scholarly journals Indolent Enhancing Spinal Lesions Mimicking Spinal Metastasis in Pediatric Patients With Malignant Primary Brain Tumors

2021 ◽  
Author(s):  
Hsin-Wei Wu ◽  
Shih-Chieh Lin ◽  
Ching-Lan Wu ◽  
Kang-Lung Lee ◽  
Chia-Hung Wu ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Spinal Metastasis ◽  
Young Patients ◽  
Pathologic Fracture ◽  
Previous Treatment ◽  
Primary Brain Tumor ◽  
Clinical Impression ◽  
Spinal Lesions ◽  
Image Characteristics ◽  
Vertebral Shape

Abstract BackgroundSpinal metastasis from malignant primary brain tumor (MPBT) in pediatric is rare, often appearing as enhancing lesions on MRI. However, some indolent enhancing spinal lesions (IESL) resulting from previous treatment mimic metastasis on MRI, leading to unnecessary investigation and treatment. MethodsIn 2005-2020, we retrospectively enrolled 12 pediatric/young patients with clinical impression of spinal metastasis, and pathological diagnosis of their spinal lesions. Three patients had MPBT with IESL, and 9 patients had malignant tumors with metastases. The histopathologic diagnosis of IESL was unremarkable marrow change. We evaluated their MRI, CT, and bone scan findings.Results Image findings of IESL vs spinal metastasis were 1) shape: round/ovoid (3/3, 100%) vs irregular (9/9, 100%) (P= .005); 2) target-shaped enhancement: (3/3, 100%) vs (0/9, 0%) (P= .005); 3) pathologic fracture of vertebral body: (1/3, 33.3%) vs (9/9, 100%) (P= .045); 4) expansile vertebral shape (0/3, 0%) vs (9/9, 100%) (P= .005); 5) obliteration of basivertebral vein: (0/3, 0%) vs (9/9, 100%) (P= .005); 6) osteoblastic change on CT: (3/3, 100%) vs (2/9, 22.2%) (P= .034).ConclusionsIESL in pediatrics with MPBT can be differentiated from metastasis by their image characteristics. We suggest close follow-up rather than aggressive investigation and treatment for IESL.

METASTATIC LESION OF THE SPINE: DIAGNOSIS AND TACTICS OF SURGICAL TREATMENT

2019 ◽  
Vol 65 (6) ◽  
pp. 868-876
Author(s):  
Anton Yarikov ◽  
Anton Yermolaev ◽  
Igor Smirnov ◽  
Anton Denisov ◽  
Olga Perlmutter ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Epidemiological Studies ◽  
Metastatic Lesion ◽  
Spinal Cord Damage ◽  
Metastatic Lesions ◽  
Spinal Lesions ◽  
Cancer Pathology ◽  
Surgical Methods ◽  
The Stability ◽  
Methods Of Treatment

Epidemiological studies show an increase in the number of people with cancer. Bone metastases are a frequent manifestation of generalized cancer, because it is in malignant tumors of the spine more often than other bones of the skeleton becomes a target for metastasis. The article describes in detail the methods of diagnosis of spinal lesions in cancer pathology. Particular attention is paid to the scales reflecting the severity of the patient’s condition, the degree of spinal cord damage, the severity of pain in metastasis to the spine, the prognosis of survival in oncovertebrology and evaluation of the stability of the spine in metastatic lesions. Further, the paper presents non-radical (decompression, vertebroplasty) and radical (spondylectomy, corporectomy) surgical methods of treatment

Primary stromal sarcoma of breast: A case report and literature review

2021 ◽  
pp. 1-7
Author(s):  
Mohammad Al-Wiswasy ◽  
Mahmoud Al-Balas ◽  
Raith Al-Saffar ◽  
Hamzeh Al-Balas
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Prognostic Significance ◽  
Total Duration ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Breast Mass ◽  
Resection Margins ◽  
Stromal Sarcoma ◽  
First Case

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

Primary Malignant Tumors of the Thyroid Gland. Histology, Age and Sex Distribution and Pathologic Correlations in 139 Cases

