scholarly journals Synthesis and Characterization of a Molecularly Imprinted Polymer of Spermidine and the Exploration of Its Molecular Recognition Properties

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1389 ◽  
Author(s):  
Yu-Jie Huang ◽  
Rui Chang ◽  
Qiu-Jin Zhu
Keyword(s):  
Molar Ratio ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Polymer Complexes ◽  
Molecular Imprinting Technology ◽  
Recognition Ability ◽  
Scatchard Equation ◽  
Factor Α

Spermidine is a functional ingredient that can extend the lifespan of many foods and indicate meat safety. However, its synthesis and enrichment is expensive and complex. To develop an effective separation material that can offer highly selective recognition of spermidine, we first applied non-covalent molecular imprinting technology using methacrylic acid as a functional monomer, azobisisobutyronitrile as an initiator, and ethylene glycol dimethacrylate as a cross-linker. The adsorption properties of the polymers were analyzed using the Scatchard equation, the Lagergren kinetic equation, and the static distribution coefficient. The optimal polymerization molar ratio of the template molecule spermidine to the functional monomer was 1:4, the maximum adsorption amount was 97.75 μmol/g, and the adsorption equilibrium time was 300 min. The selective experiment showed that the interfering substances tyramine and histamine had selectivity factor α values of 2.01 and 1.78, respectively, indicating that the prepared polymer had good spermidine recognition ability. The density function theory calculations showed that the hydrogen bond strength, steric effect, and product energy caused adsorption and separation differences among the different imprinted polymer complexes.

scholarly journals Interaction Study, Synthesis and Characterization of Molecular Imprinted Polymer Using Functional Monomer Methacrylate Acid and Dimethylamylamine as Template Molecule

2018 ◽  
Vol 16 (1) ◽  
pp. 12 ◽  
Author(s):  
Saeful Amin ◽  
Sophi Damayanti ◽  
Slamet Ibrahim
Keyword(s):  
Synthesis And Characterization ◽  
Template Molecule ◽  
Functional Monomer ◽  
Molecular Imprinted Polymer ◽  
Glycol Dimethacrylate ◽  
Interaction Study ◽  
Imprinted Polymer ◽  
Infrared Spectrophotometer ◽  
Scanning Electron

The research related to the interaction study, synthesis and characterization of molecular imprinted polymer using dimethylamylamine (DMAA) as the template molecule and the functional monomer methacrylate acid has been conducted. Molecular Imprinted Polymer (MIP) is a separation method made by the molecule template in the polymer matrix followed by removing the template molecule by washing for giving the permanent framework groove. The MIP was made by mixing the DMAA as the template molecule, with the methacrylate acid as the functional monomer, and the ethylene glycol dimethacrylate (EGDMA) as the crosslinker with the ratio 1:6:20. Porogen solvents used were the chloroform and the initiator azobisisobutyronitrile (AIBN). The crystal MIP and the NIP without the DMAA were characterized using Infrared Spectrophotometer (FTIR), and the result showed that there have been differences among the MIP, the NIP and the MIP after being extracted. The characterization using Scanning Electron Microscope (SEM) showed that the NIP as the comparison having flat morphology, while the MIP having irregular morphology and less pores. Then the MIP after being extracted has irregular, rough morphology and a lot of pores. The result reveals the interaction between the DMAA and the methacrylate acid that is the hydrogen bonded with the Gibbs free energy obtained is -5.434 j/mol. The imprinting factor of 2,353 is obtained. The highest desorption descending capacity is chloroform with the MIP 738% better. For the MIP and NIP methanol, it is found that the MIP is 123% better. Then the MIP which is desorbed by the chloroform is better 602% than the MIP resorbed by the methanol, and the ethyl acetate cannot desorb the DMAA.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

Imprinted β-Cyclodextrin Polymer for Recognition of Naringin

2011 ◽  
Vol 284-286 ◽  
pp. 1850-1853
Author(s):  
Xi Zheng ◽  
Xiu Ling Ma ◽  
Hong Fang Xie ◽  
Shao Bin Li ◽  
Yu Xi Ren ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Hexamethylene Diisocyanate ◽  
Template Molecule ◽  
Binding Property ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Cyclodextrin Polymer ◽  
Equilibrium Binding ◽  
Binding Experiment ◽  
Cross Linker

The objective of this study was to find out a kind of MIP which was suitable for recognizing NG in aqueous medium. A non-covalent NG-β-CD imprinted polymer was prepared by using β-cyclodextrine (β-CD) as a functional monomer, naringin (NG) as a template molecule and hexamethylene diisocyanate (HMDI) as cross linker. The binding property and selectivity were evaluated by the equilibrium binding experiment, its imprinting factors α is 1.39.

