Primary Malignant Tumors of the Thyroid Gland. Histology, Age and Sex Distribution and Pathologic Correlations in 139 Cases

1983 ◽  
Vol 69 (3) ◽  
pp. 205-213 ◽  
Author(s):  
Carlo D. Baroni ◽  
Liborio Manente ◽  
Vincenzo Maccallini ◽  
Giorgio Di Matteo
Keyword(s):  
Thyroid Gland ◽  
Malignant Tumors ◽  
Regional Lymph Node ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Regional Metastases ◽  
Total Female ◽  
Toxic Goiter ◽  
University Of Rome

The classification proposed by Woolner et al. (1961, 1971) has been applied to 139 cases of primary malignant tumors of the thyroid gland diagnosed in one of the largest hospitals of Rome, Italy, over a period of 5 years, from 1977 to 1981. These cases come from 1418 patients with enlargement of the thyroid surgically treated at the 5th Surgical Clinic of the University of Rome. All the histologic slides were re-examined, and the pathology records were re-evaluated. Of these tumors, 56.8% were papillary, 30.9% follicular, 9.3% anaplastic or undifferentiated, and 2.1% medullary. There was a female predominance in all age groups and for all types of tumors, reflecting a total female to male ratio of 1.9:1. Papillary carcinoma occurred most commonly in young and young-adult patients, follicular in the middle-age group, and anaplastic in the elderly. The extent of the primary tumor, the presence of regional metastases, and the association with other thyroid nonneoplastic diseases such as lymphocytic and Hashimoto's thyroiditis, and nontoxic and toxic goiter were also recorded. Multicentric rumors were found in 38.9% of cases principally represented by papillary carcinomas. Regional lymph node metastases were observed mainly in young patients, and no correlation was found between thyroid cancer incidence and other nonneoplastic thyroid diseases.

A pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small cell lung cancer (NSCLC)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7553-7553 ◽  
Author(s):  
M. Fruh ◽  
H. Tribodet ◽  
J. Pignon ◽  
T. Winton ◽  
T. Le Chevalier ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Performance Status ◽  
Age Groups ◽  
Young Patients ◽  
Disease Free Survival ◽  
The Elderly ◽  
Pooled Analysis ◽  
Severe Toxicity ◽  
Cox Models

7553 Background: Adjuvant cisplatin-based chemotherapy (CT) has been shown to increase survival in NSCLC, but uncertainty exists concerning its efficacy and toxicity in elderly patients (≥ 70). Methods: We performed a pooled analysis using individual patient data from 4,584 patients in the LACE database with resected stage IA-III NSCLC enrolled in 5 randomized trials, comparing postoperative CT to no CT (ALPI, ANITA, BLT, IALT and JBR10). Patient and treatment characteristics, CT toxicity and delivery, overall survival, disease-free survival (DFS) and cause-specific mortality were compared among 3 age groups: 3,269 (71%) young (<65), 901 (20%) mid-category (65–69) and 414 (9%) elderly (≥70). The analysis was performed on an intent-to-treat basis. Cox models stratified by trials and adjusted for age, associated drug, planned radiotherapy, total dose of cisplatin (<300, 300, >300), gender, stage, performance status, type of surgery and histology were used with a test for trend to study the effect of CT on survival according to age. Results: Baseline characteristics differed among the age groups, but this was due mainly to the different trial populations and designs. No difference in severe toxicity rate was observed among the age groups. Elderly patients received significantly smaller total doses of cisplatin than the other patients (Chi2-test: p<0.0001) and also the cisplatin doses received were more often lower than the planned one (Kruskal-Wallis test: p<0.0001). The Hazard ratio (HR) of death for the young patients was 0.82 (95% CI 0.73–0.92), 0.86 (95% CI 0.70–1.07) for the mid category and 1.01 (95% CI 0.78–1.32) for elderly patients (test for trend: p=0.17). The HR for DFS was 0.79 (95% CI 0.71–0.87) for the young, 0.76 (95% 0.62–0.93) for the mid category and 0.94 (95% CI 0.73–1.22) for the elderly patients (test for trend: p=0.35). More elderly patients died from non- lung cancer related causes (10% young, 16% mid category and 20% elderly; p<0.0001). Conclusions: The survival benefit from cisplatin-based adjuvant therapy for NSCLC patients was not significantly different according to age, but this may be due to lack of power. Supported by unrestricted grants from PHRC and LNCC No significant financial relationships to disclose.