1983 ◽  
Vol 69 (3) ◽  
pp. 205-213 ◽  
Author(s):  
Carlo D. Baroni ◽  
Liborio Manente ◽  
Vincenzo Maccallini ◽  
Giorgio Di Matteo
Keyword(s):  
Thyroid Gland ◽  
Malignant Tumors ◽  
Regional Lymph Node ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Regional Metastases ◽  
Total Female ◽  
Toxic Goiter ◽  
University Of Rome

The classification proposed by Woolner et al. (1961, 1971) has been applied to 139 cases of primary malignant tumors of the thyroid gland diagnosed in one of the largest hospitals of Rome, Italy, over a period of 5 years, from 1977 to 1981. These cases come from 1418 patients with enlargement of the thyroid surgically treated at the 5th Surgical Clinic of the University of Rome. All the histologic slides were re-examined, and the pathology records were re-evaluated. Of these tumors, 56.8% were papillary, 30.9% follicular, 9.3% anaplastic or undifferentiated, and 2.1% medullary. There was a female predominance in all age groups and for all types of tumors, reflecting a total female to male ratio of 1.9:1. Papillary carcinoma occurred most commonly in young and young-adult patients, follicular in the middle-age group, and anaplastic in the elderly. The extent of the primary tumor, the presence of regional metastases, and the association with other thyroid nonneoplastic diseases such as lymphocytic and Hashimoto's thyroiditis, and nontoxic and toxic goiter were also recorded. Multicentric rumors were found in 38.9% of cases principally represented by papillary carcinomas. Regional lymph node metastases were observed mainly in young patients, and no correlation was found between thyroid cancer incidence and other nonneoplastic thyroid diseases.

scholarly journals Giant Ossified Clival Chondrosarcoma Resection: 2-Dimensional Operative Video

2021 ◽  
Author(s):  
Walid Ibn Essayed ◽  
Ossama Al-Mefty
Keyword(s):  
Skull Base ◽  
Malignant Tumors ◽  
Young Patients ◽  
Radical Resection ◽  
Neurological Deficits ◽  
Adjuvant Radiation ◽  
Lower Grade ◽  
Grade Ii ◽  
Giant Size

Abstract Chondrosarcomas are a spectrum of tumors with variable clinical behavior, histologically classified as grades I, II, and III.1 Maximal surgical resection with adjuvant radiation is the gold standard for grade III malignant tumors.2,3 Lower-grade skull base chondrosarcomas have a slow progressive local growth pattern with an overall benign profile.1,4 In these grade I and II tumors, radical resection can be sufficient in achieving long-term control of the disease without the need for adjuvant therapy, thus avoiding the long-term side effects of irradiation in relatively young patients.4,5 As a slow-growing tumor, skull base chondrosarcoma might reach a giant size with progressive neurological deficits prior to diagnosis. In these cases, to achieve maximal resection, skull base approaches tailored to the patient's anatomy are essential.4,6 Cranial approach is frequently needed due to the calcified nature of part of the tumor that is not amenable to resection through the endonasal approach. The endoscope is extremely helpful combined with the microscopic resection. We demonstrate these techniques through in the surgery of a 39-yr-old female who presented with progressive neurological deficits from a giant ossified chondrosarcoma and underwent a combined petrosal approach for the resection of her tumor. A postoperative small enhancement remained stable on the 4-yr follow-up exam. The pathology confirmed grade II chondrosarcoma, with the patient recovering from her neurological deficit except the third nerve. The patient consented to the surgery and publication of images.  Image at 1:36 reprinted with permission from Al-Mefty O, Operative Atlas of Meningiomas. Vol 1, ©LWW, 1998.

scholarly journals Successful treatment of a patient with Turcot syndrome

2018 ◽  
Vol 8 (3) ◽  
pp. 46-50
Author(s):  
V. A. Aliev ◽  
Z. Z. Mamedli ◽  
A. I. Ovchinnikova ◽  
O. A. Rakhimov ◽  
L. N. Lyubchenko ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Malignant Tumors ◽  
Social Activity ◽  
Previous Treatment ◽  
Disease Stage ◽  
Turcot Syndrome ◽  
Accelerated Rehabilitation ◽  
One Year ◽  
Mechanical Anastomosis

