scholarly journals Maternal Testosterone Levels During Pregnancy Are Not associated with Birth Weights of Offspring: A Prospective Cohort Study

2019 ◽  
Author(s):  
GUFENG XU ◽  
Li-Juan Sun ◽  
Mei-Ling Yang ◽  
Yun Liao ◽  
Yuan Chen ◽  
...  
Keyword(s):  
Birth Weight ◽  
Prospective Cohort ◽  
Primary Outcome ◽  
Medical Complications ◽  
Premature Rupture Of Membranes ◽  
Testosterone Levels ◽  
Physiological Processes ◽  
Conflicting Evidence ◽  
Cholestasis Of Pregnancy ◽  
Maternal Testosterone

Abstract Background Testosterone is an important sex hormone which participates in many physiological processes. However, there is conflicting evidence on effect of testosterone on fetal development. We aim to investigate the associations between maternal testosterone levels and pregnancy outcomes.Design and Methods We conducted a prospective cohort in a university-affiliated hospital. A total of 1,087 singleton pregnant women were included in the study. They were followed-up until delivery. The primary outcome was birth weight. The second outcomes were the prevalence of preterm birth, low birth weight, small for gestational age, preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, premature rupture of membranes, and low APGAR score (<7).Results We did not observe any significant association between maternal testosterone level and birth weight after adjustment. Prevalence of medical complications was also not associated with maternal testosterone levels.Conclusions Maternal testosterone levels during pregnancy is not associated with birth weights as well as the prevalence of medical complications.

scholarly journals Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy

2013 ◽  
Vol 4 (4) ◽  
pp. 280-284 ◽  
Author(s):  
K. M. Voegtline ◽  
K. A. Costigan ◽  
K. T. Kivlighan ◽  
J. L. Henderson ◽  
J. A. DiPietro
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Testosterone Level ◽  
Late Pregnancy ◽  
Salivary Testosterone ◽  
Testosterone Levels ◽  
Infant Weight Gain ◽  
Postnatal Weight Gain ◽  
Maternal Testosterone ◽  
Age And Sex

Associations between maternal salivary testosterone at 36 weeks’ gestation with birth weight and infant weight gain through 6 months of age were examined in a group of 49 healthy, pregnant women and their offspring. The diurnal decline of maternal testosterone was conserved in late pregnancy, and levels showed significant day-to-day stability. Elevated maternal morning testosterone level was associated with lower birth weight Z-scores adjusted for gestational age and sex, and greater infant weight gain between birth and 6 months. Although maternal testosterone levels did not differ by fetal sex, relations were sex-specific such that maternal testosterone had a significant impact on weight for male infants; among female infants associations were nonsignificant. Results highlight the opposing influence of maternal androgens during pregnancy on decreased growth in utero and accelerated postnatal weight gain.

scholarly journals Maternal testosterone levels during pregnancy are associated with offspring size at birth

2006 ◽  
Vol 155 (2) ◽  
pp. 365-370 ◽  
Author(s):  
S M Carlsen ◽  
G Jacobsen ◽  
P Romundstad
Keyword(s):  
Birth Weight ◽  
Animal Studies ◽  
Maternal Serum ◽  
Sex Hormone Binding Globulin ◽  
Offspring Size ◽  
Testosterone Levels ◽  
Environment And Development ◽  
Maternal Testosterone ◽  
Size At Birth ◽  
Androgen Levels

Objective: Animal studies have indicated that maternal androgen levels influence the intrauterine environment and development of the offspring. Human data are missing. We therefore investigated the possible association between maternal androgens and offspring size at birth in humans. Design: A random sample of parous Caucasian women (n = 147) was followed prospectively through pregnancy. Methods: Maternal serum levels of dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone and sex hormone-binding globulin (SHBG) were measured at gestational weeks 17 and 33. The main outcome measures were weight and length at birth. Associations between maternal androgen levels and offspring birth weight and length were investigated using multiple linear regression modeling adjusted for potential confounding by maternal height, pre-pregnancy body mass index, smoking, parity, offspring gender and gestational age at birth. Results: Elevated maternal testosterone levels at week 17 and 33 were both associated with lower birth weights and lengths. Accordingly, at week 17, an increase in maternal testosterone levels from the 25th to the 75th percentile was associated with a decrease in birth weight by 160 g (95% confidence interval (CI); 29–290 g), while at week 33 that estimate was 115 g (95% CI; 21–207 g). No similar associations were observed for DHEAS, androstenedione or SHBG. Conclusions: Elevated maternal testosterone levels during human pregnancy are associated with growth restriction in utero. Our results support animal studies, which have indicated that maternal androgen levels influence intrauterine offspring environment and development.