Molecularly Imprinted Polymer Prepared by Precipitation Polymerization for Quercetin

2011 ◽  
Vol 306-307 ◽  
pp. 646-648 ◽  
Author(s):  
Hua Min Qiu ◽  
Chuan Nan Luo ◽  
Lu Lu Fan ◽  
Zhen Lv ◽  
Fu Guang Lu
Keyword(s):  
Precipitation Polymerization ◽  
Adsorption Properties ◽  
Nanometer Scale ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Adsorption Temperature ◽  
Molecular Imprinting Technology ◽  
Interference Test ◽  
Cross Linker

In this paper, molecular imprinted polymer for quercetin was synthesized by precipitation polymerization with acrylamide as functional monomer, ethylene glycol dimethacrylate as cross-linker, 2,2-azobisisobutyronitrile as initiator and acetone as the solvent. The polymers’ adsorption properties were characterized. As results shown that the synthesized imprinted polymer is microspheres with particle size in the nanometer scale, the adsorption capacity of quercetin imprinted polymers is 1.1×10-5mol/g, adsorption temperature is 60°C, adsorption time is 30 min. The molecular imprinting technology was introduced in interference test with a satisfactory result in selectivity.

scholarly journals Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

2018 ◽  
Author(s):  
Christopher S. Storer ◽  
Zachary Coldrick ◽  
Daniel Tate ◽  
Jack Marsden Donoghue ◽  
Bruce Grieve
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Nutrient Sensing ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Phosphate Nitrate ◽  
Lcr Meter ◽  
Phosphate Detection ◽  
Interference Study

An interdigitated electrode sensor was designed and microfabricated for measuring the changes in the capacitance of three phosphate selective molecularly imprinted polymer (MIP) formulations, in order to provide hydroponics users with a portable nutrient sensing tool. The MIPs investigated were synthesised using different combinations of the functional monomers methacrylic acid (MAA) and N-allylthiourea, against the template molecules diphenyl phosphate, triethyl phosphate and trimethyl phosphate. A cross-interference study between phosphate, nitrate and sulfate was carried out for the MIP materials using an inductance, capacitance and resistance (LCR) meter. Capacitance measurements were taken applying an alternating current (AC) with a potential difference of 1 V root mean square (RMS) at a frequency of 1 kHz. The cross-interference study demonstrated a strong binding preference to phosphate over the other nutrient salts tested for each formulation. The size of template molecule and length of the functional monomer side groups also determined that a combination of a short chain functional monomer in combination with a template containing large R-groups produced the optimal binding site conditions when synthesising a phosphate selective MIP.

scholarly journals A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Roberta G. Machicote ◽  
Marcela A. Castillo ◽  
Maria E. Pacheco ◽  
Liliana Bruzzone
Keyword(s):  
Hydrolysis Product ◽  
Recognition System ◽  
Molar Ratio ◽  
Functional Monomer ◽  
Molecular Imprinted Polymer ◽  
Imprinted Polymer ◽  
Retention Capacity ◽  
The Matrix ◽  
Standard Additions ◽  
Flow Through

A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. The synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. The selected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). The proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. The developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.

scholarly journals An Optimization of Functional Monomer, A Preliminary Study of Meropenem Imprinted Polymer as Selective Sorbent

2018 ◽  
Vol 3 (2) ◽  
pp. 103 ◽  
Author(s):  
Lasmaryna Sirumapea ◽  
Muhammad Ali Zulfikar ◽  
M. Bachri Amran ◽  
Anita Alni
Keyword(s):  
High Selectivity ◽  
Polymerization Process ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Lactam Ring ◽  
Preliminary Study ◽  
Main Components ◽  
The Right ◽  
Selection Of

<p>Molecularly imprinted polymer is a polymer that synthesized together with targeted molecule (analyte) through polymerization process. When the polymerization has completed, extraction is taken to pull the analyte out of the polymer, and it will give a specific “frame” of targeted molecule which leave cavities and further is used to give specific recognition of the analyte. Functional monomer, template molecule, crosslinker agent, porogenic solvent and initiator are the main components involved in the synthesis of this kind of polymer. The right functional monomer is needed to make polymer building block with high selectivity when used as sorbent. The selection of suitable and precise functional monomer has been elaborated in this study. methacrylate acid, itaconic acid and acrylamide is then studies as functional monomer that will be chosen to give the best polymer performance as sorbent. From IR spectrum results, it can be concluded that polymer has been synthesized successfully. Peak at 1157 cm<sup>-1</sup> which is a peak of C-N bond from β-lactam ring support this statement.  Finally, it can be concluded that methacrylate acid is the best functional monomer for making polymer as sorbent for meropenem</p>

Molecularly Imprinted Microspheres for Highly Selective Separation of Diosgenin

2011 ◽  
Vol 382 ◽  
pp. 303-306
Author(s):  
Jing Yi Hou ◽  
Xiao Yan Han ◽  
Ye Zhang ◽  
Shu Ding ◽  
Lei Ye
Keyword(s):  
Large Scale ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Reaction Conditions ◽  
Molecularly Imprinted ◽  
Synthetic Materials ◽  
Molecular Imprinting Polymers ◽  
Chinese Medicinal Plants ◽  
Optimal Reaction

Molecular imprinting polymers (MIPs) are synthetic materials having specific cavities which are highly specific towards the template molecule. In this paper, diosgenin-imprinted polymer microspheres (DG-MIPs) were prepared by precipitation polymerization, using diosgenin as template, methacrylic acid as functional monomer and ethyleneglycol dimethacrylate as crosslinker. The morphology and adsorption capacity of the microspheres were evaluated by HPLC and Scanning electron microscopy (SEM). The optimal reaction conditions were as follows: 2 mM DG, 6 mM MMA, 60 mM EGDMA and 4 mM AIBN. The method developed might be used to separate and extract effective constituents from Chinese medicinal plants on a large scale.

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