Vitamin D Status in Patients with Osteopenia or Osteoporosis – an Audit of an Endocrine Clinic

2006 ◽  
Vol 76 (5) ◽  
pp. 307-313 ◽  
Author(s):  
Kocjan ◽  
Tan ◽  
Conway ◽  
Prelevic
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Dietary Advice ◽  
Mineral Density ◽  
Serum 25Ohd ◽  
Number Of Patients ◽  
Increase Fracture Risk

Vitamin D deficiency and insufficiency may further increase fracture risk in patients with decreased bone mineral density. We audited serum 25-hydroxyvitamin D (25OHD) concentrations in patients with osteopenia or osteoporosis attending endocrine osteoporosis clinics in North London between January 1998 and September 2001. The total number of patients analyzed was 448 (age range 17–89 years), with 191 patients being < 50 years old (42.6%). The following cut-off points for serum 25OHD were used: levels ≤ 30 nmol/L for deficiency, > 30–50 nmol/L for insufficiency, and > 50 nmol/L for sufficiency. The overall prevalence of vitamin D deficiency was 30.5% and of vitamin D insufficiency was 35.9%. Vitamin D deficiency was as prevalent in young patients as in older ones: the prevalence of serum 25OHD ≤ 30 nmol/L in those < 50 years of age was 33.0% (n = 63 of 191), compared with 31.1% (n = 80 of 257) in patients aged ≥ 50 years. Our results indicate that vitamin D deficiency and insufficiency is a common problem in patients with osteopenia or osteoporosis. This situation persists despite dietary advice and prescription of vitamin D3 supplementation. Vitamin D deficiency affects all age groups, not merely the elderly.

scholarly journals 109 Hyponatraemia in Older Patients is Often Untreated, Despite Greater Mortality Burden; Results of A Prospective Cohort Study

2020 ◽  
Vol 49 (Supplement_1) ◽  
pp. i34-i36 ◽  
Author(s):  
O Thorpe ◽  
M Cuesta ◽  
W T Tormey ◽  
M Sherlock ◽  
D J Williams ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Older Patients ◽  
Prospective Observational Study ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Plasma Sodium ◽  
Single Centre ◽  
Similar Frequency ◽  
Mortality Burden

Abstract Introduction Hyponatraemia is associated with increased morbidity and mortality, and is commoner in elderly patients. The aetiology and outcomes of hyponatraemia in the elderly has not been defined in prospective studies. Methods A single-centre 9 month prospective observational study of hyponatraemic (HN) patients (&lt;/= 130 mmol/L) was performed. Clinical outcomes in patients ≥65 years (Elderly patients, EP) and those &lt;65 years (Young Patients, YP) were analysed, and compared with age-matched eunatremic controls, Analysis was performed using Graphpad-Prism 7. Results 1321 consecutive admissions with hyponatraemia (67% EP, median age of EP 77 (65–98) years) and 1122 eunatremic controls (63% EP, median age of EP 77 (65–99) years) were analysed. Median nadir plasma sodium was similar in both groups with HN, 128 (107–130) mmol/L EP vs 128(110–130) mmol/L YP (p = 0.62). EP hyponatraemic patients were more likely to have hypovolaemic hyponatraemia (34%) compared with YP with hyponatraemia (28%, p = 0.03). Diuretic-induced hyponatraemia was twice as common in EP (8%) compared with YP (4%, p = 0.01). Malignancy-induced SIAD occurred with similar frequency in both groups (7% in EP SIAD vs 8% in YP SIAD, p = 0.65). Respiratory disease was causative in 10% cases of EP SIAD, compared with 4% in YP SIAD, p = 0.0004. Hyponatraemia was corrected in 53% of EP, compared with 64% of YP, p = 0.0001. Length of stay and re-admissions rates were similar across hyponatraemia age groups. EP with HN were 2.4 times more likely to die in hospital, compared with eunatremic age-matched controls, (OR 2.4, 95% CI 1.6–3.7, p &lt; 0.0001). Conclusions The causation of hyponatraemia is different in elderly patients. Hyponatraemia in EP is often uncorrected, despite increased mortality compared with eunatremic age-matched controls.

