scholarly journals An Optimization of Functional Monomer, A Preliminary Study of Meropenem Imprinted Polymer as Selective Sorbent

2018 ◽  
Vol 3 (2) ◽  
pp. 103 ◽  
Author(s):  
Lasmaryna Sirumapea ◽  
Muhammad Ali Zulfikar ◽  
M. Bachri Amran ◽  
Anita Alni
Keyword(s):  
High Selectivity ◽  
Polymerization Process ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Lactam Ring ◽  
Preliminary Study ◽  
Main Components ◽  
The Right ◽  
Selection Of

<p>Molecularly imprinted polymer is a polymer that synthesized together with targeted molecule (analyte) through polymerization process. When the polymerization has completed, extraction is taken to pull the analyte out of the polymer, and it will give a specific “frame” of targeted molecule which leave cavities and further is used to give specific recognition of the analyte. Functional monomer, template molecule, crosslinker agent, porogenic solvent and initiator are the main components involved in the synthesis of this kind of polymer. The right functional monomer is needed to make polymer building block with high selectivity when used as sorbent. The selection of suitable and precise functional monomer has been elaborated in this study. methacrylate acid, itaconic acid and acrylamide is then studies as functional monomer that will be chosen to give the best polymer performance as sorbent. From IR spectrum results, it can be concluded that polymer has been synthesized successfully. Peak at 1157 cm<sup>-1</sup> which is a peak of C-N bond from β-lactam ring support this statement.  Finally, it can be concluded that methacrylate acid is the best functional monomer for making polymer as sorbent for meropenem</p>

scholarly journals Interaction Study, Synthesis and Characterization of Molecular Imprinted Polymer Using Functional Monomer Methacrylate Acid and Dimethylamylamine as Template Molecule

2018 ◽  
Vol 16 (1) ◽  
pp. 12 ◽  
Author(s):  
Saeful Amin ◽  
Sophi Damayanti ◽  
Slamet Ibrahim
Keyword(s):  
Synthesis And Characterization ◽  
Template Molecule ◽  
Functional Monomer ◽  
Molecular Imprinted Polymer ◽  
Glycol Dimethacrylate ◽  
Interaction Study ◽  
Imprinted Polymer ◽  
Infrared Spectrophotometer ◽  
Scanning Electron

The research related to the interaction study, synthesis and characterization of molecular imprinted polymer using dimethylamylamine (DMAA) as the template molecule and the functional monomer methacrylate acid has been conducted. Molecular Imprinted Polymer (MIP) is a separation method made by the molecule template in the polymer matrix followed by removing the template molecule by washing for giving the permanent framework groove. The MIP was made by mixing the DMAA as the template molecule, with the methacrylate acid as the functional monomer, and the ethylene glycol dimethacrylate (EGDMA) as the crosslinker with the ratio 1:6:20. Porogen solvents used were the chloroform and the initiator azobisisobutyronitrile (AIBN). The crystal MIP and the NIP without the DMAA were characterized using Infrared Spectrophotometer (FTIR), and the result showed that there have been differences among the MIP, the NIP and the MIP after being extracted. The characterization using Scanning Electron Microscope (SEM) showed that the NIP as the comparison having flat morphology, while the MIP having irregular morphology and less pores. Then the MIP after being extracted has irregular, rough morphology and a lot of pores. The result reveals the interaction between the DMAA and the methacrylate acid that is the hydrogen bonded with the Gibbs free energy obtained is -5.434 j/mol. The imprinting factor of 2,353 is obtained. The highest desorption descending capacity is chloroform with the MIP 738% better. For the MIP and NIP methanol, it is found that the MIP is 123% better. Then the MIP which is desorbed by the chloroform is better 602% than the MIP resorbed by the methanol, and the ethyl acetate cannot desorb the DMAA.

Cholesterol-Imprinted Receptor Using Chitosan Derivative as the Precursor

2013 ◽  
Vol 699 ◽  
pp. 712-717
Author(s):  
Huai Min Guan ◽  
Yue Jin Tong ◽  
Jin Hua Zheng ◽  
Xiang Li
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Polar Solvent ◽  
Binding Capacity ◽  
Template Molecule ◽  
Chitosan Derivative ◽  
Amino Groups ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Protection ◽  
Selection Of

Research has been focused on the development of molecularly imprinted polymers using a chitosan derivative as the precursor. An O-acyl chitosan was synthesized by the selective protection of amino groups of chitosan in MeSO3H and was cross-linked with glutaraldehyde in the presence/ absence of template molecule, cholesterol. The effect of the degree of the acyl substitution on the selection of precursor was investigated, regarding the solubility of chitosan derivative, interaction between the precursor and imprinted molecule, and degree of the cross-linking of precursor. The rebinding experiments indicated the significant recognition for cholesterol with imprinted polymer as compared with non-imprinted polymer. It was found that a good binding capacity of the imprinted polymer towards cholesterol could be achieved in a less-polar solvent. And the O-acyl chitosan-based molecularly imprinted polymer obtained displayed good recognition selectivity for cholesterol in comparison to similarly strctural analogue, cholesterol acetate.