scholarly journals Prospective cohort study of mortality in very low birthweight infants in a single centre in the Eastern Cape province, South Africa

2021 ◽  
Vol 5 (1) ◽  
pp. e000918
Author(s):  
Isabel A Michaelis ◽  
Ingeborg Krägeloh-Mann ◽  
Ncomeka Manyisane ◽  
Mikateko C Mazinu ◽  
Esme R Jordaan
Keyword(s):  
South Africa ◽  
Cohort Study ◽  
Birth Weight ◽  
Mortality Rate ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Low Birthweight ◽  
Eastern Cape Province ◽  
Eastern Cape ◽  
Overall Mortality

BackgroundNeonatal mortality is a major contributor worldwide to the number of deaths in children under 5 years of age. The primary objective of this study was to assess the overall mortality rate of babies with a birth weight equal or below 1500 g in a neonatal unit at a tertiary hospital in the Eastern Cape Province, South Africa. Furthermore, different maternal-related and infant-related factors for higher mortality were analysed.MethodsThis is a prospective cohort study which included infants admitted to the neonatal wards of the hospital within their first 24 hours of life and with a birth weight equal to or below 1500 g. Mothers who consented answered a questionnaire to identify factors for mortality.Results173 very low birth weight (VLBW) infants were recruited in the neonatal department between November 2017 and December 2018, of whom 55 died (overall mortality rate 32.0%). Twenty-three of the 44 infants (53,5%) with a birth weight below 1000 g died during the admission. One hundred and sixty-one mothers completed the questionnaire and 45 of their babies died.Main factors associated with mortality were lower gestational age and lower birth weight. Need for ventilator support and sepsis were associated with higher mortality, as were maternal factors such as HIV infection and age below 20 years.ConclusionThis prospective study looked at survival of VLBW babies in an underprivileged part of the Eastern Cape of South Africa. Compared with other public urban hospitals in the country, the survival rate remains unacceptably low. Further research is required to find the associated causes and appropriate ways to address these.

scholarly journals Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis

2021 ◽  
Vol 97 (2) ◽  
pp. 104-111
Author(s):  
Lisa M Vallely ◽  
Dianne Egli-Gany ◽  
Handan Wand ◽  
William S Pomat ◽  
Caroline S E Homer ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Perinatal Mortality ◽  
Low Income ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Middle Income ◽  
Middle Income Countries ◽  
Adverse Pregnancy

Objective To examine associations between Neisseria gonorrhoeae (NG) infection during pregnancy and the risk of preterm birth, spontaneous abortion, premature rupture of membranes, perinatal mortality, low birth weight and ophthalmia neonatorum. Data sources We searched Medline, EMBASE, the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature for studies published between 1948 and 14 January 2020. Methods Studies were included if they reported testing for NG during pregnancy and compared pregnancy, perinatal and/or neonatal outcomes between women with and without NG. Two reviewers independently assessed papers for inclusion and extracted data. Risk of bias was assessed using established checklists for each study design. Summary ORs with 95% CIs were generated using random effects models for both crude and, where available, adjusted associations. Results We identified 2593 records and included 30 in meta-analyses. Women with NG were more likely to experience preterm birth (OR 1.55, 95% CI 1.21 to 1.99, n=18 studies); premature rupture of membranes (OR 1.41, 95% CI 1.02 to 1.92, n=9); perinatal mortality (OR 2.16, 95% CI 1.35 to 3.46, n=9); low birth weight (OR 1.66, 95% CI 1.12 to 2.48, n=8) and ophthalmia neonatorum (OR 4.21, 95% CI 1.36 to 13.04, n=6). Summary adjusted ORs were, for preterm birth 1.90 (95% CI 1.14 to 3.19, n=5) and for low birth weight 1.48 (95% CI 0.79 to 2.77, n=4). In studies with a multivariable analysis, age was the variable most commonly adjusted for. NG was more strongly associated with preterm birth in low-income and middle-income countries (OR 2.21, 95% CI 1.40 to 3.48, n=7) than in high-income countries (OR 1.38, 95% CI 1.04 to 1.83, n=11). Conclusions NG is associated with a number of adverse pregnancy and newborn outcomes. Further research should be done to determine the role of NG in different perinatal mortality outcomes because interventions that reduce mortality will have the greatest impact on reducing the burden of disease in low-income and middle-income countries. PROSPERO registration number CRD42016050962.

