scholarly journals A Systematic Review on the Feasibility of Salivary Biomarkers for Alzheimer’s Disease

2019 ◽  
Author(s):  
Mohamed Bouftas
Keyword(s):  
Systematic Review ◽  
Cumulative Effect ◽  
Csf Biomarkers ◽  
Large Sample Size ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Salivary Biomarkers ◽  
And Control ◽  
Saliva Composition ◽  
Selection Of

Abstract Background: Early AD diagnosis is critical for ameliorating prognosis and treatment. The analysis of CSF biomarkers yields accurate results, but it necessitates a lumbar puncture procedure. Screening for peripheral biomarkers in saliva is advantageous since this medium is noninvasive and inexpensive to obtain. The objective of this systematic review is to analyze saliva biomarker studies which aim to diagnose AD. Methods: Titles, abstracts, and reference lists for publications from February 2004 to March 2019 were screened for by searching Google Scholar and PubMed. The inclusion criteria involved published studies that consisted of both AD and control groups. Results: 77 studies were screened, and 13 publications fulfilled the inclusion criteria. These selected publications were scrutinized and included in this review. Numerous biomarkers were analyzed, including Aβ42, tau, and various salivary metabolites. Conclusion: Aβ42, tau, lactoferrin, and various metabolites might serve as a reliable biomarkers for AD diagnosis. However, these studies must be replicated with a large sample size. It is also important to standardize the analytical methods of measuring salivary biomarkers to establish coherence for the selection of valid AD biomarkers. Saliva composition can be affected by production rate, circadian rhythms, and oral health, so their cumulative effect on the accuracy of saliva testing requires further investigation. Keywords: Alzheimer, biomarker, saliva

scholarly journals A Systematic Review on the Feasibility of Salivary Biomarkers for Alzheimer’s Disease

2019 ◽  
Author(s):  
Mohamed Bouftas
Keyword(s):  
Systematic Review ◽  
Cumulative Effect ◽  
Csf Biomarkers ◽  
Large Sample Size ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Salivary Biomarkers ◽  
And Control ◽  
Saliva Composition ◽  
Selection Of

Abstract Background: Early AD diagnosis is critical for ameliorating prognosis and treatment. The analysis of CSF biomarkers yields accurate results, but it necessitates a lumbar puncture procedure. Screening for peripheral biomarkers in saliva is advantageous since this medium is noninvasive and inexpensive to obtain. The objective of this systematic review is to analyze saliva biomarker studies which aim to diagnose AD. Methods: Titles, abstracts, and reference lists for publications from February 2004 to March 2019 were screened for by searching Google Scholar and PubMed. The inclusion criteria involved published studies that consisted of both AD and control groups. Results: 77 studies were screened, and 13 publications fulfilled the inclusion criteria. These selected publications were scrutinized and included in this review. Numerous biomarkers were analyzed, including Aβ42, tau, and various salivary metabolites. Conclusion: Aβ42, tau, lactoferrin, and various metabolites might serve as a reliable biomarkers for AD diagnosis. However, these studies must be replicated with a large sample size. It is also important to standardize the analytical methods of measuring salivary biomarkers to establish coherence for the selection of valid AD biomarkers. Saliva composition can be affected by production rate, circadian rhythms, and oral health, so their cumulative effect on the accuracy of saliva testing requires further investigation. Keywords: Alzheimer, biomarker, saliva

scholarly journals A Systematic Review on the Feasibility of Salivary Biomarkers for Alzheimer’s Disease

2020 ◽  
pp. 1-8
Author(s):  
M. Bouftas
Keyword(s):  
Systematic Review ◽  
Roc Curves ◽  
Csf Biomarkers ◽  
Oral Microbiota ◽  
Clinical Settings ◽  
Large Sample Size ◽  
Inclusion Criteria ◽  
Salivary Biomarkers ◽  
And Control ◽  
Near Future

Early AD diagnosis is critical for ameliorating prognosis and treatment. The analysis of CSF biomarkers yields accurate results, but it necessitates a lumbar puncture procedure. Screening for peripheral biomarkers in saliva is advantageous since this medium is noninvasive and inexpensive to obtain. The objective of this systematic review is to analyze saliva biomarker studies which aim to diagnose AD. Titles, abstracts, and reference lists for publications from January 2004 to February 2020 were screened for by searching Google Scholar and PubMed. The inclusion criteria involved published studies that consisted of both AD and control groups. 88 studies were screened, and 20 publications fulfilled the inclusion criteria. These selected publications were scrutinized and included in this review. Aβ42, tau, certain metabolites, and oral microbiota might serve as reliable biomarkers for AD diagnosis. These results showcase the legitimate feasibility of proteomic, metabolomic, and microbiotic compounds in saliva for AD diagnostics in the near future. Supplemental studies must consider standardizing the analytical methods of measuring salivary biomarkers to establish coherence for the selection of valid AD biomarkers. Validation studies will require a large sample size of biomarker-diagnosed individuals for independent populations. This ensures accuracy and rigidity for receiver operating characteristic (ROC) curves that can be set for the most optimal salivary biomarkers in future clinical settings.

