scholarly journals F-18 FDG PET/CT in Relapsing Polychondritis Patients with Initial Respirotory Symptoms: Imaging Features and Association with Pulmonary Function and Disease Activity

2022 ◽  
Author(s):  
Jing-Wei Yi ◽  
Peng Hou ◽  
Jin-Ling Wang ◽  
Jing Qi ◽  
Si-Yan Lin ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Disease Activity ◽  
Respiratory Symptoms ◽  
Clinical Symptoms ◽  
Relapsing Polychondritis ◽  
Corticosteroid Treatment ◽  
Wall Thickening ◽  
Imaging Features ◽  
Fdg Uptake ◽  
Pet Ct

Abstract Background: To summarize F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging features of relapsing polychondritis (RP) and to evaluate the feasibility of imaging parameters in the estimation of pulmonary function and disease activity in a cohort of RP patients with airway involvement.Methods: Thirty RP patients with respiratory symptoms who underwent PET/CT scans before corticosteroid treatment were included. Six patients underwent another post-therapeutic PET/CT scan. Imaging features were described by consensus, and FDG uptake values (SUVmax, PET FDG Burden Score (PETFBS) and PETCTindex) either for global cartilages or for the airway were calculated to correlate with clinical symptoms, pulmonary functional parameters and serological inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).Results: Laryngo-tracheo-bronchial involvement was detected by PET/CT for all patients with increased FDG uptake in 28/30 patients. The incidence of positive PET was higher in segments with wall thickening (52.68% vs. 15.48%) but was not associated with calcification or stenosis. A total of 46.7% (14/30) of patients presented with sole respiratory symptoms, while PET/CT revealed additional abnormalities in addition to laryngo-tracheo-bronchia. FDG uptake values negatively correlated with disease duration but not with fever. All FDG uptake values showed a positive correlation with FEV1/FVC, with the highest coefficient for SUVmax in the airway (rs =0.628). CRP and ESR were negatively correlated with PETFBS and PETCTindex but not with SUVmax. The largest Spearman correlation coefficient resulted in PETFBS in the airway (rs =0.67). Re-examination PET/CT in 6 patients revealed partial therapeutic response (n = 4), stable disease (n = 1) and progressive disease (n = 1).Conclusion: PET/CT is a valuable tool for assessing RP with airway involvement, especially for patients who present with sole respiratory symptoms. SUVmax and PETFBS have distinct advantages in the clinical evaluation of RP with respect to pulmonary function and disease activity.

Fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis, assessment of disease activity and therapeutic response in relapsing polychondritis

Rheumatology ◽  
2019 ◽  
Vol 59 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Aman Sharma ◽  
Rajender Kumar ◽  
Adarsh MB ◽  
G S R S N K Naidu ◽  
Vikas Sharma ◽  
...  
Keyword(s):  
Disease Activity ◽  
Fdg Pet ◽  
Therapeutic Response ◽  
Clinical Symptoms ◽  
Relapsing Polychondritis ◽  
Response To Therapy ◽  
Ct Examination ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Assessment Of Disease Activity

Abstract Objective To evaluate 18F-fluorodeoxyglucose (FDG) PET/CT in the assessment of disease activity, extent of the disease and response to therapy in relapsing polychondritis. Methods Twenty-five patients (9 men, 16 women) with a mean age of 38.2 years (s.d. 13.7; range 18–62), diagnosed to have relapsing polychondritis according to Damiani and Levine’s modification of McAdam’s criteria, who underwent PET/CT examination were included. Ten patients underwent a second PET/CT examination after therapy or during follow-up. Clinical symptoms and auxiliary examination findings were recorded. PET/CT findings were reviewed and correlated with the clinical symptoms. Results The major symptoms were aural pain (n = 21), nasal pain (n = 10), stridor (n = 5), cough (n = 9), fever (n = 8) and laryngeal tenderness (n = 8). The initial PET/CT was positive in 23/25 patients. PET/CT revealed involvement of auricular (n = 14), nasal (n = 8), laryngeal (n = 7), tracheobronchial (n = 6) and Eustachian (n = 3) cartilages with a mean maximum standardized uptake value (SUVmax) of 4.1 (s.d. 2.5; range 1.7–12.7). Fair correlation of aural/nasal pain/stridor with FDG avidity of cartilage involvement on PET/CT was noted. The key finding was detection of asymptomatic large airway involvement in seven patients (28%). Re-examination PET in 10 patients revealed complete therapeutic response (n = 5), partial response (n = 1), stable disease (n = 1), progressive disease (n = 1) and disease recurrence (n = 2). Conclusion FDG PET/CT is a useful tool for the assessment of the disease activity and extent. It identified activity in clinically inaccessible sites that are of clinical significance. It is also useful in assessing treatment response and finding relapse.

