scholarly journals Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

2019 ◽  
Author(s):  
Lin Xie ◽  
Hongli Wang ◽  
Jianyuan Jiang ◽  
Chaojun Zheng
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Univariate Analysis ◽  
Population Based ◽  
Solitary Plasmacytoma ◽  
Population Based Study ◽  
White Race ◽  
Factors Associated ◽  
Rate Of Progression ◽  
Independent Risk Factors

Abstract Background: SBP of spine is a primary spinal malignant tumor. Risk factors for progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains controversial. We aimed to analysis the risk factors for progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine. Methods: A total of 1543 patients diagnosed with SBP of spine in the Surveillance, Epidemiology, and End Results (SEER) database from 1992 to 2013 were included in the study. Factors associated of progression to multiple myeloma (MM) were assessed with univariate and multivariate methods. Results: 1543 patients with SBP of spine were collected and 659 patients progressed to MM. The overall rate of progression to MM was 42.51%, Age, race, gender, and chemotherapy were found to be associated with disease progression to MM in the univariate analysis, greater age (45-59: OR=2.017, 95%CI, 1.287 to 3.159; 60-74: OR=2.940, 95%CI, 1.891 to 4.570; 75-89: OR=3.180, 95%CI, 1.976 to 5.118; >89: OR=5.524, 95%CI, 1.965 to 15.526), patients of white race (OR = 2.032, 95% CI, 1.079 to 3.826), female patients (OR = 1.272, 95% CI, 1.027 to 1.576), and patients received chemotherapy (OR = 1.593, 95%CI, 1.243 to 2.042) was identified as independent risk factors for SBP of spine progression to MM in the multivariate analysis. Conclusions: Greater age, white race, female and chemotherapy was identified as independent risk factors for SBP of spine progression to MM.

scholarly journals Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

2020 ◽  
Author(s):  
Lin Xie ◽  
Hongli Wang ◽  
Jianyuan Jiang ◽  
Chaojun Zheng
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Regression Analysis ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Solitary Plasmacytoma ◽  
Aged Patients ◽  
Factors Associated ◽  
Risk Of Progression

Abstract Background: Spine SBP is a primary spinal malignant tumor. Risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains unknown. This study therefore aimed to identify the risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in the spine.Methods: Data of 1543 patients diagnosed with spine SBP between 1992 and 2013 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database for analysis. Risk factors associated with progression of SBP to multiple myeloma (MM) were then identified using univariate and multivariate regression analysis methods.Results: Out of the 1543 patients diagnosed with spine SBP, 659 of them progressed to MM. The overall rate of progression to MM was 42.51%. Univariate and multivariate regression analysis revealed that age, race, gender and chemotherapy were independent risk factors associated with SBP progression to MM.Conclusion: Old aged patients, patients belonging to the white race, female patients and those undergoing chemotherapy were identified to be at a high risk of progression to MM. This information will assist clinicians in evaluating patients’ risk of SBP progression to MM at the point of diagnosis and advise them accordingly.

Risk factors for blood stream infections in multiple myeloma: A population-based study of 1154 patients in Denmark

2018 ◽  
Vol 101 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Rasmus Sørrig ◽  
Tobias W. Klausen ◽  
Morten Salomo ◽  
Annette Vangsted ◽  
Peter Gimsing
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Blood Stream ◽  
Population Based ◽  
Blood Stream Infections ◽  
Population Based Study

scholarly journals Venous Thromboembolism and Its Risk Factors in Children with Acute Lymphoblastic Leukemia in Israel: A Population-Based Study

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2759
Author(s):  
Shlomit Barzilai-Birenboim ◽  
Ronit Nirel ◽  
Nira Arad-Cohen ◽  
Galia Avrahami ◽  
Miri Ben Harush ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Univariate Analysis ◽  
Population Based ◽  
Population Based Study ◽  
Inherited Thrombophilia ◽  
Severe Hypertriglyceridemia

Venous thromboembolism (VTE) is a serious complication of acute lymphoblastic leukemia (ALL) therapy. The aim of this population-based study was to evaluate the rate, risk factors, and long-term sequelae of VTE in children treated for ALL. The cohort included 1191 children aged 1–19 years diagnosed with ALL between 2003–2018, prospectively enrolled in two consecutive protocols: ALL-IC BFM 2002 and AIEOP-BFM ALL 2009. VTEs occurred in 89 patients (7.5%). Long-term sequelae were uncommon. By univariate analysis, we identified four significant risk factors for VTEs: Severe hypertriglyceridemia (p = 0.005), inherited thrombophilia (p < 0.001), age >10 years (p = 0.015), and high-risk ALL group (p = 0.039). In addition, the incidence of VTE was significantly higher in patients enrolled in AIEOP-BFM ALL 2009 than in those enrolled in ALL-IC BFM 2002 (p = 0.001). Severe VTE occurred in 24 children (2%), all of whom had at least one risk factor. Elevated triglyceride levels at diagnosis did not predict hypertriglyceridemia during therapy. In a multivariate analysis of 388 children, severe hypertriglyceridemia and inherited thrombophilia were independent risk factors for VTE. Routine evaluation for these risk factors in children treated for ALL may help identify candidates for intervention.

scholarly journals Child Maltreatment Among Singletons and Multiple Births in Japan: A Population-Based Study

2015 ◽  
Vol 18 (6) ◽  
pp. 806-811 ◽  
Author(s):  
Yoshie Yokoyama ◽  
Terumi Oda ◽  
Noriyo Nagai ◽  
Masako Sugimoto ◽  
Kenji Mizukami
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Child Maltreatment ◽  
Personal Information ◽  
Population Based ◽  
Multiple Births ◽  
Population Based Study ◽  
Factors Associated ◽  
Increased Risk ◽  
The Relationship

Background: The occurrence of multiple births has been recognized as a risk factor for child maltreatment. However, few population-based studies have examined the relationship between multiple births and child maltreatment. This study aimed to evaluate the degree of risk of child maltreatment among singletons and multiple births in Japan and to identify factors associated with increased risk. Methods: Using population-based data, we analyzed the database of records on child maltreatment and medical checkups for infants aged 1.5 years filed at Nishinomiya City Public Health Center between April 2007 and March 2011. To protect personal information, the data were transferred to anonymized electronic files for analysis. Results: After adjusting by logistic regression for each associated factor and gestation number, multiples themselves were not associated with the risk of child maltreatment. However, compared with singletons, multiples had a significantly higher rate of risk factors for child maltreatment, including low birth weight and neural abnormality. Moreover, compared with mothers of singleton, mothers of twins had a significantly higher rate of poor health, which is a risk factor of child maltreatment. Conclusion: Multiples were not associated with the risk of child maltreatment. However, compared with singletons, multiples and their mothers had a significantly higher rate of risk factors of child maltreatment.

Sign in / Sign up

Export Citation Format

Share Document