scholarly journals The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 793
Author(s):  
Chiara Montano ◽  
Luigi Auletta ◽  
Adelaide Greco ◽  
Dario Costanza ◽  
Pierpaolo Coluccia ◽  
...  
Keyword(s):  
Systematic Review ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Definitive Evidence ◽  
Dichotomous Data ◽  
And Control ◽  
Risk Ratios

The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.

scholarly journals The Current Status of Clinical Research Involving Microneedles: A Systematic Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1113
Author(s):  
Seung-Yeon Jeong ◽  
Jung-Hwan Park ◽  
Ye-Seul Lee ◽  
Youn-Sub Kim ◽  
Ji-Yeun Park ◽  
...  
Keyword(s):  
Clinical Effect ◽  
Osteoporosis Treatment ◽  
Current Status ◽  
Current Evidence ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Randomized Controlled ◽  
And Control

In recent years, a number of clinical trials have been published on the efficacy and safety of drug delivery using microneedles (MNs). This review aims to systematically summarize and analyze the current evidence including the clinical effect and safety of MNs. Three electronic databases, including PubMed, were used to search the literature for randomized controlled trials (RCTs) and clinical controlled trials (CCTs) that evaluated the therapeutic efficacy of MNs from their inception to 28 June 2018. Data were extracted according to the characteristics of study subjects; disorder, types, and details of the intervention (MNs) and control groups; outcome measurements; effectiveness; and incidence of adverse events (AEs). Overall, 31 RCTs and seven CCTs met the inclusion criteria. Although MNs were commonly used in skin-related studies, evaluating the effects of MNs was difficult because many studies did not provide adequate comparison values between groups. For osteoporosis treatment, vaccine, and insulin delivery studies, MNs were comparable to or more effective than the gold standard. Regarding the safety of MNs, most AEs reported in each study were minor (grade 1 or 2). A well-designed RCT is necessary to clearly evaluate the effectiveness of MNs in the future.

scholarly journals EFFECT OF PILATES METHOD ON PHYSICAL FITNESS RELATED TO HEALTH IN THE ELDERLY: A SYSTEMATIC REVIEW

2019 ◽  
Vol 25 (1) ◽  
pp. 76-87
Author(s):  
Gabrielle Critine Moura Fernandes Pucci ◽  
Eduardo Borba Neves ◽  
Francisco José Félix Saavedra
Keyword(s):  
Systematic Review ◽  
Physical Fitness ◽  
The Elderly ◽  
Inclusion Criteria ◽  
Level Of Evidence ◽  
Quasi Experimental ◽  
Pilates Method ◽  
Functional Autonomy ◽  
Selection Of

ABSTRACT The objective of this review was to analyze the evidence of Pilates in physical fitness related to health in the elderly. The article indexing databases (Pubmed, Medline, Science Direct, Scielo, Lilacs, and Cochrane) were reviewed along with the Pilates, elderly and aging descriptors. A total of 41 studies with a randomized experimental and quasi-experimental design met the inclusion criteria. The selection of the studies was carried out by two researchers and the quality of the articles was assessed using the PEDro scale. Interventions ranged from 4-24 weeks with 1-3 sessions/week, and balance was the most investigated variable. The studies included in this review indicate that Pilates improves health status in the elderly, promoting gains in balance, muscle strength, flexibility, functional autonomy, muscular endurance, body composition and aerobic endurance. Despite these findings, some variables need to be further investigated. Level of Evidence II; Systematic review.

scholarly journals Systematic Review and Pooled Analyses of Recent Neurointerventional Randomized Controlled Trials: Setting a New Standard of Care for Acute Ischemic Stroke Treatment after 20 Years

2016 ◽  
Vol 5 (1-2) ◽  
pp. 39-50 ◽  
Author(s):  
Mohammed Hussain ◽  
Mohammad Moussavi ◽  
Daniel Korya ◽  
Siddhart Mehta ◽  
Jaskiran Brar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Randomized Controlled Trials ◽  
Endovascular Therapy ◽  
Standard Of Care ◽  
Controlled Trials ◽  
Control Groups ◽  
Randomized Controlled ◽  
And Control ◽  
Iv Tpa

