scholarly journals A Computational Fluid Dynamics Protocol for The Hemodynamic Analysis of a Microfluidic Model of Thrombosis

2021 ◽  
Author(s):  
Yunduo Charles Zhao ◽  
Sarah Elizabeth Keogh ◽  
Parham Vatankhah ◽  
Renee Ellen Preketes-Tardiani ◽  
Lining Arnold Ju

Abstract Thrombosis is both attributed to biochemical agonists and mechanical stresses applied to platelets. Whilst the effect of biochemical agonists has been extensively studied, the mechanosensitive factors remain poorly defined. Stenotic microfluidic channels mimic the narrowing vessels, providing the real-time observation of platelets under disturbed flow. Though the experimental analysis of platelets in disturbed flow confirms the mechanosensitive behavior of platelets, it cannot explicate detailed thresholds for platelet activation. Computational Fluid Dynamics (CFD) could be utilized alongside experimental analysis to characterize thresholds for platelet behavior under imposed shear stress. CFD simulations, however, are prone to uncertainties and errors which should be minimized to obtain compelling results. Hereby, we have presented a CFD protocol for researchers in the field of microfluidic and hemodynamic studies.

1996 ◽  
Vol 33 (9) ◽  
pp. 163-170 ◽  
Author(s):  
Virginia R. Stovin ◽  
Adrian J. Saul

Research was undertaken in order to identify possible methodologies for the prediction of sedimentation in storage chambers based on computational fluid dynamics (CFD). The Fluent CFD software was used to establish a numerical model of the flow field, on which further analysis was undertaken. Sedimentation was estimated from the simulated flow fields by two different methods. The first approach used the simulation to predict the bed shear stress distribution, with deposition being assumed for areas where the bed shear stress fell below a critical value (τcd). The value of τcd had previously been determined in the laboratory. Efficiency was then calculated as a function of the proportion of the chamber bed for which deposition had been predicted. The second method used the particle tracking facility in Fluent and efficiency was calculated from the proportion of particles that remained within the chamber. The results from the two techniques for efficiency are compared to data collected in a laboratory chamber. Three further simulations were then undertaken in order to investigate the influence of length to breadth ratio on chamber performance. The methodology presented here could be applied to complex geometries and full scale installations.


2008 ◽  
Vol 5 (28) ◽  
pp. 1291-1301 ◽  
Author(s):  
Sam Van Wassenbergh ◽  
Peter Aerts

Most theoretical models of unsteady aquatic movement in organisms assume that including steady-state drag force and added mass approximates the hydrodynamic force exerted on an organism's body. However, animals often perform explosively quick movements where high accelerations are realized in a few milliseconds and are followed closely by rapid decelerations. For such highly unsteady movements, the accuracy of this modelling approach may be limited. This type of movement can be found during pivot feeding in pipefish that abruptly rotate their head and snout towards prey. We used computational fluid dynamics (CFD) to validate a simple analytical model of cranial rotation in pipefish. CFD simulations also allowed us to assess prey displacement by head rotation. CFD showed that the analytical model accurately calculates the forces exerted on the pipefish. Although the initial phase of acceleration changes the flow patterns during the subsequent deceleration phase, the accuracy of the analytical model was not reduced during this deceleration phase. Our analysis also showed that prey are left approximately stationary despite the quickly approaching pipefish snout. This suggests that pivot-feeding fish need little or no suction to compensate for the effects of the flow induced by cranial rotation.


RBRH ◽  
2021 ◽  
Vol 26 ◽  
Author(s):  
Mayara Francisca da Silva ◽  
Fábio Veríssimo Gonçalves ◽  
Johannes Gérson Janzen

ABSTRACT Computational Fluid Dynamics (CFD) simulations of a leakage in a pressurized pipe were undertaken to determine the empirical effects of hydraulic and geometric factors on the leakage flow rate. The results showed that pressure, leakage area and leakage form, influenced the leakage flow rate significantly, while pipe thickness and mean velocity did not influence the leakage flow rate. With relation to the interactions, the effect of pressure upon leakage flow rate depends on leakage area, being stronger for great leakage areas; the effects of leakage area and pressure on leakage flow rate is more pronounced for longitudinal leakages than for circular leakages. Finally, our results suggest that the equations that predict leakage flow rate in pressurized pipes may need a revision.


2021 ◽  
Author(s):  
Darren Jia

Diabolo is a popular game in which the object can be spun at up to speeds of 5000 rpm. This high spin velocity gives the diabolo the necessary angular momentum to remain stable. The shape of the diabolo generates an interesting air flow pattern. The viscous air applies a resistive torque on the fast spinning diabolo. Through computational fluid dynamics (CFD) simulations it's shown that the resistive torque has an interesting dependence on the angular speed of the diabolo. Further, the geometric shape of the diabolo affects the dependence of torque on angular speed.


Fluids ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 73 ◽  
Author(s):  
Galih Bangga

The present studies deliver the computational investigations of a 10 MW turbine with a diameter of 205.8 m developed within the framework of the AVATAR (Advanced Aerodynamic Tools for Large Rotors) project. The simulations were carried out using two methods with different fidelity levels, namely the computational fluid dynamics (CFD) and blade element and momentum (BEM) approaches. For this purpose, a new BEM code namely B-GO was developed employing several correction terms and three different polar and spatial interpolation options. Several flow conditions were considered in the simulations, ranging from the design condition to the off-design condition where massive flow separation takes place, challenging the validity of the BEM approach. An excellent agreement is obtained between the BEM computations and the 3D CFD results for all blade regions, even when massive flow separation occurs on the blade inboard area. The results demonstrate that the selection of the polar data can influence the accuracy of the BEM results significantly, where the 3D polar datasets extracted from the CFD simulations are considered the best. The BEM prediction depends on the interpolation order and the blade segment discretization.


Proceedings ◽  
2020 ◽  
Vol 49 (1) ◽  
pp. 159
Author(s):  
Knut Erik Teigen Giljarhus ◽  
Daniel Årrestad Stave ◽  
Luca Oggiano

In professional cycling, even small adjustments in position could mean that valuable seconds are gained over the course of a time-trial race. This study investigates the influence of arm position on the aerodynamic drag of a cyclist. Based on a 3D scanned model of a professional cyclist, 64 alternate positions are generated. The parameters that are investigated are the distance between elbows, elbow extension, and distance between hands. Computational fluid dynamics (CFD) simulations of all positions are performed, and a regression model is built from the results. The results indicate that the optimal posture is achieved for a minimum in all investigated parameters, which means that the hands and elbows should be kept together with hands up towards the face. Furthermore, elbow extension seems to be the most crucial parameter, followed by the distance between elbows, and then by the distance between the hands. The presented methodology can be applied to study other parameters relevant to cycling aerodynamics or be applied to other sport activities as well.


Joint Rail ◽  
2002 ◽  
Author(s):  
Robert A. MacNeill ◽  
Samuel Holmes ◽  
Harvey S. Lee

This paper describes measurement of the aerodynamic pressures produced by a Bombardier High-Speed Non-Electric Locomotive (HSNEL) on an adjacent stationary double-stack freight car. Static pressures are measured on the near and far-side faces of the freight containers over a range of locomotive speeds from 60 to 130 mph. This data is also compared with the pressures predicted by computational fluid dynamics (CFD) simulations.


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