scholarly journals Prevalence and patterns of birth defects among newborns in Southwestern Ethiopia: Retrospective study

2019 ◽  
Author(s):  
Soressa Abebe Geneti ◽  
Girmai Gebru ◽  
Demisew Amenu ◽  
Lemessa Dube
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Birth Defect ◽  
Normal Development ◽  
Abnormal Development ◽  
Intrauterine Development ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Southwestern Ethiopia

Abstract Background : Intrauterine development can be considered as normal development as well as abnormal development. Abnormal development commonly called birth defects occur because of interference of normal development from genetic disorders, environmental factors and the combination of both genetic and environment factors during the critical period of embryogenesis. The present study aimed to evaluate the prevalence and patterns of birth defects at birth in Southwestern Ethiopia. Methods : Institutions based cross-sectional study design was used. Six hospitals were selected from the existing hospitals in southwestern Ethiopia purposively based on case load. The study was conducted from September 2011 to December 2015 during which 45,951 deliveries were attained. All records of births that were occurred in the selected hospitals during the study period were identified from medical records, to locate the birth defect records.Results : Twenty-one different birth defects were recorded. Of these, 49.6 % of the birth defects recorded were Anencephaly and Hydrocephalus. Five types of birth defects namely: Anencephaly (25.0%), Hydrocephalus (24.6%), Spinal bifida (13.1%), Meningomyelocele (7.1%), and Umbilical hernia (4.8 %) accounted about three-fourth (75%) of all recorded birth defects. The present study revealed that the prevalence of the birth defects at birth was found to be 5.5 per 1000 births. Among twenty one birth defects identified in this study, the neural tube defects were the most frequent with prevalence rate of 4.1 per 1000 birth followed by gastrointestinal defects (0.7 per 1000 births)Conclusions: As compared to other study, the prevalence of birth defect identified in the present study was found to be higher. The neural tube defects were the most prevalent with the frequency of 4.05 cases per 1000.The present study also identified that nearly equal proportions of birth defect occurred among males and females newborns. The majority of the mother who gave birth to birth defects was younger than 35 years old. As the birth defect was found to be a main cases of infant mortality and morbidity, there need to an urgent interventions to control the cases.

scholarly journals Prevalence and patterns of birth defects among newborns in Southwestern Ethiopia: Retrospective study

2019 ◽  
Author(s):  
Soressa Abebe Geneti ◽  
Girmai Gebru ◽  
Demisew Amenu ◽  
Lemessa Dube
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Birth Defect ◽  
Normal Development ◽  
Abnormal Development ◽  
Intrauterine Development ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Southwestern Ethiopia

Abstract Background : Intrauterine development can be considered as normal development as well as abnormal development. Abnormal development commonly called birth defects occur because of interference of normal development from genetic disorders, environmental factors and the combination of both genetic and environment factors during the critical period of embryogenesis. The present study aimed to evaluate the prevalence and patterns of birth defects at birth in Southwestern Ethiopia. Methods : Institutions based cross-sectional study design was used. Six hospitals were selected from the existing hospitals in southwestern Ethiopia purposively based on case load. The study was conducted from September 2011 to December 2015 during which 45,951 deliveries were attained. All records of births that were occurred in the selected hospitals during the study period were identified from medical records, to locate the birth defect records. Results : Twenty-one different birth defects were recorded. Of these, 49.6 % of the birth defects recorded were Anencephaly and Hydrocephalus. Five types of birth defects namely: Anencephaly (25.0%), Hydrocephalus (24.6%), Spinal bifida (13.1%), Meningomyelocele (7.1%), and Umbilical hernia (4.8 %) accounted about three-fourth (75%) of all recorded birth defects. The present study revealed that the prevalence of the birth defects at birth was found to be 5.5 per 1000 births. Among twenty one birth defects identified in this study, the neural tube defects were the most frequent with prevalence rate of 4.1 per 1000 birth followed by gastrointestinal defects (0.7 per 1000 births) Conclusions: As compared to other study, the prevalence of birth defect identified in the present study was found to be higher. The neural tube defects were the most prevalent with the frequency of 4.05 cases per 1000.The present study also identified that nearly equal proportions of birth defect occurred among males and females newborns. The majority of the mother who gave birth to birth defects was younger than 35 years old. As the birth defect was found to be a main cases of infant mortality and morbidity, there need to an urgent interventions to control the cases.

