Pediatric oral lesions: a 15-year review from São Paulo, Brazil

2002 ◽  
Vol 26 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Fabrício Bitu Sousa ◽  
Adriana Etges ◽  
Luciana Corrêa ◽  
Ricardo Alves Mesquita ◽  
Ney Soares de Araújo
Keyword(s):  
Malignant Tumors ◽  
Dentigerous Cyst ◽  
Young Patients ◽  
Oral Pathology ◽  
Sao Paulo ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
São Paulo ◽  
Patients Âgés ◽  
Significant Difference

There are few studies on pediatric oral pathologies in the literature. This study presents data from a review of 2,356 biopsies of young patients (birth to 14 years) received over 15 years (1985-2000) in the Oral Pathology Service at the University of Sao Paulo, Brazil. Information about patients (sex, age, race) and histopathological diagnosis was retrieved. Diagnosis data of 2,356 biopsies were classified into 20 groups.There was no significant difference between male (50.0%) and female (49.0%) patients. White is the predominant race (69.0%), and patients ages were concentrated between 9 and 14 years old (70%). Mucocele was the most frequent (13.5%), followed by dentigerous cyst (6.5%) and fibrous hyperplasia (5.4%). Papilloma and Langerhans cells histiocytosis were the most common non-odontogenic benign and malignant tumors, respectively. In the group of odontogenic tumors, odontoma was the most frequent, and ameloblastoma had a significant incidence (27 cases). These data are important in order to detect differences in geographic areas, diagnosis line tendencies and for clinicians to perform judgment to evaluate of the pediatric patients before the biopsy and management of pediatric oral lesions.

scholarly journals Behavior of gastric cancer in Brazilian population

2009 ◽  
Vol 22 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Carlos Eduardo Jacob ◽  
Claudio Bresciani ◽  
Joaquim José Gama-Rodrigues ◽  
Osmar Kenji Yagi ◽  
Donato Mucerino ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Resection ◽  
Gastric Wall ◽  
Age Groups ◽  
Sao Paulo ◽  
São Paulo ◽  
Gender Ratio ◽  
Male Predominance ◽  
Number Of Patients ◽  
Significant Difference

BACKGROUND: Gastric cancer (GC) is a predominately male disease. Usually for every female that suffers from this condition there are two males and occurred an increase in the number of females in last decades. Brazil is poor in data about this issue. AIM: To verify if in Brazil it happened: a) a change in the gender ratio and on the average age of the patients; b) an increase in the number of patients with 70 years of age or more suffering from this disease; c) changes in the gender ratio and in the average age in the several gastric locations during the period of study. METHODS: The medical history of patients diagnosed with primary gastric adenocarcinoma, between 1971 and 1998 were obtained at Hospital das Clínicas of the University of São Paulo, São Paulo, SP, Brazil. Exclusion criteria were: patients suffering from a non epithelial gastric malignancy; adenocarcinoma from the intestinal metaplasia in the distal esophagus invading the proximal stomach and patients submitted to a gastric resection, due to a benign or malignant tumor during the last five years prior to the surgical procedure analyzed in this study. The patients were divided into 10 years age groups and also divided in three groups, according to their ages and time intervals. Interrelationships between gender and age, and with tumor´s location on gastric wall were analyzed. RESULTS: From 1971 to 1998, 1578 patients with GC were hospitalized. Among them, 1021 were treated with gastric resection, corresponding to 64.7% of all patients. There was an increase in the proportion of patients older than 70 years, and decrease between 41 and 70 years. There was no statistical significant difference among the average ages and the different locations. There were significant differences for the locations favoring proximal third and stump, both more prevalent in males. CONCLUSIONS: a) Occurred modifications in the ratio between genders: greater number of women and an increase in the number of male patients in the age group between 41 and 70 years; b) it was proved the greater number of occurrences in patients over 70 years of age; c) there was a greater increase in the male predominance in the tumors located in the stomach´s proximal third.

