scholarly journals Why and How to Use the Body’s Own Stem Cells for Regeneration in Musculoskeletal Disorders: A Primer

2021 ◽  
Author(s):  
John Furia ◽  
Mark Lundeen ◽  
Jason Hurd ◽  
David Pearce ◽  
Christopher Alt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Personalized Medicine ◽  
Blood Vessels ◽  
Musculoskeletal Disorders ◽  
Orthopedic Treatment ◽  
Holistic Thinking ◽  
Treatment Concepts ◽  
And Personalized Medicine

Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. The use of these autologous, unmodified stem cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which - albeit less efficiently - also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.

scholarly journals Why and How to Use the Body’s Own Stem Cells for Regeneration in Musculoskeletal Disorders: A Primer

2021 ◽  
Author(s):  
John Furia ◽  
Mark Lundeen ◽  
Jason Hurd ◽  
David Pearce ◽  
Christopher Alt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Musculoskeletal Disorders ◽  
Cultured Cells ◽  
Self Healing ◽  
Orthopedic Treatment ◽  
Isolated Cells ◽  
Healing Power ◽  
Treatment Concepts ◽  
Regenerative Cells

Background: Recently, the management of musculoskeletal disorders with the patients' own stem cells, isolated from the walls of small blood vessels, which can be found in great numbers in the adipose tissue, has received considerable attention. On the other hand, there are still misconceptions about these adipose-derived regenerative cells (ADRCs) that contain vascular-associated pluripotent stem cells (vaPS cells) in regenerative medicine. Methods: Based on our previous publications on this topic, we have developed a concept to describe the significance of the ADRCs/vaPS cells in the field of orthobiologics as briefly as possible and at the same time as precisely as possible. Results: The ADRCs/vaPS cells belong to the group of orthobiologics that are based on autologous cells. Because the latter can both stimulate a patient’s body's localized self-healing power and provide new cells that can integrate into the host tissue during the healing response when the localized self-healing power is exhausted, this group of orthobiologics appears more advantageous than cell-free orthobiologics and orthobiologics that are based on allogeneic cells. Within the group of orthobiologics that are based on autologous cells, enzymatically isolated, uncultured ADRCs/vaPS cells have several advantages over non-enzymatically isolated cells/microfragmented fat as well as over uncultured bone marrow aspirate concentrate and cultured cells (adipose-derived stem cells, bone marrow-derived mesenchymal stem cells). Conclusions: The use of ADRCs/vaPS cells can be seamlessly integrated into modern orthopedic treatment concepts, which can be understood as the optimization of a process which - albeit less efficiently - also takes place physiologically. Accordingly, this new safe and effective type of treatment is attractive in terms of holistic thinking and personalized medicine.

scholarly journals Stem cell drugs: the next generation of pharmaceutical products

2016 ◽  
Vol 3 (10) ◽  
pp. 857 ◽  
Author(s):  
Phuc Van Pham
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Personalized Medicine ◽  
Regenerative Medicine ◽  
Pharmaceutical Products ◽  
Patient Needs ◽  
Disease Treatment ◽  
New Treatment ◽  
And Personalized Medicine ◽  
Live Stem Cell

Stem cells represent a new treatment option in medicine and pharmacy. Stem cells have been increasingly used for the treatment of many diseases. In fact, they have spurred a new age of medicine called regenerative medicine. In recent years, regenerative medicine has become a new revolution in disease treatment, especially with the use of stem cell drugs. Stem cell drugs refer to live stem cell based products that used as drugs for particular diseases. Unlike autologous stem cell transplantation, stem cell drugs are “off-the-shelf” products that are ready to be used without requirement of any further manipulation. This review aims to summarize some of the approved stem cell drugs, and discuss the revolution of regenerative medicine and personalized medicine. As well, the review will discuss how stem cell drugs have led to a new direction in stem cell therapy, providing a new platform for patient needs.

scholarly journals Modeling Adipogenesis: Current and Future Perspective

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2326 ◽  
Author(s):  
Hisham F. Bahmad ◽  
Reem Daouk ◽  
Joseph Azar ◽  
Jiranuwat Sapudom ◽  
Jeremy C. M. Teo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Crucial Role ◽  
Critical Role ◽  
Treatment Modalities ◽  
Future Perspective ◽  
Adipose Derived Stem Cells ◽  
Physiological Importance ◽  
And Personalized Medicine

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells’ differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.

The future of glioma treatment: stem cells, nanotechnology and personalized medicine

2012 ◽  
Vol 8 (9) ◽  
pp. 1149-1156 ◽  
Author(s):  
Maryam Rahman ◽  
Brian Hoh ◽  
Nathan Kohler ◽  
Erin M Dunbar ◽  
Gregory JA Murad
Keyword(s):  
Stem Cells ◽  
Personalized Medicine ◽  
The Future ◽  
And Personalized Medicine

scholarly journals Identification of Angiogenic Cargo in Extracellular Vesicles Secreted from Human Adipose Tissue-Derived Stem Cells and Induction of Angiogenesis In Vitro and In Vivo

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 495
Author(s):  
Prakash Gangadaran ◽  
Ramya Lakshmi Rajendran ◽  
Ji Min Oh ◽  
Eun Jung Oh ◽  
Chae Moon Hong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Adipose Tissue ◽  
Blood Vessels ◽  
Extracellular Vesicles ◽  
Human Adipose Tissue ◽  
Antibody Array ◽  
Angiogenic Proteins