Background: Recent advances in the treatment of ischemic stroke have focused on revascularization and led to better clinical and functional outcomes. A systematic review and pooled analyses of 6 recent multicentered prospective randomized controlled trials (MPRCT) were performed to compare intravenous tissue plasminogen activator (IV tPA) and endovascular therapy (intervention) with IV tPA alone (control) for anterior circulation ischemic stroke (AIS) secondary to large vessel occlusion (LVO). Objectives: Six MPRCTs (MR CLEAN, ESCAPE, EXTEND IA, SWIFT PRIME, REVASCAT and THERAPY) incorporating image-based LVO AIS were selected for assessing the following: (1) prespecified primary clinical outcomes of AIS patients in intervention and control arms: good outcomes were defined by a modified Rankin Scale score of 0-2 at 90 days; (2) secondary clinical outcomes were: (a) revascularization rates [favorable outcomes defined as modified Thrombolysis in Cerebral Infarction scale (mTICI) score of 2b/3]; (b) symptomatic intracranial hemorrhage (sICH) rates and mortality; (c) derivation of number needed to harm (NNH), number needed to treat (NNT), and relative percent difference (RPD) between intervention and control groups, and (d) random effects model to determine overall significance (forest and funnel plots). Results: A total of 1,386 patients were included. Good outcomes at 90 days were seen in 46% of patients in the intervention (p < 0.00001) and in 27% of patients in the control groups (p < 0.00002). An mTICI score of 2b/3 was achieved in 70.2% of patients in the intervention arm. The sICH and mortality in the intervention arm compared with the control arm were 4.7 and 14.3% versus 7.9 and 17.8%, respectively. The NNT and NNH in the intervention and control groups were 5.3 and 9.1, respectively. Patients in the intervention arm had a 50.1% (RPD) better chance of achieving a good 90-day outcome as compared to controls. Conclusions: Endovascular therapy combined with IV tPA (in appropriately selected patients) for LVO-related AIS is superior to IV tPA alone. These results support establishing an endovascular therapy in addition to IV tPA as the standard of care for AIS secondary to LVO.

scholarly journals A Comparative Study of Relationship between Micronutrients and Gestational Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Farideh Akhlaghi ◽  
Seyyed Majid Bagheri ◽  
Omid Rajabi
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Gestational Age ◽  
Control Group ◽  
Study Group ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Significant Difference ◽  
Micronutrient Concentration ◽  
And Control

In this paper, we studied the relation between the micronutrient and gestational diabetes. Therefore, we measured micronutrient concentration including Ni, Al, Cr, Mg, Fe, Zn, Cu, and Se in serum of women with gestational diabetes between 24 and 28 weeks of gestational age (study group) who had inclusion criteria and comparison with micronutrient levels in normal pregnant women with same gestational age (control group). Results showed that there was no significant difference between the serum micronutrient level (Ni, Al, Cr, Mg, Zn, Cu, Se) in study and control groups except serum level of iron which in serum of gestational diabetic women was lower than normal pregnant women and difference was significant.

scholarly journals Functional Status Assessment of COPD Based on Ability to Perform Daily Living Activities: A Systematic Review of Paper and Pencil Instruments

2015 ◽  
Vol 8 (3) ◽  
pp. 210 ◽  
Author(s):  
Fateme Monjazebi ◽  
Asghar Dalvandi ◽  
Abbas Ebadi ◽  
Hamid Reza Khankeh ◽  
Mehdi Rahgozar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Data Extraction ◽  
Chronic Obstructive ◽  
Inclusion Criteria ◽  
Health Measurement ◽  
Manual Search ◽  
Paper And Pencil ◽  
Selection Of

<p><strong>CONTEXT: </strong>Activity of daily living (ADL) is an important predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Increasing ADL is important in patients with COPD and assessment of ADL is one of the best ways to evaluate the status of COPD patients.</p> <p><strong>OBJECTIVES: </strong>The objective of this systematic review was to provide an overview of the psychometric properties of paper and pencil instruments measuring ADL in patients with COPD.</p> <p><strong>DATA SOURCES:</strong> English papers published from 1980 to 2014 regarding ADL in patients with COPD were searched in  Web of Science, MEDLINE, Google Scholar, Cochrane, PubMed, ProQuest, and CINAHL databases using the following keywords: “COPD”, “ADL”, “activities of daily living”, “daily activities”, “instrument”, “questionnaire”, “paper-and-pencil instruments”, and “measure”. Following the Internet search, manual search was also done to find article references.</p> <p><strong>STUDY SELECTION:</strong> A total of 186 articles were found. Of those, 31 met the inclusion criteria. Full texts of articles meeting the inclusion criteria were studied. Consensus-based standards for the selection of health measurement instruments<strong>"</strong>(COSMIN) were used to assess the quality of the studies.</p> <p><strong>DATA EXTRACTION:</strong> Data extraction form based on research aims developed by researchers and<strong> </strong>psychometric experts, with 17 questions was used.</p> <p><strong>RESULTS: </strong>In these articles, 14 pen and paper instruments were identified for examining ADL in patients with COPD; of which, 4 dealt directly with ADL while 9 assessed other criteria i.e. dyspnea as ADL indicator. The majority of instruments only dealt with two main dimensions of ADL: Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL), and did not consider Advanced Activities of Daily Living (AADL), which is influenced by cultural and motivational factors.</p> <p><strong>CONCLUSION:</strong> Despite several ADL instruments identified, complete psychometric processes have only been done in a few of them. Selection of the appropriate instrument should focus on the aim of the study and the target construct.</p>

