scholarly journals Associations between Bioactive Algal Biomaterial Supplementation, Dietary Pattern and Metabolic Risk Markers in Japanese Women

2021 ◽  
Author(s):  
Nlandu Roger Ngatu ◽  
Tomohiro Hirao ◽  
Mitsunori Ikeda
Keyword(s):  
Corn Starch ◽  
Daily Intake ◽  
Japanese Women ◽  
Risk Markers ◽  
C Reactive Protein ◽  
Dietary Survey ◽  
Metabolic Markers ◽  
Reactive Protein ◽  
Unhealthy Diet ◽  
Marine Algal

Unhealthy diet can lead to the development of metabolic disorders, and studies have shown strong associations between those conditions and biomarkers, such as c-reactive protein (CRP) and adiponectin. Recently, marine algal biomaterials have been investigated extensively due to their health benefits. We report on associations between metabolic markers and bioactive nutrients from diet and Sujiaonori algal biomaterial (SBM), a natural adiponectin modulation inducer (NAMI) containing 60% of ulvan-rich fiber, in a sample of Japanese women. The study comprised dietary survey and intervention conducted in Kochi, Japan (2016-2017), involving 31 women who completed a dietary survey and provided biospecimen for CRP and adiponectin measurement using ELISA. Sixteen women received 3g SBM daily for one month and 15 others (controls) received 3g of corn starch. In SBM group, mean age was 23.06 (2.21) years [vs. 23.06 (1.55)], BMI was 21.11 (0.59) kg/m2 [vs. 21.43 (0.60) in controls], and daily intake of n3-PUFA [3.83 (0.24) vs. 2.21 (0.33) mg/day; p=0.042] and total fiber [364.12 (2.45) vs. 48.13 (1.57) mg/day in controls; p=0.000] were markedly higher. Furthermore, CRP was inversely associated with total fiber, total n3-PUFA, SBM-n3PUFA, vitamin D and vitamin B6, whereas adiponectin was strongly and positively associated with SBM-fiber and total n3-PUFA. Thus ulvan-rich SBM supplement, which contains ulvan-rich fiber and n3-PUFA, might be beneficial in reducing metabolic risk.

scholarly journals The inflammatory and hemostatic cardiovascular risk markers during acute hyperglycemic crisis in type 1 and type 2 diabetes

2019 ◽  
Vol 38 (2) ◽  
pp. 126-133 ◽  
Author(s):  
Dragana Popovic ◽  
Katarina Lalic ◽  
Aleksandra Jotic ◽  
Tanja Milicic ◽  
Jelena Bogdanovic ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Favorable Effect ◽  
Obese Patients ◽  
Risk Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hyperosmolar Hyperglycemic State ◽  
Group A

Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP

scholarly journals Associations of circulating biomarkers with the presence and severity of coronary, carotid and femoral arterial atherosclerosis

2022 ◽  
Vol 20 (8) ◽  
pp. 3098
Author(s):  
V. A. Metelskaya ◽  
M. V. Zhatkina ◽  
N. E. Gavrilova ◽  
E. B. Yarovaya ◽  
N. L. Bogdanova ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Metabolic Disorders ◽  
Density Lipoprotein ◽  
Duplex Ultrasound ◽  
Circulating Biomarkers ◽  
C Reactive Protein ◽  
Metabolic Markers ◽  
Reactive Protein ◽  
Severe Atherosclerosis ◽  
Nitric Oxide Metabolites

Aim. To identify and characterize the associations of the presence and severity of atherosclerosis of various localization with the blood level of biochemical parameters, as well as to assess the potential of their use as markers of metabolic disorders with increased atherogenic potential.Material and methods. The study included 216 patients (men, 53%) aged 24-87 years (mean age, 61,5±10,73 years). All patients underwent coronary angiography, carotid (CA) and femoral arterial (FA) duplex ultrasound to assess the presence and severity of atherosclerosis. In blood serum/plasma, biochemical parameters were analyzed using standard methods.Results. Based on the analysis of circulating biomarker profile, diagnostic complexes have been established that allow assessing atherosclerosis of different localization. According to the data obtained, the determinants of coronary and CA atherosclerosis are endothelial dysfunction (concentration of nitric oxide metabolites <36,0 μmol/L) and an increased level of creatinine (≥73,0 μmol/L). The specific markers associated with severe atherosclerosis of coronary and FAs (but not CA) were low high-density lipoprotein cholesterol (≤1,0/1,2 μmol/L for male/ female, respectively) and an increased C-reactive protein level (≥1,0 mg/l). Severe peripheral atherosclerosis (CA and FA involvement) was associated with hyperglycemia (glucose ≥6,1 μmol/L), while severe FA atherosclerosis — with hyperinsulinemia (insulin ≥14,0 μU/ml).Conclusion. The analysis of associations of circulating biochemical parameters with atherosclerosis localization and severity revealed a number of metabolic markers associated with the increased atherogenic potential. It is possible to distinguish both universal parameters that are associated with atherosclerosis, regardless of its localization and/or severity, and specific biomarkers that characterize either the localization or the severity of atherosclerosis, or both.