MO239ORAL FUNGAL INFECTION IN ESRD PATIENTS 

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
MohanKumar Nedunchezhiyan ◽  
Afza Anjum ◽  
Nandita Shenoy ◽  
Rohith Nayak
Keyword(s):  
Oral Health ◽  
Fungal Infection ◽  
Oral Hygiene ◽  
Clinical Signs ◽  
Prognostic Index ◽  
Categorical Variables ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
Significant Difference ◽  
Cytological Changes

Abstract Background and Aims Chronic Kidney Disease is an increasing health alarm worldwide with systemic signs like hematologic changes, bone metabolic error, and compromised immune status presenting to a dental practitioner with oral complications. Hence a study was done to assess the oral health condition, cytological changes, and presence or absence of candida in patients with chronic renal disease undergoing dialysis aged between 30 to 65 years and controls in South India. Method A cross sectional study was conducted among 80 adults with CKD and controls, attending KMC and MCODS, Mangalore. Oral manifestations and oral hygiene were assessed; Cytological smears were taken for morphometric analysis of buccal mucosal cells from the subjects. Oral smears were cultured to check for the growth of fungal species in subjects and controls. Statistical analysis was done using SPSS Version 13. Chi square test was used to compare categorical variables between the groups. Results There was a significant difference in oral hygiene status and cytological changes in patients with CKD. Oral Fungal Infection was found in 32% of our patients on dialysis and oral lesions, defined as clinical signs associated with OFI such as erythematous oral stomatitis, membranous candidiasis, or angular cheilitis, were found in 37% of the patients with OFI, while 5% of the patients without findings of fungal infection presented oral lesions associated with OFI (p=0.0002). Furthermore, patients with self-reported mouth dryness were three times more likely (p=0.02) to be diagnosed with OFI. Conclusion Hemodialysis patients are found to have significantly more OFI than controls. Oral dryness and dental plaque formation also seem to be at risk of developing OFI. Detection of oral lesions associated with OFI should be combined with a histopathological diagnosis before antifungal treatment. The prevalence of oral candida in these cases is alarming and can be a predictor of a poor prognostic index. As medicine advances, oral health care professionals should have a holistic approach to the management of patients with complex medical problems especially to diseases of the renal system as it is pivotal in maintaining a stable internal environment and homeostasis.

Prevalence of Upper Cervical Vertebrae Anomalies in Patients with Cleft Lip and/or Palate and Noncleft Patients

2009 ◽  
Vol 46 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Marta Cunha Lima ◽  
Eduardo Jacomino Franco ◽  
Guilherme Janson ◽  
Izabel Maria Marchi Carvalho ◽  
Carlos Ferreira Santos ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cervical Vertebrae ◽  
Sao Paulo ◽  
Posterior Arch ◽  
São Paulo ◽  
Craniofacial Anomalies ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Upper Cervical ◽  
School Of Dentistry

Objectives: To investigate the prevalence of upper cervical vertebrae anomalies in patients with isolated cleft lip, isolated cleft palate, and complete cleft lip and palate, as well as to compare the prevalence of these anomalies between groups, between genders, and with noncleft patients. Design: Retrospective cross-sectional study of randomly selected patients. Setting: Radiology Section, Hospital for Rehabilitation of Craniofacial Anomalies and Department of Orthodontics, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil. Participants: The sample comprised 300 lateral cephalograms of cleft patients, aged 12 to 13 years, of both genders, from the files of the Hospital for Rehabilitation of Craniofacial Anomalies–University of São Paulo and 300 lateral cephalograms from noncleft patients of the Department of Orthodontics, Bauru School of Dentistry. Cephalograms of patients with syndromes were not included. Method: Radiographs were interpreted on a film viewer by a single examiner; the profiles of vertebrae were traced on acetate paper, and cervical vertebrae anomalies were registered and categorized into posterior arch deficiencies, fusion, and association of both. Main Outcome Measures: Statistical comparison of groups using the chi-square test. Results: In the cleft group, 38.67% of the patients had cervical vertebrae anomalies. Of those in the noncleft sample, 31% showed anomalies of the cervical spine. This difference was statistically significant. There was no statistically significant difference when the types of clefts were compared with each other or when both genders were compared in both samples. Conclusions: This study confirms the association between clefts and cervical anomalies. Additional research on this topic is necessary.