scholarly journals Genotyping analysis of the Pax9 Gene in patients with maxillary canine impaction

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 254 ◽  
Author(s):  
Evy Eida Vitria ◽  
Iwan Tofani ◽  
Lindawati Kusdhany ◽  
Endang Winiati Bachtiar
Keyword(s):  
Inclusion Criteria ◽  
Nucleotide Polymorphism ◽  
Chromosome 14 ◽  
Control Groups ◽  
Maxillary Canine ◽  
Single Nucleotide ◽  
Ncbi Dbsnp ◽  
Polymerase Chain ◽  
And Control ◽  
The Relationship

Background: Paired-box gene 9 (PAX9) mutation is potentially associated with impaction in some patient populations. Here, we analyzed the relationship between PAX9 polymorphism and the occurrence of maxillary canine impaction. Methods: Patients with and without maxillary canine impaction were selected based on specific inclusion criteria, and samples of genomic DNA were obtained from a buccal mucosa swab. DNA was amplified by polymerase chain reaction and sequenced for further bioinformatics analysis to identify single nucleotide polymorphism (SNP) genotypes. Genotype and allele counting was performed in both case and control groups prior to conducting statistical analysis. Results: Four SNPs were identified in patients with maxillary canine impaction, with relative confidence determined based on chromatogram-peak assessment. All SNPs were located in exon 3 of PAX9 and in the region sequenced by the primer pair −197Fex3 and +28Rex3. Three of the SNPs (rs375436662, rs12881240, and rs4904210) were reported previously and are annotated in NCBI (dbSNP version 150), whereas another SNP mapped to chromosome 14 has not been reported. Patients with a CC genotype at SNP 3 [odds ratio (OR): 2.61 vs. TT; 1.28 vs. CT] and a CC genotype at SNP 4 [OR: 0.71 vs. GG; 0.79 vs. CG] were more likely to have maxillary canine impaction. Conclusions: These results demonstrated that the presence of SNPs 3 and 4 is associated with increased likelihood of suffering from maxillary canine impaction.

scholarly journals The neuropsychological outcomes of non-fatal strangulation in domestic and sexual violence: A systematic review.

2020 ◽  
Author(s):  
Helen Bichard ◽  
Christopher Byrne ◽  
Christopher W N Saville ◽  
Rudi Coetzer
Keyword(s):  
Acquired Brain Injury ◽  
Speech Disorders ◽  
Self Report ◽  
Loss Of Consciousness ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Physiological Mechanisms ◽  
Ischaemic Injury ◽  
Neuropsychological Outcomes ◽  
And Control

This paper reviews the neurological, cognitive, psychological, and behavioural outcomes of non-fatal strangulation and, given shared physiological mechanisms, asks whether the hypoxic-ischaemic literature can serve as a proxy. 27 empirical, peer-reviewed studies meeting the inclusion criteria were found. Neurological consequences included loss of consciousness, indicating at least mild acquired brain injury, stroke, seizures, motor and speech disorders, and paralysis. Psychological outcomes included PTSD, depression, suicidality, and dissociation. Cognitive and behavioural sequelae were described less frequently, but included amnesia and compliance. Overall, the evidence suggested strangulation in IPV and sexual assault can share all the serious consequences of hypoxic-ischaemic injury, but carries additional neuropsychological burden. However, no papers used formal neuropsychological assessment: the majority were medical case studies, or based on self-report. There is therefore a need for further neuropsychological research, focusing on cognitive and behavioural outcomes, using standardised tools, and control groups where possible. This is urgent, given societal normalisation of strangulation, and consent to ‘rough sex’ being used as a legal defence. We also discuss broader implications: the popularity of the ‘choking game’ with teenagers, and carotid injuries within mixed martial arts.

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