scholarly journals PET/CT Enterography in Crohn Disease: Correlation of Disease Activity on CT Enterography with 18F-FDG Uptake

2010 ◽  
Vol 51 (7) ◽  
pp. 1009-1014 ◽  
Author(s):  
D. Groshar ◽  
H. Bernstine ◽  
D. Stern ◽  
J. Sosna ◽  
M. Eligalashvili ◽  
...  
Keyword(s):  
Disease Activity ◽  
Crohn Disease ◽  
Ct Enterography ◽  
Fdg Uptake ◽  
Pet Ct ◽  
18F Fdg

Clinical Implications of Incidental Sinonasal Positive FDG Uptake on PET-CT

2019 ◽  
Vol 160 (4) ◽  
pp. 729-733 ◽  
Author(s):  
Sharon Tzelnick ◽  
Hanna Bernstine ◽  
Liran Domachevsky ◽  
Ethan Soudry
Keyword(s):  
Fungal Infections ◽  
Medical Center ◽  
Wall Thickening ◽  
Fdg Uptake ◽  
Sinus Wall ◽  
Positron Emission ◽  
Pet Ct ◽  
Diagnostic Biopsy ◽  
Fdg Pet Ct ◽  
Incidental Lesions

Objectives Fluorodeoxyglucose positron emission tomography–computed tomography (FDG PET-CT) has been increasingly used in the past decade. Incidental FDG-avid findings are encountered in these studies, several of which with clinical significance. However, the significance of incidental FDG-avid sinonasal findings has not been studied to date. Study Design Retrospective cohort study. Setting A single tertiary medical center. Materials and Methods The medical records were reviewed of patients with incidental sinonasal positive FDG uptake between 2007 and 2016 who referred for further otolaryngological diagnostic workup. Results A total of 26 patients were identified, all of whom underwent a diagnostic surgical procedure. Histopathology revealed chronic inflammation (n = 12, 46.1%), malignancy (n = 7, 26.9%), inverted papilloma (n = 4, 15.5%), and fungal infections (n = 3, 11.5%). A unilateral maxillary sinus with FDG uptake was documented for 16 (61.5%) patients. CT evidence of bilateral disease and mucosal or sinus wall thickening correlated with inflammatory disease. Conclusions Incidental lesions with positive FDG uptake in the sinonasal cavities are at a high risk (40%) of being neoplastic. A diagnostic biopsy is advocated in these cases.

scholarly journals 18F-FDG PET/CT Associates With Disease Activity and Clinical Recurrence of AOSD Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Xian Li ◽  
Chuning Dong ◽  
Xiaowei Ma ◽  
Yunhua Wang
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Disease Activity ◽  
Influencing Factors ◽  
Fdg Pet ◽  
Metabolic Parameters ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Recurrence Group