The Prevalence of Neural Tube Defects in Sétif University Maternity Hospital, Algeria-3 Years Review (2004-2006)

Pteridines ◽  
2008 ◽  
Vol 19 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Bakhouche Houcher ◽  
Romyla Bourouba ◽  
Farida Djabi ◽  
Zahira Houcher
Keyword(s):  
Public Health ◽  
Folic Acid ◽  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Public Health Problem ◽  
Retrospective Chart Review ◽  
High Rate ◽  
Mortality And Morbidity

Abstract Neural tube defects (NTDs) including spina bifida, anencephaly and encephalocele are among the most common birth defects, with high associated mortality and morbidity. There are no data concerning the incidence, associated anomalies, treatment and outcome of NTDs in Algeria. The objective of this study is to analyse data on NTD cases from 2004-2006 at Sétif Hospital, a hospital with 8,000-10,000 deliveries annually. A retrospective chart review of patients with NTDs was performed, who were born at Sétif Hospital 2004-2006. During the 3 year period we examined, there were 215 patients with NTDs treated in the Sétif Hospital. The incidence of NTD is 7.5 per 1,000 births. The sex distribution was not equal among NTD cases, 126 (58.6%) females, 88 (40.9%) males and one (0.5%) unidentified sex. Among all NTD cases, there where 122 (56.7%) with spina bifida, 69 (32.1%) with anencephaly, 1 (0.5%) with encephalocele and 23 (10.7%) with anencephaly and spina bifida. Hundred and seventeen (54.4%) cases died in utero and 4 cases (1.9%) unknown. The rate of consanguinity among all NTD cases was 13% (28/215). The rate of affected newborns was highest in mothers aged 31-35 years (21.9%). The peak prevalence was in June (15.8%). A half of NTDs were spina bifida and there was a high rate of mortality. This study demonstrates that NTD represents a significant public health problem in Algeria. In Algeria there were no population-wide educational campaigns about folic acid or its association with the prevention of birth defects. Public health interventions aimed at increasing the periconceptional consumption of folic acid should be implemented or enhanced to reduce the incidence of NTDs in Algeria.

scholarly journals Knowledge and intake of folic acid to prevent neural tube defects among pregnant women in urban China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mingming Cui ◽  
Xiao-Lin Lu ◽  
Yan-Yu Lyu ◽  
Fang Wang ◽  
Xiao-Lu Xie ◽  
...  
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Rural Women ◽  
Rural Areas ◽  
Urban Areas ◽  
Unplanned Pregnancy ◽  
Urban China ◽  
Cross Sectional

Abstract Background The prevalence of neural tube defects (NTDs) in China declined during 2000–2017 with periconceptional folic acid (FA) supplementation, which is effective in reducing the risk of birth defects. We aimed to assess the knowledge and actual use of FA among Chinese pregnant women and to explore factors associated with FA use before pregnancy. Methods All data were collected in face-to-face interviews during health visits among pregnant women. We collected information about knowledge and use of FA supplements and demographic, socioeconomic, and health status. One maternity and childcare hospital was chosen in each of four cities: Beijing, Huaibei, Kunming, and Haikou. In total, 435 pregnant women were randomly recruited for interviews conducted from June to December 2016. Results A total of 428 pregnant women were included in this survey. Of these, 82.0% (351/428) knew that FA can prevent NTDs, and 75.9% (325/428) knew the correct time to take FA. Overall, 65.9% (282/428) of women knew both that FA can prevent NTDs and the recommended time to take FA before pregnancy. Approximately 95.1% (407/428) of women reported having ever taken FA, only 46.3% (198/428) had begun to take FA supplementation before conception, and 64.5% (109/169) of women from rural areas failed to take FA before pregnancy. Women living in northern China (odds ratio [OR] = 1.81, 95% confidence interval [CI], 1.18–2.77), those with unplanned pregnancy (OR = 1.99, 95% CI 1.30–3.04), and highly educated women (OR = 2.37, 95% CI 1.45–3.88) were more likely to know about FA. Women who were homemakers (OR = 1.94, 95% CI 1.21–3.11) and had unplanned pregnancy (OR = 6.18, 95% CI 4.01–9.53) were less likely to begin taking FA before pregnancy. Conclusions Our survey showed that most pregnant women knew about FA. Although preconception intake of FA can help to reduce NTDs, improving the rate of FA intake before pregnancy is needed in urban areas of China, especially among homemakers and women from rural areas or with unplanned pregnancy. Campaigns are needed to increase awareness about FA and FA use before pregnancy among rural women, homemakers, and those with unplanned pregnancy and lower education levels.