Prevalence of Palatal and Alveolar Cysts in Babies with Cleft Lip and Palate

2004 ◽  
Vol 41 (5) ◽  
pp. 490-493 ◽  
Author(s):  
Karina Mirela Ribeiro Pinto Alves ◽  
Virginia Peixoto ◽  
Márcia Ribeiro Gomide ◽  
Cleide Felíciode Carvalho Carrara ◽  
Beatriz Costa
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Sao Paulo ◽  
São Paulo ◽  
Craniofacial Anomalies ◽  
Cross Sectional ◽  
Significant Difference ◽  
Different Types ◽  
Low Prevalence ◽  
Posterior Area

Objective To evaluate the prevalence of palatal and alveolar cysts in babies with cleft lip and/or palate. Design Cross-sectional. Setting Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Bauru, São Paulo, Brazil. Participants Two hundred ninety-one Caucasian babies divided into four groups according to the type of cleft: cleft lip with or without cleft alveolus (70), complete unilateral cleft lip and palate (112), complete bilateral cleft lip and palate (56), and cleft palate (53). Results A low prevalence of palatal and alveolar cysts was observed among patients with the four different types of clefts, with no statistically significant difference between genders. The maxilla and the anterior area of the mouth were more affected than the mandible and the posterior area. Conclusions The low prevalence of palatal and alveolar cysts in the four groups of babies with clefts included in this study may have been due to the high mean age of the sample.

scholarly journals Relationship between the prevalence of antibodies to hepatitis B core antigen and arbovirus in fishermen from the Ribeira Valley, Brazil

1990 ◽  
Vol 32 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Lygia Busch Iversson ◽  
Celso F. Hernandes Granato ◽  
Amélia Travassos da Rosa ◽  
Cláudio Sérgio Pannuti
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Age Groups ◽  
Sao Paulo ◽  
Core Antigen ◽  
São Paulo ◽  
Region Detection ◽  
Significant Difference ◽  
B Virus ◽  
Hepatitis B Core Antigen

Sera from 299 fishermen 16 to 80 years old, residents in Cananeia and Iguape counties, southern cost of São Paulo State, Brazil, were studied in order to identify a possible association between the prevalence of specific antibodies to the hepatitis B virus (HBV) and exposure to haematophagus mosquitoes evaluated by the prevalence of arbovirus antibodies. This professional group presented the highest prevalence of arbovirus antibodies (54.1%) in past investigations carried out in this heavily forested region. Detection of antibody to hepatitis B core antigen (anti-HBc) in the sera was done by enzyme immunoassay (Roche). Prevalence of anti-HBc antibodies in this group was 31.4% (94/299) which is very high compared with 7.2% to 15.0% for different groups of healthy adults in State of São Paulo. No significant difference is observed between the prevalences of HBV antibodies in Iguape and Cananeia. Prevalence of anti-HBc and anti-arbovirus antibodies increases with age. There is a concordance in the distribution according to age groups of the frequency of anti-HBc and anti-arbovirus positive sera. Ag HBs was detected in 4% of the studied sera. These results support the hypothesis that the transmission of the hepatitis B virus and the arboviruses may be due to the same factor, one of the possibilities would be by anthropophilic mosquitoes.

scholarly journals Giant Cell Fibroma in a Two-Year-Old Child

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Anna Carolina Volpi Mello-Moura ◽  
Ana Maria Antunes Santos ◽  
Gabriela Azevedo Vasconcelos Cunha Bonini ◽  
Cristina Giovannetti Del Conte Zardetto ◽  
Cacio Moura-Netto ◽  
...  
Keyword(s):  
Giant Cell ◽  
Oral Care ◽  
Dental Trauma ◽  
Oral Pathology ◽  
Pediatric Dentistry ◽  
Sao Paulo ◽  
Tissue Growth ◽  
São Paulo ◽  
Oral Diseases ◽  
Gingival Mucosa