Mortality and Management of Surgical Necrotizing Enterocolitis in Very Low Birth Weight Neonates: A Prospective Cohort Study

2014 ◽  
Vol 218 (6) ◽  
pp. 1148-1155 ◽  
Author(s):  
Melissa A. Hull ◽  
Jeremy G. Fisher ◽  
Ivan M. Gutierrez ◽  
Brian A. Jones ◽  
Kuang Horng Kang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Very Low Birth Weight

scholarly journals The effects of water-pipe smoking on birth weight: a population-based prospective cohort study in southern Iran

2018 ◽  
Vol 40 ◽  
pp. e2018008 ◽  
Author(s):  
Shahrzad Nematollahi ◽  
Mohammad Ali Mansournia ◽  
Abbas Rahimi Foroushani ◽  
Mahmood Mahmoodi ◽  
Azin Alavi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Population Based ◽  
Water Pipe ◽  
Southern Iran

scholarly journals Effects of Maternal food Insecurity on Birth Weight of Neonates: A Prospective Cohort

2018 ◽  
Vol 23 (4) ◽  
pp. 524-530
Author(s):  
Ayesha Saeed ◽  
Mobina Naqvi ◽  
Ahsan Javed
Keyword(s):  
Food Security ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Food Insecurity ◽  
Prospective Cohort ◽  
Multinomial Logistic Regression ◽  
Neonatal Morbidity ◽  
Household Food Security ◽  
Increased Risk

Pakistani population is seriously malnutritioned and is hunger redisposed. Based on the Global Hunger Index Pakistan is ranked at 107 of 118 countries .Food insecurity is among major causes of under-nutrition and has been associated with low birth weights. This study aimed to assess the effect of maternal foodinsecurity on birth weight of neonates in Lahore, Pakistan.Ina prospective cohort conducted at Shalamar Hospital Lahore; from April to August 2016, written informed consents were obtained from 103 eligible pregnant women. Data on demography was collected through a structured questionnaire and exposure wasassessed through 6-items Version of U.S. Household Food Security Survey and cohort was followed until delivery, and birth weight was recorded. Follow up could be completed for 50 women only and response rate was 49%. Descriptive statistics were calculated, and relative risk and multinomial logistic Regression were applied using SPSS version 22. Mean maternal age was 28.100+4.824 years, mean education was 12.400+2.138 years, mean BMI was 29.420+5.075 and mean household income was PKR 25641+16251.543. With these characteristics, the mean birth weight of2.814+0.551 kg was recorded. Four percent (n=2) had very low food security and 34% (n=17) women had low food security. Importantly, food unsecured women had a 5.439 times increased risk of delivering a low birth weight neonate (RR=5.439, CI=1.710-17.296, p=0.002). Regression analysis indicated a significant association (AOR 16.076, CI=2.381-108.564, p=0.004).Based onthese studies, it was concluded that food insecurity in pregnancy is associated with low birth weight in neonates. Antenatal screening of food insecurity and timely provision food supplements through social welfare can help reduce neonatal morbidity and mortality.

scholarly journals Short Term Outcomes of Neonates Born after Prolonged Premature Rupture of Membranes < 34 Weeks Gestation

2019 ◽  
Vol 4 (2) ◽  
pp. 83
Author(s):  
Isam Bsisu ◽  
Alaa Aldalaeen ◽  
Rawan Elrajabi ◽  
Ala AlZaatreh ◽  
Rama Jadallah ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Preterm Births ◽  
University Hospital ◽  
High Rate ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Gestational Week ◽  
The Mean

<p><strong><em>Background:</em></strong><em> Preterm premature rupture of membranes (PPROM) is responsible for one?third of all preterm births worldwide. This aim of this study was to investigate the outcome of neonates born after prolonged PPROM with gestational age below 34 weeks. </em></p><p><strong><em>Materials and methods:</em></strong><em> This retrospective study included 65 patients who were born to mothers with Prolonged PPROM &lt;34 weeks gestation between January 2011 and December 2015 and admitted to the neonatal intensive care unit (NICU) at Jordan University Hospital. </em></p><p><strong><em>Results: </em></strong><em>The mean gestational age of included patients was (31.9 ± 2.5 weeks), mean birth weight was (1840 ± 583 g) and 43 (66.2%) were males. The mortality rate in those infants was 12.3 %. Gestational age, birth weight, and Apgar score were significantly lower among mortality cases compared to surviving cases (P &lt; 0.05). </em></p><p><strong><em>Conclusion:</em></strong><em> Prolonged PPROM before the 34<sup>th</sup> gestational week is associated with high rate of morbidity and mortality, for which early identification of risk factors for developing PPROM can help in reducing the risk for preterm labors and subsequent burden on healthcare system.</em></p>

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