Highly Selectivity Molecularly Imprinted Fluorescence Sensor Based on Carbon Quantum Dots for the Determination of Anthraquinones

2021 ◽  
Vol 21 (4) ◽  
pp. 2109-2116
Author(s):  
Yangyang Li ◽  
Xiuzhen Qiu ◽  
Yulin Wang ◽  
Huishi Guo ◽  
Libo Nie
Keyword(s):  
Quantum Dots ◽  
High Selectivity ◽  
Theoretical Calculations ◽  
Carbon Quantum Dots ◽  
Fluorescence Sensor ◽  
Template Molecule ◽  
Functional Monomer ◽  
Hydrogen Binding ◽  
Molecularly Imprinted ◽  
Target Molecules

Due to the complexity of traditional Chinese medicines (TCMs), it is very important to develop a method that can recognize anthraquinones, the active ingredients in TCMs, with high selectivity. Here, a molecularly imprinted fluorescence sensor was coated on the surface of carbon quantum dots (CDs). Allobarbital was used as functional monomer for this application using theoretical calculations and was successfully synthesized and characterized. The template molecule chrysophanol was combined with the functional monomer allobarbital using a hydrogen bond array. Then, a series of adsorption experiments were performed to study the specific recognition of anthraquinones by the prepared sensors. The results showed that the prepared sensor had a good linear response to concentrations of chrysophanol in the concentration range 0.5 mg · L-1 to 8.0 mg · L-1, a low detection limit (5.0 μg · L-1), high stability, and a short response time (20 min). Additionally, the obtained fluorescence sensor was successfully applied to selectively recognize anthraquinones in TCMs with recoveries of 90.1% to 101.7%. The prepared sensor displays excellent sensitivity and high selectivity towards anthraquinones, mainly due to the specific hydrogen binding sites for the target molecules. Overall, this fluorescence sensor can selectively recognize anthraquinones in TCMs, and provide a method for quality monitoring and rational utilization of TCMs.

Imprinted β-Cyclodextrin Polymer for Recognition of Naringin

2011 ◽  
Vol 284-286 ◽  
pp. 1850-1853
Author(s):  
Xi Zheng ◽  
Xiu Ling Ma ◽  
Hong Fang Xie ◽  
Shao Bin Li ◽  
Yu Xi Ren ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Hexamethylene Diisocyanate ◽  
Template Molecule ◽  
Binding Property ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Cyclodextrin Polymer ◽  
Equilibrium Binding ◽  
Binding Experiment ◽  
Cross Linker

The objective of this study was to find out a kind of MIP which was suitable for recognizing NG in aqueous medium. A non-covalent NG-β-CD imprinted polymer was prepared by using β-cyclodextrine (β-CD) as a functional monomer, naringin (NG) as a template molecule and hexamethylene diisocyanate (HMDI) as cross linker. The binding property and selectivity were evaluated by the equilibrium binding experiment, its imprinting factors α is 1.39.

scholarly journals Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

2018 ◽  
Author(s):  
Christopher S. Storer ◽  
Zachary Coldrick ◽  
Daniel Tate ◽  
Jack Marsden Donoghue ◽  
Bruce Grieve
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Nutrient Sensing ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Phosphate Nitrate ◽  
Lcr Meter ◽  
Phosphate Detection ◽  
Interference Study

An interdigitated electrode sensor was designed and microfabricated for measuring the changes in the capacitance of three phosphate selective molecularly imprinted polymer (MIP) formulations, in order to provide hydroponics users with a portable nutrient sensing tool. The MIPs investigated were synthesised using different combinations of the functional monomers methacrylic acid (MAA) and N-allylthiourea, against the template molecules diphenyl phosphate, triethyl phosphate and trimethyl phosphate. A cross-interference study between phosphate, nitrate and sulfate was carried out for the MIP materials using an inductance, capacitance and resistance (LCR) meter. Capacitance measurements were taken applying an alternating current (AC) with a potential difference of 1 V root mean square (RMS) at a frequency of 1 kHz. The cross-interference study demonstrated a strong binding preference to phosphate over the other nutrient salts tested for each formulation. The size of template molecule and length of the functional monomer side groups also determined that a combination of a short chain functional monomer in combination with a template containing large R-groups produced the optimal binding site conditions when synthesising a phosphate selective MIP.