The giant cell fibroma is a benign nonneoplastic fibrous tumor of the oral mucosa. It occurs in the first three decades of life in the mandibular gingiva, predominantly, showing predilection for females. This article reports a case of giant cell fibroma in a 2-year-old girl, which is an uncommon age for this lesion. The patient was brought for treatment at the Research and Clinical Center of Dental Trauma in Primary Teeth, where practice for the Discipline of Pediatric Dentistry (Faculty of Dentistry, University of São Paulo, Brazil) takes place. During clinical examination, a tissue growth was detected on the lingual gingival mucosa of the lower right primary incisors teeth. The lesion was excised under local anesthesia and submitted to histological examination at the Oral Pathology Department of the Faculty of Dentistry, University of São Paulo, which confirmed the diagnosis of giant cell fibroma. There was no recurrence after 20 months of monitoring. This instance reinforces the importance of oral care from the very first months of life in order to enable doctors to make precocious diagnosis and offer more appropriate treatments for oral diseases, as well as to promote more efficient oral health in the community.

Overview of obesity and breast cancer in Brazil: 24 year of follow up.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13580-e13580
Author(s):  
Andrea Z Pereira ◽  
Bianca de Almeida Pitito ◽  
Rogério Ruscitto do Prado ◽  
Andre Mattar ◽  
Roberto Hegg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
State Government ◽  
Sao Paulo ◽  
São Paulo ◽  
Obese Women ◽  
Obesity Prevalence ◽  
Breast Cancer Patients ◽  
Significant Difference ◽  
Prevalence Of Obesity

e13580 Background: Obesity is one of the major public health challenges of the 21st century. The prevalence of obesity is growing exponentially across all age groups and on all continents and it is associated with morbidities such as cardiovascular disease, diabetes mellitus type 2, dyslipidemia, hypertension and cancer. There is a higher risk of developing breast cancer in postmenopausal obese women, and with worse outcome for women of all ages. Objectives: To evaluate obesity prevalence in breast cancer patients and its association with recovering, survival, death, age, Human Epidermal Growth Factor Receptor 2 (HER2) and anti-human KI67 antibody(KI67). Methods: A retrospective cohort study was performed between 1994 and 2018 at the Breast Cancer Department, São Paulo State Government Women's Health Reference Center (Perola Byington Hospital), São Paulo, Brazil with 8824 breast cancer patients. From those, 2899 patients were excluded because they did not have description of weight and/or Body Mass Index (BMI). Survival analysis was performed according to BMI groups. Results: The participants had mean (SD) age of 54 (12.0) years and weight of 70 (15.0) kg. There were 769 (13%) deaths and the mean survival was 20 (2.0) years. 1787 (30%) participants were stratified in obese (BMI≥30Kg/m2) and 4138 (70%) non-obese Obese were older (p < 0,001) and had a higher frequency of HER2 negative (p < 0,04) than non-obese women. There were not a significant difference in frequencies of KI67, recovering and survival between groups. The prevalence of obesity was not different over 24 years. Conclusions: There was a relevant prevalence of obesity in breast cancer patients, which was associated with HER2 negative and age, but not with recovering or survival.

scholarly journals A Sixteen-year Retrospective Study of Biopsied Pediatric Oral Lesions from North Kerala

2017 ◽  
Vol 7 (3) ◽  
pp. 144-149
Author(s):  
Resmi G Nair ◽  
Sathyabhama Sudha ◽  
Ismayil Paikkadan ◽  
Faseela Beegum
Keyword(s):  
Retrospective Study ◽  
Pediatric Population ◽  
Care Center ◽  
Dentigerous Cyst ◽  
Age Groups ◽  
Oral Pathology ◽  
Oral Lesions ◽  
Lower Lip ◽  
Health Care Center ◽  
Periapical Cyst

