Chicken or the egg: Vitamin D deficiency in Chronic Kidney Disease of Uncertain Etiology in Sri Lanka

Abstract Background Vitamin D deficiency is a poorly studied nutritional disorder in CKDu. There are no published studies on vitamin D levels in CKDu; a unique environmental nephropathy in tropical countries. This study was aimed to describe the prevalence of vitamin D, iron and vitamin B12 status in CKDu patients and to determine associations between vitamin D status and socio demographic factors, nutritional status and dietary intake of vitamin D. Method This was a cross sectional survey conducted among the CKDu patients in Wilgamuwa area, in Mathale district located in the Central province of Sri Lanka. Data was collected by laboratory evaluation, clinical examination and interviewer administered questionnaire and analyzed using SPSS statistical software. Results Out of the 150 of respondents, 74.0% (n = 111) had vitamin D deficiency, 72.0% (n = 108) had anemia, and 3.3% (n = 5) had vitamin B12 deficiency, in both genders. There was no significant difference in the prevalence of anemia, low serum ferritin and vitamin B12 deficiency between males and females. Gender was significantly associated with the vitamin D deficiency (p<0.05). Females were 7.69 times more likely to have vitamin D deficiency compared to males. Vitamin D deficiency was 1.7 times higher among those who received social welfare benefits than those who did not receive it. High intake of fish was protective against vitamin D deficiency. Conclusion Isolated Vitamin D deficiency was the most prevalent nutritional deficiency among CKDu patients of Sri Lanka. Correction of these deficiencies may have a favorable effect on CKDu outcome.

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Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study

BMC Endocrine Disorders ◽

10.1186/s12902-021-00786-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shahintaj Aramesh ◽

Touran Alifarja ◽

Ramin Jannesar ◽

Parvin Ghaffari ◽

Raziyeh Vanda ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Ovarian Reserve ◽

Intervention Study ◽

Vitamin D Supplementation ◽

Diminished Ovarian Reserve ◽

Favorable Effect ◽

Vitamin D Levels ◽

Significant Difference ◽

Before And After

Abstract Objective Evaluation of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency. Methods The study is a before-and-after intervention study that was performed on women with diminished ovarian reserve referred to Shahid Mofteh Clinic in Yasuj, Iran. Eligible women were prescribed vitamin D tablets at a dose of 50,000 units weekly for up to 3 months. Serum levels of vitamin D and AMH were evaluated at the end of 3 months. Significance level was also considered P ≤ 0.05. Results Our results have been showed there was a statistically significant difference in vitamin D levels of participants before [12.1(6.5)] and after [26(9.15)] the intervention (P < 0.001). Moreover, there was a statistically significant difference in serum AMH levels of participants before [0.50(0.44)] and after [0.79(0.15)] the intervention (P=0.02 ). Conclusion In conclusion, the results of the current study support a possible favorable effect of vitamin D on increase AMH expression by acting on the AMH gene promoter. Therefore, it is possible that vitamin D increases AMH levels without changing the antral follicle count/ovarian reserve.

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P652 Underweight patients with Crohn’s disease and without vitamin D supplementation are at high risk of vitamin D deficiency

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.780 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S536-S537

Author(s):

D Vranesic Bender ◽

V Domislović ◽

M Brinar ◽

D Ljubas Kelečić ◽

I Karas ◽

...

Keyword(s):

