Vitamin D deficiency and mortality among critically ill surgical patients in an urban Korean hospital

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Ji-hyun Lee ◽  
Seo-rin Doo ◽  
Dongha Kim ◽  
Yoo-kyoung Park ◽  
Eun-jeong Park ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Surgical Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Deficiency Group ◽  
Critically Ill Surgical Patients

Abstract. Critically ill patients in intensive care units (ICUs) are exposed to various risk factors for vitamin D deficiency. Vitamin D deficiency in extended-stay patients may result in decreased muscle mass and increased fat tissue, which may impair rehabilitation and recovery. Our study aimed to evaluate the degree of serum vitamin D deficiency in critically ill surgical patients and its association with clinical outcomes. Clinical data from 186 adult male (n = 121; 65.1%) and female (n = 65; 34.9%) patients hospitalized in surgical ICUs at Ajou University Hospital from April 2015 to September 2016 were retrospectively analyzed. All adult surgical patients between the age of 18 and 88 years were enrolled. The mean serum 25-hydroxyvitamin D (25[OH]D) level of all patients was 17.8 ng/mL. A total of 120 patients (64.5%) with serum 25(OH)D levels < 20 ng/mL were classified as the deficiency group. A prolonged hospital stay was observed among the deficiency group but was not statistically significant ( p = 0.824). Serum 25(OH)D levels were significantly correlated with age but inversely correlated with Sequential Organ Failure Assessment (SOFA) score, selenium, triglyceride, and C-reactive protein levels. There was no significant difference in mortality rates between the group with a vitamin D injection and the group without a vitamin D injection (14.6% vs. 16.9%, p = 0.074). Vitamin D deficiency was common in surgical ICU patients; however, vitamin D levels were higher in older patients. In conclusion, vitamin D deficiency was inversely associated with the SOFA severity score (Correlation Coefficient –0.165, p = 0.024) but was not associated with the length of hospital or ICU stay and mortality.

Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus

2019 ◽  
Vol 40 (11) ◽  
pp. 1309-1318 ◽  
Author(s):  
Lukas Fraissler ◽  
Sebastian Philipp Boelch ◽  
Thomas Schäfer ◽  
Matthias Walcher ◽  
Jörg Arnholdt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Osteochondritis Dissecans ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Foot And Ankle ◽  
Level Of Evidence ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Background: Low vitamin D levels are common in patients with foot and ankle disorders. We have previously demonstrated that juveniles diagnosed with osteochondritis dissecans (OCD) have a high prevalence of vitamin D deficiency. Moreover, there is evidence that OCD might be related to vitamin D deficiency in general. However, whether or not hypovitaminosis D is associated with OCD of the talus has yet to be elucidated. Methods: The aim of this study was to determine serum vitamin D levels [25(OH)D] of patients diagnosed with traumatic and idiopathic OCD of the talus. The vitamin D status of patients was measured and correlated to age, sex, season, etiology, laterality, degree of disease, and nicotine abuse. Moreover, parathyroid hormone and serum calcium levels of patients were obtained to assess for severe vitamin D deficiency and secondary hyperparathyroidism. Between January 2015 and December 2017, 65 patients with a mean age of 38.9 years and a total of 68 lesions were identified. Results: In total, 75.4% of patients had low vitamin D levels with a mean overall 25(OH)D level of 24.2 ng/mL. Specifically, 35.4% of patients were vitamin D deficient; another 40% were vitamin D insufficient, and only 24.6% of patients presented with sufficient vitamin D levels. Statistical analysis showed no significant difference comparing vitamin D levels of patients with idiopathic OCD to patients with traumatic OCD. Conclusion: We could not find any significant differences in the vitamin D status of patients with OCD of the talus compared with patients with foot and ankle disorders in general. However, we found that vitamin D deficiency was frequent in patients presenting with traumatic and idiopathic OCD of the talus. We believe it might be beneficial to routinely assess and treat the vitamin D status of patients. Level of Evidence: Level III, retrospective comparative study.

scholarly journals VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS

2020 ◽  
pp. 168-170
Author(s):  
JINAN Q MOHAMMED ◽  
ABDULSATAR J MATHKHOR ◽  
AMER S KHUDHAIRY
Keyword(s):  
Vitamin D ◽  
Psoriatic Arthritis ◽  
Vitamin D Deficiency ◽  
Disease Duration ◽  
Serum Vitamin ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Lower Vitamin

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject. Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls. Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively. Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.