Angiogenesis is defined as the generation of new blood vessels or the sprouting of endothelial cells from a pre-existing vascular network. Angiogenesis occurs during the growth and development of an organism, the response of organs or tissues to injury, and during cancer development and progression. The majority of studies on stem-cell-derived extracellular vesicles (EVs) have used cell lines, and have primarily focused on well-known solitary proteins. Here, we isolated stem cells from human adipose tissue (ADSCs), and we isolated EVs from them (ADSC-EVs). The ADSC-EVs were characterised and 20 angiogenic proteins were analysed using an angiogenic antibody array. Furthermore, we analysed the ability of ADSC-EVs to induce angiogenesis in vitro and in vivo. ADSC-EVs were positive for CD81 and negative for GM130, calnexin, and cytochrome-C. ADSC-EVs showed typical EV spherical morphology and were ~200 nm in size. ADSC-EVs were found to contain angiogenic proteins as cargo, among which interleukin 8 (IL-8) was the most abundant, followed by chemokine (C-C motif) ligand 2 (CCL2), a tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2, and vascular endothelial growth factor-D (VEGF-D). ADSC-EVs treatment increased the proliferation, migration, total vessel length, total number of junctions, and junction density of endothelial cells in vitro. The results of an in vivo Matrigel plug assay revealed that ADSC-EVs induced more blood vessels in the Matrigel compared with the control. These results demonstrate that ADSC-EVs contain angiogenic proteins as cargo and promote angiogenesis in vitro and in vivo. Therefore, ADSC-EVs have potential for therapeutic use in ischaemia.

scholarly journals Influence of Adipose Tissue-Derived Stem Cells on the Burn Wound Healing Process

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Claudio Luciano Franck ◽  
Alexandra Cristina Senegaglia ◽  
Lidiane Maria Boldrini Leite ◽  
Sérgio Adriane Bezerra de Moura ◽  
Nathália Forti Francisco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Blood Vessels ◽  
Inflammatory Infiltrate ◽  
Protein Denaturation ◽  
Healing Process ◽  
Lymphatic Vessels ◽  
The Body ◽  
Wound Healing Process ◽  
Burn Wound

Burns are lesions in which the thermal energy of the causative agent transfers heat to the surface of the body, causing superficial or deep damage to the skin with protein denaturation in cells and biochemical maladjustments, which delay and disrupt the cicatricial process, increasing the chances of functional and aesthetic sequelae. This study evaluates the influence of adipose tissue-derived stem cells (ADSCs) on burn healing in terms of the size of the cicatricial space and quantified measures of collagen deposition, inflammatory infiltrate, blood vessels, and lymphatic vessels. Initially, intra-abdominal adipose tissue was resected from a single donor Wistar rat that was not part of any of the subsequent groups to obtain ADSCs by isolation and cell culture. Burns were made in the left lateral abdominal region of Wistar rats by contact with a square ceramic paper with a 484 mm2 area heated to 100°C for 30 seconds. Intradermal ADSC transplantation was performed in two stages. The first was on the same day of the burn, when 3.2×106 ADSCs were transplanted shortly after the burned region cooled, while the second stage occurred four days later with the same number of ADSCs. The progress was evaluated by immunohistochemical methods and H&E, Masson’s trichrome, Picrosirius red, and Lyve-1 immunofluorescence staining. Despite the quantitative similarity of blood vessels and the inflammatory infiltrate observed by H&E, there were statistically significant differences between the groups on the fourteenth day of evolution. The group that received ADSCs showed a reduction in the scar tissue area, increased collagen type III deposition, and a quantifiable reduction in lymphatic vessels, so we conclude that ADSCs influence the healing of total thickness burns in rats.

scholarly journals The Future State of Newborn Stem Cell Banking

2019 ◽  
Vol 8 (1) ◽  
pp. 117 ◽  
Author(s):  
Katherine Brown ◽  
Mahendra Rao ◽  
Heather Brown
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Personalized Medicine ◽  
Blood Banks ◽  
Cell Banking ◽  
The Future ◽  
Future Potential ◽  
Stem Cell Banking ◽  
Cord Blood Banks ◽  
And Personalized Medicine

Newborn stem cell banking began with the establishment of cord blood banks more than 25 years ago. Over the course of nearly three decades, there has been considerable evolution in the clinical application of stem cells isolated from newborn tissues. The industry now finds itself at an inflection point as personalized medicine and regenerative medicine continue to advance. In this review, we summarize our perspective on newborn stem cell banking in the context of the future potential that stem cells from perinatal tissues are likely to play in nascent applications. Specifically, we describe the relevance of newborn stem cell banking and how the cells stored can be utilized as starting material for the next generation of advanced cellular therapies and personalized medicine.

scholarly journals Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine

2020 ◽  
Vol 8 ◽  
pp. 100055
Author(s):  
Angelika Lampert ◽  
David L. Bennett ◽  
Lucy A. McDermott ◽  
Anika Neureiter ◽  
Esther Eberhardt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Personalized Medicine ◽  
Sensory Neurons ◽  
Pluripotent Stem Cells ◽  
Disease Modelling ◽  
And Personalized Medicine
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