Vitamin D ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

Lower Range ◽

Total Study Population ◽

Vitamin D Levels ◽

Significant Difference ◽

Underweight Patients

Abstract Background Vitamin D deficiency is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in ulcerative colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to vitamin D deficiency. The aim of the study was to investigate the association of vitamin D deficiency according to body mass index (BMI) in adult patients with IBD. Methods A cross-sectional study was conducted on a cohort of 152 IBD patients, 68.1% (n = 104) CD and 31.9% (n = 48) UC. The mean age of the total study population was 37.3±11.8 years and 57.3% (n = 87) were male. All patients were adult, Caucasian and without vitamin D supplementation. Patients were recruited during one year period. Results Out of all IBD patients, 60.5% (n = 92) had vitamin D deficiency, 32.2%, (n = 49) insufficiency and 7.2% (n = 11) sufficiency. According to BMI categories there were 12.5% (n = 19) obese patients, 27.6% (n = 42) overweight, 51.3% (n = 78) with normal body weight, and 8.6% (n = 13) underweight. There was a significant difference in vitamin D levels according to different BMI categories in terms of underweight patients having the lowest vitamin D levels; underweight 29.84±11.94 mmol/l, normal 46 ± 20.7 mmol/l, overweight 48±20.1 mmol/l, obese 51±15.3 mmol/l. In addition, there was a significant correlation of vitamin D levels and BMI values (Rho = 0.212, 95% CI 0.069–0.345, p = 0.004), which was more clearly observed in the lower range of BMI values (Figure 1). Male underweight patients had lower levels of vitamin D compared with female patients (26.6 ± 9 vs. 34.7 ± 5.6, p < 0.05). Both patients with CD and UC had significant positive correlation of vitamin D levels and BMI values (UC Rho=0.40, 95% CI 0.16–0.59, p = 0.001, UC Rho = 0.27, 95% CI 0.01–0.05, p = 0.044). However, when comparing vitamin D levels according to phenotype, a significant difference in vitamin D levels was observed in underweight CD (28.4 ± 11.1) comparing to underweight UC patients (40.6 ± 10.6), p < 0.05. In logistic regression analysis, CD phenotype was risk factor for vitamin D deficiency (OR 2.18 95% CI 1.01–4.72, β = 1.22, p = 0.04). Conclusion Our results on untreated IBD patients show a high proportion of vitamin D deficiency both in CD and UC, and significant correlation of vitamin D levels and BMI values, especially in the lower range of BMI values. Moreover, underweight CD patients have lower vitamin D levels comparing to UC. This suggests the need for regular vitamin D monitoring and supplementation especially in IBD patients at risk.

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Baseline Characteristics Associated with Vitamin D Deficiency in Sickle Cell Disease and the Effect of Vitamin D Replacement

Blood ◽

10.1182/blood.v118.21.2139.2139 ◽

2011 ◽

Vol 118 (21) ◽

pp. 2139-2139

Author(s):

Soyoung Park ◽

Rebecca Kruse-Jarres ◽

Davis Ogitani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Sickle Cell ◽

Total Bilirubin ◽

Reticulocyte Count ◽

Outdoor Activity ◽

Vitamin D Levels ◽

Significant Difference ◽

Pain Frequency ◽

Lower Vitamin

Abstract Abstract 2139 Background: African Americans have lower vitamin D levels than the general population, which is thought to be due to decreased utilization of ultraviolet rays to convert vitamin D into an active form. Sickle cell patients have even lower vitamin D levels than African American controls. Preliminary studies at Tulane University correlated low vitamin D levels with markers of hemolysis (decreased hemoglobin (Hgb), increased reticulocyte count and lactate dehydrogenase (LDH)). Our main question was whether vitamin D deficiency in sickle cell patients is due to lack of outdoor activity or diet, or increased vitamin D metabolism during bone marrow turnover secondary to hemolysis. Design and Methods: 80 adult sickle cell patients received pain, dietary, and outdoor activity level surveys. Vitamin D 25-hydroxy (25(OH)D), hemolytic lab markers (Hgb, Hct, LDH, total bilirubin, and reticulocyte count) were obtained. Results: Baseline Assessment: Vitamin D levels were available on 70 patients: 24.3% were normal or mildly deficient (≥20 ng/mL), 30% moderately deficient (10-<20 ng/mL), and 45.7% severely deficient (<10 ng/mL). We could not verify a correlation between LDH and 25(OH)D levels, but there was a trend towards increased total bilirubin in patients severely deficient in vitamin D (p = 0.06). Severely anemic patients (Hgb 5-<7 gm/dL) had significantly lower average 25(OH)D levels (p = 0.02). When comparing patients with moderately and severely deficient 25(OH)D levels to patients with no or mild deficiency, there was a significantly increased use of healthcare facilities (see Table 1). Though there was no significant difference in intake of fish, cheese, or eggs, there was a significant decrease in milk intake (see Table 1). There was no significant difference in days spent in bed or time spent outdoors (see Table 1). Subjectively, patients did not report increased frequency of mild to moderate pain, vasocclusive crises, or use of pain medications in the moderately and severely vitamin D deficient groups but they did report higher rates of hospitalization due to sickle cell crises (p = 0.03, 0.005 respectively). Effects of Vitamin D replacement: 56 patients took vitamin D replacement. After replacement, there was no difference in frequency of pain and pain medicine use, or days in the hospital and ER. However, pain levels appeared to be less intense (see Table 2). There was a trend towards fewer days spent in the hospital and ER (p = 0.089) in the 6 months following vitamin D replacement and there were significantly fewer Sickle Cell Day Hospital visits (p = 0.037). Conclusions: Though we could not correlate vitamin D deficiency with LDH as a marker of hemolysis, lower Hgb levels seemed to be predictive of more severe vitamin D deficiency. Patients with more severe vitamin D deficiency did not report to have increased pain frequency or pain medication use, but had more ER visits and hospitalizations. When vitamin D was replaced, it did not decrease pain frequency, but it did decrease severity. We conclude that vitamin D replacement could lessen pain in sickle cell patients and thus utilization. Disclosures: Kruse-Jarres: Bayer: Consultancy; Grifols: Consultancy; Talecris: Consultancy; Inspiration: Consultancy; NovoNordisk: Consultancy; Baxter: Consultancy.

