scholarly journals A sensitive spectrophotometric determination of tadalafil in pharmaceutical preparations and industrial wastewater samples

2013 ◽  
Vol 10 (3) ◽  
pp. 1005-1013 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Standard Deviation ◽  
Industrial Wastewater ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Average Recovery ◽  
Relative Standard ◽  
Wastewater Samples ◽  
Sensitive Spectrophotometric Method

A simple, accurate, precise, rapid, economical and a high sensitive spectrophotometric method has been developed for the determination of tadalafil in pharmaceutical preparations and industrial wastewater samples, which shows a maximum absorbance at 204 nm in 1:1 ethanol-water. Beer's law was obeyed in the range of 1-7?g/ mL ,with molar absorptivity and Sandell ? s sensitivity of 0.783x105l/mol.cm and 4.97 ng/cm2respectively, relative standard deviation of the method was less than 1.7%, and accuracy (average recovery %) was 100 ± 0. 13. The limits of detection and quantitation are 0.18 and 0.54 µg .ml-1, respectively. The method was successfully applied to the determination of tadalafil in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of tadalafil in true samples.

scholarly journals Eco- Friendly Method for the Estimation of Warfarin Sodium in Pharmaceutical Preparations and Environmental Wastewater Samples

2020 ◽  
pp. 1-3
Author(s):  
Nief Rahman Ahmed ◽  
Keyword(s):  
Industrial Wastewater ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Distilled Water ◽  
Average Recovery ◽  
Warfarin Sodium ◽  
Relative Standard ◽  
Wastewater Samples

A simple, precise, accurate, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of warfarin sodium in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at 310 nm in distilled water. Beer’s law was obeyed in the range of 2-30μg/ ml ,with molar absorptivity of 1.1 ×104 L.mol-1.cm-1 , relative standard deviation of the method was less than 1.8%, and accuracy (average recovery %) was 100 ± 1.0 . The method was successfully applied to the determination of warfarin sodium in some pharmaceutical formulations (Tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of warfarin sodium in true samples.

scholarly journals Estimation of Furosemide in Pharmaceutical Preparation Samples

2020 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Standard Deviation ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Oral Solution ◽  
Average Recovery ◽  
Relative Standard

A simple, accurate, precise, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of Furosemide in pharmaceutical preparations, which shows maximum absorbance at 228 nm in. Beer’s law was obeyed in the range of 1 -10 μg/ ml, with molar absorptivity of 3.5×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.4%, and accuracy (average recovery %) was 100 ± 1.0. The method was successfully applied to the determination of Furosemide in some pharmaceutical formulations (tablets, Oral solution and injection) samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Furosemide in true samples.

scholarly journals Colorimetric Determination of Paracetamol Using 9-Chloroacridine Reagent: Application to Pharmaceutical Formulations

2020 ◽  
Vol 63 (2) ◽  
pp. 71-78
Author(s):  
Firas Hassan Awad
Keyword(s):  
Standard Deviation ◽  
Pharmaceutical Formulations ◽  
Extraction Process ◽  
Molar Absorptivity ◽  
Colorimetric Determination ◽  
Average Recovery ◽  
Relative Standard ◽  
Recovery Percentage ◽  
The Stability

This paper aims to develop a simple, sensitive and accurate spectrophotometric method for quantitative determination of paracetamol in aqueous medium. The method is based on the reaction between the hydrolyzed paracetamol and 9-chloroacridine reagent (9-CA). The spectra of the product show maximum absorption at 436 nm. Beer's law is obeyed in the concentration range of 0.25-11 µg/mL with molar absorptivity value 5.3x103 L/mol/cm. The average recovery percentage (Rec%) is 99.27% and relative standard deviation (RSD) is :: 2.82%. In addition, the stability constant has been determined and the reaction mechanism is proposed. The method has been applied successfully for the assay of paracetamol in pharmaceutical formulations. It is found that the method does not require extraction process and it agree well with British pharmacopeia.    

