scholarly journals The expression level and prognostic value of microRNA-15a-5p in endometrial carcinoma

2021 ◽  
Vol 10 (11) ◽  
pp. 4838-4844
Author(s):  
Jing Zhang ◽  
Dandan Zhang ◽  
Xiaofang Yan ◽  
Feizhou Jiang
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Value ◽  
Expression Level

scholarly journals Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 344
Author(s):  
Paul Kubelac ◽  
Cornelia Braicu ◽  
Lajos Raduly ◽  
Paul Chiroi ◽  
Andreea Nutu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Progression ◽  
Prognostic Value ◽  
Prognostic Significance ◽  
Expression Level ◽  
Additional Patient ◽  
Tumor Control ◽  
Hippo Signaling ◽  
Patient Cohort ◽  
Qrt Pcr

The Hippo signaling pathway, one of the most conserved in humans, controlling dimensions of organs and tumor growth, is frequently deregulated in several human malignancies, including ovarian cancer (OC). The alteration of Hippo signaling has been reported to contribute to ovarian carcinogenesis and progression. However, the prognostic roles of individual Hippo genes in OC patients remain elusive. Herein we investigated the expression level and prognostic value of key Hippo genes in OC using online databases, followed by a qRT-PCR validation step in an additional patient cohort. Using the GEPIA database, we observed an increased level for TP53 and reduced expression level for LATS1, LATS2, MST1, TAZ, and TEF in tumor tissue versus normal adjacent tissue. Moreover, LATS1, LATS2, TP53, TAZ, and TEF expression levels have prognostic significance correlated with progression-free survival. The qRT-PCR validation step was conducted in an OC patient cohort comprising 29 tumor tissues and 20 normal adjacent tissues, endorsing the expression level for LATS1, LATS2, and TP53, as well as for two of the miRNAs targeting the TP53 gene, revealing miR-25-3p upregulation and miR-181c-5p downregulation. These results display that there are critical prognostic value dysregulations of the Hippo genes in OC. Our data demonstrate the major role the conserved Hippo pathway presents in tumor control, underlying potential therapeutic strategies and controlling several steps modulated by miRNAs and their target genes that could limit ovarian cancer progression.

scholarly journals The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Chengquan Shen ◽  
Jing Liu ◽  
Jirong Wang ◽  
Xiaokun Yang ◽  
Haitao Niu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
T Cells ◽  
Survival Analysis ◽  
Prognostic Value ◽  
Molecular Mechanisms ◽  
Tyrosine Phosphatase ◽  
Gene Set Enrichment Analysis ◽  
Expression Level ◽  
Pathologic Features ◽  
The Relationship

PTPN6 (protein tyrosine phosphatase nonreceptor type 6), a tyrosine phosphatase, is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Previous studies have demonstrated that PTPN6 expression is relatively elevated in several malignancies. However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic value of PTPN6 in BC. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 in BC. The relationship between clinical pathologic features and PTPN6 were analyzed with the Wilcoxon signed-rank test. The prognostic and predictive value of PTPN6 was evaluated by survival analysis and nomogram. Gene Set Enrichment Analysis (GSEA) was conducted to explore the potential molecular mechanisms of PTPN6 in BC. Finally, Tumor Immune Estimation Resource (TIMER) was applied to investigate the relationship between PTPN6 and immune cell infiltration in the tumor microenvironment. Results indicated that PTPN6 was overexpressed in BC tissues compared with normal bladder tissues and was significantly correlated with grade, stage, T, and N. Survival analysis showed that low expression of PTPN6 was significantly related to the poor overall survival (OS) in BC patients. Coexpression analysis showed that PTPN6 and TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) have a close correlation in BC. GSEA showed that multiple cancer-associated signaling pathways are differentially enriched in the PTPN6 high expression phenotype. Moreover, the expression level of PTPN6 was positively associated with the infiltration of B cells, CD4+T cells, dendritic cells, and neutrophils and negatively associated with CD8+ T cells and macrophages in BC. In conclusion, we identified that PTPN6 may be a novel prognostic biomarker in BC based on the TCGA database. Further clinical trials are needed to confirm our observations and mechanisms underlying the prognostic value of PTPN6 in BC also deserve further experimental exploration.

Prognostic value of peritoneal cytology in endometrial carcinoma

1990 ◽  
Vol 33 (1) ◽  
pp. 87-87
Author(s):  
R.N. Grimshaw ◽  
W.C. Tupper ◽  
R.C. Fraser ◽  
M.G. Tompkins ◽  
J.F. Jeffrey
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Value ◽  
Peritoneal Cytology

Prognostic value of myometrial invasion and TCGA groups of endometrial carcinoma

2021 ◽  
Author(s):  
Antonio Raffone ◽  
Antonio Travaglino ◽  
Diego Raimondo ◽  
Daniele Neola ◽  
Federica Renzulli ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Value ◽  
Myometrial Invasion

scholarly journals Prognostic Value of Combined Analysis of CTLA-4 and PLR in Esophageal Squamous Cell Carcinoma (ESCC) Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Cui-Ying Zhang ◽  
Juan Zhang ◽  
Yun-Fan Ma ◽  
Hong Zhe ◽  
Ren Zhao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Cytotoxic T Lymphocyte ◽  
Expression Level ◽  
Prognostic Role ◽  
Combined Analysis