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Vitamin D status in adults and children in Transcarpathia, Ukrainein 2019

10.21203/rs.3.rs-41749/v2 ◽

2020 ◽

Author(s):

Khrystyna Shchubelka

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Adult Population ◽

Winter Season ◽

Epidemiological Data ◽

Adult Women ◽

Vitamin D Levels ◽

Significant Difference ◽

Adults And Children ◽

The Mean

Abstract Background: Vitamin D deficiency is a global health problem, it is assessed by measuring serum 25-hydroxivitamin D (25(OH) D), nevertheless epidemiological data for many countries remains underreported.Objectives:To study the prevalence of vitamin D deficiency throughout the calendar year in a large cohort recruited ina multiethnic Transcarpathian region of Ukraine.Methods: In this retrospective study 25(OH)D serum concentration was measured during all 12 months of the year 2019 by electrochemoluminescent assay on the automatic analyzer Cobas e411 in 1,823 subjects, including both children and adults (1551 females (85.03%) and 273 males (14.97%)). ResultsThe mean 25(OH) D concentration in adults demonstrates significantly lower levels compared to children (22.67±8.63 ng/ml vs. 26.00±10.72 ng/ml respectively, p<0.001). Adult women expressed significantly lower mean annual serum 25 (OH) D concentrations in comparison to men (22.29±8.46 ng/ml vs. 25.75±9.38 ng/ml respectively, p< 0.001). In contrast, children did not show a significant difference between sexes (girls 24.98±10.38 ng/ml vs. boys 27.01±11.01 ng/ml, p=0.2003). In the winter months, 25(OH)D levels fell below 20 ng/ml in 51,74 % of adult population of Thranscarpathia, and in 12.91%, - below 12 ng/ml.ConclusionsThe results of this study contradict the previously reported evaluations of the vitamin D levels in Ukraine which were assessed by measuring serum 25(OH) D. Specifically, only approximately half of the studied population is vitamin D deficient during winter season. This study features the most representative sample size in Ukraine to date.

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Prevalence of Vitamin D Deficiency and Its Associated Risk Factors Among Rural Population of the Northern Part of the Persian Gulf

10.21203/rs.3.rs-109364/v1 ◽

2020 ◽

Author(s):

Maryam Marzban ◽

Mohammadreza Kalantarhormozi ◽

Mehdi Mahmudpour ◽

Afshin Ostovar ◽

Saeed Keshmiri ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Rural Areas ◽

Persian Gulf ◽

Rural Population ◽

Vitamin D Levels ◽

Significant Difference ◽

The Persian Gulf ◽

Associated Risk Factors

Abstract Background: Accumulating evidence indicates that vitamin D deficiency has been increased globally since the last two decades. However, the majority of these studies concerned on cities and there is scant information regarding the prevalence of vitamin D in rural areas. The main aim of this study was to investigate the prevalence of vitamin D deficiency and its associated risk factors among rural population in Bushehr province which has the longest border with the Persian Gulf.Methods: The rural inhabitants with ≥25 years old from three mountainous, plain, and seashore areas of Bushehr province were selected through a stratified multi-cluster random sampling method. After obtaining the participants’ demographic and anthropometric data and their past medical history, serum 25- hydroxy vitamin D was measured using ELISA.Results: A total of 1806 (means±SD, 46.30± 14.22 years old) rural subjects (34.84% males and 64.88%) participated in this study. The prevalence of vitamin D deficiency, insufficiency and sufficiency were 27.87%, 50.39% and 21.74%, respectively. The deficiency of vitamin D in women was higher than men (OR=1.27, 95% CI: 1.05 to 1.54, P=0.040). There was a positive significant correlation between age and serum vitamin D levels. Men with vitamin D deficiency had higher BMI (P=0.008); this association was not observed among women (P=0.74). There was no significant difference between the food items consumption frequencies, and vitamin D status (P>0.05). The mountainous, and plain areas had the highest and lowest vitamin D levels, respectively.Conclusion: Although, Bushehr province is located in a sunny part of Iran, the prevalence of vitamin D deficiency was high among its rural population. The shift of their life styles patterns and rapid industrialization in these rural areas may be responsible. Therefore, the enrichment of dietary sources with vitamin D and the use of vitamin D supplements are recommended to tackle the high prevalence of vitamin D deficiency in the rural population of the northern part of the Persian Gulf.