We report a case of successful treatment of a 15-year-old female patient (body mass index 16) diagnosed with Turcot syndrome (familial adenomatous polyposis of the colon) combined with multiple primary malignant tumors, including anaplastic astrocytoma (received combination therapy in 2007), metachronous cecal cancer (underwent subtotal colectomy and 12 courses of polychemotherapy in 2016–2017), and metachronous stage III pT3N1M0 rectal cancer at 8 cm. The patient underwent laparoscopic low resection with extirpation of the ileosigmoid anastomosis, creation of a reservoir-rectal anastomosis, and preventive ileostomy. The patient had minimal intraoperative blood loss and uneventful postoperative period (with an accelerated rehabilitation protocol). She was discharged from a hospital on day 9. Considering previous treatment episodes and the disease stage, we also included into the treatment regimen adjuvant FOLFOX polychemotherapy in a reduced dose for 6 months. During one-year follow up, there was no evidence of disease progression. Later, the patient underwent ileostomy closure with forming a side-to-side mechanical anastomosis. The patient is fully rehabilitated in term of her social activity.

scholarly journals Borderline ovarian tumors

2006 ◽  
Vol 14 (1-2) ◽  
pp. 62-63
Author(s):  
Katarina Mastilovic ◽  
Tatjana Ivkovic-Kapicl ◽  
Milica Zivaljevic ◽  
Jelka Rajovic ◽  
Dejan Nincic
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumors ◽  
Young Patients ◽  
Ovarian Tumors ◽  
Disease Stage ◽  
Early Disease ◽  
Oncogenic Potential ◽  
Stage Of Disease ◽  
Borderline Ovarian Tumors ◽  
Early Disease Stage

Borderline ovarian tumors are classified between benign cystadenoma and malignant cystadenocarcinoma. They are characterized as malignant tumors by histopathological features, which make them different from the benign ones. These tumors are commonly diagnosed at the early disease stage. The treatment of these tumors is surgical. The prognosis depends on the stage of disease and histopahtological types. We present 10 patients operated at the Institute of Oncology Sremska Kamenica because of malignant tumors with low malignant oncogenic potential in the period between 2000 and 2005. All patients had surgical treatment with ex tempore diagnostics, hysterectomy and adnexectomy with total omentectomy, or unilaterals adnexectomy. All patients had negative cytoanalytic findings of the small pelvis. Histopathological findings are necessary to confirm the diagnosis of disease. In young patients who had no children fertility can be preserved.

scholarly journals Image Features of Magnetic Resonance Imaging under the Deep Learning Algorithm in the Diagnosis and Nursing of Malignant Tumors

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Lifang Sun ◽  
Xi Hu ◽  
Yutao Liu ◽  
Hengyu Cai
Keyword(s):  
Deep Learning ◽  
Brain Tumor ◽  
Learning Algorithm ◽  
Malignant Tumors ◽  
Image Features ◽  
Control Group ◽  
Deep Learning Algorithm ◽  
Image Characteristics ◽  
Traditional Algorithm ◽  
Mri Image