scholarly journals Increased Oxidative Stress Response in Granulocytes from Older Patients with a Hip Fracture May Account for Slow Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Zhiyong Wang ◽  
Sabrina Ehnert ◽  
Christoph Ihle ◽  
Lilianna Schyschka ◽  
Stefan Pscherer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Oxidative Stress Response ◽  
Proximal Femur Fracture ◽  
Mapk Activation ◽  
Stress Markers ◽  
Stress Response System

Proximal femur fracture, a typical fracture of the elderly, is often associated with morbidity, reduced quality of life, impaired physical function and increased mortality. There exists evidence that responses of the hematopoietic microenvironment to fractures change with age. Therefore, we investigated oxidative stress markers and oxidative stress-related MAPK activation in granulocytes from the young and the elderly with and without fractured long bones. Lipid peroxidation levels were increased in the elderly controls and patients. Aged granulocytes were more sensitive towards oxidative stress induced damage than young granulocytes. This might be due to the basally increased expression of SOD-1 in the elderly, which was not further induced by fractures, as observed in young patients. This might be caused by an altered MAPK activation. In aged granulocytes basal p38 and JNK activities were increased and basal ERK1/2 activity was decreased. Following fracture, JNK activity decreased, while ERK1/2 and p38 activities increased in both age groups. Control experiments with HL60 cells revealed that the observed p38 activation depends strongly on age. Summarizing, we observed age-dependent changes in the oxidative stress response system of granulocytes after fractures, for example, altered MAPK activation and SOD-1 expression. This makes aged granulocytes vulnerable to the stress stimuli of the fracture and following surgery.

scholarly journals The cerebral stroke: the structure of risk factors

2009 ◽  
Vol 15 (3) ◽  
pp. 285-289
Author(s):  
V. N. Butikov ◽  
V. V. Dudajte ◽  
G. Penina
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Elderly Population ◽  
Recurrent Stroke ◽  
Age Groups ◽  
Young Patients ◽  
Heart Rhythm ◽  
The Elderly ◽  
Cerebral Stroke ◽  
Summer Time

1357 patients with stroke, admitted to the specialized neurology department, were analyzed. The women prevail in this population and in the subgroup over 60 years old, however, males are predominant among young patients with stroke, and there number of men and women among patient of 41-60 years old is equal. If a subgroup of patients with hemorrhage stroke is analyzed, females are prevalent in all age groups. Patients with an ischemic stroke were hospitalized in the summer time more often, while patients with hemorrhage stroke were more frequently admitted in the spring. Arrhythmia and diabetes mellitus were more often reported in females, while myocardial infarction was diagnosed more frequently in males and there was higher number of smokers among men. The incidence of hypertension, heart rhythm disturbances, myocardial infarction and diabetes mellitus was higher in the elderly population. Patients with recurrent stroke are more likely to have a heart disease and myocardial infarction.

Effect of age on the pharmacokinetics of busulfan (Bu): An alliance study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 2533-2533
Author(s):  
Jan Hendrik Beumer ◽  
Lionel D. Lewis ◽  
Kouros Owzar ◽  
Chen Jiang ◽  
Julianne L. Holleran ◽  
...  
Keyword(s):  
Conditioning Regimen ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Marrow Transplant ◽  
Glutathione S Transferase ◽  
Wilcoxon Rank Sum Test ◽  
Plasma Pharmacokinetics ◽  
Age Range