Objective: The purpose of this study was to explore the value of 18F-FDG PET/CT in monitoring the disease activity and predicting the prognosis of the Adult-onset Still's disease (AOSD).Methods: We retrospectively analyzed the electronic medical records of 45 AOSD patients who underwent 18F-FDG PET/CT in the Second Xiangya Hospital. PET/CT imaging and clinical information were retrospectively reviewed and analyzed. 18F-FDG uptake was assessed by measuring standard uptake value (SUV) in the spleen, liver, bone marrow, and lymph nodes. The spleen-to-liver ratio of the SUVmax (SLRmax) and SUVmean (SLRmean), the bone-to-liver ratio of the SUVmax (BLRmax), and SUVmean (BLRmean), and the lymph nodes-to-liver ratio of the SUVmax (LyLRmax) were calculated. Clinical and laboratory information were collected and evaluated for association with metabolic parameters of 18F-FDG PET/CT. The influencing factors for recurrence within 1 year were analyzed to determine whether 18F-FDG PET/CT can predict the prognosis of AOSD patients.Results: Elevated 18F-FDG uptake could be observed in bone marrow, spleen, and lymph nodes of AOSD patients. Correlation analysis between 18F-FDG uptake of organs and laboratory examinations showed that SLRmean positively correlated with LDH, AST, ferritin, and the systemic score (r = 0.572, 0.353, 0.586, and 0.424, P < 0.05). The SLRmean had the highest correlation with ferritin (r = 0586, P < 0.001). All metabolic parameters in spleen, including SUVmax, SUVmean, SLRmax, and SLRmean, are positively correlated with LDH level (r = 0.405, 0.539, 0.481, and 0.572, P < 0.05). Bone marrow SUVmax, BLRmax, and BLRmean were correlated with C-reactive protein (CRP) level (r = 0.395, 0.437, and 0.469, P < 0.05). Analysis of the influencing factors of recurrence within 1 year showed that the spleen SUVmax, spleen SUVmean, SLRmax, SLRmean, ferritin, and the systemic score of the recurrence group was significantly higher than the non-recurrence group (P < 0.05). The SLRmean cutoff of 1.66 with a sensitivity of 72.7% and specificity of 80.0% had the highest performance in predicting recurrence.Conclusion: The glucose metabolism of the liver, spleen, and bone marrow of AOSD patients were correlated with laboratory inflammatory indicators and system score, suggesting that 18F-FDG PET/CT could be applied to evaluate disease activity. Moreover, spleen 18F-FDG uptake may be a potential biomarker for predicting clinical prognosis of AOSD patients.

scholarly journals FDG-PET/CT and Auricular Cartilage Biopsy Are Useful for Diagnosing with Relapsing Polychondritis in Patients without Auricular Symptoms

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 956
Author(s):  
Saki Okuda ◽  
Yasuaki Hirooka ◽  
Tetsu Itami ◽  
Yuji Nozaki ◽  
Masafumi Sugiyama ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Relapsing Polychondritis ◽  
Wall Thickening ◽  
Bronchial Biopsy ◽  
Auricular Cartilage ◽  
Positron Emission ◽  
Pet Ct ◽  
Old Japanese ◽  
Enhanced Computed Tomography ◽  
Fdg Pet Ct

Relapsing polychondritis (RP) is a rare autoimmune inflammatory disease characterized by recurrent inflammation and destruction of cartilage. Although auricular chondritis is a characteristic finding in RP, it can be difficult to diagnose in the absence of auricular symptoms. A 64-year-old Japanese male was referred to our hospital with fever and respiratory distress. Contrast-enhanced computed tomography (CT) revealed bronchial wall thickening and we suspected RP; however, he had no auricular symptoms and did not meet the diagnostic McAdam criteria for RP, so we used 18F-fluorodeoxyglucose positron emission tomography/CT (FDG-PET/CT) to search for other cartilage lesions. This analysis revealed FDG accumulation not only in the bronchial walls, but also in the left auricle. Instead of a bronchial biopsy using a bronchoscope, we performed a biopsy of the left auricular cartilage, which is considered a relatively less invasive site. Even though the auricle was asymptomatic, the pathology results revealed chondritis. He was diagnosed with RP, and his symptoms rapidly improved with corticosteroid therapy. A biopsy of asymptomatic auricular cartilage may be useful in the diagnosis of RP. FDG-PET/CT is a powerful tool for the early diagnosis of RP, identifying inflammatory areas even in the absence of symptoms, and guiding the selection of appropriate biopsy sites.