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Vitamin D Deficiency Is a Potential Risk for Blood Pressure Elevation and the Development of Hypertension

Medicina ◽

10.3390/medicina57121297 ◽

2021 ◽

Vol 57 (12) ◽

pp. 1297

Author(s):

Yusuf Karadeniz ◽

Fatma Özpamuk-Karadeniz ◽

Süleyman Ahbab ◽

Esra Ataoğlu ◽

Günay Can

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Blood Pressure Elevation ◽

Vitamin D Levels ◽

Significant Difference ◽

Low Levels ◽

Optimal Blood Pressure ◽

Hypertension Development

Background and objectives: Hypertension is a global health problem and a major risk factor for cardiovascular diseases. Vitamin D deficiency is closely related to high blood pressure and the development of hypertension. This study investigated the relationship between the vitamin D and blood pressure status in healthy adults, and their 8-year follow-up was added. Materials and Methods: A total of 491 healthy middle-aged participants without any chronic illness, ages 21 to 67 at baseline, were divided into two groups as non-optimal blood pressure (NOBP) and optimal blood pressure (OBP). NOBP group was divided into two subgroups: normal (NBP) and high normal blood pressure (HNBP). Serum 25-hydroxy vitamin D levels were measured with the immunoassay method. 8-year follow-up of the participants was added. Results: The average vitamin D level was detected 32.53 ± 31.50 nmol/L in the OBP group and 24.41 ± 14.40 nmol/L in the NOBP group, and a statistically significant difference was found (p < 0.001). In the subgroup analysis, the mean vitamin D level was detected as 24.69 ± 13.74 and 24.28 ± 14.74 nmol/L in NBP and HNBP, respectively. Together with parathyroid hormone, other metabolic parameters were found to be significantly higher in the NOBP. During a median follow-up of 8 years, higher hypertension development rates were seen in NOBP group (p < 0.001). Conclusions: The low levels of vitamin D were significantly associated with NBP and HNBP. The low levels of vitamin D were also associated with the development of hypertension in an 8-year follow-up.

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Vitamin D status of healthy coastal fishermen of Bangladesh

IMC Journal of Medical Science ◽

10.3329/imcjms.v13i2.45279 ◽

2020 ◽

Vol 13 (2) ◽

pp. 35-39

Author(s):

Wasim Md Mohosin Ul Haque ◽

Md Faruque Pathan ◽

MA Sayeed

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Status ◽

Ipth Level ◽

Endocrine Society ◽

Uv Index ◽

Exposed Population ◽

Vitamin D Levels ◽

Significant Difference ◽

Study Population

Background and objectives: Vitamin D deficiency is now a global concern. Industrialization, urbanization and the decreasing participation in outdoor activities, with consequent sunlight deprivation, are thought to be the key factors in the increasing prevalence of vitamin D deficiency among general population of many countries. It is presumed that healthy, adequately sun-exposed people should maintain adequate vitamin D levels. However, studies within this population are scarce. Hence, this study was conducted to find out the actual vitamin D status in healthy, adequately sun-exposed population living in coastal district of Bangladesh. Material and Methods: One hundred and forty healthy fishermen living in costal district of Cox’s Bazar (210 25' North, 910 59' East) of Bangladesh were enrolled in this study. Relevant data and blood samples were collected during August 2018, one of the months with lower zenith angle and higher UV index. Chemiluminescent micro-particle immunoassay (CMIA) was used to measure 25-hydroxy vitamin D3. Other relevant biochemical parameters measured were random blood glucose (RBG), serum creatinine, albumin, calcium, phosphate, alkaline phosphatase and intact parathyroid hormone (iPTH). Results: Mean vitamin D level of the study population was 27.04±7.20 ng/ml. Based on the cut off value of Endocrine Society, 70.7% of the study population had low vitamin D levels of which 26 (18.6%) and 73 (52.1%) were in vitamin D deficient (<20ng/ml) and insufficient (20 – 29.99 ng/ml) categories respectively. Vitamin D level was normal in 41 (29.3%) subjects. There was no significant difference in iPTH level between groups with low and normal vitamin D levels (p>.05, 95%CI= -5.68226, 1.21086). Conclusion: The unexpectedly high prevalence of vitamin D deficiency in this healthy and adequately sun-exposed population raises the question regarding the validity of the current cutoff value being used to assess the vitamin D status of Bangladeshi population. Future studies should be carried out to determine nation-specific, local cutoff values for vitamin D sufficiency. Ibrahim Med. Coll. J. 2019; 13(2): 35-39