scholarly journals Spectrophotometric determination of nicradipine and isradipine in pharmaceutical formulations

2009 ◽  
Vol 15 (2) ◽  
pp. 69-76 ◽  
Author(s):  
S.M. Al-Ghannam ◽  
A.M. Al-Olyan
Keyword(s):  
Standard Deviation ◽  
Detection Limit ◽  
Reaction Pathway ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Zinc Powder ◽  
Conditional Stability ◽  
Conditional Stability Constant

A sensitive spectrophotometric method was developed for the determination of some 1,4-dihydropyridine compounds namely, nicardipine and isradipine either in pure form or in pharmaceutical preparations. The method is based on the reduction of nicardipine and isradipine with zinc powder and calcium chloride followed by further reduction with sodium pentacyanoaminoferrate (II) to give violet and red products having the absorbance maximum at 546 and 539 nm with nicardipine and isradipine, respectively. Beer's law was obeyed over the concentration range 8.0-180 ?g/ml with the detection limit of 1.67 ?g/ml for nicardipine and 8.0-110 ?g/ml with the detection limit of 1.748 ?g/ml for isradipine. The analytical parameters and their effects on the reported methods were investigated. The molar absorptivity, quantization limit, standard deviation of intercept (Sa), standard deviation of slope (Sb) and standard deviation of the residuals (Sy/x) were calculated. The composition of the result compounds were found 1:1 for nicardipine and 1:2 for isradipine by Job's method and the conditional stability constant (Kf) and the free energy changes (?G) were calculated for compounds formed. The proposed method was applied successfully for the determination of nicardipine and isradipine in their dosage forms. The results obtained were in good agreement with those obtained using the reference or official methods. A proposal of the reaction pathway was presented.

scholarly journals Spectrophotometric Method for Determination of Paraquat in Food and Biological Samples

1997 ◽  
Vol 80 (2) ◽  
pp. 388-391 ◽  
Author(s):  
Ritu Kesari ◽  
Manish Rai ◽  
Vinay Kumar Gupta
Keyword(s):  
Standard Deviation ◽  
Metal Ions ◽  
Relative Standard Deviation ◽  
Alkaline Medium ◽  
Spectrophotometric Method ◽  
Biological Samples ◽  
Molar Absorptivity ◽  
Relative Standard ◽  
Sensitive Spectrophotometric Method

Abstract A sensitive spectrophotometric method was developed for determination of paraquat, a widely used herbicide. Paraquat was reduced with glucose in an alkaline medium, and the blue radical ion obtained was measured at 600 nm. Beer’s law was obeyed at 0.1–1.2 ppm paraquat. The molar absorptivity was 1.26 × 105 L mol-1 cm-1. The standard deviation and relative standard deviation were ± 0.007 and 2.0%, respectively, for 5 μg paraquat/10 mL analyzed over 7 days. The method was free from interference by other commonly used pesticides and metal ions. The method may be used to the determine paraquat in plants, fruits, grains, water, blood, and urine.

Spectrophotometric Determination of Boron in Dates of Some Cultivars Grown in Saudi Arabia

1993 ◽  
Vol 76 (3) ◽  
pp. 601-603 ◽  
Author(s):  
A A Al-Warthan ◽  
S S Al-Showiman ◽  
S A Al-Tamrah ◽  
A A BaOsman
Keyword(s):  
Saudi Arabia ◽  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Molar Absorptivity ◽  
Relative Standard ◽  
Sensitive Spectrophotometric Method

Abstract The formation of a red complex between boron and the quinalizarin reagent was investigated and used as the basis for a simple and sensitive spectrophotometric method for boron in date cultivars. At 620 nm, the absorbance was linear (r= 0.999) over the 0.25-2.5 μg/mL concentration range. The molar absorptivity was found to be 2.23 x 103mol-1cm-1 and the relative standard deviation for 10 replicates (1.0 μg/mL) was 0.97%.