scholarly journals 18F-FDG PET/CT findings in a possible MELAS syndrome: A case study

2019 ◽  
Author(s):  
Alireza Emami-Ardekani ◽  
Alireza Emami-Ardekani ◽  
Sara Harsini ◽  
Armaghan Fard-Esfahani ◽  
Farzaneh Baseri ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Right Hemisphere ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Melas Syndrome ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Wide Range ◽  
18F Fdg

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare congenital disorder of mitochondrial DNA, presenting a wide range of clinical symptoms comprising headaches, seizures, aphasia, hearing loss, visual defects, and hemiparesis. Herein we report a case of a previously asymptomatic 40-year-old male who presented with recurrent headache, seizures, Wernicke’s aphasia, and impaired visual acuity. Investigations included CT, MRI, MR venography, MR spectroscopy, and PET/CT with 18F-fluorodeoxyglucose (18F-FDG-PET) of the brain. PET imaging showed diffuse increased 18F-FDG uptake in the right hemisphere and left temporal lobe; additionally, decreased 18F-FDG uptake was observed in the left frontoparietal lobe. The patient underwent treatment by levetiracetam, co-enzyme Q10, riboflavin, L-carnitine, and lacosamide, followed by improvement of his clinical signs and symptoms indicative of partial response to the therapy. Key

scholarly journals Differential Diagnosis of Pulmonary Fungal Infection and Lung Cancer via 18F-FDG PET/CT: A Retrospective Study

2021 ◽  
Author(s):  
Xin Feng ◽  
Chunmei Deng ◽  
Xiaofeng Li ◽  
Ye Qiu ◽  
Jiehua Deng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Fungal Infection ◽  
Fdg Pet ◽  
Pathological Examination ◽  
Imaging Features ◽  
Antigen Test ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Background: There is limited evidence regarding the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) characteristics of lung fungal (LF) infections with nodules or masses, which are often misdiagnosed as lung cancer (LC) with indications for surgery. We aimed to investigate the PET/CT findings of LF infections with nodules in comparison to those of LC and clarify the diagnostic value of 18F-FDG PET/CT in the differential diagnosis of LF infections.Methods: We enrolled 21 patients who presented with pulmonary nodules or masses on CT, were diagnosed with LF infections, and underwent PET/CT as the LF group and randomly selected 42 patients with LC diagnosed by pathology as the LC group. Clinical and PET/CT imaging data were statistically analyzed.Results: LC was the most common misdiagnosed disease in the LF group (52.38%). There were no significant differences in lung imaging features between the two groups. The levels of white blood cells, neutrophils, and IgG and the positive rates for fungal antigen test in the LF group were significantly higher than those in the LC group (P<0.05). Lung masses larger than 3 cm were more common in the LC group (P<0.05). Overall, 80.95% (17/21) of patients in the LF group showed increased 18F-FDG uptake. There were no significant between-group differences in the maximal standardized uptake value (SUVmax, 8.20 [2.70, 12.95] vs. 8.80 [7.00, 12.38]). In the LF group, eight, five, and eight patients had cryptococcal, Aspergillus, and Talaromyces marneffei infections, respectively, with no significant difference in SUVmax among them (5.10 [1.70, 14.40] vs. 8.20 [1.50, 8.20] vs. 8.50 [5.10, 11.30]). Conclusions: Both LF infection and LC can present with increased 18F-FDG uptake on PET/CT. Thus, it is difficult to distinguish between them according to lung PET/CT and CT manifestations. Patients presenting with pulmonary masses should also be suspected to have fungal infection, even those with an increased SUVmax and simultaneous lymph node and bone involvement; particular attention is needed for patients with abnormal inflammation indexes and fungal antigen test. We should be emphasized preoperative pathological examination and fungal etiology.

CLINICAL SYMPTOMS, ULTRASOUND AND HISTOPATHOLOGY OF TUMORLIKE LESIONS OF THE BLADDER.