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Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus

Foot & Ankle International ◽

10.1177/1071100719864325 ◽

2019 ◽

Vol 40 (11) ◽

pp. 1309-1318 ◽

Cited By ~ 3

Author(s):

Lukas Fraissler ◽

Sebastian Philipp Boelch ◽

Thomas Schäfer ◽

Matthias Walcher ◽

Jörg Arnholdt ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Osteochondritis Dissecans ◽

Serum Vitamin ◽

Vitamin D Status ◽

Foot And Ankle ◽

Level Of Evidence ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference

Background: Low vitamin D levels are common in patients with foot and ankle disorders. We have previously demonstrated that juveniles diagnosed with osteochondritis dissecans (OCD) have a high prevalence of vitamin D deficiency. Moreover, there is evidence that OCD might be related to vitamin D deficiency in general. However, whether or not hypovitaminosis D is associated with OCD of the talus has yet to be elucidated. Methods: The aim of this study was to determine serum vitamin D levels [25(OH)D] of patients diagnosed with traumatic and idiopathic OCD of the talus. The vitamin D status of patients was measured and correlated to age, sex, season, etiology, laterality, degree of disease, and nicotine abuse. Moreover, parathyroid hormone and serum calcium levels of patients were obtained to assess for severe vitamin D deficiency and secondary hyperparathyroidism. Between January 2015 and December 2017, 65 patients with a mean age of 38.9 years and a total of 68 lesions were identified. Results: In total, 75.4% of patients had low vitamin D levels with a mean overall 25(OH)D level of 24.2 ng/mL. Specifically, 35.4% of patients were vitamin D deficient; another 40% were vitamin D insufficient, and only 24.6% of patients presented with sufficient vitamin D levels. Statistical analysis showed no significant difference comparing vitamin D levels of patients with idiopathic OCD to patients with traumatic OCD. Conclusion: We could not find any significant differences in the vitamin D status of patients with OCD of the talus compared with patients with foot and ankle disorders in general. However, we found that vitamin D deficiency was frequent in patients presenting with traumatic and idiopathic OCD of the talus. We believe it might be beneficial to routinely assess and treat the vitamin D status of patients. Level of Evidence: Level III, retrospective comparative study.

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Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000616 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 333-338

Author(s):

Isil Karaer ◽

Yahya Akalın

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Otoacoustic Emissions ◽

Serum Vitamin ◽

Vitamin B ◽

Cochlear Function ◽

Distortion Product ◽

Vitamin D Levels ◽

Study Participants ◽

Low Serum

Abstract. The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case–control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017–2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz ( p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.

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Vitamin D deficiency and mortality among critically ill surgical patients in an urban Korean hospital

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000639 ◽

2020 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Ji-hyun Lee ◽

Seo-rin Doo ◽

Dongha Kim ◽

Yoo-kyoung Park ◽

Eun-jeong Park ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Critically Ill ◽

Serum Vitamin ◽

Surgical Patients ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Deficiency Group ◽

Critically Ill Surgical Patients

Abstract. Critically ill patients in intensive care units (ICUs) are exposed to various risk factors for vitamin D deficiency. Vitamin D deficiency in extended-stay patients may result in decreased muscle mass and increased fat tissue, which may impair rehabilitation and recovery. Our study aimed to evaluate the degree of serum vitamin D deficiency in critically ill surgical patients and its association with clinical outcomes. Clinical data from 186 adult male (n = 121; 65.1%) and female (n = 65; 34.9%) patients hospitalized in surgical ICUs at Ajou University Hospital from April 2015 to September 2016 were retrospectively analyzed. All adult surgical patients between the age of 18 and 88 years were enrolled. The mean serum 25-hydroxyvitamin D (25[OH]D) level of all patients was 17.8 ng/mL. A total of 120 patients (64.5%) with serum 25(OH)D levels < 20 ng/mL were classified as the deficiency group. A prolonged hospital stay was observed among the deficiency group but was not statistically significant ( p = 0.824). Serum 25(OH)D levels were significantly correlated with age but inversely correlated with Sequential Organ Failure Assessment (SOFA) score, selenium, triglyceride, and C-reactive protein levels. There was no significant difference in mortality rates between the group with a vitamin D injection and the group without a vitamin D injection (14.6% vs. 16.9%, p = 0.074). Vitamin D deficiency was common in surgical ICU patients; however, vitamin D levels were higher in older patients. In conclusion, vitamin D deficiency was inversely associated with the SOFA severity score (Correlation Coefficient –0.165, p = 0.024) but was not associated with the length of hospital or ICU stay and mortality.

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