Serum vitamin D status does not correlate with the severity of obstructive sleep apnea in male adults: A controlled study design with minimized factors influencing serum vitamin D levels

2020 ◽  
Vol 90 (5-6) ◽  
pp. 470-476 ◽  
Author(s):  
Ozge Yagcioglu Yassa ◽  
Saime Fusun Domac ◽  
Gulay Kenangil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Significant Relationship ◽  
Serum Vitamin ◽  
Controlled Study ◽  
Vitamin D Status ◽  
Anthropometric Measures ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract. Observational studies performed in homogeneous groups to objectively investigate the cause and effect relationship between vitamin D deficiency and sleep disorders are scarce. In this study, it was aimed to analyze the relationship between the severity of OSAS and vitamin-D levels among the participants whose features affecting serum vit-D levels were minimised. Serum 25-OH vitamin-D levels in 121 OSAS Male patients diagnosed by polysomnography without any systemic disease or vitamin-D supplement that may effect the vitamin-D metabolism were measured. The study was conducted in winter (latitude: 41°). Anthropometric measures and biochemical tests were also performed. The distribution of vitamin-D levels was determined as severe deficiency, deficiency, insufficiency and sufficiency. Apnea-hypopne index (AHI) < 5 was considered as a control group. Patients were categorized into four groups according to AHI as control, mild, moderate and severe. The groups were similar in terms of age, BMI, lipid profile, serum calcium, anthropometric measures and smoking. There was no significant difference in the distribution of vitamin-D levels between the patient and control groups and also within OSAS subgroups (p = 0.57, p = 0.86, respectively). Odds ratio to have OSAS in patients with vitamin-D deficiency was found as 0.745 (95 %CI: 0.33–1.7). Multinominal regression analysis showed no significant relationship between the OSAS severity and the extent of vitamin-D status. Correlation analysis showed no significant relationship between vitamin-D and AHI (r = 0.017, p = 0.877). Vitamin-D status does not alter the severity of OSAS. Vitamin-D deficiency might be the result of lifestyle changes due to OSAS rather than a cause.

scholarly journals Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, Iran

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Masume Bayat ◽  
Latif Gachkar ◽  
Mahya Zahirnia ◽  
Fahimeh Hadavand
Keyword(s):  
Vitamin D ◽  
Severe Sepsis ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D insufficiency is common in critically ill patients. It is hypothesized that vitamin D deficiency would be associated with sepsis in the critically ill. Thus, the present study aimed to investigate the association between vitamin D and sepsis severity. Method: In this cross-sectional study, patients with sepsis referring to a university hospital in Tehran, Iran, from February 2018 to March 2019 were included. Plasma concentrations of vitamin D in critically ill subjects admitted were assessed. Data were analyzed using SPSS version 20.0. P-values less than 0.05 were considered statistically significant. Results: Among the investigated patients, the mean serum level of vitamin D3 was 19.03 ± 13.08 ng/mL. The prevalence of vitamin D insufficiency in critically ill subjects with sepsis was 100% (150/150). Only sex (P = 0.01) indicated a significant association with vitamin D. Patients suffering from severe sepsis had lower levels of vitamin D compared to the patients with non-severe sepsis (P = 0.07). Conclusions: The present study showed that all critically ill patients studied had vitamin D insufficiency. In line with the biological evidence, the present study suggests that vitamin D deficiency may predispose patients to sepsis. Further studies are needed to establish the causes and mechanisms underlying these interpretations.

scholarly journals CORRELATION OF SERUM VITAMIN D LEVEL WITH MORTALITY IN PATIENTS WITH SEPSIS

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Pramod Sood ◽  
Manpreet Kaur
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Medical Emergency ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels

Background: Vitamin D insufficiency is a common global phenomenon. Its insufficiency is also reported to be common in hospitalized patients and particularly in critically ill patients. Methods: Following ethical approval, consent will be sought from either the patient or assent from a near relative. Successive patients admitted to the medical emergency and ICU at tertiary care health center who fulfill the following criteria for sepsis, within a 24 h time window, were included in the study. Results: A total of 50 patients were enrolled in the study, 37 (74.00%) were discharged whereas 13(26.00%) patients expired. The majority of patients, irrespective of outcome had Vitamin D deficiency. Although normal Vitamin D levels were observed in relatively higher proportion of patients who were discharged (29 patients) as compared to those who expired (12 patients) yet this difference was not significant statistically (P = 0.481). Conclusion: Vitamin D deficiency leads to increased risk of mortality in the critically ill patients. Keywords: Sepsis, Vitamin D deficiency, Mortality.

scholarly journals SERUM VITAMIN D STATUS AMONG CRITICALLY ILL CHILDREN WITH RESPIRATORY INFECTIONS

2020 ◽  
pp. 1-3
Author(s):  
SS Kalyanshettar ◽  
Sanjeevani Umarani ◽  
M M Patil ◽  
SV Patil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Critically Ill ◽  
Serum Vitamin ◽  
Respiratory Illness ◽  
Respiratory Support ◽  
Critically Ill Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Objective: To know whether low levels of vitamin D affects severity of respiratory illness and its clinical outcomes. Design: Hospital based prospective cross sectional observational study. Setting : Pediatric Intensive Care Unit in Teaching Hospital affiliated with Medical College with study period of one and half years Methodology The study was performed on 50 cases of critically ill children with respiratory infectious disease admitted to the paediatric intensive care unit. Assessment of severity of respiratory infection was done with Paediatric respiratory severity score (PRESS). Serum vitamin D levels were assessed. Duration of PICU stay, hospital stay, need and type of respiratory support and its duration were also recorded. Results: Severe Vitamin D deficiency (<20ng/ml) was noted in 64% of total cases admitted with respiratory illness in PICU. Among these, 62.5% (20) cases had severe respiratory illness. The severity of respiratory illness was found to be highly significant with low Serum vitamin D values (p<0.01). Low serum vitamin D levels were also significantly associated with length of PICU stay (p<0.01), length of hospital stay (p=0.014), type of respiratory support (<0.001) and duration of respiratory support (p<0.001) Conclusion: A high prevalence of Vitamin D deficiency and insufficiency was found in critically ill children admitted with Respiratory infection. A strong statistical correlation was noted with Vitamin D deficiency and strongly associated with prolonged PICU care, respiratory support and hospitalization.

scholarly journals AB0434 VITAMIN D IN SYSTEMIC SCLEROSIS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1246.1-1246
Author(s):  
M. M. Sirufo ◽  
F. De Pietro ◽  
M. Raggiunti ◽  
M. De Martinis ◽  
L. Ginaldi
Keyword(s):  
Vitamin D ◽  
Systemic Sclerosis ◽  
Pulmonary Fibrosis ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Healthy Controls ◽  
Serum Vitamin D ◽  
Link Type ◽  
Vitamin D Levels ◽  
Significant Difference

