scholarly journals Emerging And Legacy PFAS And Cytokine Homeostasis In Women of Childbearing Age

2022 ◽  
Author(s):  
Min Nian ◽  
Wei Zhou ◽  
Yan Feng ◽  
Yan Wang ◽  
Qian Chen ◽  
...  
Keyword(s):  
Chinese Women ◽  
Positive Association ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Meso Scale Discovery ◽  
Kernel Machine ◽  
Cytokine Levels ◽  
Unit Increase ◽  
Th17 Cytokines ◽  
Polyfluoroalkyl Substances

Abstract The effect of legacy and emerging per- and polyfluoroalkyl substances (PFAS) on cytokine homeostasis in human remains poorly understood. This study aimed to evaluate the associations between legacy and emerging PFAS and cytokine profiles, and identify the main contributors to the disturbance of cytokine homeostasis. We quantified 21 PFAS in 198 Chinese women of childbearing age from 2015 to 2016. 13 cytokines were measured using the Meso Scale Discovery U-PLEX and V-PLEX platforms. The associations between PFAS exposure and cytokine levels were assessed using multiple linear regression (single-exposure), and Bayesian kernel machine regression (BKMR) models (PFAS mixture exposure). In single PFAS models, legacy and alternative PFAS were positively associated with Th1 and Treg cytokines, and negatively associated with Th2 and Th17 cytokines. For instance, each ln-unit increase in 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) was associated with a decrease in IL-10 by -0.228 (95% CI: -0.336, -0.120), -0.153 (95% CI: -0.277, -0.030), and -0.174 (95% CI: -0.339, -0.010), respectively. The BKMR model showed a significantly positive association of PFAS mixture with TGF-β and a negative association with IL-10. Overall, these results indicate that both legacy and emerging PFAS may affect the homeostasis of cytokines.

scholarly journals Anemia and Deficiencies of Folate and Vitamin B-6 Are Common and Vary with Season in Chinese Women of Childbearing Age

2000 ◽  
Vol 130 (11) ◽  
pp. 2703-2710 ◽  
Author(s):  
Alayne G. Ronnenberg ◽  
Marlene B. Goldman ◽  
Iain W. Aitken ◽  
Xiping Xu
Keyword(s):  
Chinese Women ◽  
Vitamin B ◽  
Women Of Childbearing Age ◽  
Childbearing Age

CONSTRUCTION AND APPLICATION OF BREP PHANTOM FOR CHINESE WOMEN OF CHILDBEARING AGE IN RADIATION PROTECTION

2020 ◽  
Vol 189 (4) ◽  
pp. 407-419
Author(s):  
Haowei Zhang ◽  
Si Sun ◽  
Heqing Lu ◽  
Ying Liu
Keyword(s):  
Radiation Protection ◽  
Chinese Women ◽  
Absorbed Dose ◽  
Organ Dose ◽  
Boundary Representation ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Protection Scheme ◽  
Dose Modulation ◽  
Female Specific

Abstract The purpose of this study is to construct boundary representation (BREP) phantom for Chinese women of childbearing age, to estimate the external radiation dose and to analyze radiation protection scheme. The BREP phantom for Chinese women of childbearing age was constructed by image segmentation, 3D reconstruction, non-uniform rational B-spline surface construction and voxelization. The photon-irradiated organ absorbed dose-conversion coefficients (DCCK) of the three female specific organs and the photon effective dose-conversion coefficient (ECCK) were calculated by Monte-Carlo method. The results showed that age, body fat-tissue thickness, direction and area of irradiation, organ location and volume all affected the dose of women specific organs when receiving medical exposure. In the case of ensuring the quality of the diagnosis, radiation protection for female specific organs can be achieved by organ dose modulation techniques and reducing exposure area or volume.

scholarly journals Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0155801 ◽  
Author(s):  
Minxue Shen ◽  
Hongzhuan Tan ◽  
Shujin Zhou ◽  
Ravi Retnakaran ◽  
Graeme N. Smith ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chinese Women ◽  
Cross Sectional Study ◽  
Serum Folate ◽  
Inverse Association ◽  
Women Of Childbearing Age ◽  
Sectional Study ◽  
Childbearing Age ◽  
Cross Sectional

scholarly journals Trends of central obesity and associations with nutrients intake and daily behaviors among women of childbearing age in China

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zichong Long ◽  
Lili Huang ◽  
Jiajun Lyu ◽  
Yuanqing Xia ◽  
Yiting Chen ◽  
...  
Keyword(s):  
Protein Intake ◽  
Central Obesity ◽  
Linear Mixed Model ◽  
Leisure Time Physical Activity ◽  
Chinese Women ◽  
Health Concern ◽  
Age Group ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Nutrients Intake