Objective. The purpose of this study was to evaluate the prognostic role of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) expression level and the platelet lymphocyte ratio (PLR) level in esophageal squamous cell carcinoma (ESCC) patients. Methods. 84 ESCC patients who received surgical treatment in our hospital were enrolled in the study. The correlation of each biomarker’s level with ESCC patients’ clinicopathological characteristics and overall survival (OS) was assessed. Results. The elevated expression rate of T-CTLA-4 (tumor cell CTLA-4) and I-CTLA-4 (interstitial lymphocyte CTLA-4) was 48.8% and 44.0%, respectively. The number of enrolled patients with a higher PLR level (≥119) was 48. The prognostic value of T-CTLA-4, I-CTLA-4, and PLR in ESCC patients was not detected. However, patients with both a low T-CTLA-4 expression level and a low PLR level that had longer OS (p=0.023) were found. The prognostic role of T-CTLA-4(-) +PLR (-) status in ESCC patients was also confirmed in multivariate analyses (p=0.027). Conclusion. These results demonstrated the potential prognostic value of combined analysis of CTLA-4 and PLR in ESCC patients.

scholarly journals The Expression Level and Prognostic Value of Y-Box Binding Protein-1 in Rectal Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119385 ◽  
Author(s):  
Yu Zhang ◽  
Ping-Wu Zhao ◽  
Gang Feng ◽  
Gang Xie ◽  
An-Qun Wang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Value ◽  
Binding Protein ◽  
Expression Level

Prognostic Value of DNA Ploidy and S-Phase Fraction in Stage I Endometrial Carcinoma

1995 ◽  
Vol 58 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Jacobus Pfisterer ◽  
Friedrich Kommoss ◽  
Willi Sauerbrei ◽  
Ina Rendl ◽  
Marion Kiechle ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Value ◽  
Dna Ploidy ◽  
S Phase ◽  
Stage I ◽  
Phase Fraction

Prospective Multicenter Validation Confirms the Prognostic Superiority of the Endometrial Carcinoma Prognostic Index in International Federation of Gynecology and Obstetrics Stage 1 and 2 Endometrial Carcinoma

2003 ◽  
Vol 21 (22) ◽  
pp. 4214-4221 ◽  
Author(s):  
Jan P.A. Baak ◽  
Wim Snijders ◽  
Bianca van Diermen ◽  
Paul J. van Diest ◽  
Fred W. Diepenhorst ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Prognostic Value ◽  
Dna Ploidy ◽  
Prognostic Index ◽  
Prognostic Indicator ◽  
International Federation ◽  
Kaplan Meier ◽  
Gynecology And Obstetrics ◽  
Stage 1 ◽  
Endometrial Carcinomas

Purpose: To validate the prognostic value of the endometrial carcinoma prognostic index (ECPI; combined myometrium invasion, flow cytometric DNA ploidy, and morphometric mean shortest nuclear axis [MSNA]) versus classic prognosticators. Patients and Methods: Prospective multicenter ECPI analysis was conducted in 463 endometrial carcinomas with a median of 6.5 years (range, 1 to 10 years) follow-up, review of pathology features, and univariate (Kaplan-Meier) and multivariate (Cox) analyses. Results: Initial routine and review diagnoses varied considerably (invasion depth, 11%; type, 20%; grade, 34%; vessel invasion, 72%); the review diagnoses were stronger prognostically. In International Federation of Gynecology and Obstetrics stage 1 (after histopathologic examination; pFIGO-1; n = 372; 38 deaths occurred as a result of disease [10.2%]), DNA ploidy was prognostic in hysterectomies (P < .00001) but not in curettages (P = .06). ECPI was a stronger prognostic indicator than other features. ECPI, MSNA, and DNA ploidy were also prognostic in pFIGO-1B and -1C subgroups. Multivariate analysis in pFIGO-1 showed that uterine MSNA ≤ versus > 7.93 μm (hazard ratio [HR], 3.4) and grade (as 1 + 2 v 3; HR, 2.6) added to the ECPI (HR, 32), but only in patients with an unfavorable ECPI of > 0.87. Adjuvant radiotherapy was not an independent prognostic factor in any of the subgroups. In pFIGO-2 (n = 46), ECPI, DNA-ploidy, and age (≤ 64, > 64 years) were significant. In FIGO-3 (n = 31) and FIGO-4 (n = 14), none of the classic or other features analyzed was of prognostic value, which explains why in previous studies using different mixtures of FIGO stages, DNA ploidy prognostic results varied. Conclusion: In endometrial carcinoma, DNA-ploidy is prognostic in hysterectomy and not in curettage samples. The ECPI is prognostically much stronger than the classic features widely used for therapy triage in pFIGO-1 and -2.

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