Molecularly Imprinted Microspheres for Highly Selective Separation of Diosgenin

2011 ◽  
Vol 382 ◽  
pp. 303-306
Author(s):  
Jing Yi Hou ◽  
Xiao Yan Han ◽  
Ye Zhang ◽  
Shu Ding ◽  
Lei Ye
Keyword(s):  
Large Scale ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Reaction Conditions ◽  
Molecularly Imprinted ◽  
Synthetic Materials ◽  
Molecular Imprinting Polymers ◽  
Chinese Medicinal Plants ◽  
Optimal Reaction

Molecular imprinting polymers (MIPs) are synthetic materials having specific cavities which are highly specific towards the template molecule. In this paper, diosgenin-imprinted polymer microspheres (DG-MIPs) were prepared by precipitation polymerization, using diosgenin as template, methacrylic acid as functional monomer and ethyleneglycol dimethacrylate as crosslinker. The morphology and adsorption capacity of the microspheres were evaluated by HPLC and Scanning electron microscopy (SEM). The optimal reaction conditions were as follows: 2 mM DG, 6 mM MMA, 60 mM EGDMA and 4 mM AIBN. The method developed might be used to separate and extract effective constituents from Chinese medicinal plants on a large scale.

scholarly journals Delayed Addition of Template Molecules Enhances the Binding Properties of Diclofenac-Imprinted Polymers

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1178 ◽  
Author(s):  
Laura Anfossi ◽  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Giulia Spano ◽  
Cristina Giovannoli ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Polymerization Process ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Binding Selectivity ◽  
Binding Properties ◽  
Imprinted Polymers ◽  
Binding Data ◽  
Binding Isotherms ◽  
The Stability

It has been reported that in the molecular imprinting technique, the use of preformed oligomers instead of functional monomers increases the stability of the non-covalent interactions with the template molecule, providing a sharp gain in terms of binding properties for the resulting imprinted polymer. Based on this theory, we assumed that the delayed addition of template molecules to a polymerization mixture enhances the binding properties of the resulting polymer. To verify this hypothesis, we imprinted several mixtures of 4-vinylpyridine/ethylene dimethacrylate (1:6 mol/mol) in acetonitrile by adding diclofenac progressively later from the beginning of the polymerization process. After polymerization, the binding isotherms of imprinted and non-imprinted materials were measured in acetonitrile by partition equilibrium experiments. Binding data confirm our hypothesis, as imprinted polymers prepared by delayed addition, with delay times of 5 and 10 min, showed higher binding affinity (Keq = 1.37 × 104 L mol−1 and 1.80 × 104 L mol−1) than the polymer obtained in the presence of template at the beginning (Keq = 5.30 × 103 L mol−1). Similarly, an increase in the imprinting factor measured vs. the non-imprinted polymer in the binding selectivity with respect to mefenamic acid was observed. We believe that the delayed addition approach could be useful in prepar imprinted polymers with higher binding affinity and increased binding selectivity in cases of difficult imprinting polymerization.

Synthesis and evaluation of a molecularly imprinted polymer with high-efficiency recognition for dibutyl phthalate based on Mn-doped ZnS quantum dots

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54615-54622 ◽  
Author(s):  
Tao Li ◽  
Zhikun Gao ◽  
Ningwei Wang ◽  
Zhiping Zhou ◽  
Wanzhen Xu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Molecularly Imprinted Polymers ◽  
Dibutyl Phthalate ◽  
High Efficiency ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Cross Linker ◽  
Mn Doped

Molecularly imprinted polymers with Mn-doped ZnS quantum dots were prepared using dibutyl phthalate as the template molecule, 3-aminopropyltriethoxysilane as the functional monomer and the tetraethoxysilane as the cross-linker.

scholarly journals Synthesis and Characterization of a Molecularly Imprinted Polymer of Spermidine and the Exploration of Its Molecular Recognition Properties

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1389 ◽  
Author(s):  
Yu-Jie Huang ◽  
Rui Chang ◽  
Qiu-Jin Zhu
Keyword(s):  
Molar Ratio ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Polymer Complexes ◽  
Molecular Imprinting Technology ◽  
Recognition Ability ◽  
Scatchard Equation ◽  
Factor Α

Spermidine is a functional ingredient that can extend the lifespan of many foods and indicate meat safety. However, its synthesis and enrichment is expensive and complex. To develop an effective separation material that can offer highly selective recognition of spermidine, we first applied non-covalent molecular imprinting technology using methacrylic acid as a functional monomer, azobisisobutyronitrile as an initiator, and ethylene glycol dimethacrylate as a cross-linker. The adsorption properties of the polymers were analyzed using the Scatchard equation, the Lagergren kinetic equation, and the static distribution coefficient. The optimal polymerization molar ratio of the template molecule spermidine to the functional monomer was 1:4, the maximum adsorption amount was 97.75 μmol/g, and the adsorption equilibrium time was 300 min. The selective experiment showed that the interfering substances tyramine and histamine had selectivity factor α values of 2.01 and 1.78, respectively, indicating that the prepared polymer had good spermidine recognition ability. The density function theory calculations showed that the hydrogen bond strength, steric effect, and product energy caused adsorption and separation differences among the different imprinted polymer complexes.

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