishra P, Kanjani S. Bilateral Hypodontia of Mandibular Second Premolars and Lateral Incisors in a Nonsyndromic Patient: A Rare Case Report. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):24-26.

scholarly journals Scanner-Assisted CO2 Laser Fissurectomy: A Pilot Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Giani Iacopo ◽  
Cioppa Tommaso ◽  
Linari Chiara ◽  
Caminati Filippo ◽  
Dreoni Paolo ◽  
...  
Keyword(s):  
Anal Fissure ◽  
Pain Control ◽  
Thermal Damage ◽  
Chronic Anal Fissure ◽  
Complete Healing ◽  
High Rate ◽  
Exclusion Criteria ◽  
Internal Sphincterotomy ◽  
Maximum Pain

Introduction: Surgery for chronic anal fissure is challenging for every proctologist. Solving the pain by guaranteeing rapid and effective healing is the objective, but what is the price to pay today in functional terms? Though this result is nowadays partially achievable through interventions that include the execution of an internal sphincterotomy among the procedures, it is necessary to underline the high rate of patients who can present faecal incontinence. The aim of this study is to explore the effectiveness of scanner-assisted CO2 laser fissurectomy.Methods: From April 2021 to September 2021, all consecutive patients who affected by chronic anal fissure suitable for surgery, meeting the inclusion and exclusion criteria, were evaluated. All planned data were recorded before surgery, then at 24 h, 1 week, and 1 month follow-up. A scanner-assisted CO2 laser was used in this study to achieve a smooth and dried wound with a minimal tissue thermal damage, to ensure good postsurgical pain control, rapid and functional, elastic and stable healing, and to prevent potential relapses. Paracetamol 1 g every 8 h was prescribed for the first 24 h and then continued according to each patient's need. Ketorolac 15 mg was prescribed as rescue.Results: Mean pain intensity ≤3, considered as the principal endpoint, was recorded in 26 out of the 29 patients who enrolled in the study with a final success rate of 89.7% at 1-month follow-up. Pain and anal itching showed a statistically significant reduction while bleeding, burning, and maximum pain, and REALIS score showed a reduction too at the end of the follow-up period. Reepithelisation proved to be extremely fast and effective: 22 of 29 (75.9%) showed a complete healing and 5 showed a partial reepithelisation at 1-month follow-up.Discussion: Outcomes of this study showed that it is undoubtedly necessary to change the surgical approach in case of anal fissure. The internal sphincterotomy procedure must be most of all questioned, where the availability of cutting-edge technological tools must be avoided and offered only in selected cases. Scanner-assisted CO2 laser showed great results in terms of pain control and wound healing, secondary to an extremely precise ablation, vaporisation, and debridement procedures with minimal lateral thermal damage.

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