ABSTRACT Aim This study aimed at providing updated information on biopsied oral and maxillofacial lesions from children below 12 years, received between 2001 and 2016, from a tertiary health care center in North Kerala, India. Materials and methods The archives of the Department of Oral Pathology and Microbiology, Government Dental College, Kozhikode, India, were retrospectively analyzed over a period of 16 years (2001—2016). Patients aged 12 years and below were considered as the pediatric population. Age, gender, site, and histopathologic diagnosis were recorded. Subjects were divided into three age groups: 0 to 6, 7 to 9, and 10 to 12 years. The oral and maxillofacial lesions were classified into eight different categories. Data were analyzed using descriptive statistics. Results Of the total 8,306 biopsied cases, 334 cases were from the pediatric population. Cases showed almost equal predilection between males (48%) and females (52%); M:F = 1:1.08. Both mandible (26.94%) and maxilla (26.05%) showed almost equal site predilection followed by lower lip (19.76%), gingiva (14.67%), and tongue (5.39%). The most common condition diagnosed individually was periapical cyst (21.86%), followed by mucocele (17.37%) and dentigerous cyst (13.17%). Regarding the diagnostic categories, most lesions were in the cystic group (37.43%) followed by the inflammatory/reactive group (31.44%) and benign odontogenic tumors (10.48%). Conclusion This study showed similar trends as well as contradictory results when compared with other studies. This can be due to geographical and ethnic variations, difference in criteria, and difference in age groups selected. How to cite this article Nair RG, Sudha S, Paikkadan I, Beegum F. A Sixteen-year Retrospective Study of Biopsied Pediatric Oral Lesions from North Kerala. J Contemp Dent 2017;7(3):144-149.

scholarly journals Integrating clinical features with genetic factors enhances survival prediction for adults with acute myeloid leukemia

2020 ◽  
Vol 4 (10) ◽  
pp. 2339-2350 ◽  
Author(s):  
Douglas R. A. Silveira ◽  
Lynn Quek ◽  
Itamar S. Santos ◽  
Anna Corby ◽  
Juan L. Coelho-Silva ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Risk Stratification ◽  
Myeloid Leukemia ◽  
Sao Paulo ◽  
Survival Prediction ◽  
São Paulo ◽  
Data Set ◽  
Significant Difference ◽  
De Medicina ◽  
Acute Myeloid

Abstract The 2017 European LeukemiaNet 2017 acute myeloid leukemia (AML) risk stratification (ELN2017) is widely used for risk-stratifying patients with AML. However, its applicability in low- and middle-income countries is limited because of a lack of full cytogenetic and molecular information at diagnosis. Here, we propose an alternative for risk stratification (the Adapted Genetic Risk [AGR]), which permits cytogenetic or molecular missing data while retaining prognostic power. We first analyzed 167 intensively treated patients with nonacute promyelocytic leukemia AML enrolled in São Paulo, Brazil (Faculdade de Medicina da Universidade de São Paulo), as our training data set, using ELN2017 as the standard for comparison with our AGR. Next, we combined our AGR with clinical prognostic parameters found in a Cox proportional hazards model to create a novel scoring system (survival AML score, SAMLS) that stratifies patients with newly diagnosed AML. Finally, we have used 2 independent test cohorts, Faculdade de Medicina de Ribeirão Preto (FMRP; Brazil, n = 145) and Oxford University Hospitals (OUH; United Kingdom, n = 157) for validating our findings. AGR was statistically significant for overall survival (OS) in both test cohorts (FMRP, P = .037; OUH, P = .012) and disease-free survival in FMRP (P = .04). The clinical prognostic features in SAMLS were age (&gt;45 years), white blood cell count (&lt;1.5 or &gt;30.0 × 103/μL), and low albumin levels (&lt;3.8 g/dL), which were associated with worse OS in all 3 cohorts. SAMLS showed a significant difference in OS in the training cohort (P &lt; .001) and test cohorts (FMRP, P = .0018; OUH, P &lt; .001). Therefore, SAMLS, which incorporates the novel AGR evaluation with clinical parameters, is an accurate tool for AML risk assessment.

