scholarly journals PO-071 Risk factors associated with mortality from kidney diseases in patients diagnosed with multiple myeloma: a population-based analysis

2018 ◽  
Author(s):  
MK Elfaituri ◽  
HA Faraj ◽  
AE Amr Ehab ◽  
A Ebied ◽  
ME Morra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Kidney Diseases ◽  
Population Based ◽  
Factors Associated

scholarly journals Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

2020 ◽  
Author(s):  
Lin Xie ◽  
Hongli Wang ◽  
Jianyuan Jiang ◽  
Chaojun Zheng
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Regression Analysis ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Population Based ◽  
Solitary Plasmacytoma ◽  
Aged Patients ◽  
Factors Associated ◽  
Risk Of Progression

Abstract Background: Spine SBP is a primary spinal malignant tumor. Risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains unknown. This study therefore aimed to identify the risk factors associated with progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in the spine.Methods: Data of 1543 patients diagnosed with spine SBP between 1992 and 2013 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database for analysis. Risk factors associated with progression of SBP to multiple myeloma (MM) were then identified using univariate and multivariate regression analysis methods.Results: Out of the 1543 patients diagnosed with spine SBP, 659 of them progressed to MM. The overall rate of progression to MM was 42.51%. Univariate and multivariate regression analysis revealed that age, race, gender and chemotherapy were independent risk factors associated with SBP progression to MM.Conclusion: Old aged patients, patients belonging to the white race, female patients and those undergoing chemotherapy were identified to be at a high risk of progression to MM. This information will assist clinicians in evaluating patients’ risk of SBP progression to MM at the point of diagnosis and advise them accordingly.

scholarly journals Risk factors for progression of solitary plasmacytoma of bone to multiple myeloma in the spine: A population-based study

2019 ◽  
Author(s):  
Lin Xie ◽  
Hongli Wang ◽  
Jianyuan Jiang ◽  
Chaojun Zheng
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Univariate Analysis ◽  
Population Based ◽  
Solitary Plasmacytoma ◽  
Population Based Study ◽  
White Race ◽  
Factors Associated ◽  
Rate Of Progression ◽  
Independent Risk Factors

Abstract Background: SBP of spine is a primary spinal malignant tumor. Risk factors for progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine remains controversial. We aimed to analysis the risk factors for progression of solitary plasmacytoma of bone (SBP) to multiple myeloma in spine. Methods: A total of 1543 patients diagnosed with SBP of spine in the Surveillance, Epidemiology, and End Results (SEER) database from 1992 to 2013 were included in the study. Factors associated of progression to multiple myeloma (MM) were assessed with univariate and multivariate methods. Results: 1543 patients with SBP of spine were collected and 659 patients progressed to MM. The overall rate of progression to MM was 42.51%, Age, race, gender, and chemotherapy were found to be associated with disease progression to MM in the univariate analysis, greater age (45-59: OR=2.017, 95%CI, 1.287 to 3.159; 60-74: OR=2.940, 95%CI, 1.891 to 4.570; 75-89: OR=3.180, 95%CI, 1.976 to 5.118; >89: OR=5.524, 95%CI, 1.965 to 15.526), patients of white race (OR = 2.032, 95% CI, 1.079 to 3.826), female patients (OR = 1.272, 95% CI, 1.027 to 1.576), and patients received chemotherapy (OR = 1.593, 95%CI, 1.243 to 2.042) was identified as independent risk factors for SBP of spine progression to MM in the multivariate analysis. Conclusions: Greater age, white race, female and chemotherapy was identified as independent risk factors for SBP of spine progression to MM.

scholarly journals A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2025
Author(s):  
Tomasz Sawicki ◽  
Monika Ruszkowska ◽  
Anna Danielewicz ◽  
Ewa Niedźwiedzka ◽  
Tomasz Arłukowicz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Physical Inactivity ◽  
Ecological Factors ◽  
Population Based ◽  
Review Article ◽  
Therapeutic Interventions ◽  
Factors Associated ◽  
Hereditary Factors ◽  
Disease Stages