scholarly journals Effect of Gum Arabic (Acacia Senegal )on C-reactive protein level among Sickle Cell Anemia patients

2020 ◽  
Author(s):  
Lamis AbdelGadir Kaddam ◽  
Anas Suliman Kaddam
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Protein Level ◽  
Daily Intake ◽  
Gum Arabic ◽  
Fetal Hemoglobin ◽  
C Reactive Protein ◽  
Acacia Senegal ◽  
Reactive Protein ◽  
Anti Inflammatory

Abstract Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia Senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients.Results : This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V=001) (95% CI, 0.943 -3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent can be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015

Effect of Gum Arabic (Acacia Senegal )on C-reactive protein level among Sickle Cell Anemia patients

2020 ◽  
Author(s):  
Lamis AbdelGadir Kaddam ◽  
Anas Suliman Kaddam
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Protein Level ◽  
Daily Intake ◽  
Gum Arabic ◽  
Fetal Hemoglobin ◽  
C Reactive Protein ◽  
Acacia Senegal ◽  
Reactive Protein ◽  
Anti Inflammatory

Abstract Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia Senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients. Results : This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V=001) (95% CI, 0.943 -3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent can be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.

Antioxidant biomarkers and cardiometabolic risk markers in an Aboriginal community in remote Australia: a cross-sectional study

2020 ◽  
pp. 1-12
Author(s):  
Lenette Knudsen ◽  
Jasmine G Lyons ◽  
Kerin O’Dea ◽  
Dirk L Christensen ◽  
Julie K Brimblecombe
Keyword(s):  
Diet Quality ◽  
Cardiometabolic Risk ◽  
Aboriginal People ◽  
Cross Sectional Study ◽  
Risk Markers ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Cardiometabolic Risk Markers

Abstract Objective: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators of diet quality, antioxidants, are associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants and cardiometabolic risk among Aboriginal people in Australia. Design: As part of a community-driven health promotion programme, we conducted a cross-sectional study including a health-behaviour questionnaire, plasma antioxidants and cardiometabolic risk markers (anthropometric, blood pressure measurements, fasting glucose, glycated Hb (HbA1c), lipids, C-reactive protein and albumin-creatinine-ratio) continuous and categorised into population-specific cut-offs. Antioxidants (β-carotene, β-cryptoxanthin, lycopene, lutein-zeaxanthin, retinol and α-tocopherol measured using HPLC) were applied to a principal component analysis, which aggregated these into a single component. Linear regression models were applied to investigate associations between the antioxidant component and cardiometabolic risk markers. Setting: Community in a remote area in Northern Territory, Australia. Participants: A total of 324 Aboriginal people, mean age 35·5 (range 15–75) years. Results: Antioxidant component levels were higher among individuals with higher self-reported vegetable intake (P < 0·01), higher among individuals with higher self-reported fruit intake (P = 0·05) and lower among current smokers (P = 0·06). Linear regression revealed an inverse association between the antioxidant component and C-reactive protein (β = –0·01, P < 0·01) after adjusting for confounders. Conclusion: Higher plasma antioxidant levels, indicators of diet quality, were associated with lower levels of high-sensitivity C-reactive protein in this Aboriginal population in remote Australia. This association suggests plasma antioxidants may be protective against inflammation; however, longitudinal studies are needed to examine this potentially protective relationship.

scholarly journals The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Karen Ingrid Tasca ◽  
Juliana Trindade Caleffi ◽  
Camila Renata Correa ◽  
Mariana Gatto ◽  
Caio Cavassan de Camargo ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
High Mobility ◽  
People Living With Hiv ◽  
C Reactive Protein ◽  
Metabolic Markers ◽  
Reactive Protein ◽  
Glycation End Products ◽  
Combined Antiretroviral Therapy ◽  
Living With Hiv ◽  
Asymptomatic Hiv

The development of the typical comorbidities of aging which currently affects people living with HIV/AIDS (PLWHA) can be partially ascribed to the persistent immune activation and chronic inflammation characterizing these individuals. The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. Analyses were performed longitudinally in 30 PLWHA, before and about 6–12 months after cART initiation. We observed that lower levels of AGEs in post-cART group were accompanied by an increase of CRP and triglyceride levels already in the early months of therapy. Because of the current ever-earlier recommendations to start cART and its prolonged use, these and other markers should be investigated in order to monitor and postpone the appearance of non-AIDS comorbidities in PLWHA.

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