2017 ◽  
pp. 41-46
Author(s):  
Van Mao Nguyen ◽  
Thi Bich Chi Nguyen
Keyword(s):  
Bladder Cancer ◽  
Bladder Tumor ◽  
Clinical Symptoms ◽  
Bladder Wall ◽  
Lower Abdominal Pain ◽  
University Hospital ◽  
Wall Thickening ◽  
Health Examination ◽  
Ultrasound Images ◽  
Key Words Bladder Cancer

Background: Bladder cancer is one of the most frequent type of urinary cancer which has been ever increasing. For the better treatment, the early discovery and definite diagnosis of this disease played an important role. Objective: To describe some clinical symptoms and ultrasound features of tumorlike lesions of the bladder. To diagnose and classify the histopathology of tumorlike lesions of the bladder. Materials, method: cross - sectional study on 64 cases in Hue University Hospital and Hue central hospital from April, 2016 to February, 2017. Results: Hematuria was the most common reason that patients went to hospital (79.7%). Lower abdominal pain and irritation during urination accounting for 9.4% and 6.2% respectively. Only 3 patients with bladder cancer were accidentally discovered through periodic health examination (4.7%). The characteristics of hematuria in bladder tumor was flesh red urine (62.5%) and total hematuria (60.7%). With ultrasonography, the results of 64 patients were divided in 3 groups as follow: bladder tumor, which was the highest rate 87.5%, bladder polyp was 3.1% and focal bladder wall thickening was 9.4%. Of which, the vast majority of these ultrasound images was tumor - like lesions protruding in the lumen of the bladder (75%), the rest was wall thickening lesions (25%). Tumors were different in size, the biggest tumor was 7cm in diameter and the smallest was 0.6cm. Those with the diameter 3cm or bigger accounting for 42.2%, the smaller was 57.8%. Most cases have only one lesion (62.5%) and at lateral wall (46.6%). Histopathologically, cancer was 59/64 case (92.2%): urothelial carcinoma was 98.3 %, squamous cell carcinomawas 1.7% and 5 cases (7.8%) were benign. Most cancerous cases were poorly differentiated, grade II (50.9%) and grade III (32.2%). The stage T1NxMx was 20.3% and worse than T2MxNx was 79.7%. Conclusion: hematuria was the most popular symptom, suggesting bladder cancer. Clinical diagnosing bladder cancer was not high sensitive (61.01%). Ultrasound could detect bladder tumor with high sensitive (89.8%). These patients also needed histopathology classification to diagnose and finally choose the best method for the appropriate treatment. Key words: bladder cancer, histopathology, ultrasound, uroepithelial carcinoma, hematuria

Prevalence of COVID-19-like Symptoms among People Living with HIV, and Using Antiretroviral Therapy for Prevention and Treatment

2020 ◽  
Vol 18 (5) ◽  
pp. 373-380 ◽  
Author(s):  
SeyedAhmad SeyedAlinaghi ◽  
Maryam Ghadimi ◽  
Mahboubeh Hajiabdolbaghi ◽  
Mehrnaz Rasoolinejad ◽  
Ladan Abbasian ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Antiretroviral Treatment ◽  
Clinical Symptoms ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Shortness Of Breath ◽  
Sectional Study ◽  
Limited Data ◽  
Cross Sectional ◽  
Living With Hiv

Background: COVID-19 has spread globally with remarkable speed, and currently, there is limited data available exploring any aspect of the intersection between HIV and SARSCoV- 2 co-infection. Objective: To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran. Design: Cross-sectional study. Methods: A total of 200 PLWH were recruited through the positive club via sampling, and completed the symptom-based questionnaire for COVID-19, which was delivered by trained peers. Results: Of 200 participants, respiratory symptoms, including cough, sputum, and shortness of breath, were the most prevalent among participants, but only one person developed symptoms collectively suggested COVID-19 and sought treatments. Conclusions: It appears that existing infection with HIV or receiving antiretroviral treatment (ART) might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. Further research is needed to understand causal mechanisms.

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