318 EFFICIENCY OF PROTOCOL P-36, ASSOCIATED WITH EQUINE CHORIONIC GONADOTROPIN OR LUTEINIZING HORMONE ADMINISTRATION, IN THE LAST DAY OF SUPERESTIMULATORY TREATMENT, IN NELLORE COWS

2011 ◽  
Vol 23 (1) ◽  
pp. 255 ◽  
Author(s):  
A. C. Oliveira ◽  
M. C. C. Mattos ◽  
M. R. Bastos ◽  
J. R. S. Gonçalves ◽  
L. H. Lunardi ◽  
...  
Keyword(s):  
Prostaglandin F2α ◽  
Fixed Time ◽  
Sao Paulo ◽  
Control Group ◽  
São Paulo ◽  
Embryo Production ◽  
Embryo Yield ◽  
Significant Difference ◽  
Equine Chorionic Gonadotropin ◽  
Viable Embryo

The objective of this study was to evaluate the use of pLH in replacement of eCG on the last day of P-36 superstimulatory treatment in Nellore donors. Recent studies demonstrated improvement in embryo production when the last 2 doses of FSH were replaced by eCG. However, consecutive use of eCG in bovine superstimulatory protocols may induce antibody against eCG, decreasing embryo production. Twenty-five Nellore cows were randomly allocated in 4 groups: P-36 (control), P-36/eCG, P-36/LH2, and P-36/LH4. All animals underwent 4 treatments in a cross-over design. Donors received an intravaginal device containing 1.0 g of progesterone (IVD, Primer®, Tecnopec, Sao Paulo, Brazil) and oestradiol benzoate (2.0 mg, IM; Estrogin®, Farmavet, Sao Paulo, Brazil) at a random stage of the oestrous cycle (D0). Cows from the control group were superestimulated with decreasing doses of pFSH (133 mg, IM; Folltropin-V®, Bioniche, Ontario, Canada; D5-8). In the P-36/eCG group, the last 2 doses of pFSH were replaced by 2 doses of eCG (200 IU each dose, IM; Folligon®, Intervet, Boxmeer, the Netherlands). In the P-36/LH2 and P-36/LH4 groups, the last 2 doses of pFSH were replaced by 2 doses of 1 and 2 mg of pLH, respectively (IM; Lutropin®, Bioniche). All animals were treated with prostaglandin F2α (150 μg d-cloprostenol, IM; Prolise®, Tecnopec) on D7, and the IVD was removed 36 h after. Ovulation was induced with 12.5 mg of pLH (IM) on D9, and all animals received fixed-time artificial insemination 12 and 24 h after pLH. Embryo flushing was performed on D16. Data were analysed by ANOVA (Proc Mixed, SAS). There was a significant difference in the number of corpus luteum in the eCG group (19.2 ± 2.4) when compared with the LH2 (12.7 ± 2.0) and LH4 groups (12.3 ± 1.5; P < 0.05). In addition, there was a tendency of lower ovulation rate in the LH2 group as compared with the eCG group (50.6 and 67.8%, respectively; P = 0.06). However, there was no difference in viable embryo yield among groups P-36 (3.3 ± 0.7), P-36/eCG (4.5 ± 0.5), P-36/LH2 (3.7 ± 0.8), and P-36/LH4 (4.2 ± 1.0); P > 0.05. In conclusion, eCG can be replaced by pLH (4.0 mg), in the last day of P-36 protocol, without affecting the production of viable embryos in Nellore cows. The authors acknowledge FAPESP (Sao Paulo, Brazil) for funding and fellowships for A. C. S. Oliveira, M. C. C. Mattos, and M. R. Bastos.

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