Estimation of thiamine hydrochloride and sulphite using charge transfer complex reaction

2021 ◽  
Vol 2 (3) ◽  
pp. 49-61
Author(s):  
Basima Ahmed Abed Al-Hadi Saleem
Keyword(s):  
Present Method ◽  
Charge Transfer Complex ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Thiamine Hydrochloride ◽  
Complex Reaction ◽  
Average Recovery ◽  
Method Accuracy

A new spectrophotometric method is used for estimating Thiamine hydrochloride in its pure form and pharmaceutical formulations, the present method depends on the reaction between Thiamine hydrochloride and chrome azurol S to form a red complex which exhibit maximum absorption at 510 nm, the addition of Sulphite to the resulted red complex is bleaching it and this step was used for the determination of Sulphite which is considered an attacker of Thiamine hydrochloride, therefore, this method was developed for determination of Thiamine hydrochloride in presence of Sulphite. The linearity of the proposed method was obeyed Beer’s law from 2 to 48 and 0.04 to 2.4 ppm for Thiamine hydrochloride and Sulphite respectively. Also, the method sensitivity was measured by molar absorptivity values 5.9×104 l.mol-1.cm-1 and 1.68×104 l.mol-1.cm-1 for Thiamine hydrochloride and Sulphite respectively. The present method accuracy (average recovery) 100.06% and 100.04% the precision (RSD) of the method is ±0.98 - ±1.27% and ±0.76 - ±1.47 of Thiamine hydrochloride and Sulphite respectively. This method was applied for the estimation of B1 and SO32- in pharmaceutical preparations and various water samples respectively.

scholarly journals Determination of Meropenem by Spectrophotometric-Application to Pharmaceutical Preparations

2020 ◽  
Vol 25 (1) ◽  
pp. 68
Author(s):  
Nada A. Khalil ◽  
Walada H. Ibrahim
Keyword(s):  
Charge Transfer Complex ◽  
Concentration Level ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Sensitivity Index ◽  
Relative Standard ◽  
Better Than

A simple and sensitive spectrophotometric method was described for the determination of Meropenem in pure and in pharmaceutical formulations. 2,3 dichloro 5,6 dicyano 1,4 benzoquinone(DDQ)has been used for determination of meropenem by formation of charge transfer complex measured at 345 nm.Beer᾽s law is obeyed in the concentration range of (0.625-12.5µg/ml) The molar absorptivity (2.3889×104)l.mol1-.cm1-,Sandellʹs sensitivity index is 0.0161µg.cm2-,The method is precise (relative standard deviation RSD% is better than ±3.32%) and accurate (relative error in the range of -0.97 to-0.60%)  depending on the concentration  level. The method was applied succefully to the assay of Meropenem in pharmaceutical preparation in the form of injection.   http://dx.doi.org/10.25130/tjps.25.2020.012

scholarly journals Eco- Friendly Ultraviolet Spectrophotometric Determination of Allopurinol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing

2021 ◽  
pp. 1-3
Author(s):  
Nief Rahman Ahmed ◽  
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Industrial Wastewater ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Content Uniformity ◽  
Distilled Water ◽  
Content Uniformity Testing ◽  
Wastewater Samples

A simple, economical and sensitive UV spectrophotometric method has been developed for the determination of allopurinol in environmental wastewater samples and, pharmaceutical preparations which shows maximum absorbance at 250 nm in distilled water. Beer’s law was obeyed in the range of 1 - 20 μg/ ml, with molar absorptive of 0.628 x104 l/mol.cm L.mol-1.cm-1 .The method was successfully applied to the determination of allopurinol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of allopurinol in true samples.

scholarly journals Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

2009 ◽  
Vol 6 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Alka Gupta ◽  
P. Mishra ◽  
K. Shah
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pure Form ◽  
Ultraviolet Region ◽  
Rosuvastatin Calcium ◽  
Sensitive Spectrophotometric Method

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies

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