Background:Systemic Sclerosis (SSc) is a generalized and systemic autoimmune disease that affects the connective tissue of the skin and internal organs, especially kidneys, heart and lungs [1].Objectives:Numerous data from recent literature confirm the regulatory action of vitamin D on the immune system and, therefore, how a deficit of this micronutrient can lead to alterations in the immune response, as is known to happen in many allergic and autoimmune diseases [2]. We studied the association between vitamin D levels and SSc, evaluating their correlation with the characteristic manifestations of the pathology.Methods:We dosed the serum levels of 25 hydroxy-vitamin D in 42 patients with SSc (average age 64.63 +/-7.33) and 40 healthy controls comparable for sex and age. The diagnosis of SSc was formulated in accordance to 2013 ACR/EULAR criteria. None of the subjects involved in the study took vitamin D products.Results:Patients’ vitamin D levels (26.22+/-9.82 ng/ml), although they tended to be lower than controls (27.80 +/- 16.53 ng/ml), showed no significant decrease. In patients with pulmonary fibrosis, vitamin D levels were 23.28 +/- 12.30 lower than in patients with trophic ulcers and compared to patients without complications 26.07 +/- 9.92, although with not statistically significant values. No statistically significant difference was found between vitamin D levels in patients with trophic ulcers compared to controls without complications.Conclusion:According to the studies in the literature, in our sample, vitamin D deficiency was therefore greater in patients with SSc, especially with pulmonary fibrosis, than in controls [3,4]. Vitamin D levels in diffused-type SSc patients were significantly lower than those in limited-type SSc patients. Further studies are needed to clarify the role that vitamin D deficiency plays in SSc, but lower vitamin D levels in these patients may suggest the need to monitor blood levels of vitamin D and supplement it appropriately.References:[1]De Martinis M, Ciccarelli F, Sirufo MM, Ginaldi L. An overview of environmental risk factors in systemic sclerosis. Expert Rev Clin Immunol. 2016;12(4):465-78. doi: 10.1586/1744666X.2016.1125782. Epub 2015 Dec 19. PMID: 26610037.[2]Yang, CY., Leung, P.S.C., Adamopoulos, I.E. et al. The Implication of Vitamin D and Autoimmunity: a Comprehensive Review. Clinic Rev Allerg Immunol45, 217–226 (2013). https://doi.org/10.1007/s12016-013-8361-3.[3]Trombetta AC, SmithV, Gotelli E, Ghio M, Paolino S, Pizzorni C, et al. (2017) Vitamin D deficiency and clinical correlationsin systemic sclerosis patients: A retrospective analysis for possible future developments. PLoS ONE 12(6): e0179062.https://doi.org/10.1371/journal. pone.0179062.[4]Sarita Gupta, Vikram K. Mahajan, Rajinder S. Yadav1, Karaninder S. Mehta, Satya Bhushan1, et al. Evaluation of Serum Vitamin D Levels in Patients with Systemic Sclerosis and Healthy Controls: Results of a Pilot Study Article July 2018 DOI: 10.4103/idoj.IDOJ_328_17.Disclosure of Interests:None declared

scholarly journals Hypovitaminosis D effect on pericranial muscle dysfunction in women with chronic tension headache

2020 ◽  
Vol 4 (39) ◽  
pp. 24-27
Author(s):  
A. A. Koloskova ◽  
O. V. Vorobieva
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Normal Level ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Muscle Dysfunction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Normal Vitamin

Background. Nowadays there are a large number of studies revealing the significance of hypovitaminosis D in chronic pain conditions and diseases, in which musculoskeletal factors are dominant in the formation of pain. In chronic tension type headache (CTTH) pathogenesis the role of muscular factor is well-established. However there is insufficient data regarding the interrelations between hypovitaminosis D, headache and pericraial muscle dysfunction (PMD) in CTTH.Objective. To investigate the effect of vitamin D level on PMD and cephalgia parameters in CTTH.Methods. One hundred twenty women with CTTH aged 25 to 55 years were enrolled. Evaluated parameters were the following: pericranial muscle tenderness (PMT), headache frequency (HF), headache duration (HD), headache intensity (HI). Vitamin D level measured by 25-hydroxyvitamin D [25(OH)D] of serum blood samples.Results. Number of CTTH with DPM cases in the group of vitamin D deficiency (serum level of 25(OH)D less than 20 ng/mL) was equal to one in normal vitamin group (higher than 30 ng/mL), p > 0.05. Greater degree of DPM was identified in vitamin D deficiency than in normal level: total PMT score 5.0 vs 3.0 score (р < 0.001). At the same time significant difference was observed in cephalgia parameters between groups of deficiency and normal vitamin D level: HF 28.0 and 23.0 days per month (р < 0.001), HD 14.5 and 10.0 hours per day respectively. Also daily headache was associated with vitamin D deficiency with a risk ratio 4.4 (95 % CI: 1.4–14,0) as compared to the normal level. Middle-power negative correlation was noted between serum vitamin D levels and total PMT score (Spearman’s r = –0.55; р < 0,001), HF (r = –0.65; р < 0,001) and HD (r = 0.67; р < 0,001).Conclusion. Vitamin D deficiency leads to increased degree of pericraial muscle dysfunction in CTTH women. That may result in rising central sensitization and finally be a reason of more severe headache.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Sign in / Sign up

Export Citation Format

Share Document