Abstract Background Obesity among women of childbearing age has becoming an important public health concern. We aimed to describe the trends of central obesity among Chinese women of childbearing age from 2004 to 2011 and to examine its associations with nutrients intake and daily behaviors. Methods Longitudinal data were derived from the China Health and Nutrition Survey. Participants consisted of 2481 women aged 15–44 years old. WC (Waist circumference) and WHtR (Waist to height ratio) were adopted as indicators of central obesity. Generalized linear mixed model was performed to analyze the associations of nutrients intake and daily behaviors with central obesity. Results From 2004 to 2011, the prevalence of central obesity among Chinese women of childbearing age increased from 21.6 to 30.7% (WC as indice) or from 22.8 to 32.6% (WHtR as indice) (both p < 0.001). Protein intake above the AMDR (Acceptable macronutrient distribution range) (OR = 1.21, 95% CI 1.05–1.39, p < 0.01) and non-participation in LTPA (Leisure time physical activity) (OR = 1.45, 95% CI 1.17–1.80, p < 0.001) were risk factors for high WC, and the latter was also associated with high WHtR (OR = 1.36, 95% CI 1.10–1.67, p < 0.01). For those women who had high WC & high WHtR, the impacts of protein intake and LTPA became stronger, especial LTPA (OR = 1.53, 95% CI 1.21–1.94, p < 0.001). Age-stratified analyses found that non-participation in LTPA was key factor for central obesity in 15–34 age group, while protein intake above the AMDR was pronounced in the 35–44 age group. Conclusions Non-participation in LTPA and protein intake above the AMDR were significant contributors of central obesity, which could be intervention targets to deal with the growing trend of central obesity among women of childbearing age.

scholarly journals Intent to have a second child among Chinese women of childbearing age following China’s new universal two-child policy: a cross-sectional study

2019 ◽  
Vol 46 (1) ◽  
pp. 59-66
Author(s):  
Jue Liu ◽  
Min Liu ◽  
Shikun Zhang ◽  
Qiuyue Ma ◽  
Qiaomei Wang
Keyword(s):  
Chinese Women ◽  
Cross Sectional Study ◽  
Central China ◽  
Women Of Childbearing Age ◽  
Sectional Study ◽  
Childbearing Age ◽  
Related Factors ◽  
Cross Sectional ◽  
Second Child ◽  
Child Policy

IntroductionChina’s one-child policy was replaced by a new universal two-child policy in 2015; however, few studies have addressed the intent to have a second child and resulting related issues.MethodsWe performed a cross-sectional study on 11 991 Chinese women, 18–49 years of age, from 11 provinces in 2016–2017, in order to assess the intent for a second child among Chinese women of childbearing age and other related factors after the introduction of China’s new universal two-child policy.ResultsWe found that the overall prevalence of the intent to have a second child was 39.4% and that economic, childrearing, and health barriers affected fertility intent. Multivariate logistic regression models showed that the age range of 25–39 years (aOR 1.28–1.30), living in Eastern (aOR 1.28, 95% CI 1.10 to 1.50) or Central China (aOR 1.52, 95% CI 1.27 to 1.78), living in a rural area (aOR 1.62, 95% CI 1.47 to 1.78), being a farmer (aOR 1.43, 95% CI 1.09 to 1.88), having a higher household income (aOR 1.13, 95% CI 1.00 to 1.28), having a history of abortion (aOR 1.18, 95% CI 1.05 to 1.31), and already having one child (aOR 3.65 for girls, aOR 2.70 for boys) were associated with a greater intent to have a second child (all p<0.05). Conversely, economic, health, childrearing, and educational barriers were associated with a lower intent to have a second child (aOR 0.65–0.75).ConclusionFour in ten women of childbearing age demonstrated an intent for a second child. We maintain that fertility-related factors be given full consideration when promoting the two-child policy.

scholarly journals Plasma folate status and dietary folate intake among Chinese women of childbearing age

2009 ◽  
Vol 5 (2) ◽  
pp. 104-116 ◽  
Author(s):  
Yaling Zhao ◽  
Ling Hao ◽  
Le Zhang ◽  
Yihua Tian ◽  
Yiwu Cao ◽  
...  
Keyword(s):  
Chinese Women ◽  
Folate Intake ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Dietary Folate ◽  
Folate Status ◽  
Plasma Folate ◽  
Dietary Folate Intake

scholarly journals Folate status in women of childbearing age with obesity: a review

2017 ◽  
Vol 30 (2) ◽  
pp. 265-271 ◽  
Author(s):  
Silvia Maffoni ◽  
Rachele De Giuseppe ◽  
Fatima Cody Stanford ◽  
Hellas Cena
Keyword(s):  
Pregnant Women ◽  
Genetic Factors ◽  
Positive Association ◽  
Folate Metabolism ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Folate Status ◽  
History Of ◽  
Previous Weight Loss ◽  
Erythrocyte Folate

AbstractSeveral studies have described a positive association between elevated BMI and birth defects risk. Data on plasma concentration of folate in pregnant women with obesity have shown values far below those recommended, regardless of diet, while folate levels should increase before pregnancy to reduce neural tube defects. We report a descriptive review of the most recent studies (from 2005 to 2015) to evaluate folate status through a population of women of childbearing age affected by obesity. The literature contains few studies, which present conflicting results regarding folate status in non-pregnant women of childbearing age affected by obesity, and it appears that there is a modification in folate metabolism, with a reduction in plasma folate levels and an increase in erythrocyte folate uptake. In conclusion, the folate status in women of childbearing age should be assessed by both plasma and erythrocyte levels to start a personalised and more adequate supplementation before conception. Further studies need to be conducted in a larger population, which take into account variables that can affect folate metabolism, such as dietary intake, lifestyle and genetic factors, oral contraceptives or other drug use, previous weight-loss programmes, or a history of bariatric surgery.

scholarly journals Correction to: Dietary patterns of Chinese women of childbearing age during pregnancy and their relationship to the neonatal birth weight

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui Yan ◽  
Shaonong Dang ◽  
Yaodong Zhang ◽  
Shuying Luo
Keyword(s):  
Birth Weight ◽  
Dietary Patterns ◽  
Chinese Women ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Neonatal Birth Weight

An amendment to this paper has been published and can be accessed via the original article.

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