This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known risk factors associated with colorectal cancer include familial and hereditary factors and lifestyle-related and ecological factors. Lifestyle factors are significant because of the potential for improving our understanding of the disease. Physical inactivity, obesity, smoking and alcohol consumption can also be addressed through therapeutic interventions. We also made efforts to systematize available literature and data on epidemiology, diagnosis, type and nature of symptoms and disease stages. Further study of colorectal cancer and progress made globally is crucial to inform future strategies in controlling the disease’s burden through population-based preventative initiatives.

scholarly journals Investigating Factors Associated with Depressive Symptoms of Chronic Kidney Diseases in China with Type 2 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Xu Wang ◽  
Biyu Shen ◽  
Xun Zhuang ◽  
Xueqin Wang ◽  
Weiqun Weng
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Depressive Symptoms ◽  
Kidney Diseases ◽  
Chronic Kidney Diseases ◽  
Factors Associated

Aim.To assess the depressive symptoms status of chronic kidney diseases in Nantong, China, with type 2 diabetes and to identify factors associated with depressive symptoms.Methods.In this cross-sectional analytic study, 210 type 2 diabetic patients were recruited from the Second Affiliated Hospital of Nantong University. Depressive symptoms were assessed with the depression subscale of the Hospital Anxiety and Depression Scale (HAD-D). The quality of life was measured with the RAND 36-Item Health Survey (SF-36). And the independent risk factors of depressive symptoms were assessed by using a stepwise forward model of logistic regression analysis.Results.The mean age of the study subjects was 57.66 years (SD: 11.68). Approximately 21.4% of subjects reported depressive symptoms (n=45). Forward stepwise logistic regression analysis showed that female gender (P=0.010), hypertension (P=0.022), Stage IV (P=0.003), and Stage V (P<0.001) were significant risk factors for depressive symptoms. The quality of life of individuals with HAD-D score <11 was significantly better compared with individuals with HAD-D score ≥ 11.Conclusions.These results indicate that clinicians should be aware that female patients with chronic kidney diseases with T2DM in their late stage with hypertension are at a marked increased risk of depressive symptoms. Providing optimal care for the psychological health of this population is vital.

scholarly journals Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: A retrospective study

2020 ◽  
Author(s):  
Masahiro Kondo ◽  
Yuji Hotta ◽  
Karen Yamauchi ◽  
Akimasa Sanagawa ◽  
Hirokazu Komatsu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Odds Ratio ◽  
Tumor Lysis Syndrome ◽  
Low Risk ◽  
Novel Therapies ◽  
Tumor Lysis ◽  
Factors Associated ◽  
Increased Risk ◽  
Male Patients

Abstract Background: Novel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a low-risk disease for developing tumor lysis syndrome (TLS), treatment with these novel therapies might increase TLS risk. Previous studies, mostly case reports or case series, have reported bortezomib-induced TLS in patients with multiple myeloma. This study aimed to investigate risk factors associated with TLS development in multiple myeloma patients.Methods: We retrospectively investigated incidences of laboratory and clinical TLS (LTLS and CTLS, respectively) in patients who received primary therapy for treatment-naive, symptomatic multiple myeloma between May 2007 and January 2018. We used multivariate logistic regression analyses to evaluate the associations between TLS and several parameters previously reported to be associated with increased risk.Results: This study included 210 patients with multiple myeloma, of which ten (4.8%) had LTLS and seven (3.3%) had CTLS. The characteristics of the administered anticancer or prophylactic antihyperuricemic agents were similar between patients with and without TLS. Multivariate analyses revealed that TLS was most strongly associated with bortezomib-containing therapy (odds ratio = 3.40, P = 0.069), followed by male sex (odds ratio = 2.29, P = 0.153). In a subgroup analysis focused on men, treatment with bortezomib-containing therapy was significantly associated with increased risk of TLS (odds ratio = 8.51, P = 0.046).Conclusion: In the present study, we investigated the risk factors associated with TLS development in 210 multiple myeloma patients, which, to the best of our knowledge, is the largest number of patients reported to date. Furthermore, this study is the first to evaluate TLS risk factors in MM by adjusting for the effects of potential confounding factors in patients’ backgrounds. Consequently, we found that bortezomib-containing therapy increases the risk of TLS in male patients with multiple myeloma. TLS risk should be evaluated further in low-risk diseases such as multiple myeloma, since a significant number of novel therapies can achieve high antitumor responses.

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