scholarly journals Mengenal Spina Bifida dan Pencegahannya

2021 ◽  
Vol 1 (12) ◽  
pp. 896-903
Author(s):  
Genta Faesal Atsani ◽  
Zanetha Mauly Ilawanda ◽  
Ilma Fahira Basyir
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Abnormality ◽  
Congenital Abnormalities ◽  
Folic Acid Supplementation ◽  
Online Portal ◽  
The Brain ◽  
Developing Spinal Cord

Neural tube defects (NTD) are one of the birth defects or congenital abnormalities that occur in the brain and spine, and commonly find in newborns worldwide. Anencephaly and spina bifida are the two prevalent forms of NTD. The incidence of spina bifida happen on average 1 in 1000 cases of birth worldwide and there are 140,000 cases per year worldwide. Source searches were carried out on the online portal of journal publications as many as 20 sources from MedScape, Google Scholar and the Nation Center for Biotechnology Information / NCBI with the keywords “Neural tube defects (NTD), prevention, and spina bifida”. Spina bifida is a congenital abnormality that occurs in the womb due to a failure of closing process the neural tube during the first few weeks of embryonic development which causes the spine not completely close around the developing spinal cord nerves. NTD can ensue multifactorial conditions such as genetic, environmental, and folate deficiency. The use of folic acid supplementation starting at least 3 months before pregnancy, those are 400 mcg (0.4 mg) per day and 800 mcg per day during pregnancy can reduce the risk of developing neural tube defects such as spina bifida. Generally, spina bifida is undertaking by surgery and the regulation of patients comorbid. Public can find out prevention to avoid or reduce the risk of spina bifida so that the incidence of spina bifida can decrease along with the increasing awareness of the community regarding this disease.

Neural Tube Defects: Prevention by Vitamin Supplements

PEDIATRICS ◽  
1982 ◽  
Vol 69 (4) ◽  
pp. 498-499
Author(s):  
R. W. Smithells
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Birth Defect ◽  
Epidemiologic Study ◽  
Neural Tube Closure ◽  
Additive Effects ◽  
Vitamin Supplements ◽  
Tube Closure

Neural tube defects (NTD) have been the object of more intense epidemiologic study than any other kind of birth defect. This is in part because of their ready recognition at birth (and, in recent years, before birth) and in part because their consequences are usually catastrophic: they kill or they cripple. Regarding their cause, no single genetic or environmental agent has been identified (or is likely to be) and a multifactorial basis is assumed. If failure of neural tube closure results from the additive effects of several adverse factors, removal or correction of any one might shift the developmental balance across the threshold from NTD to normality.

Prevalence of Neural Tube Defects (NTDs) In And Around Varanasi Region: Some Observations

2021 ◽  
Author(s):  
Vaibhav Pandey ◽  
Surendra Kumar Pandey ◽  
Praveen Kumar Tiwari ◽  
Pragati Shakya ◽  
Shashank Shekhar Jha ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Birth Defect ◽  
Neural Tube Closure ◽  
The World ◽  
Typical Type ◽  
Males And Females ◽  
One Year ◽  
Congenital Disabilities ◽  
Tube Closure

Abstract Congenital anomalies are one of the primary causes of infant mortality and disability in the world. Neural Tube Defects (NTDs) are the most typical type of birth defect resulting from the failure of Neural tube closure. In this retrospective hospital-based study, the data of the children affected byneural tube defects (NTDs) were analyzed. Prevalence of Hydrocephalous, Myelomeningocele (MMC), Encephalocele, Lipo MMC, Meningocele, Spina Bifida Occulta among children with more or less than one year of age and their occurrence in males and females was studied. The frequency of occurrence of cases of neural tube defects was significantly less among all the congenital disabilities, i.e., 5% of total cases studied. The prevalence of myelomeningocele, hydrocephalous, and Encephalocele was higher than other types of NTDs. This study concludes that the prevalence of hydrocephalous and myelomeningocele in this area raises a concern to have more research of their etiology.