In order to explore the effect of convolutional neural network (CNN) algorithm based on deep learning on magnetic resonance imaging (MRI) images of brain tumor patients and evaluate the practical value of MRI image features based on deep learning algorithm in the clinical diagnosis and nursing of malignant tumors, in this study, a brain tumor MRI image model based on the CNN algorithm was constructed, and 80 patients with brain tumors were selected as the research objects. They were divided into an experimental group (CNN algorithm) and a control group (traditional algorithm). The patients were nursed in the whole process. The macroscopic characteristics and imaging index of the MRI image and anxiety of patients in two groups were compared and analyzed. In addition, the image quality after nursing was checked. The results of the study revealed that the MRI characteristics of brain tumors based on CNN algorithm were clearer and more accurate in the fluid-attenuated inversion recovery (FLAIR), MRI T1, T1c, and T2; in terms of accuracy, sensitivity, and specificity, the mean value was 0.83, 0.84, and 0.83, which had obvious advantages compared with the traditional algorithm ( P < 0.05 ). The patients in the nursing group showed lower depression scores and better MRI images in contrast to the control group ( P < 0.05 ). Therefore, the deep learning algorithm can further accurately analyze the MRI image characteristics of brain tumor patients on the basis of conventional algorithms, showing high sensitivity and specificity, which improved the application value of MRI image characteristics in the diagnosis of malignant tumors. In addition, effective nursing for patients undergoing analysis and diagnosis on brain tumor MRI image characteristics can alleviate the patient’s anxiety and ensure that high-quality MRI images were obtained after the examination.

Metastatic Disease

2019 ◽  
pp. 325-329
Author(s):  
Stephanie McCann ◽  
Stephen Thomas
Keyword(s):  
Soft Tissue ◽  
Metastatic Disease ◽  
Bone Pain ◽  
Malignant Tumors ◽  
Pathologic Fracture ◽  
Skeletal Metastasis ◽  
Skeletal Metastases ◽  
Bone Lesions ◽  
Tissue Mass ◽  
Primary Tumors

Chapter 63 discusses metastatic disease. Metastatic disease from carcinomas accounts for approximately 70% of malignant tumors involving the skeleton. The most common primary tumors that metastasize to bone are prostate and breast carcinomas and are termed osteotropic. Other tumors with a propensity for skeletal metastasis include lung, renal, bladder, thyroid, and lymphomas. Prostate, breast, renal cell, and lung carcinomas account for up to 80% of skeletal metastases. Patients with metastatic bone lesions may be asymptomatic or may present with localized bone pain, pathologic fracture, neurologic impingement, or an associated soft tissue mass. Imaging plays an important role in detection, diagnosis, prognosis, planning, and treatment response of metastatic bone lesions. This chapter focuses on imaging strategies to detect and characterize metastatic osseous lesions from malignant tumors.

Malignant Tumors of the Head and Neck in Young Patients

1993 ◽  
Vol 20 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Hideaki Naganuma ◽  
Hiroomi Takahashi ◽  
Makito Okamoto ◽  
Kazuo Yao ◽  
Keiichi Iwabuchi
Keyword(s):  
Head And Neck ◽  
Malignant Tumors ◽  
Young Patients

Pediatric oral lesions: a 15-year review from São Paulo, Brazil

2002 ◽  
Vol 26 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Fabrício Bitu Sousa ◽  
Adriana Etges ◽  
Luciana Corrêa ◽  
Ricardo Alves Mesquita ◽  
Ney Soares de Araújo
Keyword(s):  
Malignant Tumors ◽  
Dentigerous Cyst ◽  
Young Patients ◽  
Oral Pathology ◽  
Sao Paulo ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
São Paulo ◽  
Patients Âgés ◽  
Significant Difference

There are few studies on pediatric oral pathologies in the literature. This study presents data from a review of 2,356 biopsies of young patients (birth to 14 years) received over 15 years (1985-2000) in the Oral Pathology Service at the University of Sao Paulo, Brazil. Information about patients (sex, age, race) and histopathological diagnosis was retrieved. Diagnosis data of 2,356 biopsies were classified into 20 groups.There was no significant difference between male (50.0%) and female (49.0%) patients. White is the predominant race (69.0%), and patients ages were concentrated between 9 and 14 years old (70%). Mucocele was the most frequent (13.5%), followed by dentigerous cyst (6.5%) and fibrous hyperplasia (5.4%). Papilloma and Langerhans cells histiocytosis were the most common non-odontogenic benign and malignant tumors, respectively. In the group of odontogenic tumors, odontoma was the most frequent, and ameloblastoma had a significant incidence (27 cases). These data are important in order to detect differences in geographic areas, diagnosis line tendencies and for clinicians to perform judgment to evaluate of the pediatric patients before the biopsy and management of pediatric oral lesions.

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