2533 Background: Older acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients (pts) have been excluded from myeloablative regimens including agents such as busulfan because of the potential for non-disease related morbidity and mortality. Busulfan, often used as part of myeloablative regimens, is cleared in part by glutathione–S-transferase and CYP3A4. We hypothesized that busulfan clearance (BuCL) in the elderly (> 60 years) would be reduced compared to that in young patients (< 60 years), thus potentially explaining differences in tolerability. Methods: AML and MDS pts in three CALGB bone marrow transplant studies across a wide age range (17-74) were treated with a conditioning regimen using IV busulfan, dosed at 12.8 mg/m2 in CALGB studies 10503 and 19808 and 6.4 mg/m2 in CALGB 100103. Blood samples were collected for determination of busulfan plasma pharmacokinetics (PK). Plasma busulfan was quantitated by LC-MS. BuCL was determined using non-compartmental modeling, and normalized to actual (ABW), ideal (IBW) and corrected (CBW) body weight (kg). Differences between age groups were examined using the Wilcoxon rank sum test. Results: A total of 185 pts were accrued and signed consent, of which 174 provided useable PK data. Twenty-nine pts ≥60 years old (median age 66.3) had a significantly higher mean BuCL vs those < 60 years old (median age 49.8); BuCL 263 vs 186 mL/min, p=0.0002; BuCL/ABW 3.22 vs 2.34 mL/min/kg, p=0.0001; BuCL/IBW 3.63 vs 2.91 mL/min/kg, p=0.0035; BuCL/CBW 3.50 vs 2.70 mL/min/kg, p=0.0005. Inter-patient variability in clearance (CV%) was up to 47% in the elderly and up to 48% in young patients. Phenytoin use, a potential confounder, did not affect BuCL, regardless of weight normalization (p=0.74). Conclusions: Contrary to our hypothesis, BuCL is significantly higher in pts ≥60 years old compared to younger patients and does not explain the previously reported increase in Bu toxicity observed in the elderly.

Clinicopathologic features of gastric cancer in the elderly population.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 33-33
Author(s):  
Joo Hyun Lim ◽  
Dong Ho Lee ◽  
Cheol Min Shin ◽  
Na Yung Kim ◽  
Young Soo Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Elderly Patients ◽  
Microsatellite Instability ◽  
Old Age ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Age Group ◽  
P53 Overexpression ◽  
H Pylori

33 Background: Gastric cancer is one of the most common cancers, having great incidence among the elderly. However, little is known about gastric cancer in elderly patients. This study was designed to evaluate the specific features of gastric cancer in elderly patients. Methods: We reviewed medical records of 1107 patients who had undergone radical gastrectomy for gastric cancer between June 2005 and December 2009 retrospectively. They were divided into young age group (<65, n = 676), middle age group (65 ≤ age < 75, n = 332) and old age group (≥75, n = 99). To find out potential risk factors, these following factors were reviewed; symptoms, comorbidities, tumor marker levels, stages, H. pylori status, locations, Lauren type, differentiation, complications, microsatellite instability and p53 overexpression. Results: Elevated levels of CA 19-9 (5.6%, 13.4% and 14.6%, P = 0.001), advanced diseases (42.5%, 47.0% and 57.6, P = 0.014), and node metastasis (37.6%, 38.9% and 51.5%, P = 0.029) were more frequently detected in the middle and old age groups. However, no significant differences in H. pylori status (63.6%, 56.7% and 61.2%, P = 0.324) were observed among the three groups. Elderly patients had a tendency to show intestinal type in Lauren’s classification (40.7%, 58.7%, and 56.6%, P < 0.001). The rate of surgery-related complications did not differ among the three groups (5.3%, 5.1%, and 8.1%, P = 0.497). Microsatellite instability (P < 0.001) and p53 overexpression (P < 0.001) were more frequently found among the elderly patients. Conclusions: Gastric cancer in elderly patients was related to features known for favorable prognosis except p53 overexpression, despite the more advanced stage. Surgery in the elderly was as tolerable as in young patients. We recommend looking favorably upon surgery for elderly patients with operable gastric cancers.

scholarly journals AGEDEPENDENT CHANGES IN HUMAN BUCCAL EPITELIUM

2020 ◽  
Vol 16 (2) ◽  
pp. 47-52
Author(s):  
Elena Semencova ◽  
Larisa Polushina ◽  
Ekaterina Mandra ◽  
Vladimir Bazarnyy ◽  
Yuliya Mandra ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Buccal Epithelium ◽  
Noninvasive Technique ◽  
Intact Cells ◽  
Age Related ◽  
Buccal Epithelial Cells ◽  
Cytological Features