Birth defects in the Brazilian side of the triple border: a population-based cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F K Nampo ◽  
S Souza ◽  
C R Pestana
Keyword(s):  
Birth Defects ◽  
Birth Defect ◽  
Cleft Lip ◽  
Maternal Education ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Major Birth Defect

Abstract Background Major birth defects are characterized by its severity and are a public health challenge since it chronically affects the population. Foz do Iguassu is located in Brazili's largest international border and presents a birth defect rate 50% greater than the country's average. Methods Identifying factors associated to birth defects is important to guide preventive actions toward modifiable risk factors and target the most susceptible population. In this cross-sectional study we measured the prevalence of major birth defects and associated maternal sociodemographic factors in Foz do Iguassu. Data were collected from a governmental registry and included all births that occurred in the city between 2012 to 2017. The variables measured were maternal education, maternal race, country of residence, maternal parity and onset of prenatal care. Data were analyzed through logistic regression models to verify the maternal sociodemographic factors associated with major birth defects. Results 26,214 births were analyzed; among the 305 birth defects registered, 140 (46%) corresponded to a major birth defect. Cleft lip and/or palate and gastroschisis were the most prevalent major birth defect (9.5/10,000 live births and 6.83/10,000 live births, respectively). Maternal education up to 7 years was the only variable associated with the major birth defects (ORadj=1.58; CI = 1.07-2.33; p = 0.02). Maternal age was associated with gastroschisis (mean: 21.5 years; p = 0.002) and Down syndrome (mean: 33.5 years; p = 0.007). Conclusions In this area, cleft lip and/or palate and gastroschisis are the most common major birth defects, and maternal education is weakly associated with major birth defects. Key messages The epidemiology of major birth defects in this area differs from Brazil’s. Future research should focus on inherent risk factors for congenital defects and exposure to teratogens.

Visualizing the Research Hotspots and Emerging Trends in Neural Tube Defects: A Review

2020 ◽  
Author(s):  
Baohong MAO ◽  
Chichen ZHANG ◽  
Liping YANG ◽  
Yanxia WANG ◽  
Chunhui SU ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Visualization Analysis ◽  
Emerging Trends ◽  
Bibliographic Records ◽  
Tremendous Progress ◽  
Number Of Publications ◽  
Research Domain ◽  
Research Hotspots

Background: Neural tube defects (NTDs) are among the second most common serious birth defects and constitute a major cause of infant death. Research about NTDs has achieved tremendous progress over the last 50 years. Methods: Visualization analysis has been used to explore the hot topic and their emerging trends in NTDs research domain. The scientific literature of research for NTDs has been retrieved from Web of Science™ Core Collection (1966–2014) databases, and final acquire 9125 related bibliographic records, then analyze time trend, distribution of journals, hot keywords, and try to explore the hot topic and their emerging trends in NTDs research domain using Histcite and CiteSpace. Results: The number of publications about NTDs have shown an increased tendency over the last 50 years although there was on a slight decline. Birth Defects Research Part A published the most articles on NTDs research, followed by Lance and Teratology, and the Lancet had the greatest number of total citations. The largest cited frequency keywords was the “Folate”, followed by “Pregnancy”, “Prevention”, and “Spina bifida”. The research hotspots in NTDs research were homocysteine, anencephaly, and screening. Conclusion: With the help of visualization analysis, we explore a quantitative and efficient way of understanding the NTDs knowledge field.   Keywords: Visualization analysis; Neural tube defects; Scientometrics; CiteSpace

scholarly journals Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

2012 ◽  
Vol 176 (12) ◽  
pp. 1101-1109 ◽  
Author(s):  
P. J. Lupo ◽  
M. A. Canfield ◽  
C. Chapa ◽  
W. Lu ◽  
A. J. Agopian ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Prevention Study ◽  
Diabetes And Obesity
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