Successful and Efficient Drill & Drive Conductor Operation in Offshore East Java

2021 ◽  
Author(s):  
Muhammad Ikhsan Akbar ◽  
Jerry Tobing ◽  
Mohd Zarir Bin Musa ◽  
Irshad Fajar ◽  
Fajar Ardiansyah

Abstracts Conductor setting depth is critical to provide structural support for next drilling sections. The shoe strength must suffice for drilling ahead and avoid any washout and unstable zone. The objective is to design and run conductor smoothly in regards to engineering and operation aspect. Multidisciplinary approach including geotechnical, drilling engineering, and structure, was implemented during planning strategy. The pre-determined conductor setting depth was defined on the maximum mud weight to be used during drilling surface hole section in accordance to the formation strength below the conductor with the purpose of not inducing losses to the formation. Lateral distance between conductor and platform jacket pile was also analyzed to secure the jacket integrity. Anti-collision analysis was performed to prevent collision due to the existence of production well in same platform. Conductor pipe size and specification with some feature was defined to withstand under anticipated load and environment. To determine the way to achieve target depth and the suitability of hammer type, drivability analysis was performed with various anticipated condition. Considering shallow refusal depth, drill and drive was required to reduce shaft friction of soil. Another environmental challenge arise during conductor operation was unable to contain fluid and cutting returns from clean-out process causing return to cover part of the production platform facility. Some of technology were planned to mitigate this challenge. By having comprehensive conductor design, the conductor pipe in all four wells drilled has been successfully installed without any problem on platform jacket integrity and subsequent drilling section. This approach also enabled to efficiency of conductor installation where the number of clean-out and driving run could be reduced. The overflow return challenge could be fully contained by utilizing selfdesigned equipment. The overall operation days of conductor has shown improvement with 1.02 saving days on the last well which equivalent to amount of cost saving around USD 203,500.

2018 ◽  
Vol 2 (3) ◽  
pp. 433-442 ◽  
Author(s):  
Qiong Wang ◽  
Michael J. Betenbaugh

As a complex and common post-translational modification, N-linked glycosylation affects a recombinant glycoprotein's biological activity and efficacy. For example, the α1,6-fucosylation significantly affects antibody-dependent cellular cytotoxicity and α2,6-sialylation is critical for antibody anti-inflammatory activity. Terminal sialylation is important for a glycoprotein's circulatory half-life. Chinese hamster ovary (CHO) cells are currently the predominant recombinant protein production platform, and, in this review, the characteristics of CHO glycosylation are summarized. Moreover, recent and current metabolic engineering strategies for tailoring glycoprotein fucosylation and sialylation in CHO cells, intensely investigated in the past decades, are described. One approach for reducing α1,6-fucosylation is through inhibiting fucosyltransferase (FUT8) expression by knockdown and knockout methods. Another approach to modulate fucosylation is through inhibition of multiple genes in the fucosylation biosynthesis pathway or through chemical inhibitors. To modulate antibody sialylation of the fragment crystallizable region, expressions of sialyltransferase and galactotransferase individually or together with amino acid mutations can affect antibody glycoforms and further influence antibody effector functions. The inhibition of sialidase expression and chemical supplementations are also effective and complementary approaches to improve the sialylation levels on recombinant glycoproteins. The engineering of CHO cells or protein sequence to control glycoforms to produce more homogenous glycans is an emerging topic. For modulating the glycosylation metabolic pathways, the interplay of multiple glyco-gene knockouts and knockins and the combination of multiple approaches, including genetic manipulation, protein engineering and chemical supplementation, are detailed in order to achieve specific glycan profiles on recombinant glycoproteins for superior biological function and effectiveness.


2015 ◽  
Vol 24 (3) ◽  
pp. 74-85
Author(s):  
Sandra M. Grether

Individuals with Rett syndrome (RS) present with a complex profile. They benefit from a multidisciplinary approach for diagnosis, treatment, and follow-up. In our clinic, the Communication Matrix © (Rowland, 1990/1996/2004) is used to collect data about the communication skills and modalities used by those with RS across the lifespan. Preliminary analysis of this data supports the expected changes in communication behaviors as the individual with RS ages and motor deficits have a greater impact.


Author(s):  
Oscar D. Guillamondegui

Traumatic brain injury (TBI) is a serious epidemic in the United States. It affects patients of all ages, race, and socioeconomic status (SES). The current care of these patients typically manifests after sequelae have been identified after discharge from the hospital, long after the inciting event. The purpose of this article is to introduce the concept of identification and management of the TBI patient from the moment of injury through long-term care as a multidisciplinary approach. By promoting an awareness of the issues that develop around the acutely injured brain and linking them to long-term outcomes, the trauma team can initiate care early to alter the effect on the patient, family, and community. Hopefully, by describing the care afforded at a trauma center and by a multidisciplinary team, we can bring a better understanding to the armamentarium of methods utilized to treat the difficult population of TBI patients.


2008 ◽  
Vol 18 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Vinciya Pandian ◽  
Thai Tran Nguyen ◽  
Marek Mirski ◽  
Nasir Islam Bhatti

Abstract The techniques of performing a tracheostomy has transformed over time. Percutaneous tracheostomy is gaining popularity over open tracheostomy given its advantages and as a result the number of bedside tracheostomies has increased necessitating the need for a Percutaneous Tracheostomy Program. The Percutaneous Tracheostomy Program at the Johns Hopkins Hospital is a comprehensive service that provides care to patients before, during, and after a tracheostomy with a multidisciplinary approach aimed at decreasing complications. Education is provided to patients, families, and health-care professionals who are involved in the management of a tracheostomy. Ongoing prospective data collection serves as a tool for Quality Assurance.


1995 ◽  
Vol 40 (1) ◽  
pp. 7-8
Author(s):  
Heather Cecil ◽  
Melinda A. Stanley

1978 ◽  
Vol 23 (3) ◽  
pp. 181-182
Author(s):  
ELLEN R. GRITZ

1990 ◽  
Vol 35 (6) ◽  
pp. 577-578
Author(s):  
Amy Holtzworth-Munroe

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