Background. Most age-related changes are associated with the progression of functional instability in organs and tissues. This requires promising definitions of biological age and the pace of the human body development based on laboratory and instrumental assessment of the structure and functions of tissues. The article describes the potential of buccal cells investigations. The purpose was to compare the cytological characteristics of buccal epithelial cells in patients of various age groups (children, young people, the elderly and senile). Methodology. The study of the cytological features of buccal epithelial cells involved patients (men and women) in accordance with the WHO age classification, which were divided into 4 groups. The first group included pediatric patients (under 18 years old, 231 people), the second group included young patients (18―44 years old, 121 people), the 3rd group included elderly patients (60―74 years old, 16 people), and the fourth group included senile patients (75 ―90 years, 5 people). Results. The authors presented buccal epithelium application in non-invasive diagnosis of early human aging; identified common cytological features of buccal epithelium for different ages; revealed the accumulation of cytogenetic abnormalities (epithelial cells with micronuclei, protrusions of the nucleus) and degenerative-dystrophic changes (perinuclear vacuole, condensed chromatin, karyorexis, karyolysis) with age. These findings reflect the predominance of apoptosis over reparation in the process of aging. Conclusions. On this basis, it can be assumed that the buccal cytogram reflects age-dependent processes and can serve as an adequate tool for studying the mechanisms of aging. Among various methods exfoliative cytology is a unique, noninvasive technique involving simple and pain-free collection of intact cells from the oral cavity for microscopic examination.

The Effects of Significant International Sports Events on Hungarian Suicide Rates

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Karoly Bozsonyi ◽  
Peter Osvath ◽  
Sandor Fekete ◽  
Lajos Bálint
Keyword(s):  
Significant Relationship ◽  
Olympic Games ◽  
Arima Model ◽  
Age Groups ◽  
The Elderly ◽  
Intervention Analysis ◽  
Middle Aged ◽  
Sports Events ◽  
Sport Events ◽  
The Olympic Games

Abstract. Background: Several studies found a significant relationship between important sport events and suicidal behavior. Aims: We set out to investigate whether there is a significant relationship between the raw suicide rate and the most important international sports events (Olympic Games, FIFA World Cup, UEFA European Championship) in such an achievement-oriented society as the Hungarian one, where these sport events receive great attention. Method: We examined suicide cases occurring over 15,706 days between January 1, 1970, and December 31, 2012 (43 years), separately for each gender. Because of the age-specific characteristics of suicide, the effects of these sport events were analyzed for the middle-aged (30–59 years old) and the elderly (over 60 years old) generations as well as for gender-specific population groups. The role of international sport events was examined with the help of time-series intervention analysis after cyclical and seasonal components were removed. Intervention analysis was based on the ARIMA model. Results: Our results showed that only the Olympic Games had a significant effect in the middle-aged population. Neither in the older male nor in any of the female age groups was a relationship between suicide and Olympic Games detected. Conclusion: The Olympic Games seem to decrease the rate of suicide among middle-aged men, slightly but significantly.

Projected future risk of leukemia and brain tumors from unnecessary brain CT scans: a multi-center study in Iran

2020 ◽  
Author(s):  
A. Asgari ◽  
A.A. Parach ◽  
F. Bouzarjomehri ◽  
F. Shirani-Takabi ◽  
A.H. Mehrparvar ◽  
...  
Keyword(s):  
Brain Cancer ◽  
Age Groups ◽  
Young Patients ◽  
Ct Scans ◽  
Brain Ct ◽  
Males And Females ◽  
And Gender ◽  
Multi Center Study ◽  
Gender Groups ◽  
Probability Of Cancer

Introduction: Computer Tomography (CT) scans can deliver a relatively high radiation dose to the patient, therefore radiation protection for this modality is paramount. The present study determined the frequency of no abnormality detected (NAD) brain CT scans and probability of cancer induction in different age groups and genders. Methods: In this study, brain CT reports were used to identify any findings as abnormality detected (AD) and others as NAD. Then probability of future leukemia and brain cancer was estimated for different age and gender groups. Results: On average, in 65% of the cases the results were NAD (56% and 76% among males and females, respectively). Among children, 79% of the reports were NAD. The total number of projected brain cancers was 1.8 and 1.3 for males and females, respectively. The number of projected leukemia cases was 0.75 and 0.7 for males and females, respectively. For pediatric patients, brain CT scans can lead to leukemia cases about 4.5 times more often than adults. Conclusion: Brain CT scans can lead to additional cases of brain cancer and leukemia. A significant fraction of brain CTs were NAD (non-pathologic) and could practically be replaced by other radiation-free imaging modalities, especially in pediatric and young patients.

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